Is fetal microchimerism beneficial for the fetus or the mother?;Microchimérisme fœtal : Un bien ou un mal pour le fœtus et sa mre ?

Gynecologie Obstetrique et Fertilite

Volumn 39, Issue 4, 2011, Pages 224-231

  Boyon, C ^a,b   Collinet, P ^a,b   Boulanger, L ^a,b   Vinatier, D ^a,b  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Cancer; Evolution; Fetal microchimerism; Tolerance

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ALLELE; ARTICLE; AUTOIMMUNITY; CELL MIGRATION; FETUS CELL; HEREDITY; HUMAN; MICROCHIMERISM; NEOPLASM; PREGNANCY; TISSUE INJURY; TISSUE REPAIR;

EID: 79954421813     PISSN: 12979589     EISSN: 17696682     Source Type: Journal    
DOI: 10.1016/j.gyobfe.2011.02.009     Document Type: Article

References (106)

1. A. Liegeois, J. Escourrou, E. Ouvre, and J. Charreire Microchimerism: A stable state of low-ratio proliferation of allogeneic bone marrow Transplant Proc 9 1977 273 276
2. K. Khosrotehrani, and D.W. Bianchi Fetal cell microchimerism: helpful or harmful to the parous woman? Curr Opin Obstet Gynecol 15 2003 195 199 (Pubitemid 36432887)
3. Y. Lo, M. Lau, T.K. Chan, L.Y. Leung, and A.M. Chang Quantitative analysis of the bidirectional fetomaternal transfert of nucleated cells and plasma DNA Clin Chem 46 2000 1301 1309
4. C. Guettier, M. Sebagh, and J. Buard Male cell microchimerism in normal and diseased female livers from fetal life to adulthood Hepatology 42 2005 35 43 (Pubitemid 40911309)
5. K. Johnson, and D. Bianchi Fetal cells in maternal tissus following pregnancy: what are the consequences? Hum Reprod Update 10 2004 497 502 (Pubitemid 39529882)
6. G. Douglas, L. Thomas, M. Carr, and N.M.C. Morris Trophoblastin the circulating blood during pregnancy Am J Obstet Gynecol 78 1959 960 973
7. O. Lapaire, W. Holzgreve, J.C. Oosterwijk, R. Brinkhaus, and D.W. Bianchi Georg Schmorl on trophoblasts in the maternal circulation Placenta 28 2007 1 5 (Pubitemid 44767223)
8. Schmorl G. Pathologisch-anatomische untersuchungen über puerperal-eklampsie. Leipzig (Germany) 1893; FCW Vogel.
9. L.A. Herzenberg, D.W. Bianchi, H.M. schroder, and G.M. Cann Fetal cells in the blood of pregnant women: detection and enrichment by fluorescence- activated cell sorting Proc Natl Acad Sci U S A 76 1979 1453 1455 (Pubitemid 9136883)
10. Bianchi D, Zickwolf G, Weill G, Sylvester S, DeMaria M. Male fetal progenitor cells persist in maternal blood for as long as 27 years post-partum. Proc Natl Acad Sci U S A 1996;93(2):705-8. (Pubitemid 26041153)
11. V. Lapierre, A. Auperin, and E. Robinet Immune modulation and microchimerism after unmodified versus leuko-reduced allogeneic red blood cell transfusion in cancer patients: results of a randomized study Transfusion 47 2007 1691 1699 (Pubitemid 47300616)
12. Y. Vymetalova, R. Bohuslavova, and J.A. Hubacek High prevalence of microchimerism in female patients Transplant Proc 40 2008 3685 3687
13. K.M. Adams, N.C. Lambert, and S. Heimfeld Male DNA in female donor apheresis and CD34-enriched products Blood 102 2003 3845 3847 (Pubitemid 37409410)
14. G.L. Gilmore, B. Haq, R.K. Shadduck, S.L. Jasthy, and J. Lister Fetal-maternal microchimerism in normal parous females and parous female cancer patients Exp Hematol 36 2008 1073 1077
15. T.H. Lee, T. Paglieroni, H. Ohto, P.V. Holland, and M.P. Busch Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients Blood 93 1999 3127 3139 (Pubitemid 29200808)
16. M. Thomas, R. Williamson, and I. Craft Y chromosome sequence DNA amplified from peripheral blood of women in early pregnancy Lancet 343 1994 414 417
17. H. Arigi, H. Ohto, and M. Busch Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for non-invasive prenatal diagnosis Transfusion 41 2001 1524 1530 (Pubitemid 34072677)
18. D.W. Bianchi Fetal cells in the mother: from genetic diagnosis to diseases associated with fetal cell microchimerism Eur J Obstet Gynecol Reprod Biol 92 2000 103 108
19. P.C. Evans, N. Lambert, S. Maloney, D.E. Furst, J.M. Moore, and J.L. Nelson Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma Blood 93 1999 2033 2037 (Pubitemid 29128506)
20. N.C. Lambert, Y.M. Lo, and T.D. Erickson Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer Blood 100 2002 2845 2851
21. X.Y. Zhong, S. Holzgreve, and S. Hahn Direct quantification of fetal cells in maternal blood by real-time PCR Prenat Diagn 26 2006 850 854 (Pubitemid 44519661)
22. T. Ohtsuka, Y. Miyamoto, A. Yamakage, and S. Yamazaki Quantitative analysis of microchimerism in systemic sclerosis skin tissue Arch Dermatol Res 293 2001 387 391 (Pubitemid 32939418)
23. M. Klintschar, U.D. Immel, and A. Kehlen Fetal microchimerism in Hashimoto's thyroiditis: A quantitative approach Eur J Endocrinol 154 2006 237 241
24. B. Srivatsa, S. Srivatsa, K.L. Johnson, O. Samura, S.L. Lee, and D.W. Bianchi Microchimerism of presumed fetal origin in thyroid specimens from women: A case-control study Lancet 358 2001 2034 2038 (Pubitemid 34084826)
25. K.L. Johnson, J.L. Nelson, and D.E. Furst Fetal cell microchimerism in tissue from multiple sites in women with systemic sclerosis Arthritis Rheum 44 2001 1848 1854 (Pubitemid 32758233)
26. A.M. Stevens, W.M. McDonnell, M.E. Mullarkey, J.M. Pang, W. Leisenring, and J.L. Nelson Liver biopsies from human females contain male hepatocytes in the absence of transplantation Lab Invest 84 2004 1603 1609 (Pubitemid 39600567)
27. M. Koopmans Chimerism occurs in thyroid, lungs, skin and lymp nodes of women with sons J Reprod Immunol 78 2008 68 75
28. Z. Williams, D. Zepf, and J. Longtine Foreign fetal cells persist in the maternal circulation Fertil Steril 91 2009 2593 2595
29. K. Khosrotehrani, K.L. Johnson, J. Lau, A. Dupuy, D.H. Cha, and D.W. Bianchi The influence of fetal loss on the presence of fetal cell microchimerism: A systematic review Arthritis Rheum 48 2003 3237 3241 (Pubitemid 37409338)
30. Z. Yan, N.C. Lambert, and K.A. Guthrie Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history Am J Med 118 2005 899 906 (Pubitemid 41097469)
31. T. Sato, K. Fujimori, A. Sato, and H. Ohto Microchimerism after induced or spontaneous abortion Obstet Gynecol 112 2008 593 597
32. P. Guillot, K. O'Donoghue, and N. Fisk Fetal stem cells: betwixt and between Semin Reprod Med 24 2006 340 347 (Pubitemid 44877577)
33. P. Vabres, M.C. Malinge, M. Larregue, and D. Bonneau Microchimerism from a dizygotic twin in juvenile ulcerative lichen planus Lancet 359 2002 1861 1862 (Pubitemid 34607068)
34. S.V. Brodsky, and I. Ivanov Spermatozoa-somatic cell fusion - a mechanism for microchimerism formation J Theor Biol 259 2009 190 192
35. K.L. Johnson, O. Samura, J.L. Nelson, McDonnell MdWM, and D.W. Bianchi Significant fetal cell microchimerism in a non-transfused woman with hepatitis C: evidence of long-term survival and expansion Hepatology 36 2002 1295 1297 (Pubitemid 35253450)
36. K. Khosrotehrani, K.L. Johnson, S. Guegan, H. Stroh, and D.W. Bianchi Natural history of fetal cell microchimerism during and following murine pregnancy J Reprod Immunol 66 2005 1 12 (Pubitemid 40798123)
37. K. O'Donoghue, M. Choolani, and J. Chan Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis Mol Hum Reprod 9 2003 497 502 (Pubitemid 36874308)
38. A. Bayes-Genis, B. Bellosillo, and O. de la Calle Identification of male cardiomyocytes of extra-cardiac origin in the hearts of women with male progeny: male fetal cell microchimerism of the heart J Heart Lung Transplant 24 2005 2179 2183 (Pubitemid 41814743)
39. K. Khosrotehrani, and D.W. Bianchi Multi-lineage potential of fetal cells in maternal tissue: A legacy in reverse J Cell Sci 118 2005 1559 1563 (Pubitemid 40691884)
40. R. Schofield The relationship between the spleen colony-forming cell and the haemopoietic cell Blood 4 1978 7 25 (Pubitemid 8376317)
41. K. Khosrotehrani, D.H. Johnson, R.N. Cha, R.N. Salomon, and D.W. Bianchi Transfert of fetal cells with multilineage potential to maternal tissus JAMA 292 2004 75 80 (Pubitemid 38923796)
42. Y. Fujiki, K. Johnson, I.T. Peter, and H. Bianchi Fetal cells in the pregnant mouse are diverse and express a variety of progenitor and differentiated markers Biol Reprod 81 2009 26 32
43. E. Guetta, D. Gordon, M.J. Simchen, B. Goldman, and G. Barkai Hematopoietic progenitor cells as targets for non-invasive prenatal diagnosis: detection of fetal CD34+ cells and assessment of post-delivery persistence in the maternal circulation Blood Cells Mol Dis 30 2003 13 21 (Pubitemid 36378864)
44. D. Valerio, V. Altieri, and F.R.A. Aiello Characterization of foetal haematopoietic progenitors circulating in maternal blood of seven aneuploid pregnancies Prenat Diagn 17 1997 1159 1169 (Pubitemid 28024880)
45. C.M. Artlett, L. Cox, and R. Ramos Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosis Clin Immunol 103 2002 303 308 (Pubitemid 34666754)
46. P. Fanning, J. Jonsson, and A. Clouston Deyection of male DNA in the liver of female patients with primary biliary cirrhosis J Hepatol 33 2000 690 695
47. K. O'Donoghue, J. Chan, and J. de la Fuente Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy Lancet 364 2004 179 182 (Pubitemid 38891690)
48. Tran S, Pillemer S, Dutra A, et al. Differentiation of human marrow-derived cells into buccal epithelial cells in vivo. A molecular analytical study. Lancet 2003;361(9363):1084-8. (Pubitemid 36369561)
49. A. Liegeois, M.C. Gaillard, E. Ouvre, and D. Lewin Microchimerism in pregnant mice Transplant Proc 13 1981 1250 1252 (Pubitemid 11159158)
50. C. Campagnoli, I. Roberts, S. Kumar, P. Bennett, I. Bellantuono, and N. Fisk Identification of mesenchymal stem/progenitor cells in human-first trimester fetal blood, liver, and bone marrow Blood 98 2001 2396 2402
51. P. Ln'Anker, W. Noort, and S. Scherjon Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and speen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential Haematologica 88 2003 845 852 (Pubitemid 37128084)
52. K. Khosrotehrani Pregnancy allows the transfer and differentiation of fetal lymphoid progenitors into functional T- and B-cells in mothers J Immunol 180 2008 889 897
53. K. Piper, A. McLarnon, and J. Arrazi Functional HY-specific CD8+ T-cells are found in a high proportion of women following pregnancy with a male foetus Biol Reprd 76 2007 96 101 (Pubitemid 46013452)
54. C. Gotherstrom, O. Ringden, C. Tammik, E. Zetterberg, and M. Westgren Immunologic properties of human fetal mesenchymal stem cells Am J Obstet Gynecol 190 2004 239 245 (Pubitemid 38156354)
55. E. Bonney, and P. Matzinger The maternal immune system's interaction with circulating fetal cells J Immunol 158 1997 40 47 (Pubitemid 127483839)
56. J.M. Rak, P.P. Pagni, and K. Tiev Male microchimerism and HLA compatibility in French women with sclerodema: A different profile in limited and diffuse subset Rheumatology (Oxford) 48 2009 363 366
57. N.C. Lambert, P.C. Evans, and T.L. Hashizumi Cutting edge: persistent fetal microchimerism in T lymphocytes is associated with HLA-DQA1*0501: implications in autoimmunity J Immunol 164 2000 5545 5548 (Pubitemid 30389792)
58. M. Filho, E.C. Pavarino-Bertelli, and M. Alvarenga Systemic lupus erythematosus and microchimerism in autoimmunity Transplant Proc 2002 34
59. N. Lambert, and J.L. Nelson Microchimerism in autoimmune disease: more questions than answers? Autoimmun Rev 2 2003 133 139 (Pubitemid 37443850)
60. J.L. Nelson Microchimerism and the pathogenesis of systemic sclerosis Curr Opin Rheumatol 10 1998 564 571 (Pubitemid 28508751)
61. C.M. Artlett Microchimerism and scleroderma: an update Curr Rheumatol Rep 5 2003 154 159
62. C. Scaletti, A. Vultaggio, and S. Bonifacio Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibilty complex antigens Arthitis Rheum 46 2002 445 450 (Pubitemid 34136582)
63. S.E. Burastero, S. Galbiati, and A. Vassallo Cellular microchimerism as a lifelong physiologic status in parous women: an immunologic basis for its amplification in patients with systemic sclerosis Arthritis Rheum 48 2003 1109 1116 (Pubitemid 36418254)
64. C. Corpechot, V. Barbu, O. Chazouilleres, and R. Poupon Fetal microchimerism in primary biliary cirrhosis J Hepatol 33 2000 696 700
65. P. Invernizzi, C. De Andreis, and S.M. Sirchia Blood fetal microchimerism in primary biliary cirrhosis Clin Exp Immunol 122 2000 418 422 (Pubitemid 32002201)
66. A. Tanaka, K. Lindor, and R. Gish Fetal microchimerism alone does not contribute to the induction of primary biliary cirrhosis Hepatology 30 1999 833 838 (Pubitemid 29458267)
67. C. Renne, E. Ramos Lopez, and S. Steimle-Grauer Throid fetal male microchimerism in mothers with thyroid disorders: presence of Y-chromosomal immunofluorescence in thyroid-infiltrating lymphocytes is more prevalent in Hashimoto's thyroiditis and Grave's disease than in follicular adenoams J Clin Endocrinol Metab 89 2004 5810 5814 (Pubitemid 39518475)
68. M. Imaizumi, A. Pritsker, P. Unger, and T.F. Davies Intra-thyroidal fetal microchimerism in pregnancy and postpartum Endocrinology 143 2002 247 253 (Pubitemid 34056426)
69. C. Scaletti, A. Vultaggio, E. Maggi, S. Romagnani, and M.P. Piccinni Microchimerism and systemic sclerosis Int Arch Allergy Immunol 125 2001 196 202 (Pubitemid 32722290)
70. J.L. Nelson Microchimerism and autoimmune disease N Engl J Med 338 1998 1224 1225 (Pubitemid 28180754)
71. K. Suzuki Mechanism of the induction of autoimmune disease by graft versus host reaction. Role of CD8+ cells in the development of hepatic and ductal lesions induced by CD4+ cells in MHC class I plus II different host Lab Invest 70 1994 609 619 (Pubitemid 24181173)
72. C.M. Artlett Pathophysiology of fetal microchimeric cells Clin Chim Acta 360 2005 1 8 (Pubitemid 41225389)
73. P. Christner Increased numbers of microchimeric cells of foetal origin are associated with dermal fibrosis in mice following injection of vinyl chloride Arthitis Rheum 43 2000 2598 2605
74. H. Murata, H. Nakauchi, and T. Sumida Microchimerism in Japanese women patients with systemic sclerosis Lancet 354 1999 220 (Pubitemid 29329165)
75. A. Selva-O'Callaghan, T. Mijares-Boeckh-Behrens, and E.B. Prades Lack of evidence of foetal microchimerism in female Spanish patients with systemic sclerosis Lupus 12 2003 15 20 (Pubitemid 36172657)
76. Y. Jlang, B. Jahagirdar, and R. Reinhadt Pluripotency of mesenchymal stem cells derived from adult marrow Nature 418 2002 41 49 (Pubitemid 34742565)
77. K. Khosrotehrani, R. Reyes, and K. Johnson Fetal cells participate over time in the response to sepicific types of murine maternal hepatic injury Hum Reprod 22 2007 654 661
78. P. Guillot, O. Abbass, and J. Duncan Bassett Intrauterine transplantation of human mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice Blood 111 2008 1717 1725 (Pubitemid 351213464)
79. X.W. Tan, H. Liao, L. Sun, M. Okabe, Z.C. Xiao, and G.S. Dawe Fetal microchimerism in the maternal mouse brain: A novel population of fetal progenitor or stem cells able to cross the blood-brain barrier? Stem Cells 23 2005 1443 1452 (Pubitemid 41740992)
80. J. Chen, P. Sanderg, and Y. Li Intraveinous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats Stroke 32 2001 2682 2688 (Pubitemid 33055324)
81. C. Cogle, A. Yachnis, and E. Laywell Bone marrow transdifferentiation in brain after transplantation: A retrospective study Lancet 363 2004 1432 1437 (Pubitemid 38586719)
82. L. Kowalzick, C.M. Artlett, and K. Thoss Chronic graft-versus-host- disease-like dermopathy in a child with CD4+ cell microchimerism Dermatology 210 2005 68 71 (Pubitemid 39656725)
83. H. Taylor Endometrial cells derived from donor stem cells in bone marrow transplant recipients JAMA 292 2004 81685
84. R. Harris, E. Herzog, E. Bruscia, J. Grove, J. Van Haman, and D. Krause Lack of fusion requirement for the development of bone marrow derived epithelia Science 305 2004 90 93 (Pubitemid 38869378)
85. I. Hromadnikova, D. Zlacka, T. Nguyen, L. Sedlackova, L. Zejskova, and A. Sosna Cellules fœtales mésenchymateuses dérivées de tissu synovial et de peau atteints de polyarthrite rhumatoïde Rev Rhumatisme 75 2008 835 838
86. J.L. Nelson Naturally acquired microchimerism: for better or for worse Arthritis Rheum 60 2009 5 7
87. J.M. Rak, L. Maestroni, and N. Balandraud Transfer of the shared epitope through microchimerism in women with rheumatoid arthritis Arthritis Rheum 60 2009 73 80
88. J. Hazes, B. Dijkmans, J. Vandenbroucke, R. de Vries, and A. Cats Pregnancy and risk of developping rheumatoid artritis Arthitis Rheum 33 1990 1770 1775
89. Guthrie KA, Dugowson C, Voigt L, Koepsell T, Nelson J. Does pregnancy provide vaccine-like protection against rheumatoid arthritis. Arthritis Rheum 2010;62(7):1842-8.
90. V.K. Gadi Fetal microchimerism and cancer Cancer Lett 276 2009 8 13
91. J.A. Sawicki Fetal microchimerism and cancer Cancer Res 68 2008 9567 9569
92. J. Yu, X. Ren, S. Cao, H. Li, and X. Hao Beneficial effects of fetal-maternal microchimerism on the activated haplo-identical peripheral blood stem cell treatment for cancer Cytotherapy 10 2008 331 339 (Pubitemid 351983157)
93. V. Cirello, M.P. Recalcati, and M. Muzza Fetal cell microchimerism in papillary thyroid cancer: A possible role in tumour damage and tissue repair Cancer Res 68 2008 8482 8488
94. V.K. Gadi, K.E. Malone, K.A. Guthrie, P.L. Porter, and J.L. Nelson Case-control study of fetal microchimerism and breast cancer PLoS ONE 3 2008 e1706
95. D. Cha, K. Khosrotehrani, Y. Kim, H. Stroh, D.W. Bianchi, and K.L. Johnson Cervical cancer and microchimerism Obstet Gynecol 102 2003 774 781 (Pubitemid 37206414)
96. V.K. Gadi, and J.L. Nelson Fetal microchimerism in women with breast cancer Cancer Res 67 2007 9035 9038 (Pubitemid 47535887)
97. G. Dubernard, S. Aractingi, and M. Oster Breast cancer stroma frequently recruits fetal derived cells during pregnancy Breast Cancer Res 2008 R14
98. G. Dubernard, M. Oster, and F. Chareyre Increased fetal cell microchimerism in high grade breast carcinomas occurring during pregnancy Int J Cancer 124 2009 1054 1059
99. K. O'Donoghue, H. Sultan, F. Al-Allaf, J. Anderson, and N. Wyatt-Ashmead Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy Reprod Biomed Online 16 2008 382 390 (Pubitemid 351419458)
100. L. Holmegren, A. Szeles, and E. Rajnavolgyi Horizontal transfer of DNA by the uptake of apoptotic bodies Blood 93 1999 3956 3963 (Pubitemid 29249845)
101. E. Velie, S. Nechuta, and J. Osuch Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women Breast Dis 24 2005 17 35
102. R. Frank Fetal microchimeric cells and breast cancer JAMA 292 2004 1552 1553
103. M. Horowitz, R. Gale, and P. Sondel Graft-versus-leukemia reactions after bone marrow transplantation Blood 75 1990 555 562 (Pubitemid 20069191)
104. E. Vinatier, B. Merlot, E. Poncelet, P. Collinet, and D. Vinatier Breast cancer and pregnancy Gynecol Obstet Fertil 37 2009 495 503
105. S. Lefebvre, M. Antoine, and S. Uzan Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer J Pathol 196 2002 266 274 (Pubitemid 34189414)
106. Fugazzola L, Cirello V, Beck-Peccoz P. Fetal cell microchimerism in human cancers. Cancer Lett 2010;287:136-41.