Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Xu, Juan ^a   Wang, Meizhi ^b   Gao, Xinxing ^a   Hu, Bian ^a   Du, Yinan ^a   Zhou, Jiankui ^a   Tian, Xuemei ^c   Huang, Xingxu ^a  

^a NANJING UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c SOUTH CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SEPARASE; CARRIER PROTEIN; CELL CYCLE PROTEIN; PROTEINASE; SECURIN PROTEIN, MOUSE;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DEPLETION; EMBRYO; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; FETUS; GAMETOGENESIS; GENE MUTATION; GENOMIC INSTABILITY; INFERTILITY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; OOCYTE DEVELOPMENT; PRIMORDIAL GERM CELL; SEX DIFFERENCE; ZYGOTE; ANIMAL; FERTILIZATION; GENETICS; METABOLISM; MITOSIS; OOCYTE; OVARY FOLLICLE; OVULATION; PATHOLOGY; PHOSPHORYLATION; POINT MUTATION; SEXUAL DEVELOPMENT;

MUS;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMOSOME SEGREGATION; ENDOPEPTIDASES; FEMALE; FERTILIZATION; GENOMIC INSTABILITY; MALE; MICE; MICE, MUTANT STRAINS; MITOSIS; OOGENESIS; OVARIAN FOLLICLE; OVULATION; OVUM; PHOSPHORYLATION; POINT MUTATION; SEX CHARACTERISTICS;

EID: 79954456776     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018763     Document Type: Article

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