Design, synthesis, and X-ray structure of substituted bis-tetrahydrofuran (bis-THF)-derived potent HIV-1 protease inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 4, 2011, Pages 298-302

  Ghosh, Arun K ^a   Martyr, Cuthbert D ^a   Steffey, Melinda ^a   Wang, Yuan Fang ^b   Agniswamy, Johnson ^b   Amano, Masayuki ^c   Weber, Irene T ^b   Mitsuya, Hiroaki ^c,d  

^a PURDUE UNIVERSITY   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c KUMAMOTO UNIVERSITY   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

bis THF; Darunavir; design; drug resistant; HIV 1 protease inhibitors; synthesis; X ray structure I

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; PRIORITY JOURNAL; SUBSTITUTION REACTION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79954588044     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100289m     Document Type: Article

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