Exposure to Dehydroepiandrosterone in utero Affects T-Cell Function in Males Only

NeuroImmunoModulation

Volumn 4, Issue 3, 1997, Pages 154-162

  Shelat, Suresh G ^a   Aird, Fraser ^c   Redei, Eva ^a,b,c  

^a Institute of Neurological Sciences   (United States)

^b Departments of Molecular Pharmacology   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dehydroepiandrosterone; IL 2 receptor mRNA; IL 2 receptor mRNA; Lymphocyte proliferation; Pro opiomelanocortin mRNA; Sex differences

Indexed keywords

ANDROGEN; CONCANAVALIN A; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA; PRASTERONE; PROOPIOMELANOCORTIN; RECEPTOR SUBUNIT; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENDER; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; SPLEEN LYMPHOCYTE; STRESS; T LYMPHOCYTE; THYMUS; ADENOHYPOPHYSIS; ANIMAL; CYTOLOGY; DRUG EFFECT; FETOMATERNAL TRANSFUSION; GENETICS; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; PREGNANCY; SPLEEN; SPRAGUE DAWLEY RAT;

ANIMALS; BODY WEIGHT; DEHYDROEPIANDROSTERONE; FEMALE; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; MATERNAL-FETAL EXCHANGE; PITUITARY GLAND, ANTERIOR; PREGNANCY; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031283246     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000097333     Document Type: Article

References (46)

1. Edwards CH, Cole OJ, Oycmade UJ, Knight EM, Johnson AA, Wcstncy OE, Laryca H, West W, Jones S, Wcstncy LS: Maternal stress and pregnancy outcomes in a prenatal clinic population, J Nutr 1994; 124:1006S-1021S.
2. Wadhwa PD, Sandman CA, Porto M, Dunkel-Schelter C, Garitc TJ: The association between prenatal stress and infant birth weight and gestational age at birth: A prospective investigation, Am J Obstel Gynecol 1993:169:858-865.
3. Graham NM, Woodward AJ, Ryan P, Douglas RM: Acute respiratory illness in Adelaide children, II, The relationship of maternal stress, social supports and family functioning, Int J Epidemiol 1990;19:937-944.
4. McCormick C, Smythc J, Sharma S, Mcaney M: Scx-spccific effect of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats, Dev Brain Res 1995:84:55-61
5. Takahashi LK, Baker EW, Kalin NJ: Ontogeny of behaviorial and hormonal responses to stress in prenalally stress male rat pups, Physiol Be-hav 1990:47:357-364.
6. Weinberg J: Hyperresponsiveness to stress: Differential effects of prenatal alcohol on males and females, Alcohol Clin Exp Res 1988:12: 647-652.
7. Weinstock M, Matlina E, Maor GI, Rosen H, McEwen BS: Prenatal stress selectively alters the reactivity ol' the hypothalamic-pituitary-adrenal system in the female rat, Brain Res 1992:595:195-200.
8. Fride E, Dan Y, Feldon J, Halevy G, Wein-stock M: Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats, Physiol Bchav 1986:37:681-687.
9. Meikle AW, Daynes RA, Araneo BA: Adrenal androgen secretion and biologic effects, Endocrinol Mctab Clin North Am 1991:20:381-400.
10. Hercz P, Siklos P, Ungar L: Serum dehydro-epiandrosterone and cortisol concentration in the maternal-fetoplacental hormonal system in elective caesarean section and spontaneous vaginal delivery in the 28th to 36th and 40th weeks of pregnancy, Gynecol Obstet Invest 1990;29:112-114.
11. Migeon CJ, Plager JE: Identification and isolation of dehydroisoandrosterone from peripheral human plasma, J Biol Chem 1954;209:767-772.
12. Druck WE, Blumberg JM, Gandy HM, David RR, Verde AL: Biologic activity of DHEA sulfate in man, J Clin Endocrinol Metab 1972;35: 48-54.
13. Coleman DL: Therapeutic effects of dehydro-epiandrosterone (DHEA) and its metabolites in obese-hyperglycemic mutant mice, Prog Clin Biol Res 1988;265:161-175.
14. Yen TT, Allan JA, Pearson DV, Acton JM, Greenberg MM: Prevention of obesity in Avy/a mice by dehydroepiandrosterone, Lipids 1977; 12:409-413.
15. Windruch R, McFeeters G, Walford RL: Food intake reduction and immunologic alterations in mice fed dehydroepiandrosterone, Exp Gerontol 1984;19:297-304.
16. Regelson W, Loria R, Kalimi M: Dehydroepiandrosterone (DHEA)-the ‘mother steroid', I, Immunologic action, Ann NY Acad Sci 1994:719:553-563.
17. May M, Holmes E, Rogers W, Poth M: Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone, Life Sci 1990;46:1627-1631.
18. Daynes RA, Dudley DJ, Araneo BA; Regulation of murine Ivmphokine production in vivo, II, Dehydroepiandrosterone is a natural enhancer ofIL-2 synthesis by helper T-cclls, Eur J Immunol 1990;20:793-801.
19. Daynes RA, Araneo B: Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factor interleukin 2 and interleukin 4, Eur J Immunol 1990;19:2319-2325.
20. Araneo B, Daynes R: Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury, Endocrinology 1995; 136:393-401.
21. van Weerden WM, Bierings HG, van Steen-buggc GJ, de Jong FH, Schroder FH: Adrenal gland of mouse and rat do not synthesize androgens, Life Sci 1992;50:857-861.
22. Sinha P, Halasz I, Choi JF, McGivem RF, Redei E: Maternal adrenalectomy eliminates a surge of plasma DHEA in the mother and attenuates the prenatal testosterone surge in the male fetus, Endocrinology, in press.
23. Redei E, Halasz I, Li L, Prystowsky MB, Aird F: Maternal adrenalectomy alters the immune and endocrine functions of fetal alcohol-cx-posed male offspring, Endocrinology 1993; 133: 452-460.
24. Fitch RH, McGivem RF, Redei E, Schrott L, Cowell PE, Denenberg VH: Neonatal ovariectomy and pituitary-adrenal responsiveness in the adult rat, Acta Endocrinol (Copenh) 1992; 126:44-48.
25. Leonard WJ: The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: Implications for cytokine pleiotopy and redundancy, CurrOpin Immunol 1994;6:631-635.
26. Feinberg AP, Vogelstein B: A technique of radiolabeling DNA restriction endonuclease fragments to high specific activity, Anal Bio-chem 1983;132:6-13.
27. Uhler M, Herbert E: Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of proopiomelanocortin cDNA, J Biol Chem 1983; 258:257-261.
28. Tokunaga K, Taniguchi H, Yoda K, Shimizu M, Sakiyama S: Nucleotide sequence of a full-length cDNA for mouse cvtoskeletal beta-actin mRNA, Nucleic Acids Res 1986:14:2829.
29. Simard J, Couet J, Durocher F, Labrie Y, Sanchez R, Breton N, Turgeon C, Labrie F: Structure and tissue-specific-expression of a novel member of the rat 3b-hvdroxysteroid dehydrogenase/ A5-A4-isomerase (3b-HSD) family, J Biol Chem 1993;268:19659-19668.
30. Sobrian SK, Vaughn VT, Block EF, Burton LE: Influence of prenatal maternal stress on the immunocompetence of the offspring, Pharmacol Biochem Behav 1992;43:537-547.
31. Peters DA: Maternal stress increases fetal brain and neonatal cerebral cortex 5-hydroxytrypta-mine synthesis in rats: A possible mechanism by which stress influences brain development, Pharmacol Biochem Behav 1990;35:943-947.
32. Svec F, Hilton CW, Wright B, Browne E, Porter JR: The effect of DHEA given chronically to Zucker rats, Proc Soc Exp Biol Med 1995;209: 92-97.
33. Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W: Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA), Mol Cell Biochem 1994;131:99-104.
34. Fritz H, Giese K, Suter HP: Prenatal and postnatal development of rats following the maternal treatment with testosterone during the late period of embryogenesis, Arzneimittelforschung 1984;34:780-782.
35. McGivem R, Holcomb C, Poland RE: Effects of prenatal testosterone propionate treatment on saccharin preference of adult rats exposed to ethanol in utero, Physiol Behav 1987;39:241-246.
36. Dohler KD, Coquelin A, Davis F, Hines M, Shryne J, Sickmoller PM, Jarzab B, Gorski R: Pre-and postnatal influence of an estrogen antagonist and an androgen antagonist on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats, Neuroendocrinology 1986;42:443-448.
37. Takahashi Y, Yamanaki H, Akiyama I, Saku-ma Y: Brain aromatase activity and behavioral consequences in male rat treated in utero with 4-hydroxy-androstenedione, Endocrinol Jpn 1989;36:29-36.
38. Dougherty TF: Effects of hormones on lymphatic tissue, Physiol Rev 1952;32:379-403.
39. Grossman CJ: Regulation of the immune system by sex steroids, Endocrine Rev 1984;5: 435-455.
40. Schuurs AHWM, Verheul HAM: Effects of gender and sex steroids on the immune response, J Steroid Biochem 1990;35:157-172.
41. Olsen NJ, Kovacs WJ: Increased thymic size and thymocyte interleukin-2 production in androgen-resistant mice, Scand J Immunol 1989; 29:733-738.
42. Riley V, Fitzmaurice MA, Regelson W: DHEA and thymus integrity in the mouse; in Kalimi M, Regelson W (eds): The Biologic Role of Dehydroepiandrosterone (DHEA), New York, de Gruyter, 1990, pp 131-155.
43. Crudo DF: Downregulation of glucocorticoid receptors by dehydroepiandrosterone (abstract), Program of the 71st Annual Meeting of the Endocrine Society, Seattle, 1989, p 386.
44. Weinberg J: Prenatal ethanol effects: Sex difference in offspring stress responsiveness, Alcohol 1992;9:219-223.
45. Dcarden LC, Mosier HD, Brundagc M, Thai C, Jansons R: The effects of different steroids on costal and epiphyseal cartilage of fetal and adult rats, Cell Tissue Res 1986;246:401-412.
46. Flood JF, Roberts E: Dehydroepiandrosterone sulfate improves memory in aging mice, Brain Res 1988;448:178-181.