The geometry of synthetic peptide-based immunogens affects the efficiency of T cell stimulation by professional antigen-presenting cells

International Immunology

Volumn 12, Issue 4, 2000, Pages 527-535

  Fitzmaurice, Catherine J ^a   Brown, Lorena E ^a   Kronin, Vadim ^b   Jackson, David C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Antigen presentation; Dendritic cells; Epitope; Synthetic peptide; Vaccine

Indexed keywords

ANTIGEN; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; DENDRITIC CELL; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPLEEN CELL; T LYMPHOCYTE;

EID: 0034085898     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.4.527     Document Type: Article

References (33)

1. Dyrberg, T. and Oldstone, M. B. 1986. Peptides as antigens. Importance of orientation. J. Exp. Med. 164:1344.
2. Lu, Y. A., Clavijo, P., Galantino, M., Shen, Z. Y., Liu, W. and Tam, J. P 1991. Chemically unambiguous peptide immunogen: preparation, orientation and antigenicity of purified peptide conjugated to the multiple antigen peptide system. Mol. Immunol. 28:623.
3. Partidos, C., Stanley, C. and Steward, M. 1992. The effect of orientation of epitopes on the immunogenicity of chimeric synthetic peptides representing measles virus protein sequences. Mol. Immunol. 29:651.
4. Fernandez, I. M., Snijders, A., Benaissa-Trouw, B. J., Harmsen, M., Snippe, H. and Kraaijeveld, C. A. 1993. Influence of epitope polarity and adjuvants on the immunogenicity and efficacy of a synthetic peptide vaccine against Semliki Forest virus. J. Virol. 67:5843.
5. Sharma, P., Kumar, A., Batni, S. and Chauhan, V. S. 1993. Co-dominant and reciprocal T-helper cell activity of epitopic sequences and formation of junctional B cell determinants in synthetic T:B chimeric immunogens. Vaccine 11:1321.
6. Fitzmaurice, C. J., Brown, L. E., McInerney, T. L. and Jackson, D. C. 1996. The assembly and immunological properties of non-linear synthetic immunogens containing T cell and B cell determinants. Vaccine 14:553.
7. Watts, C. 1997. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15:821.
8. Lanzavecchia, A. 1996. Mechanisms of antigen uptake for presentation. Curr. Opin. Immunol. 8:348.
9. Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L. and Shortman, K. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176:47.
10. Suss, G. and Shortman, K. 1996. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183:1789.
11. Kronin, V., Winkel, K., Suss, G., Kelso, A., Heath, W., Kirberg, J., von-Boehmer, H. and Shortman, K. 1996. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J. Immunol. 157:3819.
12. Lankar, D., Briken, V., Adler, K., Weiser, P., Cassard, S., Blank, U., Viguier, M. and Bonnerot, C. 1998. Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation. J. Immunol. 188:819.
13. Pinet, V., Vergelli, M., Martin, R., Bakke, O. and Long, E. O. 1995. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 375:603.
14. Bonnerot, C., Lankar, D., Hanau, D., Spehner, D., Davoust, J., Salamero, J. and Fridman, W. H. 1995. Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentation. Immunity 3:335.
15. Viner, N. J., Nelson, C. A., Deck, B. and Unanue, E. R. 1996. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J. Immunol. 156:2365.
16. Briken, V., Lankar, D. and Bonnerot, C. 1997. New evidence for two MHC class II-restricted antigen presentation pathways by overexpression of a small G protein. J. Immunol. 159:4653.
17. Davidson, H. W., Reid, P. A., Lanzavecchia, A. and Watts, C. 1991. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell 67:105.
18. Pinet, V., Malnati, M. S. and Long, E. O. 1994. Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus protein. J. Immunol. 152:4852.
19. Jackson, D. C. and Brown, L. E. 1991. A synthetic peptide of influenza virus hemagglutinin as a model antigen and immunogen Peptide Res. 4:114.
20. Ffrench, R. A., Tang, X.-L., Anders, E. M., Jackson, D. C., White, D. O., Drummer, H., Wade, J. D., Tregear, G. W. and Brown, L. E. 1989. Class II-restricted T cell clones to a synthetic peptide of influenza virus hemagglutinin differ in their fine specificities and in the ability to respond to virus. J. Virol. 63:3087.
21. Jackson, D. C., Tang, X. L., Brown, L. E., Murray, J. M., White, D. O. and Tregear, G. W. 1986. Antigenic determinants of influenza virus hemagglutinin. XII. the epitopes of a synthetic peptide representing the C-terminus of HA1. Virology 155:625.
22. Schoofs, P. G., Geysen, H. M., Jackson, D. C., Brown, L. E., Tang, X. L. and White, D. O. 1988. Epitopes of an influenza viral peptide recognized by antibody at single amino acid resolution. J. Immunol. 140:611.
23. + T cells within the light chain of the H3 hemagglutinin molecule of influenza virus. Virology 198:613.
24. Kim, K, J., Kanellopoulos-Langevin, C., Merwin, R. M., Sachs, D. H. and Asofsky, R. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549.
25. Watson, J. 1979. Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J. Exp. Med. 150:1510.
26. Davidson, W. F. and Parish, C. R. 1975. A procedure for removing red cells and dead cells from lymphoid suspensions. J. Immunol. Methods 7:291.
27. Ly, I. A. and Mishell, R. I. 1974. Separation of mouse spleen cells by passage through columns of Sephadex G-10. J. Immunol. Methods 5:239.
28. Harding, C.V. 1997. Presenting exogenous antigen to T cells. In Current Protocols in Immunology, p. 16.2.1. Wiley, New York.
29. Hoffmann, R., Vasko, M. and Otvos, L. J. 1997. Serum stability of phosphopeptides. Anal. Chim. Acta. 293.
30. Sallusto, F. and Lanzavecchia, A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109.
31. Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down regulation by cytokines and bacterial products. J. Exp. Med. 182:389.
32. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
33. Austyn, J. M. 1996. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183:1287.