Mechanisms of Chemically Induced Renal Carcinogenesis in the Laboratory Rodent

Toxicologic Pathology

Volumn 26, Issue 1, 1998, Pages 104-112

  Hard, Gordon C ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

cell proliferation; chronic progressive nephropathy; DNA reactivity; epigenetic carcinogens; genotoxic carcinogens; oxidative stress; Renal tubule tumor; tubule cytotoxicity

Indexed keywords

AFLATOXIN B1; ALPHA 2 GLOBULIN; BIS OXO 2 PROPYLNITROSAMINE; DIETHYLNITROSAMINE; DIMETHYLHYDRAZINE; DIMETHYLNITROSAMINE; ETHYLHYDROXYETHYLNITROSAMINE; ETHYLNITROSOUREA; HYDROQUINONE; METHYLAZOXYMETHANOL GLUCOSIDE; METHYLNITROSOUREA; NITRILOTRIACETATE IRON; NITROSAMINE; NITROSOMORPHOLINE; OCHRATOXIN; POTASSIUM BROMATE; UNCLASSIFIED DRUG;

ANIMAL CELL; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; CYTOTOXICITY; DNA ADDUCT; HISTOPATHOLOGY; KIDNEY CARCINOMA; KIDNEY TUBULE CELL; MOUSE; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; CELL DIVISION; DNA, NEOPLASM; FEMALE; KIDNEY FAILURE; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; MICE; OXIDATIVE STRESS; RATS;

EID: 0031935131     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600112     Document Type: Article

References (98)

1. Ahmadizadeh M, Echt R, Kuo CH, and Hook JB (1984). Sex and strain differences in mouse kidney; Bowman's capsule morphology and susceptibility to chloroform. Toxicol. Lett. 20: 161-172.
2. Alden CL and Frith CH (1991). Urinary system. In: Handbook of Toxicologic Pathology, WM Haschek and CG Rousseau (eds). Academic Press, San Diego, pp. 315–387.
3. Anderson LM, Souliotis VL, Chhabra SK, Moskal TJ, Harbaugh SD, and Kyrtopoulos SA (1996). N-nitrosodimethylamine-derived O6-methylguanipe in DNA of monkey gastrointestinal and urogenital organs and enhancement by ethanol. Br. J. Cancer 66: 130-134.
4. Anver MR, Cohen BJ, Lattuada CJP, and Foster SJ (1982). Age-associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap:(SD) and Crl:COBSRCDRSD stocks. Exp. Aging Res. 8: 3-24.
5. Barthold SW (1979). Chronic progressive nephropathy in aging rats. Toxicol. Pathol. 7: 1-6.
6. Benedetti A, Comporti M, and Esterbauer H (1980). Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids. Biochim. Biophys. Acta 620: 281-296.
7. Blatherwick NR and Medlar EM (1937). Chronic nephritis in rats fed high protein diets. Arch. Intern. Med. 59: 572-596.
8. Boorman GA, McDonald MR, Imoto S, and Persing R (1992). Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicol. Pathol. 20: 236-245.
9. Brady JF, Li D, Ishizaki H, Lee M, Ning SM, Xiao F, and Yang CS (1989). Induction of cytochromes P450IIE1 and P450IIB1 by secondary ketones and the role of P450IIE1 in chloroform metabolism. Toxicol. Appl. Pharmacol. 100: 342-349.
10. Butterworth BE, Templin MV, Borghoff SJ, Conolly RB, Kedderis GL, and Wolf DC (1995). The role of regenerative cell proliferation in chloroform-induced cancer. Toxicol. Lett. 82/83: 23-26.
11. Chatterjee B, Demyan WE, Song CS, Garg BD, and Roy AK (1989). Loss of androgenic induction of α2u-globulin gene family in the liver of NIH black rats. Endocrinology 125: 1385-1388.
12. Cho DH, Hong JT, Chin K, Cho TS, and Lee BM (1993). Organotropic formation and disappearance of 8-hydroxydeoxyguanosine in the kidney of Sprague-Dawley rats exposed to adriamycin and KBrO3. Cancer Lett. 74: 141-145.
13. Dietrich DR and Swenberg JA (1991). Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: Predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutat. Res. 248: 239-260.
14. Dietrich DR and Swenberg JA (1991). NCI Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce alpha-2u-globulin (α2u) nephropathy. Fundam. Appl. Toxicol. 16: 749-762.
15. Dietrich DR and Swenberg JA (1991). The presence of α2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. Cancer Res. 51: 3512-3521.
16. Driver HF, White INH, and Butler WH (1987). Dose-response relationships in chemical carcinogenesis: Renal mesenchymal tumours induced in the rat by single dose dimethylnitrosamine. Br. J. Exp. Pathol. 68: 133-143.
17. Ebina Y, Okada S, Hamazaki S, Ogino F, Li J, and Midorikawa O (1986). Nephrotoxicity and renal cell carcinoma after use of iron-and aluminum-nitrilotriacetate complexes in rat. J. Natl. Cancer Inst. 76: 107-113.
18. Elema JD and Arends A (1975). Focal and segmental glomerular hyalinosis and sclerosis in the rat. Lab. Invest. 33: 554-561.
19. English JC, Hill T, O'Donoghue JL, and Reddy MV (1994). Measurement of nuclear DNA modification by 32P-postlabeling in the kidneys of male and female Fischer 344 rats after multiple gavage doses of hydroquinone. Fundam. Appl. Toxicol. 23: 391-396.
20. English JC, Perry LG, Vlaovic M, Moyer C, and O'Donoghue JL (1994). Measurement of cell proliferation in the kidneys of Fischer 344 and Sprague-Dawley rats after gavage administration of hydroquinone. Fundam. Appl. Toxicol. 23: 397-406.
21. Fan CY, Butler WH, and O'Connor PJ (1989). Cell and tissue specific localization of O6-methylguanine in the DNA of rats given N-nitrosodimethylamine: Effects of protein deficient and normal diets. Carcinogenesis 10: 1967-1970.
22. Fan CY, Butler WH, and O'Connor PJ (1991). Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis. In: Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke and Mycotoxins, IK O'Neill, J Chen and H Bartsch (eds). IARC Scientific Publications No. 105, International Agency For Research on Cancer, Lyon, pp. 119–122.
23. Flower DR (1996). The lipocalin protein family: Structure and function. Biochem. J. 318: 1-14.
24. Floyd RA (1990). The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 11: 1447-1450.
25. Foley WA, Jones DCL, Osborn GK, and Kimeldorf DJ (1964). A renal lesion associated with diuresis in the aging Sprague-Dawley rat. Lab. Invest. 13: 439-449.
26. Gray JE (1977). Chronic progressive nephrosis in the albino rat. Crit. Rev. Toxicol. 5: 115-144.
27. Grosse Y, Baudrimont I, Castegnaro M, Betbeder AM, Creppy EE, Dirheimer G, and Pfohl-Leszkowicz A (1995). Formation of ochratoxin A metabolites and DNA-adducts in monkey kidney cells. Chem.-Biol. Interact. 95: 175-187.
28. Halliwell B and Aruoma OL (1991). DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett. 281: 9-19.
29. Hard GC (1984). High frequency single-dose model of renal adenoma/carcinoma induction using dimethylnitrosamine in Crl: (W)BR rats. Carcinogenesis 5: 1047-1050.
30. Hard GC (1985). Identification of a high-frequency model for renal carcinoma by the induction of renal tumors in the mouse with a single dose of streptozotocin. Cancer Res. 45: 703-708.
31. Hard GC (1985). Differential renal tumor response to N-ethylnitrosourea and dimethylnitrosamine in the Nb rat; basis for a new rodent model of nephroblastoma. Carcinogenesis 6: 1551-1558.
32. Hard GC (1990). Tumours of the kidney, renal pelvis and ureter. In: Pathology of Tumours in Laboratory Animals, Vol. 1, Tumours of the Rat, 2nd ed., VS Turusov and U Mohr (eds). IARC Scientific Publication No. 99, International Agency for Research on Cancer, Lyon, pp. 301–344.
33. Hard GC (1997). Comparative kidney carcinogenesis in laboratory rodents and humans In: Testing, Predicting and Interpreting Carcinogenicity, KT Kitchin (ed). Marcel Dekker, New York (in press).
34. Hard GC, Alden CL, Stula EF, and Trump BF (1995). Proliferative lesions of the kidney in rats. In: Guides for Toxicologic Pathology, STP/ARP/AFIP, Washington, DC, pp. 1–19.
35. Hard GC and Boorman GA (1997). Re-evaluation of the chloroform 2-year carcinogenicity bioassays supports sustained renal tubule injury as a mode of action underlying the renal tumor response. Toxicol. Pathol, (in preparation).
36. Hard GC and Butler WH (1970). Cellular analysis of renal neoplasia: Induction of renal tumors in dietary-conditioned rats by dimethylnitrosamine, with a reappraisal of morphological characteristics. Cancer Res. 30: 2796-2805.
37. Hard GC and Butler WH (1971). Morphogenesis of epithelial neoplasms induced in rat kidney by dimethylnitrosamine. Cancer Res. 31: 1496-1505.
38. Hard GC, Long PH, Crissman JW, Everitt JI, Yano BL, and Bertram TA (1994). Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies. Toxicol. Pathol. 22: 489-496.
39. Hard GC, Mackay RL, and Kochhar OS (1984). Electron microscopic determination of the sequence of acute tubular and vascular injury induced in the rat kidney by a carcinogenic dose of dimethylnitrosamine. Lab. Invest. 50: 659-672.
40. Hard GC, Rodgers IS, Baetcke KP, Richards WL, McGaughy RE, and Valcovic LR (1993). Hazard evaluation of chemicals that cause accumulation of α2u-gloublin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ. Health Perspect. 99: 313-349.
41. Hard GC, Whysner J, English JC, Zang E, and Williams GM (1997). Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. Toxicol. Pathol. 25: 132-143.
42. Hennig A, Fink-Gremmels J, and Leistner L (1991). Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours, M Castagnaro, R Plestina, G Dirheimer, IN Chernozemsky, and H Bartsch (eds). IARC Scientific Publication No. 115, International Agency for Research on Cancer, Lyon, pp. 255–260.
43. Hiasa Y, Ohshima M, Iwata C, and Tanikake T (1979). Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. Gann 70: 817-820.
44. Hill RN, Clemens TL, Liu DK, Vesell ES, and Johnson DW (1975). Genetic control of chloroform toxicity in mice. Science 190: 159-161.
45. Hong J, Pan J, Dong Z, Ning SM, and Yang CS (1987). Regulation of N-nitrosodimethylamine demethylase in rat liver and kidney. Cancer Res. 47: 5948-5953.
46. Ilett KE, Reid WD, Sipes IG, and Krishna G (1973). Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp. Mol. Pathol. 19: 215-229.
47. IPCS (1994). Environmental Health Criteria 163. Chloroform. World Health Organization, Geneva.
48. Ishidate M, Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, and Matsuoka A (1984). Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol. 22: 623-636.
49. Jorgenson TA, Meierhenry EF, Rushbrook CJ, Bull RJ, and Robinson M (1985). Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 5: 760-769.
50. Kanisawa M and Suzuki S (1978). Induction of renal and hepatic tumors in mice by ochratoxin A, a mycotoxin. Gann 69: 599-600.
51. Kari FW, Bucher J, Eustis SL, Haseman JK, and Huff JE (1992). Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F, mice. Food Chem. Toxicol. 30: 737-747.
52. Kasai H, Nishimura S, Kurokawa Y, and Hayashi Y (1987). Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 8: 1959-1961.
53. Kasprzak KS, Jaruga P, Zastawny TH, North SL, Riggs CW, Olinski R, and Dizdaroglu M (1997). Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats. Carcinogenesis 18: 271-279.
54. Konishi N and Ward JM (1989). Increased levels of DNA synthesis in hyperplastic renal tubules of aging nephropathy in female F344/NCr rats. Vet. Pathol. 26: 6-10.
55. Kurokawa Y, Hayashi Y, Maekawa A, Takahashi M, Kokubo T, and Odashima S (1983). Carcinogenicity of potassium bromate administered orally to F344 rats. J. Natl. Cancer Inst. 71: 965-972.
56. Larson JL, Templin MV, Wolf DC, Jamison KC, Méry S, Leininger J, Morgan KT, Wong BA, Conolly RB, and Buttterworth BE (1996). A 90-day chloroform inhalation study in male and female B6C3F1 mice: Implications for cancer risk assessment. Fundam. Appl. Toxicol. 30: 118-137.
57. Larson JL, Wolf DC, and Butterworth BE (1995). Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water. Toxicology 95: 73-86.
58. Larson JL, Wolf DC, Méry S, Morgan KT, and Butterworth BE (1995). Toxicity and cell proliferation in the liver, kidney and nasal passages of female F-344 rats, induced by chloroform administered by gavage. Food Chem. Toxicol. 33: 443-456.
59. Lehman-McKeeman LD and Caudill D (1994). d-Limonene induced hyaline droplet nephropathy in α2u-globulin transgenic mice. Fundam. Appl. Toxicol. 23: 562-568.
60. Lehman-McKeeman LD, Rivera-Torres MI, and Caudill D (1990). Lysosomal degradation of α2u-globulin and α2u-globulin-xenobiotic conjugates. Toxicol. Appl. Pharmacol. 103: 539-548.
61. Li J, Okada S, Hamazaki S, Ebina Y, and Midorikawa O (1987). Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res. 47: 1867-1869.
62. Lipsky MM and Trump BF (1988). Chemically induced renal epithelial neoplasia in experimental animals. Int. Rev. Exp. Pathol. 30: 357-383.
63. Lock EA, Charbonneau M, Strasser J, Swenberg JA, and Bus JS (1987). 2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing α2u-globulin. Toxicol. Appl. Pharmacol. 91: 182-192.
64. Magee PN (1995). The relationship of molecular interactions with DNA to cancer: Scientific developments. In: Molecular and Cellular Mechanisms of Toxicity, F De Mattheis and LL Smith (eds). CRC Press, London, pp. 125–143.
65. Malaveille C, Brun G, and Bartsch H (1991). Genotoxicity of ochratoxin A and structurally related compounds on Escherichia coli strains: Studies on their mode of action. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours, M Castagnaro, R Plestina, G Dirheimer, IN Chernozemsky, and H Bartsch (eds). IARC Scientific Publication No. 115, International Agency for Research on Cancer, Lyon, pp. 261–266.
66. Neuhaus OW, Flory W, Biswas N, and Hollerman CE (1981). Urinary excretion of α2u-globulin and aluminum by adult male rats following treatment with nephrotoxic agents. Nephron 28: 133-140.
67. Nicoll JW, Swann PF, and Pegg AE (1975). Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA. Nature 254: 261-262.
68. NTP (1989). Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F, Mice (Gavage Studies). NIH Publication No. 90-2821, NTP-TR-366. National Toxicology Program, Research Triangle Park, North Carolina.
69. Pegg AE (1978). Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA. Nature (London) 214: 182-184.
70. Pegg AE and Wiest L (1983). Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney. Cancer Res. 43: 972-975.
71. Pfohl-Leszkowicz A, Chakor K, Creppy EE, and Dirheimer G (1991). DNA adduct formation in mice treated with ochratoxin A. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours, M Castegnaro, R Pleština, G Dirheimer, IN Chernozemsky, and H Bartsch (eds). IARC Scientific Publication No. 115, International Agency for Research on Cancer, Lyon, pp. 245–253.
72. Qin X, Zhang S, Zarkovic M, Yamazaki Y, Oda H, Makatsura Y, Ishikawa T, and Ishikawa T (1995). Inhibitory effect of probucol on nephrotoxicity induced by ferric nitrilotriacetate (Fe-NTA) in rats. Carcinogenesis 16: 2549-2552.
73. Roe FJC, Palmer AK, Worden AN, and Van Abbé NJ (1979). Safety evaluation of toothpaste containing chloroform. I. Long-term studies in mice. J. Environ. Pathol. Toxicol. 2: 799-819.
74. Sai K, Takagi A, Umemura T, Hasegawa R, and Kurokawa Y (1991). Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate. Jpn. J. Cancer Res. 82: 165-169.
75. Sai K, Tyson CA, Thomas DW, Dabbs JE, Hasegawa R, and Kurokawa Y (1994). Oxidative DNA damage induced by potassium bromate in isolated rat renal proximal tubules and renal nuclei. Cancer Lett. 87: 1-7.
76. Schwerdt G, Bauer K, Gekle M, and Silbemagl S (1996). Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro. Toxicology 114: 177-185.
77. Shibutani S, Takeshita M, and Grollman AP (1991). Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxod G. Nature (London) 349: 431-434.
78. Shimoi K, Shen B, Toyokuni S, Mochizuki R, Furugori M, and Kinae N (1997). Protection by αG-rutin, a water-soluble antioxidant flavonoid, against renal damage in mice treated with ferric nitrilotriacetate. Jpn. J. Cancer Res. 88: 453-460.
79. Short BG, Burnett VL, and Swenberg JA (1989). Elevated proliferation of proximal tubule cells and localization of accumulated α2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol. Appl. Pharmacol. 101: 414-431.
80. Sippel AE, Kurtz DT, Morris HP, and Feigelson P (1976). Comparison of in vivo translational rates and messenger RNA levels of α2u-globulin in rat liver and Morris hepatoma 5123D. Cancer Res. 36: 3588-3593.
81. Smith JH, Maita K, Sleight SD, and Hook JB (1984). Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice. Toxicology 30: 305-316.
82. Sole M, Cardesa A, Domingo J, and Mohr U (1992). The carcinogenic effect of 2,2-dioxopropylnitrosamine on the renal pelvic epithelium of Sprague-Dawley rats, after chronic subcutaneous injections. J Cancer Res. Oncol. 118: 222-227.
83. Swenberg JA, Short B, Borghoff S, Strasser J, and Charbonneau M (1989). The comparative pathobiology of a2u-globulin nephropathy. Toxicol. Appl. Pharmacol. 97: 35-46.
84. Sworn MJ and Fox M (1974). Renal age changes in the rat compared with human renal senescence. An autoradiographic study. Invest. Urol. 12: 140-145.
85. Taylor DC, Brown DM, Kuble R, and Langley PF (1974). Metabolism of chloroform: II. A sex difference in the metabolism of 14C-chloroform in mice. Xenobiotica 4: 165-174.
86. Toyokuni S, Mori T, and Dizdaroglu M (1994). DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int. J. Cancer 57: 123-128.
87. Toyokuni S, Mori T, Hiai H, and Dizadaroglu M (1995). Treatment of Wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes DNA-protein cross-linking between thymine and tyrosine in their renal chromatin. Int. J. Cancer 62: 309-313.
88. Toyokuni S and Sagripanti JL (1993). DNA single-and double-strand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis. Carcinogenesis 14: 223-227.
89. Toyokuni S, Sagripanti JL, and Hitchins VM (1995). Cytotoxic and mutagenic effects of ferric nitrilotriacetate on L5178Y mouse lymphoma cells. Cancer Lett. 88: 157-162.
90. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yhoshida A, Uchida K, Hiai H, Ochi H, and Osana T (1997). Quantitative immunohis-tochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest. 76: 365-374.
91. Toyokuni S, Tanaka T, Nishiyama Y, Okamoto K, Nakashima Y, Hamazaki S, Okada S, and Hiai H (1996). Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate. Lab. Invest. 75: 239-248.
92. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, and Stadtman ER (1994). Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc. Natl. Acad. Sci. USA 91: 2616-2620.
93. Umemura TY, Sai K, Takagi A, Hasegawa R, and Kurokawa Y (1990). Formation of 8-hydroxydeoxyguanosine (8-OHdG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11: 345-347.
94. Umemura T, Sai K, Takagi A, Hasegawa R, and Kurokawa Y (1995). A possible role for oxidative stress in potassium bromate (KBrO3) carcinogenesis. Carcinogenesis 16: 593-597.
95. Whysner J, Verna L, English JC, and Williams GM (1995). Analysis of studies related to tumorigenicity induced by hydroquinone. Regul. Toxicol. Pharmacol. 21: 158-176.
96. Wilke AV, Dorman DC, and Borghoff SJ (1994). Use of primary rat proximal tubule fragments for study of α2u-globulin, 2,5-dichlorophenol, and 2,4,4-trimethyl-2-pentanol toxicity. In Vitro Toxicol. 7: 357-368.
97. Wolf DC and Hard GC (1996). Pathology of the kidneys. In: Pathobiology of the Aging Mouse, Vol. 1, U Mohr, DL Dungworth, CC Capen, WW Carlton, JP Sundberg, and JM Ward (eds). ILSI Press, Washington, DC, pp. 331–344.
98. Yamaguchi R, Hirano T, Asami S, Sugita A, and Kasai H (1996). Increase in the 8-hydroxyguanine repair activity in the rat kidney after the administration of a renal carcinogen, ferric nitrilotriacetate. Environ. Health Perspect. 104(Suppl. 3): 651-653.