Protective role of intramuscularly administered vitamin E on the levels of lipid peroxidation and the activities of antioxidant enzymes in the lens of rats made cataractous with gamma-irradiation

European Journal of Ophthalmology

Volumn 14, Issue 6, 2004, Pages 478-485

  Karslioglu I ^a   Vecdi Ertekin, M ^a,b   Kocer I ^a   Taysi, S ^a   Sezen, O ^a   Gepdiremen, A ^a   Balci, E ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Gamma irradiation; Lens; Rat; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; COBALT 60; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMICROSCOPY; CATARACTOGENESIS; COBALT TELETHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENUCLEATION; ENZYME ACTIVITY; EYE PROTECTION; FEMALE; GAMMA IRRADIATION; LENS; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RADIATION CATARACT; RADIATION DOSE; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; UPREGULATION;

EID: 12344294660     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210401400606     Document Type: Article

References (52)

1. Chylack LT Jr. Classification of human cataracts. Arch Ophthalmol 1978; 96: 888-92.
2. 2. Free Radic Biol Med 2003; 34: 521-30.
3. Noaman E, Zahran A, Kamal AM, Omran MF. Vitamin E and selenium administration as a modulator of antioxidant defense system: biochemical assessment and modification. Biol Trace Elem Res 2002; 86: 55-64.
4. Lee JH, Choi IY, Kil IS, Kim SY, Yang ES, Park JW. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochim Biophys Acta 2001; 1526: 191-8.
5. Alaoui-Jamali MA, Batist G, Lehnert S. Radiation-induced damage to DNA in drug- and radiation-resistant sublines of a human breast cancer cell line. Radiat Res 1992; 129: 37-42.
6. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition 2002; 18: 872-9.
7. Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17: 24-38.
8. Mutlu-Turkoglu U, Erbil Y, Oztezcan S, Olgac V, Toker G, Uysal M. The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci 2000; 66: 1905-13.
9. Sun J, Chen Y, Li M, Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic Biol Med 1998; 24: 586-93.
10. Polat MF, Taysi S, Gul M, et al. Oxidant/antioxidant status in blood of patients with malignant breast tumor and benign breast disease. Cell Biochem Funct 2002; 20: 327-31.
11. Abiaka C, Al-Awadi F, Al-Sayer H, Gulshan S, Behbehani A, Farghally M. Activities of erythrocyte antioxidant enzymes in cancer patients. J Clin Lab Anal 2002; 16: 167-71.
12. Demple B. Radical ideas: genetic responses to oxidative stress. Clin Exp Pharmacol Physiol 1999; 26: 64-8.
13. Bardak Y, Ozerturk Y, Ozguner F, Durmus M, Delibas N. Effect of melatonin against oxidative stress in ultraviolet-B exposed rat lens. Curr Eye Res 2000; 20: 225-30.
14. Bantseev V, Bhardwaj R, Rathbun W, Nagasawa H, Trevithick JR. Antioxidants and cataract (cataract induction in space environment and application to terrestrial aging cataract). Biochem Mol Biol Int 1997; 42: 1189-97.
15. Ross WM, Creighton MO, Trevithick JR. Radiation cataractogenesis induced by neutron or gamma irradiation in the rat lens is reduced by vitamin E. Scanning Microsc 1990; 4: 641-51.
16. Freire EJ, Brady WL, DePotter P, et al. Eye. In: Perez AC, Brady WL, eds. Principles and practice of radiation oncology. Philadelphia: Lippincott-Raven; 1997: 867-89.
17. Peus D, Meves A, Pott M, Beyerle A, Pittelkow MR. Vitamin E analog modulates UVB-induced signaling pathway activation and enhances cell survival. Free Radic Biol Med 2001; 30: 425-32.
18. Mambro VM, Azzolini AE, Valim YM, Fonseca MJ. Comparison of antioxidant activities of tocopherols alone and in pharmaceutical formulations. Int J Pharm 2003; 262: 93-9.
19. Chow CK. Vitamin E and oxidative stress. Free Radic Biol Med 1991; 11: 215-32.
20. Erin AN, Gorbunov NV, Brusovanik Vl, Tyurin VA, Prilipko LL. Stabilization of synaptic membranes by alpha-tocopherol against the damaging action of phospholipases. Possible mechanism of biological action of vitamin E. Brain Res 1986; 398: 85-90.
21. Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res 1999; 38: 309-36.
22. Weiss JF, Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 2003; 189: 1-20.
23. Srinivasan V, Weiss JF. Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. Int J Radiat Oncol Biol Phys 1992; 23: 841-5.
24. Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 1978; 19: 1053-7.
25. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
26. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
27. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
28. Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994; 65: 27-33.
29. Ross WM, Creighton MO, Inch WR, Trevithick JR. Radiation cataract formation diminished by vitamin E in rat lenses in vitro. Exp Eye Res 1983; 36: 645-53.
30. Linklater HA, Dzialoszynski T, McLeod HL, Sanford SE, Trevithick JR. Modelling cortical cataractogenesis. XI. Vitamin C reduces gamma-crystallin leakage from lenses in diabetic rats. Exp Eye Res 1990; 51: 241-7.
31. Creighton MO, Trevithick JR. Cortical cataract formation prevented by vitamin E and glutathione. Exp Eye Res 1979; 29: 689-93.
32. Reddy GB, Bhat KS. Protection against UVB inactivation (in vitro) of rat lens enzymes by natural antioxidants. Mol Cell Biochem 1999; 194: 41-5.
33. Bantseev V, McCanna D, Banh A, et al. Mitochondria of lens epithelial and superficial cortical fibre cells as sensitive indicators of a chemical's ocular toxicity potential. Invest Ophthalmol Vis Sci 2001; 42 (Suppl.): S 4729.
34. Kilic F, Trevithick JR. Modelling cortical cataractogenesis. XXIX. Calpain proteolysis of lens fodrin in cataract. Biochem Mol Biol Int 1998; 45: 963-78.
35. Barros PS, Angelotti AC, Nobre F, Morales A, Fantoni DT, Barros SB. Antioxidant profile of cataractous English Cocker Spaniels. Vet Ophthalmol 1999; 2: 83-6.
36. Wahlman J, Hirst M, Roberts JE, Prickett CD, Trevithick JR. Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens. Photochem Photobiol 2003; 78: 88-92.
37. Anwar MM, Moustafa MA. The effect of melatonin on eye lens of rats exposed to ultraviolet radiation. Comp Biochem Physiol C Toxicol Pharmacol 2001; 129: 57-63.
38. Bhuyan DK, Huang X, Kuriakose G, Garner WH, Bhuyan KC. Menadione-induced oxidative stress accelerates onset of Emory mouse cataract in vivo. Curr Eye Res 1997; 16: 519-26.
39. Bono A, Militello A, Bongiorno A, Livrea MA, Pandolfo L. Effects of bendazac L-lysine salt on some metabolic enzymes of glutathione in the rabbit lens after X-irradiation. J Biochem 1987; 36: 153-65.
40. Traber MG, Packer L. Vitamin E: beyond antioxidant function. Am J Clin Nutr 1995; 62 (Suppl): S 1501-9.
41. Wolf R, Wolf D, Ruocco V. Vitamin E: the radical protector. J Eur Acad Dermatol Venereol 1998; 10: 103-17.
42. Fryer MJ. Vitamin E as a protective antioxidant in progressive renal failure. Nephrology 2000; 5: 1-7.
43. Beatty S, Koh HH, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45: 115-34.
44. Kumar B, Jha MN, Cole WC, Bedford JS, Prasad KN. D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. J Am Coll Nutr 2002; 21: 339-43.
45. Yoshimura M, Kashiba M, Oka J, Sugisawa A, Umegaki K. Vitamin E prevents increase in oxidative damage to lipids and DNA in liver of ODS rats given total body X-ray irradiation. Free Radic Res 2002; 36: 107-12.
46. Yanardag R, Bolkent S, Kizir A. Protective effects of DL-alpha-tocopherol acetate and sodium selenate on the liver of rats exposed to gamma radiation. Biol Trace Elem Res 2001; 83: 263-73.
47. Nam SY, Cho CK, Kim SG. Correlation of increased mortality with the suppression of radiation-inducible microsomal epoxide hydrolase and glutathione S-transferase gene expression by dexamethasone: effects on vitamin C and E-induced radioprotection. Biochem Pharmacol 1998; 56: 1295-304.
48. Yargicoglu P, Yaras N, Agar A, Gumuslu S, Bilmen S, Ozkaya G. The effect of vitamin E on stress-induced changes in visual evoked potentials (VEPs) in rats exposed to different experimental stress models. Acta Ophthalmol 2003; 81: 181-7.
49. Ohta Y, Okada H, Majima Y, Ishiguro I. Anticataract action of vitamin E: its estimation using an in vitro steroid cataract model. Ophthalmic Res 1996; 28 (Suppl): S 16-25.
50. Cai QY, Chen XS, Zhu LZ, et al. Biochemical and morphological changes in the lenses of selenium and/or vitamin E deficient rats. Biomed Environ Sci 1994; 7: 109-15.
51. Naziroglu M, Dilsiz N, Cay M. Protective role of intraperitoneally administered vitamins C and E and selenium on the levels of lipid peroxidation in the lens of rats made diabetic with streptozotocin. Biol Trace Elem Res 1999; 70: 223-32.
52. Umegaki K, Sugisawa A, Shin SJ, Yamada K, Sano M. Different onsets of oxidative damage to DNA and lipids in bone marrow and liver in rats given total body irradiation. Free Radic Biol Med 2001; 31: 1066-74.