Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid-liquid extraction work-up

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 3, 2011, Pages 737-746

  Wohlfarth, Ariane ^a   Toepfner, Nicole ^a   Hermanns Clausen, Maren ^a   Auwärter, Volker ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Clozapine; Clozapine N oxide; LC MS MS; Liquid liquid extraction; Norclozapine

Indexed keywords

ALKALINE CONDITIONS; AMMONIUM FORMATE; ANALYTES; CALIBRATION CURVES; CEREBRO SPINAL FLUIDS; CLOZAPINE; ETHYL ACETATES; EXTRACTION EFFICIENCIES; GRADIENT ELUTION; INTERNAL STANDARDS; LC-MS/MS; LIMITS OF QUANTIFICATION; LIQUID-LIQUID EXTRACTION; MATRIX EFFECTS; MULTIPLE-REACTION MONITORING MODES; NORCLOZAPINE; POSITIVE ELECTROSPRAY IONIZATION; REGRESSION COEFFICIENT; RELATIVE STANDARD DEVIATIONS; SIMPLE LIQUIDS; SINGLE-STEP; URINE SAMPLE;

AMMONIUM COMPOUNDS; BODY FLUIDS; CALIBRATION; CHEMICAL ANALYSIS; DEUTERIUM; ELECTROSPRAY IONIZATION; ESTERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; ORGANIC SOLVENTS; SOLVENT EXTRACTION;

LIQUIDS;

CLOZAPINE; CLOZAPINE N OXIDE; CLOZAPINE N-OXIDE; DRUG DERIVATIVE; NEUROLEPTIC AGENT; NORCLOZAPINE;

ARTICLE; BLOOD; ECONOMICS; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; TANDEM MASS SPECTROMETRY; URINE; VALIDATION STUDY;

ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, LIQUID; CLOZAPINE; HUMANS; LIMIT OF DETECTION; TANDEM MASS SPECTROMETRY;

EID: 79954434081     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-4831-8     Document Type: Article

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