Effect of mianserin on gastric sensorimotor function and gastric emptying: A randomized, placebo-controlled, double-blind, crossover study in healthy volunteers

Neurogastroenterology and Motility

Volumn 23, Issue 5, 2011, Pages

  Janssen, P ^a   Van Oudenhove, L ^a   Vos, R ^a   Verbeke, K ^a   Tack, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Gastric accommodation; Gastric barostat; Gastric emptying; Gastric sensation; Mianserin

Indexed keywords

ANTIDEPRESSANT AGENT; MIANSERIN; PLACEBO;

ADULT; ARTICLE; BAROSTAT; BREATH ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; DYSPEPSIA; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EMPTYING; STOMACH FUNCTION; TEST MEAL;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BREATH TESTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GASTRIC EMPTYING; HUMANS; MALE; MIANSERIN; PLACEBOS; STOMACH;

EID: 79954419395     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2011.01671.x     Document Type: Article

References (55)

1. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001; 121: 526-35.
2. Kindt S, Tack J. Impaired gastric accommodation and its role in dyspepsia. Gut 2006; 55: 1685-91.
3. Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003; 98: 783-8.
4. Suzuki H, Masaoka T, Sakai G, Ishii H, Hibi T. Improvement of gastrointestinal quality of life scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy. J Gastroenterol Hepatol 2005; 20: 1652-60.
5. Wilmer A, Van CE, Andrioli A, Tack J, Coremans G, Janssens J. Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying. Gut 1998; 42: 235-42.
6. Cheng C, Hui WM, Lam SK. Psychosocial factors and perceived severity of functional dyspeptic symptoms: a psychosocial interactionist model. Psychosom Med 2004; 66: 85-91.
7. Van Oudenhove L, Vandenberghe J, Geeraerts B et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation? Gut 2008; 57: 1666-73.
8. Jones MP, Dilley JB, Drossman D, Crowell MD. Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. [Review] [96 refs]. Neurogastroenterol Motil 2006; 18: 91-103.
9. Tanum L, Malt UF. A new pharmacologic treatment of functional gastrointestinal disorder. A double-blind placebo-controlled study with mianserin. Scand J Gastroenterol 1996; 31: 318-25.
10. Bouras EP, Talley NJ, Camilleri M et al. Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 2008; 103: 2043-50.
11. Mertz H, Fass R, Kodner A, Yan-Go F, Fullerton S, Mayer EA. Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol 1998; 93: 160-5.
12. Wu CY, Chou LT, Chen HP, Chang CS, Wong PG, Chen GH. Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia. Hepatogastroenterology 2003; 50: 278-83.
13. Hojo M, Miwa H, Yokoyama T et al. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol 2005; 40: 1036-42.
14. Jackson JL, O'Malley PG, Tomkins G, Balden E, Santoro J, Kroenke K. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000; 108: 65-72.
15. van Kerkhoven LA, Laheij RJ, Aparicio N et al. Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2008; 6: 746-52.
16. Thumshirn M, Camilleri M, Choi MG, Zinsmeister AR. Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology 1999; 116: 573-85.
17. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132: 397-414.
18. Marzio L, Cappello G, Grossi L, Manzoli L. Effect of the 5-HT3 receptor antagonist, ondansetron, on gastric size in dyspeptic patients with impaired gastric accommodation. Dig Liver Dis 2008; 40: 188-93.
19. Dubois A, Castell DO. Histamine H2-receptor involvement in the regulation of gastric emptying. Am J Physiol 1986; 250: G244-7.
20. Ameloot K, Janssen P, Scarpellini E et al. Endocannabinoid control of gastric sensorimotor function in man. Aliment Pharmacol Ther 2010; 31: 1123-31.
21. Van Oudenhove L, Kindt S, Vos R, Coulie B, Tack J. Influence of buspirone on gastric sensorimotor function in man. Aliment Pharmacol Ther 2008; 28: 1326-33.
22. Maes BD, Ghoos YF, Geypens BJ et al. Combined carbon-13-glycine/carbon-14-octanoic acid breath test to monitor gastric emptying rates of liquids and solids. J Nucl Med 1994; 35: 824-31.
23. Sarnelli G, Sifrim D, Janssens J, Tack J. Influence of sildenafil on gastric sensorimotor function in humans. Am J Physiol Gastrointest Liver Physiol 2004; 287: 988-92.
24. Lee KJ, Vos R, Tack J. Effects of capsaicin on the sensorimotor function of the proximal stomach in humans. Aliment Pharmacol Ther 2004; 19: 415-25.
25. Lee KJ, Vos R, Janssens J, Tack J. Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans. Aliment Pharmacol Ther 2003; 18: 199-207.
26. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut 1999; 45(Suppl 2): II37-42.
27. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346-52.
28. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998; 42: 814-22.
29. Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18: 663-80.
30. Budavari AI, Olden KW. Psychosocial aspects of functional gastrointestinal disorders. Gastroenterol Clin North Am 2003; 32: 477-506.
31. Mayer EA, Craske M, Naliboff BD. Depression, anxiety, and the gastrointestinal system. J Clin Psychiatry 2001; 62(Suppl 36): 28-36.
32. Lydiard RB. Irritable bowel syndrome, anxiety, and depression: what are the links? J Clin Psychiatry 2001; 62(Suppl 45): 38-45.
33. Van Oudenhove L, Vandenberghe J, Geeraerts B et al. Relationship between anxiety and gastric sensorimotor function in functional dyspepsia. Psychosom Med 2007; 69: 455-63.
34. Choung RS, Cremonini F, Thapa P, Zinsmeister AR, Talley NJ. The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: a double-blind, randomized, placebo-controlled trial. Neurogastroenterol Motil 2008; 20: 220-7.
35. Brogden RN, Heel RC, Speight TM, Avery GS. Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs 1978; 16: 273-301.
36. Salzman SK, Kelly G, Chavin J et al. Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment. J Pharmacol Exp Ther 1994; 269: 322-8.
37. Coulie B, Tack J, Maes B, Geypens B, De Roo M, Janssens J. Sumatriptan, a selective 5-HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans. Am J Physiol 1997; 272: G902-8.
38. Tack J, Caenepeel P, Piessevaux H, Cuomo R, Janssens J. Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia. Gut 2003; 52: 1271-7.
39. Bonnafous C, Lefevre P, Bueno L. Benzodiazepine-withdrawal-induced gastric emptying disturbances in rats: evidence for serotonin receptor involvement. J Pharmacol Exp Ther 1995; 273: 995-1000.
40. Akkermans LM, Vos A, Hoekstra A, Roelofs JM, Horowitz M. Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects. Gut 1988; 29: 1249-52.
41. Hayes MR, Moore RL, Shah SM, Covasa M. 5-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying. Am J Physiol Regul Integr Comp Physiol 2004; 287: R817-23.
42. Kwiatek MA, Fox MR, Steingoetter A et al. Effects of clonidine and sumatriptan on postprandial gastric volume response, antral contraction waves and emptying: an MRI study. Neurogastroenterol Motil 2009; 21: 928-e71.
43. Fulop K, Zadori Z, Ronai AZ, Gyires K. Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence. Eur J Pharmacol 2005; 528: 150-7.
44. Gorard DA, Libby GW, Farthing MJ. Influence of antidepressants on whole gut and orocaecal transit times in health and irritable bowel syndrome. Aliment Pharmacol Ther 1994; 8: 159-66.
45. Chial HJ, Camilleri M, Burton D, Thomforde G, Olden KW, Stephens D. Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. Am J Physiol Gastrointest Liver Physiol 2003; 284: G130-7.
46. Lee JS, Camilleri M, Zinsmeister AR et al. Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test. Am J Gastroenterol 2000; 95: 2751-61.
47. Punkkinen J, Konkka I, Punkkinen O, Korppi-Tommola T, Farkkila M, Koskenpato J. Measuring gastric emptying: comparison of 13C-octanoic acid breath test and scintigraphy. Dig Dis Sci 2006; 51: 262-7.
48. Ladabaum U, Glidden D. Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans. Neurogastroenterol Motil 2002; 14: 395-402.
49. Tack J, Broekaert D, Coulie B, Fischler B, Janssens J. Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans. Aliment Pharmacol Ther 2003; 17: 603-8.
50. Tack J, Coulie B, Wilmer A, Janssens J. Sumatriptan, a 5-HT1-receptor agonist, causes a significant relaxation of the gastric fundus in man. Gastroenterology 1995; 108: A696.
51. 7-receptor-mediated gastric relaxation in conscious dogs. Am J Physiol Gastrointest Liver Physiol 2005; 289: G108-15.
52. Janssen P, Prins NH, Meulemans AL, Lefebvre RA. Pharmacological characterization of the 5-HT receptors mediating contraction and relaxation of canine isolated proximal stomach smooth muscle. Br J Pharmacol 2002; 136: 321-9.
53. Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA. Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. Br J Pharmacol 2001; 134: 1351-9.
54. Baxter GS, Murphy OE, Blackburn TP. Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle. Br J Pharmacol 1994; 112: 323-31.
55. Wilson JA, Read JR, Boyd EJ, Wormsley KG. Inhibition of pentagastrin-stimulated and overnight gastric secretion by mianserin. Br J Clin Pharmacol 1983; 15(Suppl 2): 329S-33S.