-
1
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
DOI 10.1038/nri2094, PII NRI2094
-
IB McInnes G Schett 2007 Cytokines in the pathogenesis of rheumatoid arthritis Nat Rev Immunol 7 429 442 1:CAS:528:DC%2BD2sXls1Kgt74%3D 10.1038/nri2094 17525752 (Pubitemid 46834849)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.6
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
2
-
-
0023942493
-
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
-
1:STN:280:DyaL1c3ltFGisA%3D%3D 10.1002/art.1780310614 3260102
-
FA Houssiau JP Devogelaer J Van Damme CN de Deuxchaisnes J Van Snick 1988 Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides Arthritis Rheum 31 784 788 1:STN:280:DyaL1c3ltFGisA%3D%3D 10.1002/art.1780310614 3260102
-
(1988)
Arthritis Rheum
, vol.31
, pp. 784-788
-
-
Houssiau, F.A.1
Devogelaer, J.P.2
Van Damme, J.3
De Deuxchaisnes, C.N.4
Van Snick, J.5
-
3
-
-
0034058109
-
Soluble interleukin-6 receptor in plasma and in lymphocyte culture supernatants of healthy individuals and patients with systemic lupus erythematosus and rheumatoid arthritis
-
A Polgar M Brozik S Toth M Holub K Hegyi A Kadar L Hodinka A Falus 2000 Soluble interleukin-6 receptor in plasma and in lymphocyte culture supernatants of healthy individuals and patients with systemic lupus erythematosus and rheumatoid arthritis Med Sci Monit 6 13 18 1:CAS:528:DC%2BD3cXit1GitLs%3D 11208277 (Pubitemid 30158232)
-
(2000)
Medical Science Monitor
, vol.6
, Issue.1
, pp. 13-18
-
-
Polgar, A.1
Brozik, M.2
Toth, S.3
Holub, M.4
Hegyi, K.5
Kadar, A.6
Hodinka, L.7
Falus, A.8
-
4
-
-
0031744306
-
Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis
-
T Robak A Gladalska H Stepien E Robak 1998 Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis Mediators Inflamm 7 347 353 1:STN:280:DyaK1M%2FpvVCguw%3D%3D 10.1080/09629359890875 9883970 (Pubitemid 28552768)
-
(1998)
Mediators of Inflammation
, vol.7
, Issue.5
, pp. 347-353
-
-
Robak, T.1
Gladalska, A.2
Stepien, H.3
Robak, E.4
-
5
-
-
0346035929
-
Interleukin-6, soluble interleukin-2 receptor and soluble interleukin-6 receptor in the sera of patients with different histological patterns of rheumatoid synovitis
-
PA Klimiuk S Sierakowski R Latosiewicz JP Cylwik B Cylwik J Skowronski J Chwiecko 2003 Interleukin-6, soluble interleukin-2 receptor and soluble interleukin-6 receptor in the sera of patients with different histological patterns of rheumatoid synovitis Clin Exp Rheumatol 21 63 69 1:STN:280:DC%2BD3s7ls1eqtw%3D%3D 12673891 (Pubitemid 36267533)
-
(2003)
Clinical and Experimental Rheumatology
, vol.21
, Issue.1
, pp. 63-69
-
-
Klimiuk, P.A.1
Sierakowski, S.2
Latosiewicz, R.3
Cylwik, J.P.4
Cylwik, B.5
Skowronski, J.6
Chwiecko, J.7
-
6
-
-
0023432812
-
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
-
1:CAS:528:DyaL2sXmtlCmtrw%3D 10.1073/pnas.84.20.7251 2444978
-
J Gauldie C Richards D Harnish P Lansdorp H Baumann 1987 Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells Proc Natl Acad Sci USA 84 7251 7255 1:CAS:528: DyaL2sXmtlCmtrw%3D 10.1073/pnas.84.20.7251 2444978
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7251-7255
-
-
Gauldie, J.1
Richards, C.2
Harnish, D.3
Lansdorp, P.4
Baumann, H.5
-
7
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
DOI 10.1038/368339a0
-
M Kopf H Baumann G Freer M Freudenberg M Lamers T Kishimoto R Zinkernagel H Bluethmann G Kohler 1994 Impaired immune and acute-phase responses in interleukin-6-deficient mice Nature 368 339 342 1:CAS:528:DyaK2cXisVahtrc%3D 10.1038/368339a0 8127368 (Pubitemid 24104268)
-
(1994)
Nature
, vol.368
, Issue.6469
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
Zinkernagel, R.7
Bluethmann, H.8
Kohler, G.9
-
8
-
-
0023920214
-
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
-
1:CAS:528:DyaL1cXhvVCqsLw%3D 10.1084/jem.167.3.1253 3127525
-
M Lotz F Jirik P Kabouridis C Tsoukas T Hirano T Kishimoto DA Carson 1988 B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes J Exp Med 167 1253 1258 1:CAS:528:DyaL1cXhvVCqsLw%3D 10.1084/jem.167.3.1253 3127525
-
(1988)
J Exp Med
, vol.167
, pp. 1253-1258
-
-
Lotz, M.1
Jirik, F.2
Kabouridis, P.3
Tsoukas, C.4
Hirano, T.5
Kishimoto, T.6
Carson, D.A.7
-
9
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
DOI 10.1016/0092-8674(89)90438-8
-
T Taga M Hibi Y Hirata K Yamasaki K Yasukawa T Matsuda T Hirano T Kishimoto 1989 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 58 573 581 1:CAS:528:DyaL1MXlsFWksLg%3D 10.1016/0092-8674(89)90438-8 2788034 (Pubitemid 19203542)
-
(1989)
Cell
, vol.58
, Issue.3
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
Hirano, T.7
Kishimoto, T.8
-
10
-
-
0032518415
-
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
-
Z Xing J Gauldie G Cox H Baumann M Jordana XF Lei MK Achong 1998 IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses J Clin Invest 101 311 320 1:CAS:528:DyaK1cXmtF2jug%3D%3D 10.1172/JCI1368 9435302 (Pubitemid 28067327)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.2
, pp. 311-320
-
-
Xing, Z.1
Gauldie, J.2
Cox, G.3
Baumann, H.4
Jordana, M.5
Lei, X.-F.6
Achong, M.K.7
-
11
-
-
0035164602
-
The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
-
DOI 10.1096/fj.99-1003rev
-
SA Jones S Horiuchi N Topley N Yamamoto GM Fuller 2001 The soluble interleukin 6 receptor: mechanisms of production and implications in disease Faseb J 15 43 58 1:CAS:528:DC%2BD3MXht1Sns7Y%3D 10.1096/fj.99-1003rev 11149892 (Pubitemid 32061655)
-
(2001)
FASEB Journal
, vol.15
, Issue.1
, pp. 43-58
-
-
Jones, S.A.1
Horiuchi, S.2
Topley, N.3
Yamamoto, N.4
Fuller, G.M.5
-
12
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
DOI 10.1016/S0167-4889(02)00319-1, PII S0167488902003191
-
SA Jones S Rose-John 2002 The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex Biochim Biophys Acta 1592 251 263 1:CAS:528:DC%2BD38Xotl2gu7Y%3D 10.1016/S0167-4889(02)00319-1 12421670 (Pubitemid 35284882)
-
(2002)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1592
, Issue.3
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
13
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
J Mullberg H Schooltink T Stoyan M Gunther L Graeve G Buse A Mackiewicz PC Heinrich S Rose-John 1993 The soluble interleukin-6 receptor is generated by shedding Eur J Immunol 23 473 480 1:STN:280:DyaK3s7ntVequw%3D%3D 10.1002/eji.1830230226 8436181 (Pubitemid 23075080)
-
(1993)
European Journal of Immunology
, vol.23
, Issue.2
, pp. 473-480
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
Gunther, M.4
Graeve, L.5
Buse, G.6
Mackiewicz, A.7
Heinrich, P.C.8
Rose-John, S.9
-
14
-
-
0028270409
-
The soluble human IL-6 receptor: Mutational characterization of the proteolytic cleavage site
-
J Mullberg W Oberthur F Lottspeich E Mehl E Dittrich L Graeve PC Heinrich S Rose-John 1994 The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site J Immunol 152 4958 4968 1:STN:280: DyaK2c3jtV2ktg%3D%3D 8176214 (Pubitemid 24139089)
-
(1994)
Journal of Immunology
, vol.152
, Issue.10
, pp. 4958-4968
-
-
Mullberg, J.1
Oberthur, W.2
Lottspeich, F.3
Mehl, E.4
Dittrich, E.5
Graeve, L.6
Heinrich, P.C.7
Rose-John, S.8
-
16
-
-
4644371697
-
Polymorphisms in the IL-6 receptor (IL-6R) gene: Strong evidence that serum levels of soluble IL-6R are genetically influenced
-
DOI 10.1038/sj.gene.6364120
-
JC Galicia H Tai Y Komatsu Y Shimada K Akazawa H Yoshie 2004 Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced Genes Immun 5 513 516 1:CAS:528:DC%2BD2cXntFCgu70%3D 10.1038/sj.gene.6364120 15306846 (Pubitemid 39263887)
-
(2004)
Genes and Immunity
, vol.5
, Issue.6
, pp. 513-516
-
-
Galicia, J.C.1
Tai, H.2
Komatsu, Y.3
Shimada, Y.4
Akazawa, K.5
Yoshie, H.6
-
17
-
-
0023945481
-
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
-
FC Arnett SM Edworthy DA Bloch DJ McShane JF Fries NS Cooper LA Healey SR Kaplan MH Liang HS Luthra, et al. 1988 The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 31 315 324 1:STN:280:DyaL1c7pt1Ohsg%3D%3D 10.1002/art.1780310302 3358796 (Pubitemid 18091653)
-
(1988)
Arthritis and Rheumatism
, vol.31
, Issue.3
, pp. 315-324
-
-
Arnett, F.C.1
Edworthy, S.M.2
Bloch, D.A.3
McShane, D.J.4
Fries, J.F.5
Cooper, N.S.6
Healey, L.A.7
Kaplan, S.R.8
Liang, M.H.9
Luthra, H.S.10
Medsger Jr., T.A.11
Mitchell, D.M.12
Neustadt, D.H.13
Pinals, R.S.14
Schaller, J.G.15
Sharp, J.T.16
Wilder, R.L.17
Hunder, G.G.18
-
18
-
-
0028815803
-
Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
-
1:STN:280:DyaK2M7hvVeqtA%3D%3D 10.1002/art.1780380107 7818570
-
ML Prevoo MA van 't Hof HH Kuper MA van Leeuwen LB van de Putte PL van Riel 1995 Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis Arthritis Rheum 38 44 48 1:STN:280: DyaK2M7hvVeqtA%3D%3D 10.1002/art.1780380107 7818570
-
(1995)
Arthritis Rheum
, vol.38
, pp. 44-48
-
-
Prevoo, M.L.1
Van 'T Hof, M.A.2
Kuper, H.H.3
Van Leeuwen, M.A.4
Van De Putte, L.B.5
Van Riel, P.L.6
-
19
-
-
27844552551
-
Does a positive anti-CCP test identify a distinct arthritis entity?
-
DOI 10.1186/ar1836
-
T Skogh 2005 Does a positive anti-CCP test identify a distinct arthritis entity? Arthritis Res Ther 7 230 232 1:CAS:528:DC%2BD2MXht1Wnu7fN 10.1186/ar1836 16277697 (Pubitemid 41655699)
-
(2005)
Arthritis Research and Therapy
, vol.7
, Issue.6
, pp. 230-232
-
-
Skogh, T.1
-
20
-
-
27844610761
-
Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: Anti-CP status predicts worse disease activity and greater radiological progression
-
DOI 10.1136/ard.2004.033571
-
J Ronnelid MC Wick J Lampa S Lindblad B Nordmark L Klareskog RF van Vollenhoven 2005 Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression Ann Rheum Dis 64 1744 1749 1:STN:280:DC%2BD2Mngtl2ntg%3D%3D 10.1136/ard.2004.033571 15843452 (Pubitemid 41667149)
-
(2005)
Annals of the Rheumatic Diseases
, vol.64
, Issue.12
, pp. 1744-1749
-
-
Ronnelid, J.1
Wick, M.C.2
Lampa, J.3
Lindblad, S.4
Nordmark, B.5
Klareskog, L.6
Van Vollenhoven, R.F.7
-
21
-
-
33646348123
-
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
-
DOI 10.1002/art.21739
-
AH van der Helm-van Mil KN Verpoort FC Breedveld TW Huizinga RE Toes RR de Vries 2006 The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis Arthritis Rheum 54 1117 1121 10.1002/art.21739 16572446 (Pubitemid 43672924)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.4
, pp. 1117-1121
-
-
Van Der Helm-Van Mil, A.H.M.1
Verpoort, K.N.2
Breedveld, F.C.3
Huizinga, T.W.J.4
Toes, R.E.M.5
De Vries, R.R.P.6
-
22
-
-
0031590163
-
Interleukin-6, soluble interleukin-2-receptor and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis: Influences of disease activity and drug therapy
-
1:CAS:528:DyaK2sXmvVOhur0%3D 9300938
-
S Franke D Herrmann G Hein A Muller G Stein 1997 Interleukin-6, soluble interleukin-2-receptor and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis: influences of disease activity and drug therapy Eur J Med Res 2 401 406 1:CAS:528:DyaK2sXmvVOhur0%3D 9300938
-
(1997)
Eur J Med Res
, vol.2
, pp. 401-406
-
-
Franke, S.1
Herrmann, D.2
Hein, G.3
Muller, A.4
Stein, G.5
-
23
-
-
0344534939
-
Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies
-
J Uson A Balsa D Pascual-Salcedo JA Cabezas JM Gonzalez-Tarrio E Martin-Mola G Fontan 1997 Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies J Rheumatol 24 2069 2075 1:STN:280:DyaK1c%2FktFOisg%3D%3D 9375862 (Pubitemid 27474022)
-
(1997)
Journal of Rheumatology
, vol.24
, Issue.11
, pp. 2069-2075
-
-
Uson, J.1
Balsa, A.2
Pascual-Salcedo, D.3
Cabezas, J.A.4
Gonzalez-Tarrio, J.M.5
Martin-Mola, E.6
Fontan, G.7
-
24
-
-
77953697828
-
A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility
-
1:CAS:528:DC%2BC3cXos1Ghtr8%3D 10.1136/ard.2008.100644 19713205
-
I Marinou K Walters J Winfield DE Bax AG Wilson 2010 A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility Ann Rheum Dis 69 1191 1194 1:CAS:528:DC%2BC3cXos1Ghtr8%3D 10.1136/ard.2008.100644 19713205
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1191-1194
-
-
Marinou, I.1
Walters, K.2
Winfield, J.3
Bax, D.E.4
Wilson, A.G.5
-
25
-
-
33749363027
-
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
DOI 10.1002/art.22033
-
RN Maini PC Taylor J Szechinski K Pavelka J Broll G Balint P Emery F Raemen J Petersen J Smolen D Thomson T Kishimoto 2006 Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate Arthritis Rheum 54 2817 2829 1:CAS:528:DC%2BD28XhtFWksLjK 10.1002/art.22033 16947782 (Pubitemid 44497760)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.9
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
Pavelka, K.4
Broll, J.5
Balint, G.6
Emery, P.7
Raemen, F.8
Petersen, J.9
Smolen, J.10
Thomson, D.11
Kishimoto, T.12
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