Liquid chromatographic analysis of cephalexin in human plasma by fluorescence detection of the 9-fluorenylmethyl chloroformate derivative

Analytical Letters

Volumn 42, Issue 12, 2009, Pages 1844-1854

  Meng, Xia ^a   Peng, Jingdong ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

9 fluorenylmerthyl chloroformate; Cephalexin; Fluorometric detection; High performance liquid chromatography

Indexed keywords

EID: 70449347662     PISSN: 00032719     EISSN: 1532236X     Source Type: Journal    
DOI: 10.1080/00032710903060743     Document Type: Article

References (27)

1. Abdalla, M. A., A. G. Fogg, and C. Burgess. 1982. Selective spectrophotometric determination of cephalosporins by alkaline degradation to hydrogen sulphide and formation of methylene blue. Analyst 107: 213-217.
2. Basaez, L., and P. Vanysek. 1999. Transport studies of b-lactam antibiotics and their degradation products across electrified water=oil interface. J. Pharm. Biomed. Anal. 19: 183-192.
3. Becker, H., G. Wilking, and K. Hostettmann. 1977. Separation of isomeric glycoflavones by high-pressure liquid chromatography. J. Chromatogr. A 136: 170-173.
4. Benner, E. J. 1970. Two-hour assay for content of penicillins and cephalosporins in serum. Antimicrob. Agents Chemother. 10: 201-204.
5. Buhs, R. P., T. E. Maxim, N. Allen, T. A. Jacob, and F. J. Wolf. 1974. Analysis of cefoxitin, cephalothin, and their deacylated metabolites in human urine by high-performance liquid chromatography. J. Chromatogr. 99: 609-618.
6. Coran, S. A., M. Bambagiotti-Alberti, V. Giannellini, A. Baldi, G. Picchioni, and F. Paoli. 1998. Development of a densitometric method for the determination of cephalexin as an alternative to the standard HPLC procedure. J. Pharm. Biomed. Anal. 18: 271-274.
7. Devi, A. R., K. S. Rani, and V. S. Rao. 1994. Polarographic determination of cephalosporins in pure form and in pharmaceutical preparations. Indian J. Pharm. Sci. 56: 64-66.
8. Einarsson, S., B. Josefsson, and S. Lagerkvist. 1983. Determination of amino acids with 9-fluorenylmethyl chloroformate and reversed-phase highperformance liquid chromatography. J. Chromatogr. 282: 609-618.
9. Erceg, M., V. Kapetanovic, D. Suznjevic, and D. Dumanovic. 1997. Study of cephalexin and cefaclor adsorption at the mercury=solution interface by AC polarography. Microchem. J. 57: 73-80.
10. Farag, S. A. 1998. Simultaneous liquid chromatographic analysis of the b-lactam antibiotics cefazolin, cefadroxil, cephalexin, ampicillin, and cephradine in solution. J. AOAC Int. 81: 381-385.
11. Fogg, A. G., N. M. Fayad, and C. Burgess. 1979. Differential pulse polarographic study of the degradation of cephalexin: Determination of hydrogen sulphide and other degradation products. Anal. Chim. Acta 110: 107-115.
12. Fogg, A. G., N. M. Fayad, C. Burgess, and A. Mcglynn. 1979. Differential pulse polarographic determination of cephalosporins and their degradation products. Anal. Chim. Acta 108: 205-211.
13. Fogg, A. G., N. M. Fayad, and R. N. Goyal. 1980. Differential pulse polarographic determination of cephalexin after hydrolysis in neutral phosphate buffer. J. Pharm. Pharmacol. 32: 302-303.
14. Hall, D. A., D. M. Berry, and C. J. Schneider. 1977. The electrochemistry of cephalosporin C derivatives, part II: Cephalothin, sodium salt. J. Electroanal. Chem. 80: 155-170.
15. Hernandez, M. J., P. A. Sanchez, Z. M. Delgado, and L. L. Vega. 1984. Differential pulse polarographic determination of cephalexin based on the catalytic pre-wave of nickel(II). Anal. Chim. Acta 160: 335-340.
16. Ivaska, A., and F. Nordstroem. 1983. Determination of some cephalosporins by differential pulse polarography and linear scan voltammetry. Anal. Chim. Acta 146: 87-95.
17. Kirschbaum, J. 1974. Pharmaceutical analysis colorimetric determination of cephradine, a cephalosporin antibiotic. J. Pharm. Sci. 63: 923-925.
18. Li, Q. L., and S. A. Chen. 1993. Studies on electrochemical behaviour of cephalexin. Anal. Chim. Acta 282: 145-152.
19. Liu, Z., Y. Sha, T. Huang, B. Yang, and G. Duan. 2005. High-performance liquid chromatographic determination of vertilmicin in rat plasma using sensitive fluorometric derivatization. J. Chromatogr. B 828: 2-8.
20. Mays, D. L., F. K. Bangert, W. C. Cantrell, and W. G. Evans. 1975. Hydroxylamine determination of cephalosporins. Anal. Chem. 47: 2229-2234.
21. Nunez-Vergara, L. J. S. J. A., and M. M. Silva. 1982. Polarography of an acidic degradation product from cephalexin. Talanta 29: 137-138.
22. Padoin, C., M. Tod, G. Perret, and O. Petitjean. 1998. Analysis of the pharmacokinetic interaction between cephalexin and quinapril by a nonlinear mixed-effect model. Antimicrob. Agents Chemother. 42: 1463-1469.
23. Pecavar, A., A. Smidovnik, D. Milivojevic, and M. Prosek. 1997. A reversed phase high-performance liquid chromatographic method for determination of cephalexin in human plasma. J. High Resolut. Chromatogr. 20: 674-678.
24. Stead, D. A., and R. M. E. Richards. 1996. Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography. J. Chromatogr. B 675: 295-302.
25. Stead, D. A., and R. M. E. Richards. 1997. Sensitive high-performance liquid chromatographic assay for aminoglycosides in biological matrices enables the direct estimation of bacterial drug uptake. J. Chromatogr. B 693: 415-421.
26. Wahbi, A. M., B. Unterhalt, and Z. Fresenius. 1977. Spectrophotometric determination of some cephalosporins. Anal. Chem. 284: 128.
27. Zhi, Z. L., U. J. Meyer, J. W. Van den Bedem, and M. Meusel. 2001. Evaluation of an automated and integrated flow-through immunoanalysis system for the rapid determination of cephalexin in raw milk. Anal. Chim. Acta 442: 207-219.