The protective effects of L-carnitine and vitamin E in rat lenses in irradiation-induced oxidative injury

Advances in Clinical and Experimental Medicine

Volumn 20, Issue 1, 2011, Pages 15-21

  Taysi, Seyithan ^a   Okumus, Seydi ^a   Ezirmik, Sinan ^b   Uzun, Naim ^c   Yilmaz, Adnan ^d   Akyuz, Mehmet ^e   Tekelioglu, Umit ^f   Dirier, Ahmet ^a   Al, Behcet ^a  

^a GAZIANTEP UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

^c ATATURK UNIVERSITY   (Turkey)

^d RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

^e MINISTRY OF HEALTH   (Turkey)

^f Birecik State Hospital   (Turkey)

Author keywords

Antioxidant enzymes; Carnitine; Irradiation; Lens; Oxidative stress; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CARNITINE; FREE RADICAL; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; SODIUM CHLORIDE; SUPEROXIDE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CATARACT; CONTROLLED STUDY; ENZYME ACTIVITY; GAMMA IRRADIATION; IONIZING RADIATION; LENS; NONHUMAN; OXIDATIVE STRESS; RAT; SHAM PROCEDURE; SKULL; SPECTROPHOTOMETRY; SPRAGUE DAWLEY RAT;

MURINAE; RATTUS;

EID: 79954497306     PISSN: 1230025X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Taysi S, Koc M, Buyukokuroglu ME, Altinkaynak K, Sahin YN: Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003, 34(3), 173-177. (Pubitemid 36356843)
2. Nair CK, Parida DK, Nomura T: Radioprotectors in radiotherapy. J Radiat Res (Tokyo) 2001, 42(1), 21-37. (Pubitemid 33658568)
3. Shirazi A, Ghobadi G, Ghazi-Khansari M: A radiobiological review on melatonin, a novel radioprotector. J Radiât Res (Tokyo) 2007, 48(4), 263-272. (Pubitemid 47105598)
4. Taysi S, Memisogullari R, Koc M, Yazici AT, Aslankurt M, Gumustekin K et al.: Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injury. Int J Radiat Biol 2008, 84(10), 803-808.
5. Chuyen NV, Arai H, Nakanishi T, Utsunomiya N: Are Food Advanced Glycation End Products Toxic in Biological Systems? Ann NY Acad Sci 2005, 1043, 467-473.
6. Mansour HH: Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res 2006, 54(3), 165-171.
7. Karslioglu I, Ertekin MV, Kocer I, Taysi S, Sezen O, Gepdiremen A et al: Protective role of intramuscularly administered vitamin E on the levels of lipid peroxidation and the activities of antioxidant enzymes in the lens of rats made cataractous with gamma-irradiation. Eur J Ophthalmol 2004, 14(6), 478-485. (Pubitemid 40136573)
8. Karslioglu I, Ertekin MV, Taysi S, Kocer I, Sezen O, Gepdiremen A et al.: Radioprotective effects of melatonin on radiation-induced cataract. J Radiat Res (Tokyo) 2005, 46(2), 277-282. (Pubitemid 41190665)
9. Merriam GR Jr, Focht EF: A clinical study of radiation cataracts and the relationship to dose. Am J Roentgenol Radium Ther Nucl Med 1957, 77(5), 759-785.
10. Kocer I, Taysi S, Ertekin MV, Karslioglu I, Gepdiremen A, Sezen O et al.: The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts, a rat model. Graefes Arch Clin Exp Ophthalmol 2007, 245(4), 588-594. (Pubitemid 46477321)
11. Weiss JF, Landauer MR: Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 2003, 189(1-2), 1-20. (Pubitemid 36725020)
12. Srinivasan V, Weiss JF: Radioprotection by vitamin E, injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. Int J Radiat Oncol Biol Phys 1992, 23(4), 841-845.
13. Gulcin I: Antioxidant and antiradical activities of L-carnitine. Life Sci 2006, 78(8), 803-811.
14. Yasui F, Matsugo S, Ishibashi M, Kajita T, Ezashi Y, Oomura Y et al.: Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice. Neurosci Lett 2002, 334(3), 177-180. (Pubitemid 35346853)
15. Gul M, Demircan B, Taysi S, Oztasan N, Gumustekin K, Siktar E et al.: Effects of endurance training and acute exhaustive exercise on antioxidant defense mechanisms in rat heart. Comp Biochem Physiol A Mol Integr Physiol 2006, 143(2), 239-245. (Pubitemid 43197691)
16. Oztasan N, Taysi S, Gumustekin K, Altinkaynak K, Aktas O, Timur H et al.: Endurance training attenuates exercise-induced oxidative stress in erythrocytes in rat. Eur J Appl Physiol 2004, 91(5-6), 622-627. (Pubitemid 38647628)
17. Aktan B, Taysi S, Gumustekin K, Bakan N, Sutbeyaz Y: Evaluation of oxidative stress in erythrocytes of guinea pigs with experimental otitis media and effusion. Ann Clin Lab Sci 2003, 33(2), 232-236. (Pubitemid 36705935)
18. Durak I, Canbolat O, Kacmaz M, Ozgen G, Ozturk HS: Antioxidant interferences in superoxide dismutase activity methods using superoxide radical as substrate. Clin Chem Lab Med 1998, 36(6), 407-408. (Pubitemid 28379052)
19. Carlberg I, Mannervik B: Glutathione reductase. Methods Enzymol 1985, 113, 484-490. (Pubitemid 16195819)
20. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249(22), 7130-7139.
21. Hashimoto S: A new spectrophotometric assay method of xanthine oxidase in crude tissue homogenate. Anal Biochem 1974, 62(2), 426-435.
22. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72, 248-254.
23. Yagci R, Aydin B, Erdurmus M, Karadag R, Gurel A, Durmus M et al.: Use of melatonin to prevent selenite-induced cataract formation in rat eyes. Curr Eye Res 2006, 31(10), 845-850. (Pubitemid 44581307)
24. Ertekin MV, Tekin SB, Erdogan F, Karslioglu I, Gepdiremen A, Sezen O et al.: The effect of zinc sulphate in the prevention of radiation-induced dermatitis. J Radiat Res (Tokyo) 2004, 45(4), 543-548. (Pubitemid 40255927)
25. Cengiz M, Gurkaynak M, Atahan IL, Kilic K, Totan Y: The effect of verapamil in the prevention of radiation-induced cataract. Int J Radiat Oncol Biol Phys 1999, 43(3), 623-626. (Pubitemid 29107186)
26. Spector A, Garner WH: Hydrogen peroxide and human cataract. Exp Eye Res 1981, 33(6), 673-681. (Pubitemid 12253597)
27. Barros PS, Angelotti AC, Nobre F, Morales A, Fantoni DT, Barros SB: Antioxidant profile of cataractous English Cocker Spaniels. Vet Ophthalmol 1999, 2(2), 83-86. (Pubitemid 129640550)
28. Fecondo JV, Augusteyn RC: Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. Exp Eye Res 1983, 36(1), 15-23. (Pubitemid 13188394)