An alternative view of the proposed alternative activities of hemopexin

Protein Science

Volumn 20, Issue 5, 2011, Pages 791-805

  Mauk, Marcia R ^a   Smith, Ann ^b   Mauk, Grant ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Anti inflammatory; Cell adhesion; Heme binding; Hemopexin; Lymphocyte necrosis factor; Metal ion binding; Pro inflammatory; Serine protease

Indexed keywords

HEMOPEXIN; HYALURONIDASE; METAL ION; RECOMBINANT PROTEIN; SERINE PROTEINASE;

AMINO ACID SEQUENCE; BIOLOGICAL ACTIVITY; BLOOD; CATALYSIS; CELL ADHESION; CELL SURFACE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; GLYCOSYLATION; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REVIEW;

EID: 79954456288     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.616     Document Type: Review

References (133)

1. Paoli M, Anderson BF, Baker HM, Morgan WT, Smith A, Baker EN (1999) Crystal structure of hemopexi reveals a novel high-affinity heme site formed between two b-propeller domains. Nat Struct Biol 6: 926-931. (Pubitemid 29463305)
2. Grabar P, de Vaux St-Cyr C, Cleve H (1960) Presence of b1-B-globulin in the perchloric acid extracts of human normal serums. Bull Soc Chim Biol 42: 853-856.
3. Immenschuh S, Song DX, Satoh H, Müller-Eberhard U (1995) The type II hemopexin interleukin-6 response element predominates the transcriptional regulation of the hemopexin acute phase responsiveness. Biochem Biophys Res Commun 207:202-208.
4. Morgan WT, Smith A (2001) Binding and transport of iron-porphyrins by hemopexin. Adv Inorg Chem 51: 205-241.
5. Delanghe JR, Langlois MR (2001) Hemopexin: a review of biological aspects and the role in laboratory medicine. Clin Chim Acta 312:13-23. (Pubitemid 32913576)
6. Ascenzi P, Fasano M (2007) Heme-hemopexin: a 'chronosteric' heme-protein. IUBMB Life 59:700-708. (Pubitemid 350035587)
7. Tolosano E, Fagoonee S, Morello N, Vinchi F, Fiorito V (2010) Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal 12: 305-320.
8. Faber HR, Groom CR, Baker HM, Morgan WT, Smith A, Baker EN (1995) 1.8 Å crystal structure of the Cterminal domain of rabbit serum haemopexin. Structure 3:551-559.
9. Morgan WT (1975) Porphyrin-binding proteins in serum. Ann NY Acad Sci 244:624-650. 10.
10. Müller-Eberhard U (1988) Hemopexin. Methods Enzymol 163:536-565.
11. Hrkal Z, Cabart P, Kalousek I (1992) Isolation of human haemopexin in apo-form by chromatography on S-sepharose fast flow and blue sepharose CL-6B. Biomed Chromatogr 6:212-214.
12. Jensen PE, Birkenmeier G, Stigbrand T (1991) Zinc chelates bind human hemopexin. Acta Chem Scand 45:537-538.
13. Morgan WT (1985) The histidine-rich glycoprotein of serum has a domain rich in histidine, proline, and glycine that binds heme and metals. Biochemistry 24: 1496-1501.
14. Suttnar J, Hrkal Z, Vodrazka Z (1977) Affinity chromatography of serum haemopexin. J Chromatogr 131: 453-457.
15. Strop P, Borvak J, Kasicka V, Prusik Z, Moravek L (1981) Isolation of human haemopexin by bioaffinity chromatography on haeme-sepharose. J Chromatogr 214:317-325. (Pubitemid 12245726)
16. Suttnar J, Hrkal Z, Vodrazka Z, Rejnkova J (1979) Haeme-Sepharose 4B as a chromatographic matrix for the isolation of haemopexin from human serum. J Chromatogr 169:500-504. (Pubitemid 9151326)
17. Olsen KW (1980) A new method for affinity chromatography of heme-binding protein synthesis and characterization of hematin- and hematoporphyrinagarose. Anal Biochem 109:250-254. (Pubitemid 11101277)
18. Tsutsui K, Mueller GC (1982) Affinity chromatography of heme-binding proteins: An improved method for the synthesis of hemin-agarose. Anal Biochem 121: 244-250. (Pubitemid 12052000)
19. Tsutsui K (1986) Affinity chromatography of hemebinding proteins: synthesis of hemin-agarose. Methods Enzymol 123:331-338. (Pubitemid 16045269)
20. Olsen KW (1986) Affinity chromatography of hemebinding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol 123:324-331. (Pubitemid 16045268)
21. Mauk MR, Rosell FI, Mauk AG (2007) Structural modelling of metal ion binding to human haemopexin. Nat Prod Rep 24:523-532. (Pubitemid 46848709)
22. Satoh T, Satoh H, Iwahara S, Hrkal Z, Peyton DH, Müller-Eberhard U (1994) Roles of heme iron-coordinating histidine residues of human hemopexin expressed in baculovirus-infected insect cells. Proc Natl Acad Sci USA 91:8423-8427. (Pubitemid 24273676)
23. Bakker WW, Borghuis T, Harmsen MC, van den Berg A, Kema IP, Niezen KE, Kapojos JJ (2005) Protease activity of plasma hemopexin. Kidney Int 68: 603-610. (Pubitemid 43323115)
24. Lennon R, Singh A, Welsh GI, Coward RJ, Satchell S, Ni L, Mathieson PW, Bakker WW, Saleem MA (2008) Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes. J Am Soc Nephrol 19:2140-2149.
25. Liang X, Lin T, Sun G, Beasley-Topliffe L, Cavaillon JM, Warren HS (2009) Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol 86:229-235.
26. Baker SC, Saunders NF, Willis AC, Ferguson SJ, Hajdu J, Fulop V (1997) Cytochrome cd1 structure: unusual haem environments in a nitrite reductase and analysis of factors contributing to b-propeller folds. J Mol Biol 269:440-455. (Pubitemid 27267764)
27. Gomis-Rüth XF. Hemopexin domains. In: Messerschmidt A, Bode W, Cygler M, Eds. (2004) Handbook of metalloproteins. New York: Wiley, pp 631-646.
28. Smith TF, Gaitatzes C, Saxena K, Neer EJ (1999) The WD repeat: a common architecture for diverse functions. Trends Biochem Sci 24:181-185. (Pubitemid 29348450)
29. Suttnar J, Hrkal Z (1986) The reactivity of the disulfide bonds of human serum haemopexin. Int J Biochem 18:283-284. (Pubitemid 16153806)
30. Morgan WT, Müller-Eberhard U (1972) Interactions of porphyrins with rabbit hemopexin. J Biol Chem 247: 7181-7187.
31. Wu ML, Morgan WT (1993) Characterization of hemopexin and its interaction with heme by differential scanning calorimetry and circular dichroism. Biochemistry 32:7216-7222. (Pubitemid 23223125)
32. Wu ML, Morgan WT (1994) Conformational analysis of hemopexin by Fourier-transform infrared and circular dichroism spectroscopy. Proteins 20:185-190. (Pubitemid 24329481)
33. Hider RC, Kupryszewski G, Rekowski P, Lammek B (1988) Origin of the positive 225-230 nm circular dichroism band in proteins. Its application to conformational analysis. Biophys Chem 31:45-51.
34. Woody RW (1994) Contributions of tryptophan side chains to the far-ultraviolet circular dichroism of proteins. Eur Biophys J 23:253-262. (Pubitemid 24331689)
35. Morgan WT, Smith A (1984) Domain structure of rabbit hemopexin. Isolation and characterization of a hemebinding glycopeptide. J Biol Chem259:12001-12006. (Pubitemid 14022130)
36. Baker HM, Anderson BF, Baker EN (2003) Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci USA 100:3579-3583. (Pubitemid 36418076)
37. Cox MC, Le Brun N, Thomson AJ, Smith A, Morgan WT, Moore GR (1995) MCD, EPR and NMR spectroscopic studies of rabbit hemopexin and its heme binding domain. Biochim Biophys Acta 1253:215-223.
38. Freydank AC, Brandt W, Drager B (2008) Protein structure modeling indicates hexahistidine-tag interference with enzyme activity. Proteins 72:173-183. (Pubitemid 351809156)
39. Chant A, Kraemer-Pecore CM, Watkin R, Kneale GG (2005) Attachment of a histidine tag to the minimal zinc finger protein of the Aspergillus nidulans gene regulatory protein AreA causes a conformational change at the DNA-binding site. Protein Expr Purif 39:152-159. (Pubitemid 40084600)
40. Seery VL, Müller-Eberhard U (1973) Binding of porphyrins to rabbit hemopexin and albumin. J Biol Chem 248:3796-3800.
41. Morgan WT, Smith A, Koskelo P (1980) The interaction of human serum albumin and hemopexin with porphyrins. Biochim Biophys Acta 624:271-285. (Pubitemid 11245029)
42. Suzuki K, Kato H, Sakuma Y, Namiki H (2001) Hemopexins suppress phorbol ester-induced necrosis of polymorphonuclear leucocytes. Cell Struct Funct 26: 235-241. (Pubitemid 33048936)
43. Suzuki K, Kobayashi N, Doi T, Hijikata T, Machida I, Namiki H (2003) Inhibition of Mg2p-dependent adhesion of polymorphonuclear leukocytes by serum hemopexin: differences in divalent-cation dependency of cell adhesion in the presence and absence of serum. Cell Struct Funct 28:243-523.
44. Cheung PK, Stulp B, Immenschuh S, Borghuis T, Baller JF, Bakker WW (1999) Is 100KF an isoform of hemopexin? Immunochemical characterization of the vasoactive plasma factor 100KF. J Am Soc Nephrol 10:1700-1708. (Pubitemid 29364668)
45. Hrkal Z, Kodicek MB, Vodrazka Z (1976) Kinetics of the conformational changes of hemopexin in acid media. Ann Clin Res 8(Suppl 17):239-243.
46. Müller-Eberhard U, English EC (1967) Purification and partial characterization of human hemopexin. J Lab Clin Med 70:619-626.
47. Aisen P, Leibman A, Harris DC, Moss T (1974) Human hemopexin. Preparation and magnetic properties. J Biol Chem 249:6824-6827.
48. Hvidberg V, Maniecki MB, Jacobsen C, Hojrup P, Moller HJ, Moestrup SK (2005) Identification of the receptor scavenging hemopexin-heme complexes. Blood 106:2572-2579. (Pubitemid 41510836)
49. Takahashi N, Takahashi Y, Putnam FW (1984) Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues. Proc Natl Acad Sci USA 81:2021-2025. (Pubitemid 14146597)
50. Takahashi N, Takahashi Y, Putnam FW (1985) Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. Proc Natl Acad Sci USA 82:73-77. (Pubitemid 15168216)
51. Theorell H, Åkeson A (1955) Reversible splitting of a homogeneous horse myoglobin. Ann Acad Sci Fennicae Ser A II:303-312.
52. Tsemakhovich VA, Bamm VV, Shaklai M, Shaklai N (2005) Vascular damage by unstable hemoglobins: the role of heme-depleted globin. Arch Biochem Biophys 436:307-315. (Pubitemid 40576270)
53. Altruda F, Poli V, Restagno G, Argos P, Cortese R, Silengo L (1985) The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. Nucleic Acids Res 13: 3841-3859.
54. Hrkal Z, Müller-Eberhard U (1971) Partial characterization of the heme-binding serum glycoproteins rabbit and human hemopexin. Biochemistry 10: 1746-1750.
55. Kamboh MI, Ferrell RE (1987) Genetic studies of lowabundance human plasma proteins. VI. Polymorphism of hemopexin. Am J Hum Genet 41:645-653. (Pubitemid 18031537)
56. Kamboh MI, Bunker CH, Nwankwo MU, Ferrell RE (1993) Hemopexin: a unique genetic polymorphism in populations of African ancestry. Hum Biol 65:655-660.
57. Mauk MR, Rosell FI, Lelj-Garolla B, Moore GR, Mauk AG (2005) Metal ion binding to human hemopexin. Biochemistry 44:1864-1871. (Pubitemid 40223617)
58. Mauk MR, Rosell FI, Mauk AG (2007) Chromatographically distinguishable heme insertion isoforms of human hemopexin. Biochemistry 46:15033-15041. (Pubitemid 350308895)
59. Goldfarb V, Trimble RB, De Falco M, Liem HH, Metcalfe SA, Wellner D, Müller-Eberhard U (1986) An avian serum a1-glycoprotein, hemopexin, differing significantly in both amino acid and carbohydrate composition from mammalian (b-glycoprotein) counterparts. Biochemistry 25:6555-6562. (Pubitemid 17217902)
60. Coddeville B, Stratil A, Wieruszeski JM, Oliver RW, Green BN, Spik G (1995) Characterization of sheep hemopexin glycovariants. Glycoconj J 12:645-650.
61. van Gelder W, Huijskes-Heins MI, Hukshorn CJ, de Jeu-Jaspars CM, van Noort WL, van Eijk HG (1995) Isolation, purification and characterization of porcine serum transferrin and hemopexin. Comp Biochem Physiol B Biochem Mol Biol 111:171-179.
62. Debruyne EN, Vanderschaeghe D, Van Vlierberghe H, Vanhecke A, Callewaert N, Delanghe JR (2010) Diagnostic value of the hemopexin N-glycan profile in hepatocellular carcinoma patients. Clin Chem 56:823-831.
63. Inglis AS (1983) Cleavage at aspartic acid. Methods Enzymol 91:324-332.
64. BeMiller JN (1967) Acid-catalyzed hydrolysis of glycosides. Adv Carbohydr Chem Biochem 22:85-91.
65. Flatmark T (1966) On the heterogeneity of beef heart cytochrome c. 3. A kinetic study of the non-enzymic deamidation of the main subfractions (Cy I-Cy 3). Acta Chem Scand 20:1487-1496.
66. Robinson NE, Robinson AB (2001) Prediction of protein deamidation rates from primary and threedimensional structure. Proc Natl Acad Sci USA 98: 4367-4372. (Pubitemid 32294983)
67. Wang W, Antonsen K, Wang YJ, Wang DQ (2008) pH dependent effect of glycosylation on protein stability. Eur J Pharm Sci 33:120-127.
68. Mauk MR, Mauk AG (2010) Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH. J Biol Chem 285: 20499-20506.
69. Yu HL, Chertkow HM, Bergman H, Schipper HM (2003) Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma. Proteomics 3:2240-2248. (Pubitemid 37414088)
70. Rottoli P, Magi B, Cianti R, Bargagli E, Vagaggini C, Nikiforakis N, Pallini V, Bini L (2005) Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 5:2612-2618. (Pubitemid 40966488)
71. Zhu L, Hope TJ, Hall J, Davies A, Stern M, Müller- Eberhard U, Stern R, Parslow TG (1994) Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein. J Biol Chem 269:32092-32097.
72. Laurent TC, Fraser JR (1992) Hyaluronan. FASEB J 6:2397-2404.
73. Hrkal Z, Kuzelova K, Müller-Eberhard U, Stern R (1996) Hyaluronan-binding properties of human serum hemopexin. FEBS Lett 383:72-74. (Pubitemid 26092637)
74. Yang B, Yang BL, Savani RC, Turley EA (1994) Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 13:286-296. (Pubitemid 24034210)
75. Morgan WT, Muster P, Tatum F, Kao SM, Alam J, Smith A (1993) Identification of the histidine residues of hemopexin that coordinate with heme-iron and of a receptor-binding region. J Biol Chem 268:6256-6262. (Pubitemid 23099317)
76. Banerji S, Hide BR, James JR, Noble ME, Jackson DG (2010) Distinctive properties of the hyaluronanbinding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function. J Biol Chem 285:10724-10735.
77. Bakker WW, Baller JF, van Luijk WH (1988) A kallikrein- like molecule and plasma vasoactivity in minimal change disease. Increased turnover in relapse versus remission. Contrib Nephrol 67:31-36.
78. Blau EB, Haas JE (1973) Glomerular sialic acid and proteinuria in human renal disease. Lab Invest 28: 477-481.
79. Bakker WW, Roskam G, Hardonk MJ, Vos JT, Bleumink E (1985) The glomerular polyanion (GPA) of the rat kidney. III. Further characterization of a vasoactive serum factor which reduces GPA. Br J Exp Pathol 66:47-55. (Pubitemid 15168890)
80. Cheung PK, Klok PA, Baller JF, Bakker WW (2000) Induction of experimental proteinuria in vivo following infusion of human plasma hemopexin. Kidney Int 57:1512-1520. (Pubitemid 30207910)
81. Yonan CR, Duong PT, Chang FN (2005) High-efficiency staining of proteins on different blot membranes. Anal Biochem 338:159-161. (Pubitemid 40228909)
82. Bakker WW, Henning RH, van Son WJ, van Pampus MG, Aarnoudse JG, Niezen-Koning KE, Borghuis T, Jongman RM, van Goor H, Poelstra K, Navis G, Faas MM (2009) Vascular contraction and preeclampsia: downregulation of the angiotensin receptor 1 by hemopexin in vitro. Hypertension 53:959-964.
83. Bakker WW, van Dael CM, Pierik LJ, van Wijk JA, Nauta J, Borghuis T, Kapojos JJ (2005) Altered activity of plasma hemopexin in patients with minimal change disease in relapse. Pediatr Nephrol 20: 1410-1415. (Pubitemid 41403414)
84. Krikken JA, van Ree RM, Klooster A, Seelen MA, Borghuis T, Lems SP, Schouten JP, Bakker WW, Gans RO, Navis G, Bakker SJ (2010) High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients. Transpl Int 23:805-812.
85. Bakker WW, Donker RB, Timmer A, van Pampus MG, van Son WJ, Aarnoudse JG, van Goor H, Niezen-Koning KE, Navis G, Borghuis T, Jongman RM, Faas MM (2007) Plasma hemopexin activity in pregnancy and preeclampsia. Hypertens Pregnancy 26:227-239. (Pubitemid 46676548)
86. Cheung PK, Baller JF, Bakker WW (1998) Oxygen-dependent injury by a human plasma factor associated with minimal change disease. Pediatr Nephrol 12: 452-458. (Pubitemid 28396030)
87. Kapojos JJ, Poelstra K, Borghuis T, Banas B, Bakker WW (2004) Regulation of plasma hemopexin activity by stimulated endothelial or mesangial cells. Nephron Physiol 96:P1-P10. (Pubitemid 38456623)
88. Dönges R, Römisch J, Stauss H, Brazel D (2001) Separation of antithrombin III variants by micellar electrokinetic chromatography. J Chromatogr A 924: 307-313. (Pubitemid 32721863)
89. Franzén LE, Svensson S, Larm O (1980) Structural studies on the carbohydrate portion of human antithrombin III. J Biol Chem 255:5090-5093. (Pubitemid 10015827)
90. Jensen LB, Dam J, Teisner B (1994) Identification and removal of polymer- and aggregate-forming proteins in human plasma albumin preparations. Vox Sang 67:125-131. (Pubitemid 24247526)
91. Rosell FI, Mauk MR, Mauk AG (2007) Effects of metal ion binding on structural dynamics of human hemopexin. Biochemistry 46:9301-9309. (Pubitemid 47255042)
92. Gallimore MJ, Friberger P (1982) Simple chromogenic peptide substrate assays for determining prekallikrein, kallikrein inhibition and kallikrein "like"activity in human plasma. Thromb Res 25:293-298. (Pubitemid 12192395)
93. Andrew M, Manno M, Karpatkin M (1983) Demonstration of kallikrein-like protease activity in nonactivated plasma of patients with Cooley's anemia. Blood 61:232-237. (Pubitemid 13137639)
94. Ewald GA, Eisenberg PR (1995) Plasmin-mediated activation of contact system in response to pharmacological thrombolysis. Circulation 91:28-36.
95. Stellwagen E (1977) Use of blue dextran as a probe for the nicotinamide adenine dinucleotide domain in proteins. Acc Chem Res 10:92-98.
96. Stellwagen E (1990) Chromatography on immobilized reactive dyes. Methods Enzymol 182:343-357. (Pubitemid 20154401)
97. Wierenga RK, Terpstra P, Hol WG, Prediction of the occurrence of the ADP-binding bab-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol 1986: 187:101-107.
98. Chambers BB, Dunlap RB (1979) Interaction of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei with cibacron blue, blue dextran, and affi-gel blue. J Biol Chem 254:6515-6521.
99. Stefanovic V, Vlahovic P (1995) Divalent cation-activated ecto-ATPase activity of rat glomerular mesangial cells. Arch Physiol Biochem 103:15-20.
100. Vretblad P, Hjorth R (1977) The use of wheat-germ lectin-Sepharose for the purification of human haemopexin. Biochem J 167:759-764. (Pubitemid 8240994)
101. Smith A, Morgan WT (1979) Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein. Biochem J 182:47-54. (Pubitemid 9240663)
102. Bakker WW, Melgert BN, Faas MM (2010) Hemopexin: anti-inflammatory, pro-inflammatory, or both? J Leukoc Biol 87:1-2.
103. Fink MP (2009) Editorial: hemopexin: newest member of the anti-inflammatory mediator club. J Leukoc Biol 86:203-204.
104. Warren HS, Lin T (2010) Response to the letter of Drs. Bakker, Melgert, and Faas regarding our parent article. J Leukoc Biol 87:3.
105. Gasteiger E, Hoogland C, Gattiker A, Duvaud S, Wilkins MR, Appel RD, Bairoch A, Protein identification and analysis tools on the ExPASy Server. In: Walker JM, Ed. (2005) The proteomics protocols handbook. Totowa: Humana Press, pp 571-607.
106. Gekko K, Ohmae E, Kameyama K, Takagi T (1998) Acetonitrile-protein interactions: amino acid solubility and preferential solvation. Biochim Biophys Acta 1387:195-205. (Pubitemid 28529220)
107. Noiva R, Pete MJ, Babin DR (1987) Bovine serum hemopexin: properties of the protein from a single animal. Comp Biochem Physiol B Biochem Mol Biol 88:341-347.
108. Heumann D, Adachi Y, Le Roy D, Ohno N, Yadomae T, Glauser MP, Calandra T (2001) Role of plasma, lipopolysaccharide-binding protein, and CD14 in response of mouse peritoneal exudate macrophages to endotoxin. Infect Immun 69:378-385. (Pubitemid 32038335)
109. Esterbauer H, Gebicki J, Puhl H, Jurgens G (1992) The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 13: 341-390.
110. Miller YI, Smith A, Morgan WT, Shaklai N (1996) Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation. Biochemistry 35:13112-13117. (Pubitemid 26349462)
111. Nagy E, Eaton JW, Jeney V, Soares MP, Varga Z, Galajda Z, Szentmiklosi J, Mehes G,Csonka T, Smith A, Vercellotti GM, Balla G, Balla J (2010) Red cells, hemoglobin, heme, iron, and atherogenesis. Arterioscler Thromb Vasc Biol 30:1347-1353.
112. Watanabe J, Chou KJ, Liao JC, Miao Y, Meng HH, Ge H, Grijalva V, Hama S, Kozak K, Buga G, Whitelegge JP, Lee TD, Farias-Eisner R, Navab M, Fogelman AM, Reddy ST (2007) Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis. J Biol Chem 282:23698-23707. (Pubitemid 47311940)
113. Kunitake ST, Carilli CT, Lau K, Protter AA, Naya- Vigne J, Kane JP (1994) Identification of proteins associated with apolipoprotein A-I-containing lipoproteins purified by selected-affinity immunosorption. Biochemistry 33:1988-1993. (Pubitemid 24099592)
114. Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P (2005) Assignment of the binding site for haptoglobin on apolipoprotein A-I. J Biol Chem 280: 1193-1198.
115. Watanabe J, Grijalva V, Hama S, Barbour K, Berger FG, Navab M, Fogelman AM, Reddy ST (2009) Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. J Biol Chem 284:18292-18301.
116. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A (2006) CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood 107:373-380. (Pubitemid 43053566)
117. Okazaki H, Taketani S, Kohno H, Tokunaga R, Kobayashi Y (1989) The hemopexin receptor on the cell surface of human polymorphonuclear leukocytes. Cell Struct Funct 14:129-140. (Pubitemid 19094516)
118. Stanley KK (1986) Homology with hemopexin suggests a possible scavenging function for S-protein/ vitronectin. FEBS Lett 199:249-253. (Pubitemid 16072567)
119. Jenne D, Stanley KK (1987) Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution. Biochemistry 26:6735-6742. (Pubitemid 17153333)
120. Suzuki S, Argraves WS, Pytela R, Arai H, Krusius T, Pierschbacher MD, Ruoslahti E (1986) cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Proc Natl Acad Sci USA 83: 8614-8618. (Pubitemid 17194920)
121. Terentiev AA, Moldogazieva NT (2007) Cell adhesion proteins and a-fetoprotein. Similar structural motifs as prerequisites for common functions. Biochemistry (Mosc) 72:920-935. (Pubitemid 47518847)
122. Morgan WT, Muster P, Tatum FM, McConnell J, Conway TP, Hensley P, Smith A (1988) Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport. J Biol Chem 263:8220-8225.
123. Rothwangl KB, Rong L (2009) Analysis of a conserved RGE/RGD motif in HCV E2 in mediating entry. Virol J 6:12. doi: 10.1186-1743-422X6-12.
124. Porath J, Olin B (1983) Immobilized metal ion affinity adsorption and immobilized metal ion affinity chromatography of biomaterials. Serum protein affinities for gel-immobilized iron and nickel ions. Biochemistry 22: 1621-1630.
125. Porath J, Olin B, Granstrand B (1983) Immobilizedmetal affinity chromatography of serum proteins on gel-immobilized group III A metal ions. Arch Biochem Biophys 225:543-547.
126. Mantovaara T, Pertoft H, Porath J (1991) Further characterization of carboxymethylated aspartic acid agarose. Purification of human a2-macroglobulin and hemopexin. Biotechnol Appl Biochem 13:371-379.
127. Andersson L (1984) Fractionation of human serum proteins by immobilized metal affinity chromatography. J Chromatogr 315:167-174. (Pubitemid 15156193)
128. Rosell FI, Mauk MR, Mauk AG (2005) pH- and metal ion-linked stability of the hemopexin-heme complex. Biochemistry 44:1872-1879. (Pubitemid 40223618)
129. Vidaud C, Dedieu A, Basset C, Plantevin S, Dany I, Pible O, Quemeneur E (2005) Screening of human serum proteins for uranium binding. Chem Res Toxicol 18:946-953. (Pubitemid 40880883)
130. Smith A, Rish KR, Lovelace R, Hackney JF, Helston RM (2009) Role for copper in the cellular and regulatory effects of heme-hemopexin. Biometals 22:421-437.
131. Shipulina NV, Smith A, Morgan WT (2001) Effects of reduction and ligation of heme iron on the thermal stability of heme-hemopexin complexes. J Protein Chem 20:145-154.
132. Carter P, Wells JA (1988) Dissecting the catalytic triad of a serine protease. Nature 332:564-568.
133. Rawlings ND, Barrett AJ, Bateman A (2010) MEROPS: the peptidase database. Nucleic Acids Res 38: D227-D233.