Efficient and rapid osteoinduction in an immune-competent host

Human Gene Therapy

Volumn 18, Issue 8, 2007, Pages 733-745

  Fouletier Dilling, Christine M ^a   Gannon, Francis H ^a,b   Olmsted Davis, Elizabeth A ^a,b   Lazard, Zawaunyka ^a   Heggeness, Michael H ^b   Shafer, Jessica A ^a,b   Hipp, John A ^b   Davis, Alan R ^a,b  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; C57BL 6 MOUSE; CELL BASED GENE THERAPY; CELL STRAIN 3T3; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; GENE TARGETING; GENETIC TRANSDUCTION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOGENICITY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; OSTEOBLAST; PROTEIN EXPRESSION; SCID MOUSE;

3T3 CELLS; ANIMALS; BONE MORPHOGENETIC PROTEINS; GENE THERAPY; HUMANS; IMMUNOCOMPETENCE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; OSTEOGENESIS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; MURINAE;

EID: 34548478160     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2006.190     Document Type: Article

References (40)

1. ALDEN, T.D., PITTMAN, D.D., HANKINS, G.R., BERES, E.J., ENGH, J.A., DAS, S., HUDSON, S.B., KERNS, K.M., KALLMES, D.F., and HELM, G.A. (1999). In vivo endochondral bone formation using a bone morphogenic protein 2 adenoviral vector. Hum. Gene Ther. 10, 2245-2253.
2. BONADIO, J., SMILEY, E., PATIL, P., and GOLDSTEIN, S. (1999). Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration. Nat. Med. 5, 753-759.
3. BOSCH, P., FOULETIER-DILLING, C., OLMSTED-DAVIS, E.A., DAVIS, A.R., and STICE, S.L. (2006). Efficient adenoviral-mediated gene delivery into porcine mesenchymal stem cells. Mol. Reprod. Dev. 73, 1393-1403.
4. CHRIST, M., LUSKY, M., STOECKEL, F., DREYER, D., DIETERLE, A., MICHOU, A.I., PAVIRANI, A., and MEHTALI, M. (1997). Gene therapy with recombinant adenovirus vectors: Evaluation of the host immune response. Immunol. Lett. 57, 19-25.
5. DAVIS, A.R., WIVEL, N.A., PALLADINO, J.T., TAO, L., and WILSON, J.M. (2000). Construction of adenoviral vectors. Methods Mol. Biol. 135, 1219-1230.
6. DRAGOO, J.L., LIEBERMAN, J.R., LEE, R.S., DEUGARTE, D.A., LEE, Y., ZUK, P.A., HEDRICK, M.H., and BENHAIM., P. (2005). Tissue-engineered bone from BMP2-transduced stem cells derived from human fat. Plastic Reconstr. Surg. 115, 1665-1673.
7. ENGSTRAND, T., DALUISKI, A., BAHAMONDE, M.E., MELHUS, H., and LYONS, K.M. (2000). Transient production of bone morphogenetic protein 2 by allogeneic transplanted transduced cells induces bone formation. Hum. Gene Ther. 11, 205-211.
8. FOULETIER-DILLING, C.M., BOSCH, P., DAVIS, A.R., SHAFER, J.A., STICE, S.L., GUGALA, Z., GANNON, F.H., and OLMSTED-DAVIS, E.A. (2005). Novel compound enables high-level adenovirus transduction in the absence of an adenovirus specific receptor. Hum. Gene Ther. 16, 1287-1297.
9. GAMRADT, S.C., ABE, N., BHAMONDE, M.E., LEE, Y.-P., NELSON, S.D., LYONS, K.M., and LIBERMAN, J.R. (2006). Tracking expression of virally mediated BMP2 in gene therapy for bone repair. Clin. Orthop. Relat. Res. 450, 238-245.
10. GAZIT, D., TURGEMAN, G., KELLEY, P., WANG, E.. JALENAK, M., ZILBERMAN, Y., and MOUTSATSOS, I. (1999). Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy. J. Gene Med. 1, 121-133.
11. GUGALA, Z., OLMSTED-DAVIS, E.A., GANNON, F.H., LINDSEY, R.W., and DAVIS, A.R. (2003). Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type. Gene Ther. 10, 1289-1296.
12. KAIHARA, S., BESSHO, K., OKUBO, Y., SONOBE, J., KAWAI, M., and IIZUKA, T. (2004). Simple and effective osteoinduction gene therapy by local injection of a bone morphogenetic protein-2 expressing recombinant adenoviral vector and FK506 mixture in rats. Gene Ther. 11, 439-447.
13. KOEHLER, D.R., SAJJAN, U., CHOW, Y.H., MARTIN, B., KENT, G., TRANSWELL, A.K., MCKERLIE, C., FORSTNER, J.F., and HU, J. (2003). Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc. Natl. Acad. Sci. U.S.A. 100, 15364-15369.
14. KOH, J.T, GE, C., ZHAO, M., WANG, Z., KREBSBACH, P.H., ZHAO, Z., and FRANCESCHI, R.T. (2006). Use of a stringent dimerizer-regulated gene expression system for controlled BMP2 delivery. Mol. Ther. 14, 684-691.
15. LEE, J.Y., MUSGRAVE, D., PELINKOVIC, D., FUKUSHIMA, K., CUMMINS, J., USAS, A., ROBBINS, P., FU, F.H., and HUARD, J. (2001). Effect of bone morphogenetic protein-2 expressing muscle-derived cells on healing of critical-sized bone defects in mice. J. Bone Joint Surg. 83, 1032-1039.
16. LEE, J.Y., PENG, H., USAS, A., MUSGRAVE, D., CUMMINS, J., PELINKOVIC, D., JANKOWSKI, R., ZIRAN, B., ROBBINS, P., and HUARD, J. (2002). Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum. Gene Ther. 13, 1201-1211.
17. LIEBERMAN, J.R., LE, L.Q., WU, L., FINERMAN, G.A., BERK, A., WITTE, O.N., and STEVENSON, S. (1998). Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J. Orthop. Res. 16, 330-339.
18. MALLAM, J.N., HURWITZ, M.Y., MAHONEY, T., CHEVEZ-BARRIOS, P., and HURWITZ, R.L. (2004). Efficient gene transfer into retinal cells using adenoviral vectors: Dependence on receptor expression. Invest. Ophthalmol. Vis. Sci. 45, 1680-1687.
19. MOLINIER-FRENKEL, V., LENGAGNE, R., GADEN, F., HONG, S.S., CHOPPIN, J., GAHERY-SEGARD, H., BOULANGER, P., and GUILLET, J.G. (2002). Adenovirus hexon protein is a potent adjuvant for activation of a cellular immune response. J. Virol. 76, 127-135.
20. MOUTSATSOS, I.K., TURGEMAN, G., ZHOU, S., KURKALLI, B.G., PELLED, G., TZUR, L., KELLEY, P., STUMM, N., MI, S., MULLER, R., ZILBERMAN, Y., and GAZIT, D. (2001). Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol. Ther. 3, 449-451.
21. MUSGRAVE, D.S., BOSCH, P., GHIVIZZANI, P.D., ROBBINS, P.D., EVANS, C.H., and HUARD, J. (1999). Adenovirus-mediated direct gene therapy with bone morphogenic protein-2 produces bone. Bone 24, 541-547.
22. NIYIBIZI, C., WANG, S., MI, Z., and ROBBINS, P.D. (2004). The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells. Mol. Ther. 9, 955-963.
23. OKUBO, Y., BESSHO, K., FUJIMURA, K., IIZUKA, T., and MIYATAKE, S. (2000). Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression. Biochem. Biophys. Res. Commun. 267, 382-387.
24. OLMSTED, E.A., BLUM, J.S., RILL, D., YOTNDA, P., GUGALA, Z., LINDSEY, R.W., and DAVIS, A.R. (2001). Adenovirus-mediated BMP2 expression in human bone marrow stromal cells. J. Cell Biochem. 82, 11-21.
25. OLMSTED-DAVIS, E.A., GUGALA, Z., GANNON, F.H., YOTNDA, P., MCALHANY, R.E., LINDSEY, R.W., and DAVIS, A.R. (2002). Use of a chimeric adenovirus vector enhances BMP2 production and bone formation. Hum. Gene Ther. 13, 1337-1347.
26. OLMSTED-DAVIS, E.A., GUGALA, Z., CAMARGO, F., GANNON, F.H., JACKSON, K., KIENSTRA, K.A., SHINE, H.D., LINDSEY, R.W., HIRSCHI, K.K., GOODELL, M.A., BRENNER, M.K., and DAVIS, A.R. (2003). Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc. Natl. Acad. Sci. U.S.A. 100, 15877-15882.
27. OLMSTED-DAVIS, E.A., GANNON, F.H., OZEN, M., ITTMANN, M.M., GUGALA, Z., HIPP, J.A., MORAN, K.M., FOULETIER-DILLING, C.M., SCHUMARA-MARTIN, S., LINDSEY, R.W., HEGGENESS, M.H., BRENNER, M.K., and DAVIS, A.R. (2007). Hypoxic adipocytes pattern early heterotopic bone formation. Am. J. Pathol. 170, 1-13.
28. SHAFER, J., DAVIS, A.R., GANNON, F.H., FOULETIER-DILLING, C.M., LAZARD, Z., MORAN, K., GUGALA, Z., OZEN, M., ITTMANN, M., HEGGENESS, M. H., and OLMSTED-DAVIS, E.A. (2007). Oxygen tension directs chondrogenic differentiation of myelo-monocytic progenitors during endochondral bone formation. Tissue Eng. 13, 2011-2019.
29. SONOBE, J., BESSHO, K., KAIHARA, S., OKUBO, Y., and IIZUKA, T. (2002). Bone induction by BMP2 expressing adenoviral vector in rats under treatment with FK506. J. Musculoskel. Res. 6, 23-29.
30. SONOBE, J., OKUBO, Y., KAIHARA, S., MIYATAKE, S., and BESSHO, K. (2004). Osteoinduction by bone morphogenetic protein 2-expressing adenoviral vector: Application of biomaterial to mask the host immune response. Hum. Gene Ther. 15, 659-668.
31. THIES, R.S., BAUDUY, M., ASHTON, B.A., KURTZBERG, L., WOZNEY, J.M., and ROSEN, V. (1992). Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130, 1318-1324.
32. ULUDAG, H., GAO T., PORTER T.J., FRIESS W. and WOZNEY J.M. (2001). Delivery systems for BMPs: Factors contributing to protein retention at an application site. J. Bone Joint Surg. 83, 128-135.
33. URIST, M.R. (1965). Bone: Formation by autoinduction. Science 150, 893-899.
34. WEISS, K.R., COOPER, G.M., JADLOWIEC, J.A., MCGOUGH, R.L., and HUARD, J. (2006). VEGF and BMP expression in mouse osteosarcoma cells. Clin. Orthop. Relat. Res. 450, 111-117.
35. WOZNEY, J.M., ROSEN, V., CELESTE, A.J., MITSOCK, L.M., WHITTERS, M.J., KRIZ, R., HEWICK, R., and WANG, E.A. (1988). Novel regulators of bone formation: Molecular clones and activities. Science 242, 1528-1534.
36. YANG, Y., and WILSON, J.M. (1996). CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40. Science 273, 1862-1864.
37. YANG, Y., NUNES, F.A., BERENCSI, K., GONCZOL, E., ENGELHARDT, J.F., and WILSON, J.M. (1994). Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat. Genet. 7, 362-369.
38. YANG, Y., GREENOUGH, K., and WILSON, J.M. (1996a). Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther. 3, 412-420.
39. YANG, Y., SU, Q., GREWAL, I.S., SCHILZ, R., FLAVELL, R.A., and WILSON, J.M. (1996b). Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J. Virol. 70, 6370-6377.
40. YANG, Y., SU, Q., and WILSON, J.M. (1996c). Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J. Virol. 70, 7209-7212.