Enterovirus 71 in Malaysia: A decade later

Neurology Asia

Volumn 16, Issue 1, 2011, Pages 1-15

  Chan, Yoke Fun ^a   Sam, I Ching ^a   Wee, Kai Li ^a   Abubakar, Sazaly ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; ANTIBODY; ANTIVIRUS AGENT; IMMUNOGLOBULIN; INTERFERON; LACTOFERRIN; PLECONARIL; PROTEINASE INHIBITOR; RIBAVIRIN; SMALL INTERFERING RNA; VIRUS VACCINE;

AGE; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM INFECTION; CLEANING; CROSS PROTECTION; DEATH; DISEASE SEVERITY; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; EPIDEMIC; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAND FOOT AND MOUTH DISEASE; HAND WASHING; HERPANGINA; HUMAN; HYPOTENSION; INFECTION CONTROL; INFECTION PREVENTION; LABORATORY DIAGNOSIS; LUNG EDEMA; MALAYSIA; MIXED INFECTION; MORBIDITY; NEUROLOGIC DISEASE; NONHUMAN; PREVALENCE; PUBLIC HEALTH; REVIEW; RISK FACTOR; SEASONAL VARIATION; VIROLOGY; VIRUS ENCEPHALITIS; VIRUS MENINGITIS; VIRUS TRANSMISSION;

EID: 79954463162     PISSN: 18236138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (114)

1. Poyry T, Kinnunen L, Hyypia T, et al. Genetic and phylogenetic clustering of enteroviruses. J Gen Virol 1996;77: 1699-717.
2. Hyypia T, Hovi T, Knowles NJ, Stanway G. Classification of enteroviruses based on molecular and biological properties. J Gen Virol 1997; 78:1-11.
3. Institute for Animal Health, UK. Human enterovirus A. Available from http://www.picornaviridae.com/enterovirus/hev-a/hev-a.htm.
4. Melnick J. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Fields BN KD, Howley PM, eds: Fields Virology. Philadelphia: Lippincott-Raven Publishers, 1996:655-705.
5. Chumakov M, Voroshilova M, Shindarov L, et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol 1979; 60:329-40.
6. Hagiwara A, Tagaya I, Yoneyama T. Epidemic of hand, foot and mouth disease associated with enterovirus 71 infection. Intervirology 1978; 9:60-3.
7. Nagy G, Takatsy S, Kukan E, Mihaly I, Domok I. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch Virol 1982; 71:217-27.
8. Gilbert GL, Dickson KE, Waters MJ, Kennett ML, Land SA, Sneddon M. Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement. Pediatr Infect Dis J 1988; 7:484-8.
9. McMinn P, Stratov I, Nagarajan L, Davis S. Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clin Infect Dis 2001; 32:236-42.
10. Zheng ZM, He PJ, Caueffield D, et al. Enterovirus 71 isolated from China is serologically similar to the prototype E71 BrCr strain but differs in the 5'- noncoding region. J Med Virol 1995; 47:161-7.
11. AbuBakar S, Chee HY, Al-Kobaisi MF, Xiaoshan J, Chua KB, Lam SK. Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia. Virus Res 1999; 61:1-9.
12. Wu TN, Tsai SF, Li SF, et al. Sentinel surveillance for enterovirus 71, Taiwan, 1998. Emerg Infect Dis 1999; 5:458-60.
13. Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF. Neurologic complications in children with enterovirus 71 infection. N Engl J Med 1999; 341:936-42.
14. Ng DK, Law AK, Cherk SW, Mak KL. First fatal case of enterovirus 71 infection in Hong Kong. Hong Kong Med J 2001; 7:193-6.
15. Jee YM, Cheon DS, Kim K, et al. Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Korea during 2000. Arch Virol 2003; 148:1735-46.
16. Ryu WS, Kang B, Hong J, Hwang S, Kim J, Cheon DS. Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea. J Clin Microbiol 2010; 48:2490-4.
17. ProMED-mail. Enterovirus, childhood deaths - Vietnam: suspected. ProMED-mail 2003. 2003;08 Apr:20030408.0853.
18. ProMED-mail. Enterovirus 71 encephalitis, fatal - China (Macao). ProMED-mail 2004. 2004;15 Apr:20040415.1027.
19. AbuBakar S, Sam IC, Yusof J, et al. Enterovirus 71 outbreak, Brunei. Emerg Infect Dis 2009; 15:79-82.
20. Yang F, Ren L, Xiong Z, et al. Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol 2009; 47:2351-2.
21. Kehle J, Roth B, Metzger C, Pfitzner A, Enders G. Molecular characterization of an enterovirus 71 causing neurological disease in Germany. J Neurovirol 2003; 9:126-8.
22. Witso E, Palacios G, Ronningen KS, et al. Asymptomatic circulation of HEV71 in Norway. Virus Res 2007; 123:19-29.
23. Bible JM, Iturriza-Gomara M, Megson B, et al. Molecular epidemiology of human enterovirus 71 in the United Kingdom from 1998 to 2006. J Clin Microbiol 2008; 46:3192-200.
24. Huemer HP, Ortner B, Huang CW, et al. Isolating Asian enterovirus 71 subgenogroup C4 in two Austrian clinical samples from 2004. Euro Surveill 2008;13.
25. Van der Sanden S, Koopmans M, Uslu G, Van der Avoort H. Epidemiology of enterovirus 71 in the Netherlands, 1963 to 2008. J Clin Microbiol 2009; 47:2826-33.
26. Mirand A, Schuffenecker I, Henquell C, et al. Phylogenetic evidence for a recent spread of two populations of human enterovirus 71 in European countries. J Gen Virol 2010; 91:2263-77.
27. Kapusinszky B, Szomor KN, Farkas A, Takacs M, Berencsi G. Detection of non-polio enteroviruses in Hungary 2000-2008 and molecular epidemiology of enterovirus 71, coxsackievirus A16, and echovirus 30. Virus Genes 2010; 40:163-73.
28. Cardosa MJ, Perera D, Brown BA, et al. Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes. Emerg Infect Dis 2003; 9:461-8.
29. Khetsuriani N, LaMonte-Fowlkes A, Oberste S, Pallansch M. Enterovirus surveillance - United States, 1970-2005. MMWR Morb Mortal Wkly Rep 2006; 55:1-20.
30. Infectious Disease Surveillance Center. Isolation and detection report of viruses by year, 1982-2008: enterovirus 1 & enterovirus 2. Infectious agent surveillance report 2008; Available from http://idsc.nih.go.jp/iasr/index.html.
31. Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics 2007; 120:244-52.
32. Ang LW, Koh BK, Chan KP, Chua LT, James L, Goh KT. Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007. Ann Acad Med Singapore 2009; 38:106-12.
33. Abubakar S, Chee HY, Shafee N, Chua KB, Lam SK. Molecular detection of enteroviruses from an outbreak of hand, foot and mouth disease in Malaysia in 1997. Scand J Infect Dis 1999; 31:331-5.
34. Cardosa MJ, Krishnan S, Tio PH, Perera D, Wong SC. Isolation of subgenus B adenovirus during a fatal outbreak of enterovirus 71-associated hand, foot, and mouth disease in Sibu, Sarawak. Lancet 1999; 354:987-91.
35. AbuBakar S, Shafee N, Chee HY. Adenovirus in EV71-associated hand, foot, and mouth disease. Lancet 2000; 355:146.
36. Lum LCS, Wong KT, Lam SK, et al. Fatal enterovirus 71 encephalomyelitis. J Pediatr 1998; 133:795-8.
37. Lum LCS, Chua KB, McMinn PC, et al. Echovirus 7 associated encephalomyelitis. J Clin Virol 2002; 23:153-60.
38. Ooi MH, Wong SC, Mohan A, et al. Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak. BMC Infect Dis 2009; 9:3.
39. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010; 10;778-90.
40. Podin Y, Gias EL, Ong F, et al. Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years. BMC Public Health 2006; 6:180.
41. Ministry of Health, Malaysia. Incidence and mortality rate of HFMD in Malaysia. Health Facts 2000-2009; Available from http://www.moh.gov.my/v/stats_si.
42. Chan YF, Sam IC, AbuBakar S. Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences. Infect Genet Evol 2010; 10:404-12.
43. Tee KK, Lam TT, Chan YF, et al. Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene. J Virol 2010; 84:3339-50.
44. Yu H, Chen W, Chang H, et al. Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008. Virus Genes 2010; 41:1-4.
45. Ministry Of Health. Air/droplets-borne diseases - Hand, foot and mouth disease. Weekly Infectious Disease Bulletin Singapore 2002-2009; Available from http://www.moh.gov.sg/mohcorp/statisticsweeklybulletins.aspx.
46. Chung PW, Huang YC, Chang LY, Lin TY, Ning HC. Duration of enterovirus shedding in stool. J Microbiol Immunol Infect 2001; 34:167-70.
47. Han J, Ma XJ, Wan JF, et al. Long persistence of EV71 specific nucleotides in respiratory and feces samples of the patients with hand-foot-mouth disease after recovery. BMC Infect Dis 2010; 10:178.
48. Chang LY, Tsao KC, Hsia SH, et al. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA 2004; 291:222-7.
49. Hsu BM, Chen CH, Wan MT. Prevalence of enteroviruses in hot spring recreation areas of Taiwan. FEMS Immunol Med Microbiol 2008; 52:253-9.
50. Chen CH, Hsu BM, Wan MT. Detection of enteroviruses within brackish water from the damshui river watershed, Taiwan. J Environ Eng-Asce 2008; 134:486-92.
51. Chan YF, AbuBakar S. Virucidal activity of Virkon S on enterovirus 71. Med J Malaysia 2005; 60:246-8.
52. Welch J, Maclaran K, Jordan T, Simmonds P. Frequency, viral loads, and serotype identification of enterovirus infections in Scottish blood donors. Transfusion 2003; 43:1060-6.
53. Nishikii Y, Nakatomi A, Doi T, Oka S, Moriuchi H. Favorable outcome in a case of perinatal enterovirus 71 infection. Pediatr Infect Dis J 2002; 21:886-7.
54. Chang LY, King CC, Hsu KH, et al. Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. Pediatrics 2002; 109:88.
55. Chang LY, Hsia SH, Wu CT, et al. Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002. Pediatr Infect Dis J 2004; 23:327-32.
56. Chang LY, Huang LM, Gau SS, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med 2007; 356:1226-34.
57. Gau SS, Chang LY, Huang LM, Fan TY, Wu YY, Lin TY. Attention-defi cit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. Pediatrics 2008; 122:452-8.
58. Ooi MH, Wong SC, Podin Y, et al. Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis 2007; 44:646-56.
59. Wang JR, Tuan YC, Tsai HP, Yan JJ, Liu CC, Su IJ. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000. J Clin Microbiol 2002; 40:10-5.
60. Huang SW, Hsu YW, Smith DJ, et al. Reemergence of enterovirus 71 in 2008 in Taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008. J Clin Microbiol 2009; 47:3653-62.
61. Yoke-Fun C, AbuBakar S. Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes. BMC Microbiol 2006; 6:74.
62. Chan YF, AbuBakar S. Recombinant human enterovirus 71 in hand, foot and mouth disease patients. Emerg Infect Dis 2004; 10:1468-70.
63. Chan YF, AbuBakar S. Human enterovirus 71 subgenotype B3 lacks coxsackievirus A16-like neurovirulence in mice infection. Virol J 2005; 2:74.
64. Yan JJ, Su IJ, Chen PF, Liu CC, Yu CK, Wang JR. Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identifi cation of enterovirus 71 and coxsackievirus A16 by RT-PCR. J Med Virol 2001; 65:331-9.
65. Chang GH, Lin L, Luo YJ, et al. Sequence analysis of six enterovirus 71 strains with different virulences in humans. Virus Res 2010; 151:66-73.
66. McMinn P, Lindsay K, Perera D, Chan HM, Chan KP, Cardosa MJ. Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J Virol 2001; 75:7732-8.
67. Singh S, Poh CL, Chow VT. Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000). Microbiol Immunol 2002; 46:801-8.
68. Shih SR, Ho MS, Lin KH, et al. Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998. Virus Res 2000; 68:127-36.
69. Rabenau HF, Richter M, Doerr HW. Hand, foot and mouth disease: seroprevalence of coxsackie A16 and enterovirus 71 in Germany. Med Microbiol Immunol 2010; 199:45-51.
70. Diedrich S, Weinbrecht A, Schreier E. Seroprevalence and molecular epidemiology of enterovirus 71 in Germany. Arch Virol 2009; 154:1139-42.
71. Luo ST, Chiang PS, Chao AS, et al. Enterovirus 71 maternal antibodies in infants, Taiwan. Emerg Infect Dis 2009; 15:581-4.
72. Gomes Mde L, de Castro CM, Oliveira MJ, da Silva EE. Neutralizing antibodies to enterovirus 71 in Belem, Brazil. Mem Inst Oswaldo Cruz 2002; 97:47-9.
73. Ooi EE, Phoon MC, Ishak B, Chan SH. Seroepidemiology of human enterovirus 71, Singapore. Emerg Infect Dis 2002; 8:995-7.
74. Ho M. Enterovirus 71: the virus, its infections and outbreaks. J Microbiol Immunol Infect 2000; 33:205-16.
75. Zhu Z, Zhu S, Guo X, et al. Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. Virol J 2010; 7:300.
76. Kung SH, Wang SF, Huang CW, Hsu CC, Liu HF, Yang JY. Genetic and antigenic analyses of enterovirus 71 isolates in Taiwan during 1998-2005. Clin Microbiol Infect 2007; 13:782-7.
77. Van der Sanden S, Van der Avoort H, Lemey P, Uslu G, Koopmans M. Evolutionary trajectory of the VP1 gene of human enterovirus 71 genogroup B and C viruses. J Gen Virol 2010; 91:1949-58.
78. Chang LY, Chang IS, Chen WJ, et al. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics 2008; 122:1271-6.
79. Ho HY, Cheng ML, Weng SF, et al. Glucose-6- phosphate dehydrogenase deficiency enhances enterovirus 71 infection. J Gen Virol 2008; 89:2080-9.
80. Yang KD, Yang MY, Li CC, et al. Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan. J Infect Dis 2001; 183:850-6.
81. Wang SM, Lei HY, Yu CK, Wang JR, Su IJ, Liu CC. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71- associated brainstem encephalitis. J Infect Dis 2008; 198:1002-6.
82. Wang SM, Lei HY, Su LY, et al. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin Microbiol Infect 2007; 13:677-82.
83. Chang LY, Hsiung CA, Lu CY, et al. Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatr Res 2006; 60:466-71.
84. Wang SM, Lei HY, Huang KJ, et al. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 2003; 188:564-70.
85. Lin TY, Chang LY, Huang YC, Hsu KH, Chiu CH, Yang KD. Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections: implications for early recognition and therapy. Acta Paediatr 2002; 91:632-5.
86. Chang LY, Lin TY, Hsu KH, et al. Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet 1999; 354:1682-6.
87. Hsia SH, Wu CT, Chang JJ, et al. Predictors of unfavorable outcomes in enterovirus 71-related cardiopulmonary failure in children. Pediatr Infect Dis J 2005; 24:331-4.
88. Chong CY, Chan KP, Shah VA, et al. Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatr 2003; 92:1163-9.
89. Huang YF, Chiu PC, Chen CC, et al. Cardiac troponin 1: a reliable marker and early myocardial involvement with meningoencephalitis after fatal enterovirus-71 infection. J Infect 2003; 46:238-43.
90. Melnick JL, Proctor RO, Ocampo AR, Diwan AR, Ben-Porath E. Free and bound virus in serum after administration of oral poliovirus vaccine. Am J Epidemiol 1966; 84:329-42.
91. Ooi MH, Solomon T, Podin Y, et al. Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand-foot-and-mouth disease. J Clin Microbiol 2007; 45:1858-66.
92. Wang JR, Tsai HP, Chen PF, et al. An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis. J Clin Virol 2000; 17:91-9.
93. Bessaud M, Jegouic S, Joffret ML, et al. Characterization of the genome of human enteroviruses: design of generic primers for amplifi cation and sequencing of different regions of the viral genome. J Virol Methods 2008; 149:277-84.
94. Xu F, Yan Q, Wang H, et al. Performance of detecting IgM antibodies against enterovirus 71 for early diagnosis. Plos One 2010; 5:11388.
95. Wang SM, Lei HY, Huang MC, et al. Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. J Clin Virol 2006;37:47-52.
96. Wang SM, Ho TS, Shen CF, Liu CC. Enterovirus 71, one virus and many stories. Pediatr Neonatol 2008;49:113-5.
97. Rotbart HA. Treatment of picornavirus infections. Antiviral Res 2002;53:83-98.
98. Li ZH, Li CM, Ling P, et al. Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication. J Infect Dis 2008;197:854-7.
99. Weng TY, Chen LC, Shyu HW, et al. Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells. Antiviral Res 2005;67:31-7.
100. Chen HL, Wang LC, Chang CH, et al. Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71. Vaccine 2008; 26:891-8.
101. Arita M, Wakita T, Shimizu H. Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity. J Gen Virol 2008; 89:2518-30.
102. Shia KS, Li WT, Chang CM, et al. Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors. J Med Chem 2002; 45:1644-55.
103. Chen TC, Liu SC, Huang PN, Chang HY, Chern JH, Shih SR. Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants. J Biomed Sci 2008; 15:291-300.
104. Lin CW, Wu CF, Hsiao NW, et al. Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71. Int J Antimicrob Agents 2008; 32:355-9.
105. Tan EL, Tan TM, Tak Kwong Chow V, Poh CL. Inhibition of enterovirus 71 in virus-infected mice by RNA interference. Mol Ther 2007; 15:1931-8.
106. Wu CN, Lin YC, Fann C, Liao NS, Shih SR, Ho MS. Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine 2001; 20:895-904.
107. Lin YC, Wu CN, Shih SR, Ho MS. Characterization of a Vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate. Vaccine 2002; 20:2485-93.
108. Wu TC, Wang YF, Lee YP, et al. Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice. J Virol 2007; 81:10310-5.
109. Chen HF, Chang MH, Chiang BL, Jeng ST. Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71. Vaccine 2006; 24:2944-51.
110. Chung YC, Ho MS, Wu JC, et al. Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine 2008; 26:1855-62.
111. Chiu CH, Chu C, He CC, Lin TY. Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71. Microbes Infect 2006; 8:1671-8.
112. Tung WS, Bakar SA, Sekawi Z, Rosli R. DNA vaccine constructs against enterovirus 71 elicit immune response in mice. Genet Vaccines Ther 2007; 5:6.
113. Foo DG, Alonso S, Chow VT, Poh CL. Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide. Microbes Infect 2007; 9:1299-306.
114. Ministry of Health Malaysia. Hand foot and mouth disease (HFMD) guidelines 2007.