Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors

Journal of the American Chemical Society

Volumn 133, Issue 15, 2011, Pages 5976-5986

  Feng, Li ^a   Geisselbrecht, Yann ^a   Blanck, Sebastian ^a   Wilbuer, Alexander ^a   Atilla Gokcumen, G Ekin ^a   Filippakopoulos, Panagis ^b   Kräling, Katja ^a   Celik, Mehmet Ali ^a   Harms, Klaus ^a   Maksimoska, Jasna ^c,d   Marmorstein, Ronen ^c,d   Frenking, Gernot ^a   Knapp, Stefan ^b   Essen, Lars Oliver ^a   Meggers, Eric ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP BINDING POCKETS; CHEMICAL PROBES; HIGH SELECTIVITY; HOMOLOGOUS PROTEINS; HOT SPOT; INDIVIDUAL PROTEINS; INHIBITION PROPERTY; METAL CENTERS; METAL COMPOUNDS; METAL COORDINATION SPHERES; MOLECULAR GEOMETRIES; NOVEL DESIGN; OCTAHEDRAL COORDINATION; OCTAHEDRAL COORDINATION GEOMETRY; ORGANIC MOLECULES; PROTEIN KINASE; PROTEIN KINASE INHIBITORS; SIGNIFICANT IMPACTS; STABLE METALS; STRUCTURAL COMPLEXITY; STRUCTURAL FEATURE; SYNTHETIC COMPOUNDS;

AMINO ACIDS; COMPLEXATION; DESIGN; ENZYMES; IRIDIUM; IRIDIUM COMPOUNDS; METAL COMPLEXES; METALS; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; RUTHENIUM; SPHERES;

SCAFFOLDS;

ADENOSINE TRIPHOSPHATE; GLYCINE; GLYCOGEN SYNTHASE KINASE 3ALPHA; IRIDIUM COMPLEX; METAL COMPLEX; P21 ACTIVATED KINASE 1; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN RET; RUTHENIUM COMPLEX; SOLVENT; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 3;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; PROTEIN BINDING; PROTEIN INTERACTION;

BINDING SITES; COORDINATION COMPLEXES; CRYSTALLOGRAPHY, X-RAY; HUMANS; IRIDIUM; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RUTHENIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79954541159     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1112996     Document Type: Article

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