Effect of alpha-ketoglutarate on neurobehavioral, neurochemical and oxidative changes caused by sub-chronic cyanide poisoning in rats

Neurochemical Research

Volumn 36, Issue 3, 2011, Pages 540-548

  Mathangi, D C ^a   Shyamala, R ^a   Vijayashree, R ^a   Rao, K R ^a   Ruckmani, A ^a   Vijayaraghavan, R ^b   Bhattacharya, R ^b  

^a CHETTINAD HOSPITAL AND RESEARCH INSTITUTE   (India)

^b DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Alpha ketoglutarate; Cyanide; Neurobehavior; Neurochemicals; Oxidative stress; Protectio

Indexed keywords

2 OXOGLUTARIC ACID; ASPARTIC ACID; CATALASE; DOPAMINE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; POTASSIUM CYANIDE; SODIUM THIOSULFATE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; CYANIDE POISONING; DRUG MECHANISM; FEMALE; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MOTOR ACTIVITY; MOTOR COORDINATION; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT;

ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BRAIN; CYANIDES; DOPAMINE; HUMANS; KETOGLUTARIC ACIDS; LIPID PEROXIDATION; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; THIOSULFATES;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 79954414539     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0376-z     Document Type: Article

References (49)

1. Bhattacharya R, Flora SJS (2009) Cyanide toxicity and its treatment. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents, vol Chapter 19. Elsevier Inc, New York, pp 255-270.
2. Bryson DD (1987) Acute industrial cyanide intoxication and its treatment. In: Ballantyne B, Marrs TC (eds) Clinical and experimental toxicology of cyanides, Wright, Bristol, pp 348-358.
3. Rumack BH (1983) In: Respiratory are of chemical casualities. Proceedings of the symposium of respiratory care of chemical casualities, Virginia, pp 28-30.
4. Osuntokun BO (1981) Cassava diet, chronic cyanide intoxication and neuropathy in the Nigerian Africans. World Rev Nutr Diet 36:141-173.
5. Tylleskar T, Legue FD, Peterson S, Kpizingui E, Stecker P (1994) Konzo in the Central African Republic. Neurology 44(5): 959-961. (Pubitemid 24158819)
6. Kamalu BP (1995) The adverse effects of long-term cassava (Manihot esculenta Crantz) consumption. Int J Food Sci Nutr 46(1):65-93.
7. Rosling H (1989) Cassava associated neurotoxicity in Africa. In: Volans GN, Sims J, Sullivan FM, Turner P (eds) Proceedings of the 5th international congress of toxicology, Taylor and Francis, Brighton, pp 605-614.
8. Madhusudanan M, Menon MK, Ummer K, Radhakrishnanan K (2008) Clinical and etiological profile of tropical ataxic neuropathy in Kerala, South India. Eur Neurol 60(1):21-26. (Pubitemid 351799063)
9. Tshala-Katumbay DD, Spencer PS (2007) Chapter 18 toxic disorders of the upper motor neuron system. Handb Clin Neurol 82:353-372.
10. Ogunniyi A (2009) History of tropical neurology. Handb Clin Neurol 9:815-830.
11. Mathangi DC, Mohan V, Namasivayam A (1999) Effect of cassava on motor co-ordination and neurotransmitter level in the albino rat. Food Chem Toxicol 37(1):57-60. (Pubitemid 29015805)
12. Mathangi DC, Namasivayam A (2000) Effect of chronic cyanide intoxication on memory in albino rats. Food Chem Toxicol 38(1):51-55. (Pubitemid 30102213)
13. Mathangi DC, Namasivayam A (2000) Effect of cassava consumption on open-field behavior and brain neurotransmitters in albino rats. Physiol Behav 70(1-2):89-93.
14. Philbrick DJ, Hopkins JB, Hill DC, Alexander JC, Thomson RG (1979) Effects of prolonged cyanide and thiocyanate feeding in rats. J Toxicol Environ Health 5(4):579-592. (Pubitemid 9237177)
15. Mathangi DC, Namasivayam A (2000) Neurochemical and behavioural correlates in cassava-induced neurotoxicity in rats. Neurotox Res 2(1):29-35.
16. van Heijst AN, Douze JM, van Kesteren RG, van Bergen JE, van Dijk A (1987) Therapeutic problems in cyanide poisoning. J Toxicol Clin Toxicol 25(5):383-398. (Pubitemid 18043979)
17. Baskin SI, Horowitz AM, Nealley EW (1992) The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. J Clin Pharmacol 32:368-375.
18. Bhattacharya R (2004) α-ketoglutarate: a promising antidote to cyanide poisoning. In: Flora SJS, Romano JA, Baskin SI, Sekhar K (eds) Pharmacological perspectives of toxic chemicals and their antidotes. Narosa Publishing House, New Delhi, pp 411-430.
19. Niknahad H, Khan S, Sood C, O'Brien PJ (1994) Prevention of cyanide-induced cytotoxicity by nutrients in isolated rat hepatocytes. Toxicol Appl Pharmacol 128(2):271-279. (Pubitemid 24330849)
20. Bhattacharya R, Rao PVL, Vijayaraghavan R (2002) Invitro and in vivo attenuation of experimental cyanide poisoning by alphaketoglutarate. Toxicol Letts 128:185-195. (Pubitemid 34183461)
21. Bhattacharya R, Vijaraghavan R (2002) Promising role of a-ketoglutarate in protecting the lethal effects of cyanide. Hum Exp Toxicol 21:297-303.
22. Tulsawani RK, Debnath M, Pant SC, Kumar O, Prakash AO, Vijayaraghavan R et al (2005) Effect of sub-acute oral cyanide administration in rats: protective efficacy of alpha-ketoglutarate and sodium thiosulfate. Chem Biol Interact 156(1):1-12. (Pubitemid 41306427)
23. Tulsawani R, Kumar D, Bhattacharya R (2007) Effect of pretreatment of alpha-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents. Biomed Environ Sci 20(1):56-63. (Pubitemid 46591305)
24. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351-358. (Pubitemid 9194347)
25. Moron MS, Depierre JW, Mannervik B (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 582(1): 67-78. (Pubitemid 9065588)
26. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179(73):588-590.
27. Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469-474.
28. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47(2):389-394.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193(1): 265-275.
30. Saravanan C, Sunil AG, Vasanthi Hannah R, Muthusamy VS, Ramanathan M (2007) Development and validation of an HPTLC method for simultaneous estimation of excitatory neurotransmitters in rat brain. J Liq Chrom and Rel Tech 30(19):2891- 2902. (Pubitemid 47341169)
31. McManus JFA, Mowry RW (1965) General methods for study of cell and its structure. In: McManus JFA, Mowry RW (eds) Staining methods: histologic and histochemical. Harper Bros, New York, pp 73-90.
32. Borowitz JL, Kanthasamy AG, Isom GE (1992) Toxicodynamics of cyanide. In: Somani SM (ed) Chemical warfare agents. Academic Press, San Diego, CA, pp 209-236.
33. Mbelesso P, Yogo ML, Yangatimbi E, Paul-Senekian VD, Nali NM, Preux PM (2009) Outbreak of konzo disease in health region No. 2 of the Central African Republic. Rev Neurol (Paris) 165(5):466-470.
34. Tashala Katumbay DD, Feq-Olofsson KE, Kazadi-Kayembe T, Tylleskar T, Fallmar P (2002) Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation. Muscle Nerve 25(2):230-235. (Pubitemid 34117070)
35. Oluwole OS, Onabolu AO, Sowunmi A (2002) Exposure to cyanide following a meal of cassava food. Toxicol Lett 135(1-2): 19-23. (Pubitemid 35266715)
36. Tor-Agbidye J, Palmer VS, Spencer PS, Craig AM, Blythe LL, Sabri MI (1999) Sodium cyanate alters glutathione homeostasis in rodent brain: relationship to neurodegenerative diseases in protein-deficient malnourished populations in Africa. Brain Res 820(1-2):12-19. (Pubitemid 29225474)
37. Paula Cardosa A, Ernesto M et al (2004) Combination of cassava flour cyanide and urinary thiocyanate measurement of school children in Mozambique. Int J Food Sci Nutr 55(3):183- 190. (Pubitemid 38996830)
38. Johnson JD, Conroy WG, Burris KD, Isom GE (1987) Peroxidation of brain lipids following cyanide intoxication in mice. Toxicology 46(1):21-28. (Pubitemid 17142865)
39. Ardelt BK, Borowitz JL, Isom GE (1989) Brain lipid peroxidation and antioxidant defense mechanisms following acute cyanide intoxication. Toxicology 56:147-154. (Pubitemid 19143975)
40. Ardelt BK, Borowitz JL, Maduh EU, Swain SL, Isom GE (1994) Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology 89(2):127-137. (Pubitemid 24154933)
41. Mills EM, Gunasekar PG, Pavlakovic G, Isom GE (1996) Cyanide- induced apoptosis and oxidative stress in differentiated PC12 cells. Neurochem 67(3):1039-1046. (Pubitemid 26277916)
42. Tulsawani R, Bhattacharya R (2006) Effect of alpha-ketoglutarate on cyanide-induced biochemical alterations in rat brain and liver. Biomed Environ Sci 19(1):61-66.
43. Okolie NP, Osagie AU (1999) Liver and kidney lesions and associated enzyme changes induced in rabbits by chronic cyanide exposure. Food Chem Toxicol 37(7):745-750. (Pubitemid 29397363)
44. Sousa AB, Soto-Blanco B, Guerra JL, Kimura ET, Gorniak SL (2002) Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity? Toxicology 174(2):87-95. (Pubitemid 34457800)
45. Moore SJ, Norris JC, Ho IK, Hume AS (1986) The efficacy of alpha-ketoglutaric acid in the antagonism of cyanide intoxication. Toxicol Appl Pharmacol 82(1):40-44. (Pubitemid 16146443)
46. Norris JC, Utley WA, Hume AS (1990) Mechanism of antagonizing cyanide-induced lethality by alpha-ketoglutaric acid. Toxicology 62(3):275-283. (Pubitemid 20198814)
47. Bhattacharya R, Tulsawani R (2008) In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid. Drug Chem Toxicol 31(1):149-161.
48. Bhattacharya R, Satpute RM, Hariharakrishnan J, Tripathi H, Saxena PB (2009) Acute toxicity of some synthetic cyanogens in rats and their response to oral treatment with alpha-ketoglutarate. Food Chem Toxicol 47(9):2314-2320.
49. Pangborn JB, Hicks JT, Chambers JR, and Shahani KM (eds) (1990) A monograph on alpha-ketoglutaric acid. Bionostics, Inc., Lisle, pp 1-3.