Prior and concomitant dehydroepiandrosterone treatment affects immunologic response of cultured macrophages infected with Trypanosoma cruzi in vitro?

Veterinary Parasitology

Volumn 177, Issue 3-4, 2011, Pages 242-246

  Kuehn, Christian C ^a   Oliveira, Luiz Gustavo R ^a   Santos, Carla Domingues ^a   Augusto, Mariana B ^a   Toldo, Míriam P Alonso ^a   Do Prado, José Clóvis ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dehydroepiandrosterone; Interleukin 12; Macrophage; Nitric oxide; Trypanosoma cruzi; Tumor necrosis factor alpha

Indexed keywords

INTERLEUKIN 12; NITRIC OXIDE; PRASTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE SYSTEM; LYMPHOCYTE; MACROPHAGE; MALE; MOLECULAR DYNAMICS; NATURAL KILLER CELL; NONHUMAN; RAT; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; DEHYDROEPIANDROSTERONE; INTERLEUKIN-12; MACROPHAGES, PERITONEAL; MALE; NITRIC OXIDE; RATS; RATS, WISTAR; TRYPANOSOMA CRUZI; TUMOR NECROSIS FACTOR-ALPHA;

TRYPANOSOMA CRUZI;

EID: 79954551150     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2010.12.009     Document Type: Article

References (44)

1. Abrahamsohn I.A. Cytokines in innate and acquired immunity to Trypanosoma cruzi infection. Braz. J. Med. Biol. Res. 1998, 31:117-121.
2. Aliberti J.C., Cardoso M.A., Martins G.A., Gazzinelli R.T., Vieira L.Q., Silva J.S. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect. Immun. 1996, 64:1961-1967.
3. Baulieu E.E. Dehydroepiandrosterone (DHEA): a fountain of youth?. J. Clin. Endocrinol. Metab. 1996, 81:3147-3151.
4. Brunet L.R. Review-nitric oxide in parasitic infections. Int. Immunopharmacol. 2001, 1:1457-1467.
5. Brener Z., Gazzinelli R.T. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Aller. Imm. 1997, 114:103-110.
6. Camussi G., Albano E., Tetta C., Bussolino F. The molecular action of tumor necrosis factor-alpha. Eur. J. Biochem. 1991, 202:3-14.
7. Daynes R.A., Araneo B.A., Dowell T.A., Huang K., Dudley D. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T-helper cell function. J. Exp. Med. 1990, 171:979-996.
8. Dos Reis G.A. Cell-mediated immunity in experimental Trypanosoma cruzi infection. Parasitol. Today 1997, 13:335-342.
9. Dos Santos C.D., Toldo M.P., do Prado J.C. Trypanosoma cruzi: the effects of dehydroepiandrosterone (DHEA) treatment during experimental infection. Acta Trop. 2005, 95:109-115.
10. Gazzinelli R.T., Hieny S., Wynn T.A., Wolf S., Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:6115-6119.
11. Griess P. Bemerkungen zu der Abhandlung der H.H. Weselsky und Benedikt Uber einige Azoverbindungen. Chem. Ber. 1879, 12:426-428.
12. Hennebold J.D., Daynes R.A. Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 1994, 135:67-75.
13. The Biological Role of Dehydroepiandrosterone (DHEA) 1990, Walter de Gruyter, New York. M. Kalimi, W. Regelson (Eds.).
14. Khalifa A.M., Ibrahim I.R., El-Kerdany E.D. Coccidial infection in immunosuppressed mice: prophylaxis and treatment with dehydroepiandrosterone. J. East. Mediterr. Health 2000, 6:908-918.
15. Kim S.K., Shin M.S., Jung B.K., Shim J.Y., Won H.S., Lee P.R., Kim A. Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophages cells. J. Reprod. Immun. 2006, 70:71-81.
16. Kroboth P.D., Salek F.S., Pittenger A.L., Fabian T.J., Frye R.F. DHEA and DHEA-S: a review. J. Clin. Pharmacol. 1999, 39:327-348.
17. Kuehn C.C., Oliveira L.G.R., Santos C.D., Ferreira D.S., Toldo M.P.A., Albuquerque S., Prado J.C. Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection?. J. Pineal Res. 2009, 47:253-259.
18. Leenstra T., Kuile F.O., Kariuki S.K., Nixon C.P., Oloo A.J., Kager P.A., Kurtis J.D. Dehydroepiandrosterone sulfate levels associated with decreased malaria parasite density and increased hemoglobin concentration in pubertal girls from western Kenya. J. Infect. Dis. 2003, 188:297-304.
19. Lösel R., Wehling M. Nongenomic actions of steroid hormones. Nat. Rev. Mol. Cell. Biol. 2003, 1:46-56.
20. Minoprio P., Itohara S., Heusser C., Tonegawa S., Coutinho A. Immunobiology of murine T. cruzi infection: the predominance of parasite nonspecific responses and the activation of TCRI T cells. Immunol. Rev. 1989, 112:183-207.
21. Morales-Montor J., Newhouse E., Mohamed F., Baghdati A., Damian R.T. Altered levels of hypothalamic-pituitary-adrenocortical axis hormones in baboons and mice during the course of infection with Schistosoma mansoni. J. Infect. Dis. 2001, 183:313-320.
22. Nathan D., Padgett D.A., Loria R.M. Androstenodiol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity. J. Med. Microbiol. 1999, 48:421-431.
23. Negrette B., Bonilla E., Valero N., Giraldoth D., Medina Leendertz S., Añez F. In mice the efficiency of immunization with Venezuelan equine encephalomyelitis virus TC-83 is transiently increased by dehydroepiandrosterone. Invest. Clín. 2001, 42:235-240.
24. Nieschlang E., Loriaux D.L., Ruder H.J., Zucker I.R., Kirschner M.A., Lipsett M.B. The secretion of dehydroepiandrosterone and dehydroepiandrosterone sulphate in man. J. Clin. Endocrinol. 1973, 57:123-134.
25. Nogueira N., Cohn Z.A. Trypanosoma cruzi: in vitro induction of macrophage microbicidal activity. J. Exp. Med. 1978, 148:288-300.
26. Piemonte M.R., Buchi D.F. Analysis of IL-2, IFN-γ and TNF-α production, α5, β1 integrins and actin filaments distribution in intraperitoneal mouse macrophages treated with homeopathic medicament. J. Submicrosc. Cytol. Pathol. 2002, 34:225-263.
27. Powell J.M., Sonnenfeld G. The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production. J. Interf. Cytok. Res. 2006, 26:34-39.
28. Rasmussen K.R., Healey M.C., Cheng L., Yang S. Effects of dehydroepiandrosterone in immunosuppressed adult mice infected with Cryptosporidium parvum. J. Parasitol. 1995, 81:429-433.
29. Reed S.G. In vivo administration of recombinant IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J. Immun. 1988, 140:4342-4347.
30. Reyes J.L., Terrazas L.I., Espinoza B., Cruz-Robles D., Soto V., Rivera-Montoya I. Macrophage migration inhibitory factor contributes to host defense against acute Trypanosoma cruzi infection. Infect. Immun. 2006, 74:3170-3179.
31. Santos C.D., Toldo M.P., Levy A.M., Kawasse L.M., Zucoloto S., do Prado J.C. Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats. Acta Trop. 2007, 102:143-150.
32. Santos C.D., Toldo M.P., Santello F.H., Filipin M.D.V., Brasão V., Prado J.C. Dehydroepiandrosterone increases resistance to experimental infection by Trypanosoma cruzi. Vet. Parasitol. 2008, 153:238-243.
33. Schmidt M., Kreutz M., Löffer G., Schölmerich J., Straub R.H. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J. Endocrinol. 2000, 164:161-169.
34. Schule R., Rangarajan P., Kliewer S., Ransone U., Bolada J., Yang N., Verma I.M., Evans R.M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. J. Cell 1990, 62:1217-1226.
35. Shelat S.G., Aird F., Redel E. Exposure to dehydroepiandrosterone in utero affects T-cell function in males only. Neuroimmunomodulation 1997, 4:154-162.
36. Silva J.S., Aliberti J.C., Martins G.A., Souza M.A., Souto J.T., Padua M.A. The role of IL-12 in experimental Trypanosoma cruzi infection. Braz. J. Med. Biol. Res. 1998, 31:111-115.
37. Silva J.S., Morrissey P.J., Grabstein K.H., Mohler K.M., Anderson D., Reed S.G. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 1992, 175:169-174.
38. Silva J.C., Vespa G.N.R., Cardoso M.A.G., Aliberti J.C.S., Cunha F.Q. Tumor-necrosis-factor-alpha mediates resistance to Trypanosoma-cruzi infection in mice by inducing nitric-oxide production in infected gamma-interferon-activated macrophages. Infect. Immun. 1995, 63:4862-4867.
39. Tanowitz H.B., Kirchhoff L.V., Simon D., Morris S.A., Weiss L.M., Wittner M. Chagas' disease. Clin. Microbiol. Rev. 1992, 5:400-419.
40. Tarleton R.L. The role of T cells in Trypanosoma cruzi infections. Parasitol. Today 1995, 11:7-9.
41. World Health Organization, 2002. Technical Report Series n° 905. Control of Chagas' disease. WHO, Geneva.
42. Vespa G.N.R., Cunha F.Q., Silva J.S. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect. Immun. 1994, 62:5177-5182.
43. Yamamoto K.R. Steroid receptor regulated transcription of specific genes and gene networks. Ann. Rev. Genet. 1985, 19:209-252.
44. Zhang L., Tarleton R.L. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur. J. Immunol. 1996, 26:102-109.