Determination of trace amino acids in human serum by a selective and sensitive pre-column derivatization method using HPLC-FLD-MS/MS and derivatization optimization by response surface methodology

Amino Acids

Volumn 40, Issue 4, 2011, Pages 1185-1193

  Li, Guoliang ^a,b   Cui, Yanyan ^e   You, Jinmao ^a,c   Zhao, Xianen ^d   Sun, Zhiwei ^a,b   Xia, Lian ^a,b,c   Suo, Yourui ^a   Wang, Xiao ^d  

^a NORTHWEST INSTITUTE OF PLATEAU BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c QUFU NORMAL UNIVERSITY   (China)

^d QILU UNIVERSITY OF TECHNOLOGY   (China)

^e No 88 Hospital of PLA   (China)

Author keywords

HPLC FLD MS MS; Human serum; Pre column derivatization; Response surface methodology; Trace amino acids analysis

Indexed keywords

2 [2 (7H DIBENZO[A,G]CARBAZOL 7 YL)ETHOXY]ETHYL CHLOROFORMATE; AMINO ACID; REAGENT; UNCLASSIFIED DRUG;

ADULT; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DERIVATIZATION; ELUTION; HEPATITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC FLD MS; HUMAN; LIMIT OF DETECTION; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROGNOSIS; REPRODUCIBILITY; RESPONSE SURFACE METHOD; ROOM TEMPERATURE; SENSITIVITY AND SPECIFICITY;

AMINO ACIDS, ACIDIC; AMINO ACIDS, BASIC; AMINO ACIDS, NEUTRAL; BLOOD CHEMICAL ANALYSIS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETHYL ETHERS; FLUORESCENCE; FORMIC ACID ESTERS; HEPATITIS; HUMANS; INDICATORS AND REAGENTS; LIMIT OF DETECTION; MIDDLE AGED; MODELS, STATISTICAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 79954436122     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0742-9     Document Type: Article

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