Congenital heart defects and maternal genetic, metabolic, and lifestyle factors

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 91, Issue 4, 2011, Pages 195-203

  Hobbs, Charlotte A ^a   Macleod, Stewart L ^a   Jill James, S ^a   Cleves, Mario A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Folic acid; Homocysteine; Malformations; Methionine; Recursive partitioning; SNPs

Indexed keywords

BIOLOGICAL MARKER; GLUTATHIONE; GLUTATHIONE DISULFIDE; HOMOCYSTEINE; METHIONINE;

ADULT; ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; FEMALE; FOLATE METABOLISM; GENETIC VARIABILITY; GENOTYPE; GLUTATHIONE METABOLISM; HEREDITY; HUMAN; HUMAN TISSUE; LIFESTYLE; MAJOR CLINICAL STUDY; PREGNANCY; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ARKANSAS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FOLIC ACID; GENETIC VARIATION; GENOTYPE; GLUTATHIONE DISULFIDE; HEART DEFECTS, CONGENITAL; HUMANS; LIFE STYLE; LINEAR MODELS; LOGISTIC MODELS; METHIONINE; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RISK FACTORS;

EID: 79954557224     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20784     Document Type: Article

References (37)

1. Alpsoy L, Yildirim A, Agar G. 2009. The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes. Toxicol Ind Health 25: 121-127.
2. Anderson TW, Darling DA. 1952. Asymptotic theory of certain "goodness-of-fit" criteria based on stochastic processes. Ann Math Statist 23: 193-212.
3. Botto LD, Lin AE, Riehle-Colarusso T, et al. 2007. Seeking causes: classifying and evaluating congenital heart defects in etiologic studies. Birth Defects Res A Clin Mol Teratol 79: 714-727.
4. Botto LD, Mulinare J, Erickson JD. 2003. Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps. Am J Med Genet A 121A: 95-101.
5. Christianson A, Howson C, Modell B. 2006. March of Dimes Global Report of Birth Defects: the hidden toll of dying and disabled children. White Plains, NY: March of Dimes Birth Defects Foundation.
6. Cleves M. 1999. sg120: Receiver Operating Characteristic (ROC) analysis. Stata Technical Bulletin 52: 19-33.
7. Dorfman DD, Alf E. 1969. Maximum-likelihood estimation of parameters of signal-detection theory and determination of confidence intervals-rating method data. J Math Psychol 6: 487-496.
8. Fiore G, Capasso A. 2008. Effects of vitamin E and C on placental oxidative stress: an in vitro evidence for the potential therapeutic or prophylactic treatment of preeclampsia. Med Chem 4: 526-530.
9. Goldmuntz E, Woyciechowski S, Renstrom D, et al. 2008. Variants of folate metabolism genes and the risk of conotruncal cardiac defects. Circ Cardiovasc Genet 1: 126-132.
10. Grewal J, Carmichael SL, Ma C, et al. 2008. Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies. Birth Defects Res A Clin Mol Teratol 82: 519-526.
11. Hobbs CA, Cleves MA, Melnyk S, et al. 2005a. Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism. Am J Clin Nutr 81: 147-153.
12. Hobbs CA, Cleves MA, Zhao W, et al. 2005b. Congenital heart defects and maternal biomarkers of oxidative stress. Am J Clin Nutr 82: 598-604.
13. Hobbs CA, James SJ, Jernigan S, et al. 2006a. Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. Am J Obstet Gynecol 194: 218-224.
14. Hobbs CA, James SJ, Parsian A, et al. 2006b. Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene. J Med Genet 43: 162-166.
15. Jenkins KJ, Correa A, Feinstein JA, et al. 2007. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 115: 2995-3014.
16. Jongbloet PH. 2007. Non-optimal maturation of the oocyte, maternal MTHFR polymorphisms, periconceptional folate, and decrease of congenital heart defects. Eur Heart J 28: 2043.
17. Källén K. 1999. Maternal smoking and congenital heart defects. Eur J Epidemiol 15: 731-737.
18. Lievers KJ, Afman LA, Kluijtmans LA, et al. 2002. Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem 48: 1383-1389.
19. Lyerly AD, Little MO, Faden RR. 2009. The National Children's Study: a golden opportunity to advance the health of pregnant women. Am J Public Health 99: 1742-1745.
20. Malik S, Cleves MA, Honein MA, et al. 2008. Maternal smoking and congenital heart defects. Pediatrics 121: e810-816.
21. Molloy AM. 2010. Folate-vitamin B12 interrelationships: links to disease risk. In: Bailey LB, editor. Folate in Health and Disease.Second ed. Boca Raton: CRC Press. pp 381-408.
22. Morin I, Platt R, Weisberg I, et al. 2003. Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A 119A: 172-176.
23. Refsum H, Smith DA, Ueland PM, et al. 2004. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50: 3-32.
24. Shaw GM, Lu W, Zhu H, et al. 2009. 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet 10: 49.
25. Shaw GM, O'Malley CD, Wasserman CR, et al. 1995. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 59: 536-545.
26. Stothard KJ, Tennant PW, Bell R, Rankin J. 2009. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301: 636-650.
27. van Beynum IM, den Heijer M, Blom HJ, Kapusta L. 2007. The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis. QJM 100: 743-753.
28. van Beynum IM, Kapusta L, Bakker MK, et al. 2010. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur Heart J 31: 464-471.
29. van Beynum IM, Kapusta L, den Heijer M, et al. 2006. Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation. Eur Heart J 27: 981-987.
30. van Driel LM, Verkleij-Hagoort AC, de Jonge R, et al. 2008. Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs. Birth Defects Res A Clin Mol Teratol 82: 474-481.
31. Verkleij-Hagoort A, Bliek J, Sayed-Tabatabaei F, et al. 2007. Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis. Am J Med Genet A 143A: 952-960.
32. Verkleij-Hagoort AC, van Driel LM, Lindemans J, et al. 2008. Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study. Mol Genet Metab 94: 112-119.
33. von Castel-Dunwoody KM, Kauwell GP, Shelnutt KP, et al. 2005. Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism. Am J Clin Nutr 81: 1436-1441.
34. Wenstrom KD, Johanning GL, Johnston KE, DuBard M. 2001. Association of the C677T methylenetetrahydrofolate reductase mutation and elevated homocysteine levels with congenital cardiac malformations. Am J Obstet Gynecol 184: 806-812, discussion 812-817.
35. Yoon PW, Rasmussen SA, Lynberg MC, et al. 2001. The National Birth Defects Prevention Study. Public Health Rep 116 Suppl 1: 32-40.
36. Zhang HP. 1998. Classification trees for multiple binary responses. J Am Stat Assoc 93: 180-193.
37. Zhu H, Curry S, Wen S, et al. 2005. Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? Am J Med Genet A 135: 274-277.