메뉴 건너뛰기




Volumn 35, Issue 5, 2011, Pages 579-584

Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia

Author keywords

Acute myeloid leukemia; HIF 1 ; Hypoxia; Marrow immunohistochemistry; VEGF

Indexed keywords

ANTHRACYCLINE; CYTARABINE; FLT3 LIGAND; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEOPHOSMIN; VASCULOTROPIN A; VASCULOTROPIN C;

EID: 79954591044     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.10.020     Document Type: Article
Times cited : (64)

References (48)
  • 1
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3(10):721-732.
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 2
    • 70249099280 scopus 로고    scopus 로고
    • Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3
    • Selvendiran K., Bratasz A., Kuppusamy M.L., Tazi M.F., Rivera B.K., Kuppusamy P. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer 2009, 125(9):2198-2204.
    • (2009) Int J Cancer , vol.125 , Issue.9 , pp. 2198-2204
    • Selvendiran, K.1    Bratasz, A.2    Kuppusamy, M.L.3    Tazi, M.F.4    Rivera, B.K.5    Kuppusamy, P.6
  • 3
    • 77954661120 scopus 로고    scopus 로고
    • Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells
    • Fiegl M., Samudio I., Mnjoyan Z., Korchin B., Fritsche H., Andreeff M. Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells. Leukemia 2010, 24(7):1364-1367.
    • (2010) Leukemia , vol.24 , Issue.7 , pp. 1364-1367
    • Fiegl, M.1    Samudio, I.2    Mnjoyan, Z.3    Korchin, B.4    Fritsche, H.5    Andreeff, M.6
  • 4
    • 78149468597 scopus 로고    scopus 로고
    • Low bone marrow oxygen tension and hypoxia-inducible factor-1alpha overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138(+) cells
    • Colla S., Storti P., Donofrio G., Todoerti K., Bolzoni M., Lassaretti M., et al. Low bone marrow oxygen tension and hypoxia-inducible factor-1alpha overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138(+) cells. Leukemia 2010.
    • (2010) Leukemia
    • Colla, S.1    Storti, P.2    Donofrio, G.3    Todoerti, K.4    Bolzoni, M.5    Lassaretti, M.6
  • 5
    • 34447616779 scopus 로고    scopus 로고
    • Oxygen saturation in the bone marrow of healthy volunteers
    • Harrison J.S., Rameshwar P., Chang V., Bandari P. Oxygen saturation in the bone marrow of healthy volunteers. Blood 2002, 99(1):394.
    • (2002) Blood , vol.99 , Issue.1 , pp. 394
    • Harrison, J.S.1    Rameshwar, P.2    Chang, V.3    Bandari, P.4
  • 6
    • 73949121249 scopus 로고    scopus 로고
    • The hematopoietic stem cell niche: low in oxygen but a nice place to be
    • Eliasson P., Jonsson J. The hematopoietic stem cell niche: low in oxygen but a nice place to be. J Cell Physiol 2010, 222(1):17-22.
    • (2010) J Cell Physiol , vol.222 , Issue.1 , pp. 17-22
    • Eliasson, P.1    Jonsson, J.2
  • 7
    • 38349000624 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent
    • Song L.P., Zhang J., Wu S.F., Huang Y., Zhao Q., Cao J.P., et al. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene 2008, 27(4):519-527.
    • (2008) Oncogene , vol.27 , Issue.4 , pp. 519-527
    • Song, L.P.1    Zhang, J.2    Wu, S.F.3    Huang, Y.4    Zhao, Q.5    Cao, J.P.6
  • 8
    • 77957335239 scopus 로고    scopus 로고
    • Hypoxia increases HIF-1alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells
    • Hatfield K.J., Bedringsaas S.L., Ryningen A., Gjertsen B.T., Bruserud O. Hypoxia increases HIF-1alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. Eur Cytokine Netw 2010.
    • (2010) Eur Cytokine Netw
    • Hatfield, K.J.1    Bedringsaas, S.L.2    Ryningen, A.3    Gjertsen, B.T.4    Bruserud, O.5
  • 9
    • 2542643823 scopus 로고    scopus 로고
    • Bone marrow microvessel density and its prognostic significance in AML
    • Rabitsch W., Sperr W.R., Lechner K., Chott A., Prinz E., Valent P., et al. Bone marrow microvessel density and its prognostic significance in AML. Leuk Lymphoma 2004, 45(7):1369-1373.
    • (2004) Leuk Lymphoma , vol.45 , Issue.7 , pp. 1369-1373
    • Rabitsch, W.1    Sperr, W.R.2    Lechner, K.3    Chott, A.4    Prinz, E.5    Valent, P.6
  • 10
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • Aguayo A., Estey E., Kantarjian H., Mansouri T., Gidel C., Keating M., et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia. Blood 1999, 94(11):3717-3721.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3    Mansouri, T.4    Gidel, C.5    Keating, M.6
  • 11
    • 0036785053 scopus 로고    scopus 로고
    • New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: does it matter?
    • de Bont E.S., Neefjes V.M., Rosati S., Vellenga E., Kamps W.A. New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: does it matter?. Leuk Lymphoma 2002, 43(10):1901-1909.
    • (2002) Leuk Lymphoma , vol.43 , Issue.10 , pp. 1901-1909
    • de Bont, E.S.1    Neefjes, V.M.2    Rosati, S.3    Vellenga, E.4    Kamps, W.A.5
  • 12
    • 73949133917 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway
    • Chien M.H., Ku C.C., Johansson G., Chen M.W., Haiao M., Su J.L., et al. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis 2009, 30(12):2005-2013.
    • (2009) Carcinogenesis , vol.30 , Issue.12 , pp. 2005-2013
    • Chien, M.H.1    Ku, C.C.2    Johansson, G.3    Chen, M.W.4    Haiao, M.5    Su, J.L.6
  • 13
    • 0037085765 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
    • Dias S., Choy M., Alitalo K., Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 2002, 99(6):2179-2184.
    • (2002) Blood , vol.99 , Issue.6 , pp. 2179-2184
    • Dias, S.1    Choy, M.2    Alitalo, K.3    Rafii, S.4
  • 14
    • 77956587147 scopus 로고    scopus 로고
    • High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia
    • de Jonge H.J., Valk P.J., Veeger N.J., Chen M.W., Haiao M., Su J.L., et al. High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia. Blood 2010, 110(10):1747-1754.
    • (2010) Blood , vol.110 , Issue.10 , pp. 1747-1754
    • de Jonge, H.J.1    Valk, P.J.2    Veeger, N.J.3    Chen, M.W.4    Haiao, M.5    Su, J.L.6
  • 15
    • 77956228968 scopus 로고    scopus 로고
    • Se-methylselenocysteine sensitizes hypoxic cells to irinotecan by targeting hypoxia-inducible factor 1alpha
    • Sreenivasulu C., Toth K., Cao S., Durrani F.A., Vaughan M.M., Jensen R.L., et al. Se-methylselenocysteine sensitizes hypoxic cells to irinotecan by targeting hypoxia-inducible factor 1alpha. Cancer Chemother Pharmacol 2010, 66(5):899-911.
    • (2010) Cancer Chemother Pharmacol , vol.66 , Issue.5 , pp. 899-911
    • Sreenivasulu, C.1    Toth, K.2    Cao, S.3    Durrani, F.A.4    Vaughan, M.M.5    Jensen, R.L.6
  • 16
    • 0038365363 scopus 로고    scopus 로고
    • Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay
    • Murphy K.M., Levis M., Hafez M.J., Geiger T., Cooper L.C., Smith B.D., et al. Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay. J Mol Diagn 2003, 5(2):96-102.
    • (2003) J Mol Diagn , vol.5 , Issue.2 , pp. 96-102
    • Murphy, K.M.1    Levis, M.2    Hafez, M.J.3    Geiger, T.4    Cooper, L.C.5    Smith, B.D.6
  • 17
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria. Treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    • Cheson B.D., Bennett J.M., Kopecky K.J., Buchner T., Willman C.L., Estey E.H., et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria. Treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol 2003, 21(24):4642-4649.
    • (2003) J Clin Oncol , vol.21 , Issue.24 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3    Buchner, T.4    Willman, C.L.5    Estey, E.H.6
  • 18
    • 0036841072 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes
    • Aguayo A., Kantarjian H.M., Estey E.H., Giles F.J., Verstovsek S., Manshouri T., et al. Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes. Cancer 2002, 95(9):1923-1930.
    • (2002) Cancer , vol.95 , Issue.9 , pp. 1923-1930
    • Aguayo, A.1    Kantarjian, H.M.2    Estey, E.H.3    Giles, F.J.4    Verstovsek, S.5    Manshouri, T.6
  • 19
    • 33947642080 scopus 로고    scopus 로고
    • Autocrine VEGF loops, signaling pathways, and acute leukemia regulation
    • Fragoso R., Elias A.P., Dias S. Autocrine VEGF loops, signaling pathways, and acute leukemia regulation. Leuk Lymphoma 2007, 48(3):481-488.
    • (2007) Leuk Lymphoma , vol.48 , Issue.3 , pp. 481-488
    • Fragoso, R.1    Elias, A.P.2    Dias, S.3
  • 20
    • 34548176273 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells
    • Tomita M., Semenza G.L., Michiels C., Matsuda T., Uchihara J.N., Okudaira T., et al. Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. Biochem J 2007, 406(2):317-323.
    • (2007) Biochem J , vol.406 , Issue.2 , pp. 317-323
    • Tomita, M.1    Semenza, G.L.2    Michiels, C.3    Matsuda, T.4    Uchihara, J.N.5    Okudaira, T.6
  • 21
    • 2342578097 scopus 로고    scopus 로고
    • Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF
    • Wellmann S., Guschmann M., Griethe W., Eckert C., von Stackelberg A., Lottaz C., et al. Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF. Leukemia 2004, 18(5):926-933.
    • (2004) Leukemia , vol.18 , Issue.5 , pp. 926-933
    • Wellmann, S.1    Guschmann, M.2    Griethe, W.3    Eckert, C.4    von Stackelberg, A.5    Lottaz, C.6
  • 22
    • 33745022323 scopus 로고    scopus 로고
    • Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization
    • Zheng X., Ruas J.L., Cao R., Poellinger L., Pereira T. Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol Cell Biol 2006, 26(12):4628-4641.
    • (2006) Mol Cell Biol , vol.26 , Issue.12 , pp. 4628-4641
    • Zheng, X.1    Ruas, J.L.2    Cao, R.3    Poellinger, L.4    Pereira, T.5
  • 23
    • 39849102836 scopus 로고    scopus 로고
    • HIF-1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K.V., Petritsch C., Lu K., Liu P., Haller A., et al. HIF-1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008, 13(3):206-220.
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Lu, K.4    Liu, P.5    Haller, A.6
  • 24
    • 77951040369 scopus 로고    scopus 로고
    • Metabolism and the leukemic stem cell
    • Abdel-Wahab O., Levine R.L. Metabolism and the leukemic stem cell. J Exp Med 2010, 207(4):677-680.
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 677-680
    • Abdel-Wahab, O.1    Levine, R.L.2
  • 25
    • 77952673654 scopus 로고    scopus 로고
    • Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming
    • Zhao F., Mancuso A., Bui T.V., Tong A., Gruber J.J., Swider C.R., et al. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming. Oncogene 2010, 29(20):2962-2972.
    • (2010) Oncogene , vol.29 , Issue.20 , pp. 2962-2972
    • Zhao, F.1    Mancuso, A.2    Bui, T.V.3    Tong, A.4    Gruber, J.J.5    Swider, C.R.6
  • 26
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group
    • Boissel N., Nibourel O., Renneville A., Gardin C., Reman O., Contentin N., et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2010, 28(23):3717-3723.
    • (2010) J Clin Oncol , vol.28 , Issue.23 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3    Gardin, C.4    Reman, O.5    Contentin, N.6
  • 27
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Marcucci G., Maharry K., Wu Y.Z., Radmacher M.D., Mrozek K., Margeson D., et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28(14):2348-2355.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrozek, K.5    Margeson, D.6
  • 28
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P., Schlenk R.F., Gaidzik V.I., Habdank M., Kronke J., Bullinger L., et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28(22):3636-3643.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 29
    • 69349102011 scopus 로고    scopus 로고
    • Hypoxia-HIF-1alpha-C/EBPalpha/Runx1 signaling in leukemic cell differentiation
    • Zhang J., Chen G.Q. Hypoxia-HIF-1alpha-C/EBPalpha/Runx1 signaling in leukemic cell differentiation. Pathophysiology 2009, 16(4):297-303.
    • (2009) Pathophysiology , vol.16 , Issue.4 , pp. 297-303
    • Zhang, J.1    Chen, G.Q.2
  • 30
    • 43449117496 scopus 로고    scopus 로고
    • HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4 mediated production of IL-6
    • Lall H., Coughlan K., Sumbayev V. HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4 mediated production of IL-6. Mol Immunol 2008, 45:3045-3049.
    • (2008) Mol Immunol , vol.45 , pp. 3045-3049
    • Lall, H.1    Coughlan, K.2    Sumbayev, V.3
  • 31
    • 70449720501 scopus 로고    scopus 로고
    • FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression
    • Jin G., Matsushita H., Asai S., Tsukamato H., Ono R., Nosaka T., et al. FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression. Biochem Biophys Res Commun 2009, 390(3):1001-1006.
    • (2009) Biochem Biophys Res Commun , vol.390 , Issue.3 , pp. 1001-1006
    • Jin, G.1    Matsushita, H.2    Asai, S.3    Tsukamato, H.4    Ono, R.5    Nosaka, T.6
  • 33
    • 63849150122 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma
    • Dorevic G., Matusan-Ilijas K., Babarovic E., Hadzisejdic I., Grahovac M., Grahovac B., et al. Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma. J Exp Clin Cancer Res 2009, 28:40.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 40
    • Dorevic, G.1    Matusan-Ilijas, K.2    Babarovic, E.3    Hadzisejdic, I.4    Grahovac, M.5    Grahovac, B.6
  • 34
    • 33747589866 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer
    • Schoppmann S.F., Fenzl A., Schindl M., Bachleitner-Hofmann T., Nagy K., Gnant M., et al. Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat 2006, 99(2):135-141.
    • (2006) Breast Cancer Res Treat , vol.99 , Issue.2 , pp. 135-141
    • Schoppmann, S.F.1    Fenzl, A.2    Schindl, M.3    Bachleitner-Hofmann, T.4    Nagy, K.5    Gnant, M.6
  • 35
    • 13844276107 scopus 로고    scopus 로고
    • Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer
    • Katsuta M., Miyashita M., Makino H., Nomura T., Shinji S., Yamashita K., et al. Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol 2005, 78(2):123-130.
    • (2005) Exp Mol Pathol , vol.78 , Issue.2 , pp. 123-130
    • Katsuta, M.1    Miyashita, M.2    Makino, H.3    Nomura, T.4    Shinji, S.5    Yamashita, K.6
  • 36
    • 45949094637 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma
    • Liang X., Yang D., Hu J., Hao X., Gao J., Mao Z. Hypoxia inducible factor-1alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma. Anticancer Res 2008, 28(3A):1659-1666.
    • (2008) Anticancer Res , vol.28 , Issue.3 A , pp. 1659-1666
    • Liang, X.1    Yang, D.2    Hu, J.3    Hao, X.4    Gao, J.5    Mao, Z.6
  • 37
    • 40749117992 scopus 로고    scopus 로고
    • Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia
    • Liersch R., Schliemann C., Bieker R., Hintelmann H., Buechner T., Berdel W.E., et al. Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia. Leuk Res 2008, 32(6):954-961.
    • (2008) Leuk Res , vol.32 , Issue.6 , pp. 954-961
    • Liersch, R.1    Schliemann, C.2    Bieker, R.3    Hintelmann, H.4    Buechner, T.5    Berdel, W.E.6
  • 38
    • 38949171393 scopus 로고    scopus 로고
    • Endogenous vascular endothelial growth factor-C expression is associated with decreased drug responsiveness in childhood acute myeloid leukemia
    • de Jonge H.J., Weidenaar A.C., Ter Elst A., den Boer M.L., Cloos J., de Haas V., et al. Endogenous vascular endothelial growth factor-C expression is associated with decreased drug responsiveness in childhood acute myeloid leukemia. Clin Cancer Res 2008, 14(3):924-930.
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 924-930
    • de Jonge, H.J.1    Weidenaar, A.C.2    Ter Elst, A.3    den Boer, M.L.4    Cloos, J.5    de Haas, V.6
  • 39
    • 0030923575 scopus 로고    scopus 로고
    • Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia
    • Fielder W., Graeven U., Ergun S., Verago S., Kilic N., Stockschlader M., et al. Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia. Leukemia 1997, 11(8):1234-1237.
    • (1997) Leukemia , vol.11 , Issue.8 , pp. 1234-1237
    • Fielder, W.1    Graeven, U.2    Ergun, S.3    Verago, S.4    Kilic, N.5    Stockschlader, M.6
  • 40
    • 51449105857 scopus 로고    scopus 로고
    • Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
    • Liu L., Marti G.P., Wei X., Zhang X., Zhang H., Liu Y.V., et al. Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 2008, 217(2):319-327.
    • (2008) J Cell Physiol , vol.217 , Issue.2 , pp. 319-327
    • Liu, L.1    Marti, G.P.2    Wei, X.3    Zhang, X.4    Zhang, H.5    Liu, Y.V.6
  • 41
    • 33751172127 scopus 로고    scopus 로고
    • Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B
    • Frohling S., Schlenk R.F., Kayser S., Morhardt M., Benner A., Dohner K., et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B. Blood 2006, 108(10):3280-3288.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3280-3288
    • Frohling, S.1    Schlenk, R.F.2    Kayser, S.3    Morhardt, M.4    Benner, A.5    Dohner, K.6
  • 42
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow R.G., Hill R.P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008, 8(3):180-192.
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 43
    • 20444445152 scopus 로고    scopus 로고
    • Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells
    • Mayerhofer M., Aichberger K.J., Florian S., Krauth M.T., Hauswirth A.W., Derdak S., et al. Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. FASEB J 2005, 19(8):960-962.
    • (2005) FASEB J , vol.19 , Issue.8 , pp. 960-962
    • Mayerhofer, M.1    Aichberger, K.J.2    Florian, S.3    Krauth, M.T.4    Hauswirth, A.W.5    Derdak, S.6
  • 44
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C., Steudel C., Mohr B., Schaich M., Schakel U., Platzbecker U., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002, 99(12):4326-4335.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6
  • 45
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
    • Mrozek K., Marcucci G., Paschka P., Whitman S.P., Bloomfield C.D. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 2007, 109(2):431-448.
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 46
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1alpha transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee K., Qian D.Z., Rey S., Wei H., Liu J.O., Semenza G.L. Anthracycline chemotherapy inhibits HIF-1alpha transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 2009, 106(7):2353-2358.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.7 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 47
    • 67349201377 scopus 로고    scopus 로고
    • Targeting tumor angiogenesis with histone deacetylase inhibitors
    • Ellis L., Hammers H., Pili R. Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 2009, 280(2):145-153.
    • (2009) Cancer Lett , vol.280 , Issue.2 , pp. 145-153
    • Ellis, L.1    Hammers, H.2    Pili, R.3
  • 48
    • 50349091316 scopus 로고    scopus 로고
    • Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors
    • Verheul H.M., Salumbides B., Van Erp K., Hammers H., Qian D.Z., Sanni T., et al. Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors. Clin Cancer Res 2008, 14(11):3589-3597.
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3589-3597
    • Verheul, H.M.1    Salumbides, B.2    Van Erp, K.3    Hammers, H.4    Qian, D.Z.5    Sanni, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.