Cell-based gene therapy for repair of critical size defects in the rat fibula

Journal of Cellular Biochemistry

Volumn 112, Issue 6, 2011, Pages 1563-1571

  Lazard, Zawaunyka W ^a   Heggeness, Michael H ^b   Hipp, John A ^b   Sonnet, Corinne ^a   Fuentes, Angie S ^b   Nistal, Rita P ^a   Davis, Alan R ^a,b   Olabisi, Ronke M ^c   West, Jennifer L ^a,c   Olmsted Davis, Elizabeth A ^a,b,d  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Rice University   (United States)

^d NONE   (United States)

Author keywords

bone repair; critical size defect; heterotopic ossification

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE REMODELING; CONTROLLED STUDY; DRUG EFFECT; FIBULA FRACTURE; FRACTURE HEALING; GENE THERAPY; HETEROTOPIC OSSIFICATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; FIBULA; GENE THERAPY; HUMANS; MICE; OSTEOGENESIS; RATS; TISSUE THERAPY; WOUND HEALING;

ADENOVIRIDAE; RATTUS; RODENTIA;

EID: 79954497853     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23068     Document Type: Article

References (34)

1. Baltzer AW, Lattermann C, Whalen JD, Ghivizzani S, Wooley P, Krauspe R, Robbins PD, Evans CH,. 2000. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop Relat Res (379 Suppl): S120-S125.
2. Blum JS, Li RH, Mikos AG, Barry MA,. 2001. An optimized method for the chemiluminescent detection of alkaline phosphatase levels during osteodifferentiation by bone morphogenetic protein 2. J Cell Biochem 80: 532-537. (Pubitemid 32127468)
3. DeCoster TA, Simpson AH, Wood M, Li G, Kenwright J,. 1999. Biologic model of bone transport distraction osteogenesis and vascular response. J Orthop Res 17: 238-245. (Pubitemid 29190497)
4. DeCoster TA, Gehlert RJ, Mikola EA, Pirela-Cruz MA,. 2004. Management of posttraumatic segmental bone defects. J Am Acad Orthop Surg 12: 28-38.
5. Endo M, Kuroda S, Kondo H, Maruoka Y, Ohya K, Kasugai S,. 2006. Bone regeneration by modified gene-activated matrix: Effectiveness in segmental tibial defects in rats. Tissue Eng 12: 489-497. (Pubitemid 43673454)
6. Finkemeier CG,. 2002. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am 84-A: 454-464. (Pubitemid 37107720)
7. Fouletier-Dilling CM, Gannon FH, Olmsted-Davis EA, Lazard Z, Heggeness MH, Shafer JA, Hipp JA, Davis AR,. 2007. Efficient and rapid osteoinduction in an immune-competent host. Hum Gene Ther 18: 733-745. (Pubitemid 47378070)
8. Gafni Y, Pelled G, Zilberman Y, Turgeman G, Apparailly F, Yotvat H, Galun E, Gazit Z, Jorgensen C, Gazit D,. 2004. Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system. Mol Ther 9: 587-595. (Pubitemid 38578809)
9. Gelse K, Jiang QJ, Aigner T, Ritter T, Wagner K, Poschl E, von der Mark K, Schneider H,. 2001. Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum 44: 1943-1953. (Pubitemid 32758242)
10. Giannoudis PV, Atkins R,. 2007. Management of long-bone non-unions. Injury 38 (Suppl 2): S1-S2. (Pubitemid 47498400)
11. Gugala Z, Olmsted-Davis EA, Gannon FH, Lindsey RW, Davis AR,. 2003. Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type. Gene Ther 10: 1289-1296. (Pubitemid 36987119)
12. Haidar ZS, Hamdy RC, Tabrizian M,. 2009. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering. Biotechnol Lett 31: 1825-1835.
13. Hollinger JO, Schmitt JM, Buck DC, Shannon R, Joh SP, Zegzula HD, Wozney J,. 1998. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res 43: 356-364. (Pubitemid 28544095)
14. Jeon O, Song SJ, Kang SW, Putnam AJ, Kim BS,. 2007. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold. Biomaterials 28: 2763-2771. (Pubitemid 46413347)
15. Kloen P, Doty SB, Gordon E, Rubel IF, Goumans MJ, Helfet DL,. 2002. Expression and activation of the BMP-signaling components in human fracture nonunions. J Bone Joint Surg Am 84-A: 1909-1918. (Pubitemid 35283352)
16. Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ,. 2003. BMP signaling components are expressed in human fracture callus. Bone 33: 362-371. (Pubitemid 37103253)
17. Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI,. 2005. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 280: 35704-35712. (Pubitemid 41532763)
18. Laurencin C, Khan Y, El-Amin SF,. 2006. Bone graft substitutes. Expert Rev Med Devices 3: 49-57.
19. Lieberman JR, Le LQ, Wu L, Finerman GA, Berk A, Witte ON, Stevenson S,. 1998. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 16: 330-339. (Pubitemid 28337629)
20. Motsitsi NS,. 2008. Management of infected nonunion of long bones: The last decade (1996-2006). Injury 39: 155-160.
21. Moutsatsos IK, Turgeman G, Zhou S, Kurkalli BG, Pelled G, Tzur L, Kelley P, Stumm N, Mi S, Muller R, Zilberman Y, Gazit D,. 2001. Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther 3: 449-461. (Pubitemid 32509838)
22. Olmsted EA, Blum JS, Rill D, Yotnda P, Gugala Z, Lindsey RW, Davis AR,. 2001. Adenovirus-mediated BMP2 expression in human bone marrow stromal cells. J Cell Biochem 82: 11-21.
23. Olmsted-Davis EA, Gugala Z, Gannon FH, Yotnda P, McAlhany RE, Lindsey RW, Davis AR,. 2002. Use of a chimeric adenovirus vector enhances BMP2 production and bone formation. Hum Gene Ther 13: 1337-1347. (Pubitemid 35034513)
24. Sciadini MF, Johnson KD,. 2000. Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model. J Orthop Res 18: 289-302. (Pubitemid 30304759)
25. Sen MK, Miclau T,. 2007. Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions ? Injury 38 (Suppl 1): S75-S80. (Pubitemid 46440932)
26. Sorger JI, Hornicek FJ, Zavatta M, Menzner JP, Gebhardt MC, Tomford WW, Mankin HJ,. 2001. Allograft fractures revisited. Clin Orthop Relat Res (382): 66-74. (Pubitemid 32047431)
27. Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V,. 1992. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130: 1318-1324.
28. Tzioupis C, Giannoudis PV,. 2007. Prevalence of long-bone non-unions. Injury 38 (Suppl 2): S3-S9. (Pubitemid 47498401)
29. Vogelin E, Brekke JH, Jones NF,. 2000. Heterotopic and orthotopic bone formation with a vascularized periosteal flap, a matrix and rh-BMP-2 (bone morphogenetic protein) in the rat model. Mund Kiefer Gesichtschir 4 (Suppl 2): S454-S458.
30. Vogelin E, Jones NF, Huang JI, Brekke JH, Lieberman JR,. 2005. Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein. J Bone Joint Surg Am 87: 1323-1331. (Pubitemid 40756635)
31. Vyrostek SB, Annest JL, Ryan GW,. 2004. Surveillance for fatal and nonfatal injuries-United States, 2001. MMWR Surveill Summ 53: 1-57.
32. Watson JT, Anders M, Moed BR,. 1995. Management strategies for bone loss in tibial shaft fractures. Clin Orthop Relat Res (315): 138-152.
33. Winn SR, Hu Y, Sfeir C, Hollinger JO,. 2000. Gene therapy approaches for modulating bone regeneration. Adv Drug Deliv Rev 42: 121-138. (Pubitemid 30609638)
34. Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Bostrom KI,. 2010. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res 107: 485-494.