Anti-inflammatory functions of caspase-8

Advances in Experimental Medicine and Biology

Volumn 691, Issue , 2011, Pages 253-260

  Rajput, Akhil ^a   Kang, Tae Bong ^a   Bogdanov, Konstantin ^a   Kim, Jin Chul ^a   Ben Moshe, Tehila ^a   Kovalenko, Andrew ^a   Wallach, David ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1; NERVE GROWTH FACTOR RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; ANTIINFLAMMATORY AGENT; DEAD BOX PROTEIN; NERVE GROWTH FACTOR; TUMOR NECROSIS FACTOR;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CASP8 GENE; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE; GENE DELETION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SKIN INFLAMMATION; TRANSCRIPTION INITIATION; ANIMAL; ARTICLE; ENZYMOLOGY; EPIDERMIS; HUMAN; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CASPASE 8; DEAD-BOX RNA HELICASES; EPIDERMIS; HUMANS; INTERFERON REGULATORY FACTOR-3; MICE; NERVE GROWTH FACTORS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS;

EID: 79954438688     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6612-4_25     Document Type: Conference Paper

References (16)

1. Rothe M, Wong SC, Henzel WJ, Goeddel DV (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-692
2. Brakebusch C, Nophar Y, Kemper O, Engelmann H, Wallach D (1992) Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor. Embo J 11:943-950
3. Itoh N, Nagata S (1993) A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268:10932-10937
4. Tartaglia LA, Ayres TM, Wong GH, Goeddel DV (1993) A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845-853
5. Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH, Wallach D (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 270:7795-7798
6. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM (1995) FADD, a novel death domaincontaining protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512
7. Chung JY, Park YC, Ye H, Wu H (2002) All TRAFs are not created equal: Common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci 115: 679-688
8. Zapata JM, Martinez-Garcia V, Lefebvre S (2007) Phylogeny of the TRAF/MATH domain. Adv Exp Med Biol 597:1-24
9. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-666
10. Ben Moshe T, Kang TB, Kovalenko A, Barash H, Abramovitch R, Galun E,Wallach D (2008) Cell-autonomous and non-cell-autonomous functions of caspase-8. Cytokine Growth Factor Rev 19:209-217
11. Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D (2009) Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206:2161-2177
12. Kang TB, Oh G-S, Scandella E, Bolinger B, Ludewig B, Kovalenko A, Wallach D (2008) Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol 181:2522-2532
13. Ben Moshe T, Barash H, Kang TB, Kim JC, Kovalenko A, Gross E, Schuchmann M, Abramovitch R, Galun E, Wallach D (2007) Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 45:1014-1024
14. Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I (2002) TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417: 861-866
15. Stratis A, Pasparakis M, Rupec RA, Markur D, Hartmann K, Scharffetter-Kochanek K, Peters T, van Rooijen N, Krieg T, Haase I (2006) Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest 116:2094-2104
16. Okabe Y, Kawane K, Nagata S (2008) IFN regulatory factor (IRF) 3/7- dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol 38:3150-3158