Genetic markers of obesity risk: Stronger associations with body composition in overweight compared to normal-weight children

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Beyerlein, Andreas ^a   von Kries, Rüdiger ^a   Ness, Andrew R ^b   Ong, Ken K ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b Oral Nanoscience School of Oral and Dental Sciences   (United Kingdom)

^c INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; BODY WEIGHT; CHILD; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MALE; OBESITY; RISK FACTOR; SCHOOL CHILD; SCORING SYSTEM; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; REGRESSION ANALYSIS;

ADIPOSITY; BODY COMPOSITION; CHILD; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; OBESITY; OVERWEIGHT; REGRESSION ANALYSIS; RISK FACTORS;

EID: 79954563590     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019057     Document Type: Article

References (24)

1. Wang Y, Lobstein T, (2006) Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 1: 11-25.
2. Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, et al. (1990) The response to long-term overfeeding in identical twins. N Engl J Med 322: 1477-1482.
3. Stunkard AJ, Foch TT, Hrubec Z, (1986) A twin study of human obesity. JAMA 256: 51-54.
4. Locard E, Mamelle N, Billette A, Miginiac M, Munoz F, et al. (1992) Risk factors of obesity in a five year old population. Parental versus environmental factors. Int J Obes Relat Metab Disord 16: 721-729.
5. Toschke AM, Beyerlein A, von Kries R, (2005) Children at high risk for overweight: a classification and regression trees analysis approach. Obesity Research 13: 1270-1274.
6. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
7. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
8. Elks CE, Loos RJ, Sharp SJ, Langenberg C, Ring SM, et al. (2010) Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med 7: e1000284.
9. Beyerlein A, Toschke AM, von Kries R, (2010) Risk factors for childhood overweight: shift of the mean body mass index and shift of the upper percentiles: results from a cross-sectional study. Int J Obes (Lond) 34: 642-648.
10. Toschke AM, von Kries R, Beyerlein A, Rückinger S, (2008) Risk factors for childhood obesity: shift of the entire BMI distribution vs. shift of the upper tail only in a cross sectional study. BMC Public Health 8: 115.
11. Beyerlein A, Toschke AM, von Kries R, (2008) Breastfeeding and childhood obesity: shift of the entire BMI distribution or only the upper parts? Obesity (Silver Spring) 16: 2730-2733.
12. Koenker R, (2005) Quantile regression. New York Cambridge University Press.
13. Beyerlein A, Fahrmeir L, Mansmann U, Toschke AM, (2008) Alternative regression models to assess increase in childhood BMI. BMC Med Res Methodol 8: 59.
14. Golding J, (2004) The Avon Longitudinal Study of Parents and Children (ALSPAC)-study design and collaborative opportunities. Eur J Endocrinol 151 (Suppl 3): U119-123.
15. Cole TJ, Green PJ, (1992) Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11: 1305-1319.
16. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH, (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320: 1240-1243.
17. Wells JC, Cole TJ, (2002) Adjustment of fat-free mass and fat mass for height in children aged 8 y. Int J Obes Relat Metab Disord 26: 947-952.
18. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
19. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
20. Koenker R, (1994) Intervals for regression quantiles. In: Mandl P, Huskova M, editors. Asymptotic Statistics New York: Springer pp. 349-359.
21. Terry MB, Wei Y, Esserman D, (2007) Maternal, birth, and early-life influences on adult body size in women. Am J Epidemiol 166: 5-13.
22. Bressler J, Kao WH, Pankow JS, Boerwinkle E, (2010) Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS One 5: e10521.
23. Liu C, Ackerman HH, Carulli JP, (2011) A genome-wide screen of gene-gene interactions for rheumatoid arthritis susceptibility. Hum Genet [epub ahead of print].
24. Reinehr T, Hebebrand J, Friedel S, Toschke AM, Brumm H, et al. (2009) Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) 17: 382-389.