A modular approach to assembly of totally synthetic self-adjuvanting lipopeptide-based vaccines allows conformational epitope building

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 12944-12951

  Zeng, Weiguang ^a   Horrocks, Kylie J ^a   Robevska, Gorjana ^a   Yi Wong, Chinn ^a   Azzopardi, Kristy ^a   Tauschek, Marija ^a   Robins Browne, Roy M ^a   Jackson, David C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE EFFECT; ANTIBODY RESPONSE; BIOLOGICAL ACTIVITIES; CELL EPITOPES; CHEMICAL GROUP; CHEMICAL LINKAGE; CHEMICAL SYNTHESIS; CHEMOSELECTIVE LIGATION; CONFORMATIONAL EPITOPES; CONFORMATIONAL INTEGRITY; CYTOTOXIC T LYMPHOCYTES; DISULFIDE BONDS; ENTEROTOXIGENIC ESCHERICHIA COLI; HEAT-STABLE ENTEROTOXIN; IMMUNE RESPONSE; INFLUENZA VIRUS; LIPOPEPTIDES; MODULAR APPROACH; PEPTIDE SEQUENCES; PLUG AND PLAY APPROACH; REPRODUCTIVE HORMONES; T CELLS; THIOETHER BONDS;

AMINO ACIDS; ANIMALS; ANTIBODIES; CHEMICAL PROPERTIES; CONFORMATIONS; COVALENT BONDS; ESCHERICHIA COLI; SYNTHESIS (CHEMICAL); VACCINES; VIRUSES;

ANTIGENS;

ACID POLYMERASE DISULFIDE [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; ACID POLYMERASE OXIME [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; ACID POLYMERASE THIOETHER [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; EPITOPE; GAMMA INTERFERON; GONADORELIN ANTIBODY; GONADORELIN DISULFIDE [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLALANYLLEUCYLASPARAGINYLASPARAGINYLARGINYLPHENYLALANYLGLUTAMINYLISOLEUCYLLYSYLGLYCYLVALYLGLUTAMINYLLEUCYLLYSYLSERINE; GONADORELIN DISULFIDE [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; GONADORELIN OXIME [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLALANYLLEUCYLASPARAGINYLASPARAGINYLARGINYLPHENYLALANYLGLUTAMINYLISOLEUCYLLYSYLGLYCYLVALYLGLUTAMINYLLEUCYLLYSYLSERINE; GONADORELIN OXIME [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; GONADORELIN OXIME [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLLYSYLLEUCYLISOLEUCYLPROLYLASPARAGINYLALANYLSERYLLEUCYLISOLEUCYLGLUTAMYLASPARAGINYLCYSTEINYLTHREONYLLYSYLALANYLGLUTAMYLLYSINE; GONADORELIN THIOETHER [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLALANYLLEUCYLASPARAGINYLASPARAGINYLARGINYLPHENYLALANYLGLUTAMINYLISOLEUCYLLYSYLGLYCYLVALYLGLUTAMINYLLEUCYLLYSYLSERINE; GONADORELIN THIOETHER [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYLHISTIDYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; HEAT STABLE ENTEROTOXIN OXIME [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLLYSYLLEUCYLISOLEUCYLPROLYLASPARAGINYLALANYLSERYLLEUCYLISOLEUCYLGLUTAMYLASPARAGINYLCYSTEINYLTHREONYLLYSYLALANYLGLUTAMYLLYSINE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; PEPTIDE VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY TEST; DISULFIDE BOND; FEASIBILITY STUDY; FEMALE; HELPER CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FOLDING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACTERIAL TOXINS; CD8-POSITIVE T-LYMPHOCYTES; ENTEROTOXIGENIC ESCHERICHIA COLI; ENTEROTOXINS; EPITOPES, T-LYMPHOCYTE; GONADOTROPIN-RELEASING HORMONE; LIPOPEPTIDES; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE; VACCINES, SYNTHETIC;

ANIMALIA; ESCHERICHIA COLI; ORTHOMYXOVIRIDAE;

EID: 79953875922     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.227744     Document Type: Article

References (31)

1. BenMohamed, L., Belkaid, Y., Loing, E., Brahimi, K., Gras-Masse, H., and Druilhe, P. (2002) Eur. J. Immunol. 32, 2274-2281
2. Brown, L. E., and Jackson, D. C. (2005) Curr. Drug Deliv. 2, 383-393
3. Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W., and Hart, D. N. (2002) Curr. Drug Targets 3, 175-196
4. Purcell, A. W., McCluskey, J., and Rossjohn, J. (2007) Nat. Rev. Drug Discov. 6, 404-414
5. Alphs, H. H., Gambhira, R., Karanam, B., Roberts, J. N., Jagu, S., Schiller, J. T., Zeng, W., Jackson, D. C., and Roden, R. B. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5850-5855
6. Batzloff, M. R., Hartas, J., Zeng, W., Jackson, D. C., and Good, M. F. (2006) J. Infect. Dis. 194, 325-330
7. Deliyannis, G., Kedzierska, K., Lau, Y. F., Zeng, W., Turner, S. J., Jackson, D. C., and Brown, L. E. (2006) Eur. J. Immunol. 36, 770-778
8. Jackson, D. C., Lau, Y. F., Le, T., Suhrbier, A., Deliyannis, G., Cheers, C., Smith, C., Zeng, W., and Brown, L. E. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 15440-15445
9. Zeng, W., Ghosh, S., Lau, Y. F., Brown, L. E., and Jackson, D. C. (2002) J. Immunol. 169, 4905-4912
10. Fitzmaurice, C. J., Brown, L. E., Kronin, V., and Jackson, D. C. (2000) Int. Immunol. 12, 527-535
11. Zeng, W., Eriksson, E. M., Lew, A., and Jackson, D. C. (2011) Mol. Immunol. 48, 490-496
12. Chua, B. Y., Zeng, W., Lau, Y. F., and Jackson, D. C. (2007) Vaccine 25, 92-101
13. Zeng, W., Ghosh, S., Macris, M., Pagnon, J., and Jackson, D. C. (2001) Vaccine 19, 3843-3852
14. Shimonishi, Y., Hidaka, Y., Koizumi, M., Hane, M., Aimoto, S., Takeda, T., Miwatani, T., and Takeda, Y. (1987) FEBS Lett. 215, 165-170
15. Taxt, A., Aasland, R., Sommerfelt, H., Nataro, J., and Puntervoll, P. (2010) Infect. Immun. 78, 1824-1831
16. Ghosh, S., Walker, J., and Jackson, D. C. (2001) Immunology 104, 58-66
17. Walker, J., Ghosh, S., Pagnon, J., Colantoni, C., Newbold, A., Zeng, W., and Jackson, D. C. (2007) Vaccine 25, 7111-7119
18. Zeng, W., Pagnon, J., and Jackson, D. C. (2007) Mol. Immunol. 44, 3724-3731
19. Belz, G. T., Xie, W., Altman, J. D., and Doherty, P. C. (2000) J. Virol. 74, 3486-3493
20. Day, E. B., Zeng, W., Doherty, P. C., Jackson, D. C., Kedzierska, K., and Turner, S. J. (2007) J. Immunol. 179, 2187-2194
21. Jackson, D. C., Drummer, H. E., and Brown, L. E. (1994) Virology 198, 613-623
22. Robertson, J. M., Jensen, P. E., and Evavold, B. D. (2000) J. Immunol. 164, 4706-4712
23. Gali, H., Sieckman, G. L., Hoffman, T. J., Owen, N. K., Mazuru, D. G., Forte, L. R., and Volkert, W. A. (2002) Bioconjug. Chem. 13, 224-231
24. Rose, K., Zeng, W., Regamey, P. O., Chernushevich, I. V., Standing, K. G., and Gaertner, H. F. (1996) Bioconjug. Chem. 7, 552-556
25. Brown, L. E., Murray, J. M., Anders, E. M., Tang, X. L., White, D. O., Tregear, G. W., and Jackson, D. C. (1988) J. Virol. 62, 1746-1752
26. Coles, R. M., Mueller, S. N., Heath, W. R., Carbone, F. R., and Brooks, A. G. (2002) J. Immunol. 168, 834-838
27. Robins-Browne, R. M., and Levine, M. M. (1981) Gastroenterology. 80, 321-326
28. Zeng, W., Gauci, S., Ghosh, S., Walker, J., and Jackson, D. C. (2005) Vaccine 23, 4427-4435
29. Lau, Y. F., Deliyannis, G., Zeng, W., Mansell, A., Jackson, D. C., and Brown, L. E. (2006) Int. Immunol. 18, 1801-1813
30. Ng, W. C., Gilbertson, B., Lim, B., Zeng, W., Jackson, D. C., and Brown, L. E. (2009) Influenza Other Respi. Viruses 3, 177-182
31. Pejoski, D., Zeng, W., Rockman, S., Brown, L. E., and Jackson, D. C. (2010) Immunol. Cell Biol. 88, 605-611