Branched-chain amino acid supplementation lowers perceived exertion but does not affect performance in untrained males

Journal of Strength and Conditioning Research

Volumn 25, Issue 2, 2011, Pages 539-544

  Greer, Beau Kjerulf ^a   White, Jim P ^b   Arguello, Eric M ^b   Haymes, Emily M ^b  

^a SACRED HEART UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Amino acids; Central fatigue; Ergogenics aids

Indexed keywords

BRANCHED CHAIN AMINO ACID; CARBOHYDRATE;

ADULT; ANAEROBIC THRESHOLD; ANALYSIS OF VARIANCE; ARTICLE; BICYCLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; ENDURANCE; ENERGY METABOLISM; EXERCISE; HUMAN; MALE; METABOLISM; MUSCLE FATIGUE; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; SINGLE BLIND PROCEDURE; SKELETAL MUSCLE;

AMINO ACIDS, BRANCHED-CHAIN; ANAEROBIC THRESHOLD; ANALYSIS OF VARIANCE; BICYCLING; CARBOHYDRATES; DIETARY SUPPLEMENTS; ENERGY METABOLISM; HUMANS; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PHYSICAL EXERTION; REFERENCE VALUES; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 79953860286     PISSN: 10648011     EISSN: None     Source Type: Journal    
DOI: 10.1519/JSC.0b013e3181bf443a     Document Type: Article

References (37)

1. ACSM. Guidelines for Exercise Testing and Prescription (6th ed.). Baltimore, MD: Lippincott Williams & Wilkins, 2000. pp. 65-79.
2. Astrand PO. Work Tests With the Bicycle Ergometer. Varberg, Sweden: AB Cykelfabriken Monark, 1965.
3. Backhouse, SH, Bishop, NC, Biddle, SJ and Williams, C. Effect of carbohydrate and prolonged exercise on affect and perceived exertion. Med Sci Sports Exerc 37: 1768-1773, 2005. (Pubitemid 41567252)
4. Blomstrand, E, Celsing F, and Newsholme EA. Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta Physiol Scand 133: 115-121, 1988.
5. Blomstrand, E, Hassmen, P Ek, S, Ekblom, B, and Newsholme, EAB, and Newsholme, EA. Influence of ingesting a solution of branchedchain amino acids on perceived exertion during exercise. Acta Physiol Scand 159: 41-49, 1997. (Pubitemid 27014005)
6. Chaouloff, F, Kennett, GA, Serrurrier, B, Merino, D, and Curzon G. Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rat. J Neurochem 46: 1647-1650, 1986. (Pubitemid 16062573)
7. Chaouloff, F, Laude, D, and Elghozi, JL.Physical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. J Neural Transm 78: 121-130, 1989. (Pubitemid 19246658)
8. Clarkson, PM and Sayers, SP. Etiology of exercise-induced muscle damage. Can J Appl Physiol 24: 234-248, 1999.
9. Coombes, JS and McNaughton, LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness 40: 240-246, 2000.
10. Coyle, EF. Carbohydrate supplementation during exercise. J Nutr 122: 788-795, 1992.
11. Crowe, MJ, Weatherson, JN, and Bowden, BF. Effects of dietary leucine supplementation on exercise performance. Eur J Appl Physiol 97: 664-672, 2006. (Pubitemid 44144999)
12. Dill, DB and Costill, DL. Calculation of percentage changes in volume of blood, plasma, and red cells in dehydration. J Appl Physiol 37: 247-248, 1974.
13. Fernstrom, JD. Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. J Nutr Biochem 1: 508-517, 1990. (Pubitemid 20360410)
14. Gleeson, M, Maughan, RJ, and Greenhaff, PL. Comparison of the effects of pre-exercise feeding of glucose, glycerol and placebo on endurance and fuel homeostasis in man. Eur J Appl Physiol Occup Physiol 55: 645-653, 1986. (Pubitemid 17034997)
15. Gollnick, PD. Metabolism of substrates: energy substrate metabolism during exercise and as modified by training. Fed Proc 44: 353-357, 1985. (Pubitemid 15173215)
16. Greer, BK,Woodard, JL,White, JP, Arguello, EM, and Haymes, EM. Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. Int J Sport Nutr Exerc Metab 17: 595-607, 2007.
17. Hargreaves, MH and Snow, R. Amino acids and endurance exercise. Int J Sport Nutr Exerc Metab 11: 133-145, 2001.
18. Hoerr, RA, Matthews, DE, Bier, DM, and Young, VR. Leucine kinetics from [2H3]- and [13C]leucine infused simultaneously by gut and vein. Am J Physiol 260: E111-E117, 1991.
19. Ivy, JL, Res, PT, Sprague, RC, and Widzer, MO. Effect of a carbohydrate-protein supplement on endurance performance during exercise of varying intensity. Int J Sport Nutr Exerc Metab 13: 382-395, 2003. (Pubitemid 37108369)
20. Jentjens, RL, Moseley, L,Waring, RH, Harding, LK, and Jeukendrup, AE. Oxidation of combined ingestion of glucose and fructose during exercise. J Appl Physiol 96: 1277-1284, 2004. (Pubitemid 38392661)
21. Jeukendrup, AE and Jentjens, R. Oxidation of carbohydrate feedings during prolonged exercise: current thoughts, guidelines and directions for future research. Sports Med 29: 407-424, 2000. (Pubitemid 30392021)
22. Laurent, D, Schneider, KE, Prusaczyk, WK, Franklin, C, Vogel, SM, Krssak, M, Petersen, KF, Goforth, HW, and Shulman, GI. Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise. J Clin Endocrinol Metab 85: 2170-2175, 2000. (Pubitemid 32269240)
23. Madsen, K, MacLean, DA, Kiens, B, and Christensen, D. Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km. J Appl Physiol 81: 2644-2650, 1996. (Pubitemid 27043383)
24. Mittleman, KD, Ricci, MR, and Bailey, SP. Branched-chain amino acids prolong exercise during heat stress in men and women. Med Sci Sports Exerc 30: 83-91, 1998. (Pubitemid 28071387)
25. Osterberg, KL, Zachwieja, JJ, and Smith, JW. Carbohydrate and carbohydrate + protein for cycling time-trial performance. J Sports Sci 26: 227-233, 2008. (Pubitemid 350302167)
26. Pardridge, WM. Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J Neurochem 28: 103-108, 1977. (Pubitemid 8022771)
27. Pfeifer, R, Karol, R, Korpi, J, Burgoyne, R, and McCourt, D. Practical application of HPLC to amino acid analysis. Am Lab 715: 77-84, 1983.
28. Phillips, SM, Green, HJ, Tarnopolsky, MA, Heigenhauser, GF, Hill, RE, and Grant, SM. Effects of training duration on substrate turnover and oxidation during exercise. J Appl Physiol 81: 2182-2191, 1996. (Pubitemid 26384548)
29. Saunders, MJ, Kane, MD, and Todd, MK. Effects of a carbohydrateprotein beverage on cycling endurance and muscle damage. Med Sci Sports Exerc 36: 1233-1238, 2004. (Pubitemid 38879001)
30. Shimomura, Y, Murakami, T, Nakai, N, Nagasaki, M, Obayashi, M, Li, Z, Xu, M, Sato, Y, Kato, T, Shimomura, N, Fujitsuka, N, Tanaka, K, and Sato, M. Suppression of glycogen consumption during acute exercise by dietary branched-chain amino acids in rats. J Nutr Sci Vitaminol (Tokyo) 46: 71-77, 2000. (Pubitemid 30397399)
31. Utter, AC, Kang, J, Nieman, DC, Dumke, CL, McAnulty, SR, Vinci, DM, and McAnulty, LS. Carbohydrate supplementation and perceived exertion during prolonged running. Med Sci Sports Exerc 36: 1036-1041, 2004. (Pubitemid 38720786)
32. van Essen,Mand Gibala,MJ. Failure of protein to improve time trial performance when added to a sports drink. Med Sci Sports Exerc 38: 1476-1483, 2006.
33. Vandebuerie, F, Vanden Eynde, B, Vandenberghe, K, and Hespel, P. Effect of creatine loading on endurance capacity and sprint power in cyclists. Int J Sports Med 19: 490-495, 1998. (Pubitemid 28508613)
34. Varnier, M, Sarto, P, Martines, D, Lora, L, Carmignoto, F, Leese, GP, and Naccarato, R. Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content. Eur J Appl Physiol Occup Physiol 69: 26-31, 1994. (Pubitemid 24221015)
35. Wagenmakers, AJ. Muscle amino acid metabolism at rest and during exercise. Diabetes Nutr Metab 12: 316-322, 1999.
36. Wallis, GA, Dawson, R, Achten, J, Webber, J, and Jeukendrup, AE. Metabolic response to carbohydrate ingestion during exercise in males and females. Am J Physiol Endocrinol Metab 290: E708-E715, 2006.
37. Wilson, WM and Maughan, RJ.Evidence for a possible role of 5- hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Exp Physiol 77: 921-924, 1992.