Channels and transporters in salivary glands

Cell and Tissue Research

Volumn 343, Issue 2, 2011, Pages 263-287

  Roussa, Eleni ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Acid base transport; Chloride transport; Mammals; Parotid; Potassium transport; Salivary gland; Submandibular

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AQUAPORIN; BICARBONATE; BICARBONATE SODIUM COTRANSPORTER; BICARBONATE TRANSPORTER; CARRIER PROTEIN; CHLORIDE BICARBONATE EXCHANGER; CHLORIDE CHANNEL; CHLORIDE ION; ELECTROLYTE; ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHLORIDE COTRANSPORTER 1; POTASSIUM ION; PROTON TRANSPORTER; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CHANNEL; SODIUM ION; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; UNCLASSIFIED DRUG;

ACINAR CELL; ELECTROLYTE TRANSPORT; HUMAN; MOLECULAR CLONING; MOLECULAR INTERACTION; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; SALIVA; SALIVARY GLAND; SALIVATION; SIGNAL TRANSDUCTION;

ANIMALS; ELECTROLYTES; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICE; SALIVA; SALIVARY GLANDS; SIGNAL TRANSDUCTION; SODIUM CHLORIDE;

MAMMALIA; MUS;

EID: 79954425501     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-010-1089-y     Document Type: Review

References (193)

1. Akamatsu T, Parvin MN,Murdiastuti K, Kosugi-Tanaka C, Yao C, Miki O, Kanamori N, Hosoi K (2003) Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland. Pflugers Arch 446:641-651 (Pubitemid 37214999)
2. Alper SL (1994) The band 3-related AE anion exchanger gene family. Cell Physiol Biochem 4:265-281 (Pubitemid 24094651)
3. Alper SL (2002) Genetic diseases of acid-base transporters. Annu Rev Physiol 64:899-923 (Pubitemid 34259253)
4. Alper SL, Kopito RR, Libresco SM, Lodish HF (1988) Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem 263:17092-17099 (Pubitemid 18268897)
5. +- ATPase. Proc Natl Acad Sci USA 86:5429-5433 (Pubitemid 19185562)
6. Arreola J, Melvin JE, Begenisich T (1995) Volume-activated chloride channels in rat parotid acinar cells. J Physiol (Lond) 484:677-687
7. Arreola J, Park K, Melvin JE, Begenisich T (1996) Three distinct chloride channels control anion movements in rat parotid acinar cells. J Physiol (Lond) 490:351-362 (Pubitemid 26032951)
8. - channel gene. J Physiol (Lond) 545:207-216 (Pubitemid 35402011)
9. Augustus J (1976) Evidence for electrogenic sodium pumping in the ductal epithelium of rabbit salivary gland and its relationship with Na-K-ATPase. Biochim Biophys Acta 419:63-75
10. 2+-activated potassium channel Kcnn4. J Biol Chem 279:47681-47687 (Pubitemid 39540914)
11. Beroukas D, Hiscock J, Jonsson R, Waterman SA, Gordon TP (2001) Subcellular distribution of aquaporin-5 in salivary glands in primary Sjögren syndrome. Lancet 358:1875-1876 (Pubitemid 34008658)
12. Beroukas D, Hiscock J, Gannon BJ, Jonsson R, Gordon TP, Wateman SA (2002) Selective down-regulation of aquaporin-1 in salivary glands in primary Sjögren syndrome. Lab Invest 82:1547-1552 (Pubitemid 35332913)
13. Best JA, Quinton PM (2005) Salivary secretion assay for drug efficacy for cystic fibrosis in mice. Exp Physiol 90:189-193 (Pubitemid 40364797)
14. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S (1989) Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245:855-857 (Pubitemid 19223662)
15. Bok D, Schibler MJ, Pushkin A, Sassani P, Abuladze N, Naser Z, Kurtz I (2001) Immunolocalization of electrogenic sodiumbicarbonate cotransporters pNBC1 and kNBC1 in the rat eye. Am J Physiol Renal Physiol 281:F920-F935 (Pubitemid 33123838)
16. - transport. J Gen Physiol 81:53-94 (Pubitemid 13174486)
17. Brandes A, Oehlke O, Schümann A, Heidrich S, Thévenod F, Roussa E (2007) Adaptive redistribution of NBCe1-A and NBCe1-B in rat kidney proximal tubule and striated ducts of salivary glands during acid-base disturbances. Am J Physiol Regul Integr Comp Physiol 293:R2400-R2411 (Pubitemid 350224035)
18. Breton S, Brown D (2007) New insights into the regulation of VATPase- dependent proton secretion. Am J Physiol Renal Physiol 292:F1-F10 (Pubitemid 46115927)
19. + ATPase. Nat Med 2:470-472
20. +-ATPase in opposite plasma membrane domains in kidney epithelial cell subpopulations. Nature 331:622-624 (Pubitemid 18049527)
21. Brown PD, Elliot AC, Lau KR (1989) Indirect evidence for the presence of non-specific anion channels in rabbit mandibular salivary gland acinar cells. J Physiol (Lond) 414:415-431 (Pubitemid 19177311)
22. Brown D, Breton S, Ausiello DA, Marshansky V (2009) Sensing, signaling and sorting events in kidney epithelial cell physiology. Traffic 10:275-284
23. Brugnara C (1993) Membrane transport of Na and K and cell dehydration in sickle erythrocytes. Experientia 49:100-109 (Pubitemid 23063409)
24. + transport, and cell density in human erythrocytes. Am J Physiol 252:C269-C276
25. Burgoyne RD, Morgan A (2003) Secretory granule exocytosis. Physiol Rev 83:581-632 (Pubitemid 36378679)
26. Butterworth MB, Edinger RS, Frizzell RA, Johnson JP (2009) Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol 296:F10-F24
27. + channel is made of three homologous subunits. Nature 367:463-467 (Pubitemid 24046048)
28. Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (2008) TMEM16A, a membrane protein associated with calciumdependent chloride channel activity. Science 322:590-594
29. Catalan MA, Nakamoto T, Ganzalez-Begne M, Camden JM, Wall SM, Clarke LL, Melvin JE (2010) Cftr and ENaC ion channels mediate NaCl reabsorption in the mouse submandibular gland. J Physiol (Lond) 588:713-724
30. + transporters in the main excretory duct of the mouse mandibular salivary gland. J Physiol (Lond) 503:583-598 (Pubitemid 27496670)
31. Compton J, Martinez JR, Martinez AM, Young JA (1981) Fluid and electrolyte secretion from the isolated, perused submandibular and sublingual glands of the rat. Arch Oral Biol 26:555-561 (Pubitemid 11000425)
32. Cook DI, Van Lennep EW, Roberts ML, Young J (1994) Secretion by the major salivary glands. In: Johnson L, Christensen J, Jackson M, Jacobson E, Walsh J (eds) Physiology of the gastrointestinal tract. Raven, New York, pp 1061-1117
33. +. Eur J Morphol 36 (Suppl):67-73
34. Cook DI, Dinudom A, Komwatana P, Kumar S, Young JA (2002) Patch-clamp studies on epithelial sodium channels in salivary duct cells. Cell Biochem Biophys 36:105-113 (Pubitemid 41270715)
35. Cutler LS, Chaudhry AP (1973) Release and restoration of the secretory granules in the convoluted granular tubules of the rat submandibular gland. Anat Rec 176:405-420
36. Da Silva N, Pisitkun T, Belleannée C, Miller LR, Nelson R, Knepper MA, Brown D, Breton S (2010) Proteomic analysis of V-ATPaserich cells harvested from the kidney and epididymis by fluorescence-activated cell sorting. Am J Physiol Cell Physiol 298:C1326-C1342
37. +-dependent anion transporters in selected human tissues. Am J Physiol Regul Integr Comp Physiol 293: R2136-R2246
38. De Camilli P, Peluchetti D, Meldolesi J (1976) Dynamic changes of the luminal plasmalemma in stimulated parotid acinar cells. A freeze-fracture study. J Cell Biol 701:59-74
39. Dehaye JP, Turner RJ (1991) Isolation and characterization of rat submandibular intralobular ducts. Am J Physiol 261:C490-C496
40. Delporte C, Steinfeld S (2006) Distribution and roles of aquaporins in salivary glands. Biochim Biophys Acta 1758:1061-1070 (Pubitemid 44373853)
41. Denniss AR, Young JA (1978) Modification of salivary duct electrolyte transport in rat and rabbit by physalaemin, VIP, GIP and other enterohormones. Pflugers Arch 376:73-80 (Pubitemid 9021900)
42. Dinour D, Chang MH, Satoh JI, Smith BL, Angle N, Knecht A, Serban I, Holtzman EJ, Romero MF (2004) A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/ SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem 279:52238-52246 (Pubitemid 39662729)
43. + current in the granular duct cells of mouse mandibular glands. Pflugers Arch 423:164-166 (Pubitemid 23114610)
44. - concentration in the intralobular duct cells of mouse mandibular glands. J Membr Biol 135:289-295 (Pubitemid 23291563)
45. Dinudom A, Young JA, Cook DI (1994) Ion channels in the basolateral membrane of intralobular duct cells of mouse mandibular glands. Pflugers Arch 428:202-208 (Pubitemid 24287368)
46. - current in mouse mandibular duct cells. Am J Physiol 268:G806-G812
47. + transport properties of isolated rat parotid acini. Am J Physiol 259:G1044-G1055
48. Dorey G, Bhoola KD (1972) II. Ultrastructure of duct cell granules in mammalian submaxillary glands. Z Zellforsch 126:335-347
49. Drenckhahn D, Schluter K, Allen DP, Bennet V (1985) Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney. Science 230:1287-1289 (Pubitemid 16194538)
50. Eladari D, Leviel F, Pezy F, Paillard M, Chambrey R (2002) Rat proximal NHE3 adapts to chronic acid-base disorders but not to chronic changes in dietary NaCl intake. Am J Physiol Renal Physiol 282:F835-F843 (Pubitemid 34654489)
51. Elkjaer ML, Nejsum LN, Gresz V, Kwon TH, Jensen UB, Frøkiaer J, Nielsen S (2001) Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Am J Physiol Renal Physiol 281:F1047-F1057
52. Endo Y, Yamazaki S, Moriyama N, Li Y, Ariizumi T, Kudo A, Kawakami H, Tanaka Y, Horita S, Yamada H, Seki G, Fujita T (2006) Localization of NBC1 variants in rat kidney. Nephron Physiol 104:87-94
53. Evans RL, Lau KR, Case RM (1993) Structural and functional characterization of striated ducts isolated from the rabbit mandibular salivary gland. Exp Physiol 78:49-64 (Pubitemid 23056783)
54. + exchange in mouse parotid acinar cells. J Biol Chem 274:29025-29030
55. - cotransporter (NKCC1)- deficient mice. J Biol Chem 275:26720-26726
56. + transport in the rat submaxillary main duct perfused in vitro. Pflugers Arch 345:207-220
57. +-ATPase: A universal proton pump of eukaryotes. Biochem J 324:697-712 (Pubitemid 27285526)
58. Flon H, Gerstner R, Mitchell OG, Feldman A (1970) Salivary glands of heteromyid rodents with a summary of the literature on rodent submandibular gland morphology. J Morphol 131:179-194
59. 2+ in parotid acinar cells. Proc Natl Acad Sci USA 86:167-171 (Pubitemid 19036349)
60. Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS (1995) Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J Cell Sci 108:2993-3002
61. Funaki H, Yamamoto T, Koyama Y, Kondo D, Yaoita E, Kawasaki K, Kobayashi H, Sawaguchi S, Abe H, Kihara I (1998) Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells. Am J Physiol 275:C1151-C1157
62. Gallacher DV, Morris AP (1986) A patch-clamp study of potassium currents in resting and acetylcholine-stimulated mouse submandibular acinar cells. J Physiol (Lond) 373:379-395 (Pubitemid 16078319)
63. Gamba G (2005) Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol Rev 85:423-493 (Pubitemid 40404634)
64. - exchanger are achlorhydric. J Biol Chem 279:30531-30539 (Pubitemid 38937984)
65. - cotransporter. J Biol Chem 282:9042-9052
66. Gillen CM, Brill S, Payne JA, Forbush B (1996) Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. J Biol Chem 27:16237-16244
67. - transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem 282:35125-35132 (Pubitemid 350232456)
68. Greeley T, Shumaker H, Wang Z, Schweinfest CW, Soleimani M (2001) Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells. Am J Physiol 281:G1301-G1308
69. Gresz V, Kwon TH, Hurley PT, Varga G, Zelles T, Nielsen S, Case RM, Steward MC (2001) Identification and localization of aquaporin water channels in human salivary glands. Am J Physiol Gastrointest Liver Physiol 281:G247-G254
70. - cotransporters in human and rat salivary glands. Am J Physiol Gastrointest Liver Physiol 283:G473-G480 (Pubitemid 34791315)
71. - exchanger. J Biol Chem 276:8358-8363
72. Haas M, Forbush B (2000) The Na-K-Cl cotransport of secretory epithelia. Annu Rev Physiol 62:515-534
73. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS (1994) Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem 269:5497-5500 (Pubitemid 24242908)
74. + current in mouse mandibular secretory cells. Single channel studies. J Membr Biol 151:19-27
75. + channel in bovine parotid acinar cells: Possible involvement of Kir2.1. J Physiol (Lond) 547:255-269 (Pubitemid 36285179)
76. He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ (1997) Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch 433:3268-3273
77. - cotransporter. J Biol Chem 274:10661-10667
78. Hiratsuka K, Kamino Y, Nagata T, Takahashi Y, Asai S, Ishikawa K, Abiko Y (2002) Microarray analysis of gene expression changes in aging in mouse submandibular gland. J Dent Res 81:679-682
79. Holtzman EJ, Kumar S, Faaland CA, Warner F, Logue PJ, Erickson SJ, Ricken G, Waldman J, Kumar S, Dunham PB (1998) Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans. Am J Physiol 275:F550-F564
80. Homann V, Rosin-Steiner S, Stratmann T, Arnold WH, Gaengler P, Kinne RK (2005) Sodium-phosphate cotransporter in human salivary glands: Molecular evidence for the involvement of NPT2b in acinar phosphate secretion and ductal phosphate reabsorption. Arch Oral Biol 50:759-768 (Pubitemid 40817367)
81. Horita S, Yamada H, Inatomi J, Moriyama N, Sekine T, Igarashi T, Endo Y, Dasouki M, Ekim M, Al-Gazali L, Shimadzu M, Seki G, Fujita T (2005) Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. J Am Soc Nephrol 16:2270-2278 (Pubitemid 41725044)
82. Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H (1999) Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet 23:264-266 (Pubitemid 29526418)
83. Ishibashi K, Yamazaki J, Okamura K, Teng Y, Kitamura K, Abe K (2006) Roles of CLCA and CFTR in electrolyte re-absorption from rat saliva. J Dent Res 85:1101-1105 (Pubitemid 44935529)
84. - reabsorption in rat submandibular gland. Am J Physiol Regul Integr Comp Physiol 294:R1729-R1736
85. Ishikawa Y, Yuan Z, Inoue N, Skowronski MT, Nakae Y, Shono M, Cho G, Yasui M, Agre P, Nielsen S (2005) Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. Am J Physiol Cell Physiol 289:C1303-C1311 (Pubitemid 41456847)
86. +-ATPase in rat parotid gland. J Histochem Cytochem 35:871-880
87. + conductances in rat and mouse acinar cells. Jpn J Physiol 35:933-944 (Pubitemid 16128556)
88. + channel. Am J Physiol Cell Physiol 275:C848-C856 (Pubitemid 28436048)
89. - symporter in human thyroid tissues and salivary gland tissues. Endocrinology 39:4416-4419 (Pubitemid 28513732)
90. Jirakulsomchok D, Schneyer CA (1984) Effects of adrenergic agonists on electrolyte transport in perfused salivary duct of rat. J Auton Nerv Syst 11:233-241 (Pubitemid 15207500)
91. - transport in perfused rat submandibular duct. J Auton Nerv Syst 19:255-259 (Pubitemid 17087508)
92. - exchanger Ae2 results in osteopetrosis in mice. Proc Natl Acad Sci USA 106:1638-1641
93. Kawedia JD, Nieman ML, Boivin GP, Melvin JE, Kikuchi K, Hand AR, Lorenz JN, Menon AG (2007) Interaction between transcellular and paracellular water transport pathways through aquaporin 5 and the tight junction complex. Proc Natl Acad Sci USA 104:3621-3626 (Pubitemid 46364208)
94. - cotransporter and its role in pH regulation in mouse parotid acinar cells. Biochem Biophys Res Commun 304:593-598 (Pubitemid 36513527)
95. King LS, Nielsen S, Agre P (1997) Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat. Am J Physiol 273:C1541-C1548
96. + exchanger (NHE5/SLC9A5) to chromosome 16q22.1. Genomics 25:615-622
97. Knauf H (1972) The minimum requirements for the maintenance of active sodium transport across the isolated salivary duct epithelium of the rabbit. Pflugers Arch 333:326-336
98. + transport by the rat salivary epithelium. Fortschr Zool 23:307-321
99. Knauf H, Lubcke R, Kreutz W, Sachs W (1982) Interrelationships of ion transport in rat submaxillary duct epithelium. Am J Physiol 242:F132-F139 (Pubitemid 12047830)
100. - exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol 283:C1206-C1218
101. + current in salivary duct cells by extracellular sodium. J Membr Biol 150:133-141 (Pubitemid 26116324)
102. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K (2006) Molecualr cloning and functional expression of a sodium bicarbonate cotransporter from guinea-pig parotid glands. Biochem Biophys Res Commun 342:1114-1122
103. Kopito RR, Lee BS, Simmons DM, Lindsey AE, Morgens CW, Schneider K (1989) Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger. Cell 59:927-937 (Pubitemid 20022381)
104. Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T, Menon AG (2001) Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem 276:23413-23420
105. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D (1998) Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247-306 (Pubitemid 28070981)
106. Larsen HS, Ruus AK, Galtung HK (2009) Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci 117:655-662
107. Larsen HS, Ruus A-K, Schreurs O, Galtung HK (2010) Aquaporin 11 in the developing mouse submandibular gland. Eur J Oral Sci 118:9-13
108. Lau KR, Elliott AC, Brown PD (1989) Acetylcholine-induced intracellular acidosis in rabbit salivary gland acinar cells. Am J Physiol 256:C288-C295
109. - concentration in striated intralobular ducts from rabbit mandibular salivary glands. Pflugers Arch 427:24-32
110. Lauf PK, Adragna NC (2000) K-Cl cotransport: Properties and molecular mechanism. Cell Physiol Biochem 10:341-354 (Pubitemid 32008917)
111. + exchanger isoforms by P2 receptors in the rat submandibular gland duct. J Physiol (Lond) 513:341-357 (Pubitemid 28562953)
112. +-ATPase and microfilaments during osteoclast activation. J Biol Chem 274:29164-29171 (Pubitemid 129625648)
113. - exchange in mouse submandibular and pancreatic ducts. J Biol Chem 274:14670-14677
114. + reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest 120:1627-1635
115. Li J, Ha YM, Kü NY, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Lee EB, Song YW, Park K (2004) Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome. Lab Invest 84:1430-1438 (Pubitemid 39482160)
116. - cotransporter and its role in pHi regulation in guinea pig salivary glands. Am J Physiol Gastrointest Liver Physiol 291:G1031-G1040 (Pubitemid 44904157)
117. - salvage mechanism in the submandibular gland acinar and duct cells. J Biol Chem 30:9808-9816
118. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1999) Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem 274:20071-20074
119. - channels and ClC-3 in acinar cells isolated from the rat lacrimal and submandibular salivary gland. J Physiol (Lond) 534:409-421 (Pubitemid 32677737)
120. + exchange in rat parotid basolateral membrane vesicles. J Membr Biol 102:247-254
121. +-ATPase in vesicular trafficking: Targeting, regulation and function. Curr Opin Cell Biol 20:415-426
122. Martinez JR, Cassity N (1983) Effect of transport inhibitors on secretion by perfused rat submandibular gland. Am J Physiol 245:G711-G716 (Pubitemid 14244426)
123. - requirement for saliva secretion in the isolated, perused rat submandibular gland. Am J Physiol 249: G464-G469 (Pubitemid 16201173)
124. 2+ omission and of the ionophore A23187. Pflugers Arch 407:615-619 (Pubitemid 17049019)
125. Martinez JR, Holzgreve H, Frick A (1966) Micropuncture study of submaxillary glands of adult rats. Pflugers Arch Gesamte Physiol Menschen Tiere 290:124-133
126. + channel in basolateral acinar cell membranes of mammalian salivary glands. Nature 302:827-829 (Pubitemid 13125121)
127. + current in single isolated salivary acinar cells from rat. Pflugers Arch 406:69-72 (Pubitemid 16177570)
128. Matsuzaki T, Suzuki T, Koyama H, Tanaka S, Takata K (1999) Aquaporin-5 (AQP5), a water channel protein, in the rat salivary and lacrimal glands: Immunolocalization and effect of secretory stimulation. Cell Tissue Res 295:513-521
129. - exchange. Am J Physiol 262:G393-G398
130. Melvin JE, Kawaguchi M, Baum BJ, Turner RJ (1987) A muscarinic agonist-stimulated chloride efflux pathway is associated with fluid secretion in rat parotid acinar cells. Biochem Biophys Res Commun 145:754-759 (Pubitemid 17093514)
131. + exchange in the response of rat parotid and acinar cells to muscarinic stimulation. J Biol Chem 263:19564-19569 (Pubitemid 19016438)
132. - cotransporters KCC1 and KCC4. J Biol Chem 275:30326-30334
133. Mount DB, Hoover RS, Hebert SC (1997) The molecular physiology of electroneutral cation-chloride cotransport. J Membr Biol 158:177-186 (Pubitemid 27348563)
134. Mount DB, Mercado A, Song L, Xu J, Georg AL Jr, Delpire E, Gamba G (1999) Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem 274:16355-16362
135. +-ATPase in perfused rat mandibular gland. J Physiol (Lond) 426:127-143 (Pubitemid 20224860)
136. Murakami M, Shachar-Hill B, Steward MC, Hill AE (2001) The paracellular component of water flow in the rat submandibular salivary gland. J Physiol (Lond) 537:899-906 (Pubitemid 34026616)
137. Murakami M, Murdiastuti K, Hosoi K, Hill AE (2006) AQP and the control of fluid transport in a salivary gland. J Membr Biol 210:91-103 (Pubitemid 44337051)
138. Murdiastuti K, Miki O, Yao C, Parvin MN, Kosugi-Tanaka C, Akamatsu T, Kanamori N, Hosoi K (2002) Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats. Pflugers Arch 445:405-412 (Pubitemid 35447505)
139. Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE (2007) Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol 292:R2380-R2390 (Pubitemid 47080701)
140. + secretion by the mouse submandibualr exocrine gland. Am J Physiol Cell Physiol 294:C810-C819 (Pubitemid 351468688)
141. 2 uptake in rat parotid acini. Am J Physiol 251: C175-C185
142. - current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem 277:23604-23611 (Pubitemid 34952197)
143. + channels in parotid acinar cells. Am J Physiol Cell Physiol 284:C535-C546 (Pubitemid 36120091)
144. + exchanger-1 deficient mice. J Physiol (Lond) 523:139-146 (Pubitemid 30135827)
145. 2+]i increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol 286:G312-G320 (Pubitemid 38134043)
146. Nielsen S, King LS, Christensen BM, Agre P (1997) Aquaporins in complex
147. Novak I, Young JA (1986) Two independent ion transport systems in rabbit mandibular salivary glands. Pflugers Arch 407:649-656 (Pubitemid 17049025)
148. + exchanger. J Biol Chem 273:6951-6959 (Pubitemid 28160361)
149. - influx in rat medullary thick ascending limb. J Physiol (Lond) 555:205-218 (Pubitemid 38313071)
150. + exchanger isoforms are differentially regulated in rat submandibular gland during acid-base disturbances in vivo. Cell Tissue Res 323:253-262 (Pubitemid 43100267)
151. Oehlke O, Martin HW, Osterberg N, Roussa E (2010) Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. J Cell Physiol. doi:10.1002/jcp.22388
152. Ogawa Y, Fernley RT, Ito R, Ijuhin N (1998) Immunhistochemistry of carbonic anhydrase isoenzymes VI and II during development of the rat salivary glands. Histochem Cell Biol 110:81-88 (Pubitemid 28293877)
153. Okada S, Misaka T, Tanaka Y, Matsumoto I, Ishibashi K, Sasaki S, Abe K (2008) Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation. FASEB J 22:3672-3684
154. + exchange gene family. J Biol Chem 267:9331-9339
155. + exchanger isoforms in rat parotid acinar and ductal cells. Am J Physiol 276: G470-G478 (Pubitemid 29104161)
156. - channels in human parotid acinar cells. Arch Oral Biol 46:801-810 (Pubitemid 32744417)
157. + exchanger-deficient mice. J Biol Chem 276:27042-27050
158. Park K, Hurley PT, Roussa E, Cooper GJ, Smith CP, Thévenod F, Steward MC, Case RM (2002) Expression of a sodium bicarbonate cotransporter in human parotid salivary glands. Arch Oral Biol 47:1-9 (Pubitemid 34052665)
159. Passow H (1986) Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane. Rev Physiol Biochem Pharmacol 103:61-203
160. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S (2003) Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem 278:49523-49529
161. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S (2008) Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol 294:C488-C494 (Pubitemid 351264400)
162. Paulais M, Cragoe EJ Jr, Turner RJ (1994) Ion transport in rat parotid intralobular striated ducts. Am J Physiol 266:C1594-C1602
163. Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D (2010) cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol 298:F643-F654
164. Payne JA, Stevenson TJ, Donaldson LF (1996) Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronalspecific isoform. J Biol Chem 271:16245-16252 (Pubitemid 26236243)
165. - cotransporter, KCC3, in the central and peripheral nervous systems: Expression in the choroid plexus, large neurons and white matter tracts. Neuroscience 103:481-491 (Pubitemid 32201934)
166. Perry C, Baker OJ, Reyland ME, Grichtchenko II (2009) PKCα, β, γ, and PKCδ-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells. Am J Physiol Cell Physiol 297: C1409-C1423
167. Petersen OH (1986) Calcium-activated potassium channels and fluid secretion by exocrine glands. Am J Physiol 251:G1-G13
168. Petersen OH, Poulsen JH (1967) Inhibition of salivary secretion and secretory potentials by g-strophantin, dinitrophenol and cyanide. Acta Physiol Scand 71:194-202
169. Pflüger EFW (1866) Ueber die Epithelian der Glandula submandibularis. Zbl Med Wiss 4:193-195
170. -HCO3 antiports in secretion. Pflugers Arch 408:178-184 (Pubitemid 17036569)
171. Planells-Cases R, Jentsch TJ (2009) Chloride channelopathies. Biochim Biophys Acta 1792:173-189
172. --dependent AChactivated Na + influx in sheep parotid secretory end pieces. Pflugers Arch 429:852-858
173. Race JE, Makhlouf FN, Logue PJ, Wilson FH, Dunham PB, Holtzman EJ (1999) Molecular cloning and functional characterizartion of KCC3, a new K-Cl cotransporter. Am J Physiol 277:C1210-C1219 (Pubitemid 30045978)
174. Rajendran VM, Black J, Ardito TA, Sangan P, Alper SL, Schweinfest C, Kashgarian M, Binder HJ (2000) Regulation of DRA and AE1 in rat colon by dietary Na depletion. Am J Physiol 279:G931-G942
175. Reddy MM, Quinton PM (2003) Functional interaction of CFTR and ENaC in sweat glands. Pflugers Arch 445:499-503 (Pubitemid 36222999)
176. - channel function. Nature 402:301-304 (Pubitemid 129516267)
177. Riordan JR (2005) Assembly of functional CFTR chloride channels. Annu Rev Physiol 67:701-718 (Pubitemid 40404507)
178. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397:251-255
179. + antiporter in salivary acinar cells. J Biol Chem 272:287-294 (Pubitemid 27021157)
180. Romanenko V, Nakamoto T, Srivastava A, Melvin JE, Begenisich T (2006) Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem 281:27964-27972 (Pubitemid 44414509)
181. + channels in mouse submandibular glands. J Physiol (Lond) 581:801-817 (Pubitemid 46831773)
182. Romanenko VG, Nakamoto T, Catalán MA, Gonzalez-Begne M, Schwartz GJ, Jaramillo Y, Sepúlveda FV, Figueroa CD, Melvin JE (2008) Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol 295:G1058-G1067
183. 2+-activated Clchannel in mouse submandibular salivary gland acinar cells. J Biol Chem 285:12990-13001
184. - cotransporter. Nature 387:409-413 (Pubitemid 27227206)
185. Rossmann H, Sonnentag T, Heinzmann A, Seidler B, Bachmann O, Vieillard-Baron D, Gregor M, Seidler U (2001a) Differential expression and regulation of Na(+)/H(+) exchanger isoforms in rabbit parietal and mucous cells. Am J Physiol Gastrointest Liver Physiol 281:G447-G458
186. Rossmann H, Bachmann O, Wang Z, Shull GE, Obermaier B, Stuart- Tilley A, Alper SL, Seidler U (2001b) Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. J Physiol (Lond) 534:837-848 (Pubitemid 32700880)
187. - transporters in human salivary ducts. An immunohistochemical study. Histochem J 33:337-344 (Pubitemid 33078969)
188. Roussa E, Thévenod F (1998) Distribution of V-ATPase in rat salivary glands. Eur J Morphol 36 (Suppl):147-152
189. +-ATPase in rat submandibular gland and adaptive changes induced by acid-base disturbances. J Histochem Cytochem 46:91-100 (Pubitemid 28030514)
190. - cotransporter in rat parotid and submandibular glands. Am J Physiol Gastrointest Liver Physiol 40:G1288-G1296 (Pubitemid 30046032)
191. +-ATPase in rat pancreas. J Histochem Cytochem 49:463-474 (Pubitemid 32295168)
192. Roussa E, Shmukler BE, Wilhelm S, Casula S, Stuart-Tilley AK, Thévenod F, Alper SL (2002) Immunolocalization of potassiumchloride cotransporter polypeptides in rat exocrine glands. Histochem Cell Biol 117:335-344 (Pubitemid 34985039)
193. Roussa E, Nastainszyk W, Thévenod F (2004) Differential expression of electrogenic NBC1 (SLC4A4) variants in rat kidney and pancreas. Biochem Biophys Res Commun 314:382-389 (Pubitemid 38084728)