Bilateral and unilateral arm training improve motor function through differing neuroplastic mechanisms: A single-blinded randomized controlled trial

Neurorehabilitation and Neural Repair

Volumn 25, Issue 2, 2011, Pages 118-129

  Whitall, Jill ^a,b   McCombe Waller, Sandy ^a,b   Sorkin, John D ^a,b   Forrester, Larry W ^a,b   Macko, Richard F ^a,b   Hanley, Daniel F ^a,b,c   Goldberg, Andrew P ^a,b   Luft, Andreas ^a,b,d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Brain imaging; Hemiparesis; Neuroplasticity; Rehabilitation; Stroke

Indexed keywords

ADULT; ANTERIOR CINGULATE; ARM; ARM DISEASE; ARTICLE; BILATERAL ARM TRAINING WITH RHYTHMIC AUDITORY CUEING; BRAIN CORTEX; CONTROLLED STUDY; CORTICAL REORGANIZATION; DOSE MATCHED THERAPEUTIC EXERCISE; FEMALE; FUGL MEYER UPPER EXTREMITY TEST; FUNCTION TEST; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; MUSCLE TRAINING; NERVE CELL PLASTICITY; NEUROLOGIC EXAMINATION; PARESIS; PATIENT SATISFACTION; POSTCENTRAL GYRUS; PRIMARY MOTOR CORTEX; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STROKE PATIENT; SUPERIOR FRONTAL GYRUS; SUPPLEMENTARY MOTOR AREA; WOLF MOTOR FUNCTION TEST;

AGED; ARM; CEREBRAL CORTEX; EXERCISE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURONAL PLASTICITY; PARESIS; PHYSICAL THERAPY MODALITIES; RECOVERY OF FUNCTION; SINGLE-BLIND METHOD; STROKE;

EID: 79954551470     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968310380685     Document Type: Article

References (62)

1. French B, Thomas LH, Leathley MJ, et al. Repetitive task training for improving functional ability after stroke. Cochrane Database Syst Rev. 2007;(4):CD006073.
2. Masiero S, Carraro E. Upper limb movements and cerebral plasticity in post-stroke rehabilitation. Aging Clin Exp Res. 2008;20:103-108. (Pubitemid 351756762)
3. McCombe Waller S, Whitall J. Bilateral arm training: why and who benefits? NeuroRehabilitation. 2008;23:29-41. (Pubitemid 352038560)
4. Stewart KC, Cauraugh JH, Summers JJ. Bilateral movement training and stroke rehabilitation: a systematic review and meta-analysis. J Neurol Sci. 2006;244:89-95.
5. Van Peppen RP, Kwakkel G, Wood-Dauphinee S, Hendriks HJ, Van der Wees PJ, Dekker J. The impact of physical therapy on functional outcomes after stroke: what's the evidence? Clin Rehabil. 2004;18:833-862. (Pubitemid 39642264)
6. Wolf SL, Winstein CJ, Miller JP, et al. Effect of constraintinduced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA. 2006;296:2095-2104. (Pubitemid 44664704)
7. Wolf SL, Winstein CJ, Miller JP, et al. Retention of upper limb function in stroke survivors who have received constraintinduced movement therapy: the EXCITE randomised trial. Lancet Neurol. 2008;7:33-40. (Pubitemid 50013946)
8. Taub E, Miller N, Novack T, et al. Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil. 1993;74:347-354 (Pubitemid 23115348)
9. Lin K-C, Wu C-Y, Liu J-S, Chen Y-T, Hsu C-J. Constraintinduced therapy versus dose-matched control intervention to improve motor ability, basic/extended daily functions, and quality of life in stroke. Neurorehabil Neural Repair. 2009;23:160-165.
10. Stoykov ME, Lewis G, Corcos DM. Comparison of bilateral and unilateral training for upper extremity hemiparesis in stroke. Neurorehabil Neural Repair. 2009;23:945-953.
11. Boake C, Noser EA, Ro T, et al. Constraint-induced movement therapy during early stroke rehabilitation. Neurorehabil Neural Repair. 2007;21:4-21.
12. Rijntjes M, Hobbeling V, Hamzei F, et al. Individual factors in constraint-induced movement therapy after stroke. Neurorehabil Neural Repair. 2005;19:238-249. (Pubitemid 41216300)
13. Van der Lee JH, Wagenaar RC, Lankhorst GJ, Vogelaar T, Deville WL, Bouter LM. Forced use of the upper extremity in chronic stroke patients: results from a single-blind randomized clinical trial. Stroke. 1999;30:2369-2375. (Pubitemid 29517737)
14. Volpe BT, Lynch D, Rykman-Berland A, et al. Intensive sensorimotor arm training mediated by therapist or robot improves hemiparesis in patients with chronic stroke. Neurorehabil Neural Repair. 2008;22:305-310. (Pubitemid 351561668)
15. Cauraugh JH, Kim S. Two coupled motor recovery protocols are better than one: electromyogram-triggered neuromuscular stimulation and bilateral movements. Stroke. 2002;33:1589-1594. (Pubitemid 34619963)
16. Chan M, Tong R, Chung K. Bilateral upper limb training with functional electric stimulation in patyients with chronic stroke. Neurorehabil Neural Repair. 2009;23:357-365.
17. Mudie M, Matyas T. Responses of the densely hemiplegic upper extremity to bilateral training. Neurorehabil Neural Repair. 2001;15:129-140. (Pubitemid 34031133)
18. Donchin O, Gribova A, Steinberg O, Bergman H, Vaadia E. Primary motor cortex is involved in bimanual coordination. Nature. 1998;395:274-278. (Pubitemid 28447551)
19. Donchin O, Gribova A, Steinberg O, Bergman H, Cardoso de Oliveira S, Vaadia E. Local field potentials related to bimanual movements in the primary and supplementary motor cortices. Exp Brain Res. 2001;140:46-55. (Pubitemid 32758973)
20. Donchin O, Gribova A, Steinberg O, Mitz AR, Bergman H, Vaadia E. Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices. J Neurophysiol. 2002;88:3498-3517. (Pubitemid 35448725)
21. Toyokura M, Muro I, Komiya T, Obara M. Relation of bimanual coordination to activation in the sensorimotor cortex and supplementary motor area: analysis using functional magnetic resonance imaging. Brain Res Bull. 1999;48:211-217. (Pubitemid 29177396)
22. Toyokura M, Muro I, Komiya T, Obara M. Activation of presupplementary motor area (SMA) and SMA proper during unimanual and bimanual complex sequences: An analysis using functional magnetic resonance imaging. J Neuroimaging. 2002;12:172-178. (Pubitemid 34252435)
23. Smith AL, Staines WR. Cortical adaptations and motor performance improvements associated with short-term bimanual training. Brain Res. 2006;1071:165-174. (Pubitemid 43255487)
24. Renner CI, Woldag H, Atanasova R, Hummelsheim H. Change of facilitation during voluntary bilateral hand activation after stroke. J Neurol Sci. 2005;239:25-30. (Pubitemid 41622120)
25. Stinear JW, Byblow WD. Disinhibition in the human motor cortex is enhanced by synchronous upper limb movements. J Physiol. 2002;543:307-316. (Pubitemid 34947316)
26. Stinear JW, Byblow WD. The contribution of cervical propriospinal premotoneurons in recovering hemiparetic stroke patients. J Clin Neurophysiol. 2004;21:426-434. (Pubitemid 40076282)
27. Whitall J, McCombe Waller S, Silver KHC, Macko RF. Repetitive bilateral arm training with rhythmic auditory cueing improves motor function in chronic hemiparetic stroke. Stroke. 2000;31:2390-2395.
28. McCombe Waller S, Whitall J. Fine motor control in adults with and without chronic hemiparesis: Baseline comparison to nondisabled adults and effects of bilateral arm training. Arch Phys Med Rehabil. 2004;85:1076-1083. (Pubitemid 38962363)
29. McCombe Waller S, Whitall J. Hand dominance and side of stroke affect rehabilitation in chronic stroke. Clin Rehabil. 2005;19:544-551. (Pubitemid 41131799)
30. Luft AR, McCombe-Waller S, Whitall J, et al. Repetitive bilateral arm training and motor cortex activation in chronic stroke: a randomized controlled trial. JAMA. 2004;292:1853-1861. (Pubitemid 40169296)
31. Berglund K, Fugl-Meyer A. Upper extremity function in hemiplegia. Scand J Rehabil Med. 1986;18:155-157.
32. Filiatraut J, Arsenault A, Dutil E, Bourbonnais D. Motor function and activities of daily living assessments: a study of three tests for persons with hemiplegia. Am J Occup Ther. 1991;45:806-810.
33. Hsueh IP, Hsu M, Sheu C, Lee S, Hsieh CL, Lin JH. Psychometric comparisons of 2 versions of the Fugl-Meyer Motor Scale. Neurorehabil Neural Repair. 2008;22:737-744.
34. Whitall J, Savin DN Jr, Harris-Love M, Waller SM. Psychometric properties of a modified Wolf Motor Function Test for people with mild and moderate upper-extremity hemiparesis. Arch Phys Med Rehabil. 2006;87:656-660.
35. Fritz SL, Blanton S, Uswatte G, Taub E, Wolf SL. Minimal detectable change scores for the Wolf Motor Function Test. Neurorehabil Neural Repair. 2009;23:662-667.
36. Wolf S, Catlin P, Ellis M, Archer A, Morgan B, Piacentino A. Assessing Wolf Motor Function Test as outcome measure for research in patients after stroke. Stroke. 2001;32:1635-1639. (Pubitemid 32631916)
37. Duncan PW, Wallace D, Lai SM, Johnson D, Embretson S, Laster LJ. The Stroke Impact Scale version 2.0: evaluation of reliability, validity, and sensitivity to change. Stroke. 1999;30:2131-2140. (Pubitemid 29473260)
38. Duncan PW, Wallace D, Studenski S, Lai SM, Johnson D. Conceptualization of a new stroke-specific outcome measure: the Stroke Impact Scale. Top Stroke Rehabil. 2001;8:19-33. (Pubitemid 32730154)
39. Norkin C, White D. Measurement of joint motion: A guide to goniometry. 2nd ed. Philadelphia, PA: F.A. Davis Company; 1995.
40. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in spm using a macroscopic anatomical parcellation of the mni mri single-subject brain. Neuroimage. 2002;15:273-289. (Pubitemid 34852226)
41. Shaughnessy M, Michael KM, Resnick B, Nahm E, Kopunek S, Orwig D. Clinical trials and tribulations: challenges to realizing intervention research. J Gerontol Soc Am. 2005;45:670.
42. Richards LG, Senesac CR, Davis SB, Woodbury ML, Nadeau SE. Bilateral arm training with rhythmic auditory cueing in chronic stroke: not always efficacious. Neurorehabil Neural Repair. 2008;22:180-184. (Pubitemid 351287592)
43. Sawaki L, Butler AJ, Leng X, et al. Constraint-induced movement therapy results in increased motor map area in subjects 3-9 months after stroke. Neurorehabil Neural Repair. 2008;22:505-513.
44. Nudo RJ. Adaptive plasticity in motor cortex: implications for rehabilitation after brain injury. J Rehabil Med. 2003; 41(suppl):7-10. (Pubitemid 36833479)
45. Desrosiers J, Bourbonnais D, Noreau L, Rochette A, Bravo G, Bourget A. Participation after stroke compared to normal aging. J Rehabil Med. 2005;37:353-357. (Pubitemid 41823730)
46. Platz T, Eickhof C, van Kaick S, et al. Impairment-oriented training or Bobath therapy for severe arm paresis after stroke: a single-blind, multicentre randomized controlled trial. Clin Rehabil. 2005;19:714-724. (Pubitemid 41489525)
47. Pang MY, Harris JE, Eng JJ. A community-based upperextremity group exercise program improves motor function and performance of functional activities in chronic stroke: a randomized controlled trial. Arch Phys Med Rehabil. 2006; 87:1-9. (Pubitemid 43053296)
48. McCombe Waller S, Liu W, Whitall J. Temporal and spatial control following bilateral versus unilateral training. Hum Mov Sci. 2008;27:749-758.
49. Schaechter JD. Motor rehabilitation and brain plasticity after hemiparetic stroke. Prog Neurobiol. 2004;73:61-72. (Pubitemid 38749091)
50. Carey JR, Kimberley TJ, Lewis SM, et al. Analysis of fMRI and finger tracking training in subjects with chronic stroke. Brain. 2002;125:773-788. (Pubitemid 34279773)
51. Loubinoux I, Carel C, Pariente J, et al. Correlation between cerebral reorganization and motor recovery after subcortical infarcts. Neuroimage. 2003;20:2166-2180. (Pubitemid 37543631)
52. Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of motor recovery after stroke: a longitudinal fmri study. Brain. 2003;126:2476-2496. (Pubitemid 37314437)
53. Page SJ, Szaflarski J, Eliassen J, Pan H, Cramer SC. Cortical plasticity following motor skill learning during mental practice in stroke. Neurorehabil Neural Repair. 2009;23:382-388.
54. Gauthier LV, Taub E, Perkins C, Ortmann M, Mark VW, Uswatte G. Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. Stroke. 2008;39:1520-1525.
55. Ciaramelli E, Grady CL, Moscovitch M. Top-down and bottom-up attention to memory: a hypothesis (atom) on the role of the posterior parietal cortex in memory retrieval. Neuropsychologia. 2008;46:1828-1851.
56. McKeever WF. An x-linked three allele model of hand preference and hand posture for writing. Laterality. 2004;9: 149-173. (Pubitemid 38519078)
57. Golay L, Schnider A, Ptak R. Cortical and subcortical anatomy of chronic spatial neglect following vascular damage. Behav Brain Funct. 2008;4:43.
58. Ertelt D, Small S, Solodkin A, et al. Action observation has a positive impact on rehabilitation of motor deficits after stroke. Neuroimage. 2007;36(suppl 2):T164-T173. (Pubitemid 46702737)
59. Grafton ST, Schmitt P, Van Horn J, Diedrichsen J. Neural substrates of visuomotor learning based on improved feedback control and prediction. Neuroimage. 2008;39: 1383-1395.
60. Juenger H, Linder-Lucht M, Walther M, Berweck S, Mall V, Staudt M. Cortical neuromodulation by constraint-induced movement therapy in congenital hemiparesis: an fmri study. Neuropediatrics. 2007;38:130-136. (Pubitemid 350195629)
61. Dong Y, Winstein C, Albistegui-DuBois R, Dobkin BH. Evolution of fMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after chronic stroke. Neurorehabil Neural Repair. 2007;21: 412-428. (Pubitemid 47246438)
62. Kreisel SH, Hennerici MG, Bazner H. Pathophysiology of stroke rehabilitation: the natural course of clinical recovery, use-dependent plasticity and rehabilitative outcome. Cerebrovasc Dis. 2007;23:243-255. (Pubitemid 46425791)