Suppression of glycogen consumption during acute exercise by dietary branched-chain amino acids in rats

Journal of Nutritional Science and Vitaminology

Volumn 46, Issue 2, 2000, Pages 71-77

  Shimomura, Yoshiharu ^a   Murakami, Taro ^a   Nakai, Naoya ^b   Nagasaki, Masaru ^b   Obayashi, Mariko ^b   Li, Zhihao ^b   Xu, Ming ^b   Sato, Yuzo ^b   Kato, Tetsuya ^c   Shimomura, Noriko ^d   Fujitsuka, Noriaki ^a   Tanaka, Kazunori ^e   Sato, Manabu ^e  

^a NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Chukyo Junior College   (Japan)

^e Shiga 525 0055   (Japan)

Author keywords

Branched chain amino acids; Glycogen; Pyruvate dehydrogenase complex; Rat liver; Rat skeletal muscle

Indexed keywords

2 OXOACID DEHYDROGENASE; BRANCHED CHAIN AMINO ACID; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOGEN; INSULIN; ISOLEUCINE; LEUCINE; PYRUVATE DEHYDROGENASE COMPLEX; VALINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CATABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; EXERCISE; FOOD INTAKE; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; GLYCOGEN MUSCLE LEVEL; LIVER WEIGHT; MALE; NONHUMAN; RAT;

EID: 0034123385     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.46.71     Document Type: Article

References (28)

1. Poortmans JR. 1988. Protein metabolism. In: Principles of Exercise Biochemistry (Poortmans JR. ed), p 164-193. Karger, Basel.
2. Harper AE, Miller RH, Block KP. 1984 Branched-chain amino acid metabolism. Annu Rev Nutr 4: 409-454.
3. Harris RA, Zhang B, Goodwin GW, Kuntz MJ, Shinomura Y, Rougraff P, Dexter P, Zhao Y, Gibson R, Crabb DW. 1990. Regulation of the branched-chain α-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Adv Enzyme Regul 30: 245-263.
4. Wolfe RR, Goodenough RD, Wolfe MH, Royle GT, Nadle ER. 1982. Isotopic analysis of leucine and urea metabolism in exercising humans. J Appl Physiol 52: 458-466.
5. Lemon PWR, Nagle FJ, Mullin JP, Benevenga NJ. 1982. In vivo leucine oxidation at rest and during two intensities of exercise. J Appl Physiol 53: 947-954.
6. Hood DA, Terjung RL. 1987. Leucine metabolism in perfused rat skeletal muscle during contractions. Am J Physiol 253: E636-E647.
7. MacLean DA, Graham TE, Saltin B. 1994. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol 267: E1010-E1022.
8. MacLean DA, Graham TE, Saltin B. 1996. Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans. J Physiol 493: 909-922.
9. Mittleman KD, Ricci MR, Bailey SP. 1998. Branched-chain amino acids prolonged exercise during heat stress in men and women. Med Sci Sports Exerc 30: 83-91.
10. Calders P, Pannier JL, Matthys DM, Lacroix EM. 1997. Pre-exercise branched-chain amino acid administration increases endurance performance in rats. Med Sci Sports Exerc 29: 1182-1186.
11. Blomstrand E. Hassmen P, Ek S, Ekblom B, Newsholme EA. 1997. Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise. Acta Physiol Scand 159: 41-49.
12. Saltin B, Gollnick PD. 1988. Fuel for muscular exercise: role of carbohydrate. In: Exercise, Nutrition, and Energy Metabolism (Horton ES, Terjung, RL, eds), p 45-71. Macmillan, New York.
13. American Institute of Nutrition. 1977. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107: 1340-1348.
14. Reeves PG, Nielsen FH, Fahey GC. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 rodent diet. J Nutr 123: 1939-1951.
15. Anderson SA, Tews JK, Harper AE. 1990. Dietary branched-chain amino acids and protein selection by rats. J Nutr 20: 52-63.
16. Nakai N, Sato Y, Oshida Y, Fujitsuka N, Yoshimura A, Shimomura Y. 1999. Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training. Metabolism 48: 865-869.
17. Fujiwara M, Ishida Y, Nimura N, Toyama A, Kinoshita T. 1987. Postcolumn fluorometric detection system for liquid chromatographic analysis of amino and imino acids using o-phthalaldehyde/N-acetyl-L-cysteine reagent. Anal Biochem 166: 72-78.
18. Morgan CR, Lazarow A. 1963. Immunoassay of insulin: two-antibody system. Diabetes 12: 115-126.
19. Nakai N, Shimomura Y, Ohsaki N, Sato J, Oshida Y, Ohsawa I, Fujitsuka N, Sato Y. 1996. Exercise training prevents maturation-induced decrease in insulin sensitivity. J Appl Physiol 80: 1963-1967.
20. Kobayashi R, Shimomura Y, Murakami T, Nakai N, Fujitsuka N, Otsuka M, Arakawa N, Popov KM, Harris RA. 1997. Gender difference in regulation of branched-chain amino acid catabolism. Biochem J 327: 449-453.
21. Harris RA, Paxton R, Parker RA. 1982. Activation of the branched-chain α-ketoacid dehydrogenase complex by a broad specificity protein phosphatase. Biochem Biophys Res Commun 107: 1497-1503.
22. Ott RL. 1993. Multiple comparisons. In: An Introduction to Statistical Methods and Data Analysis. 4th ed. p 807-841. Duxbury Press. Belmont. CA.
23. Goodyear LJ, Kahn BB. 1998. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49: 235-261.
24. Behal RH, Buxton DB, Robertson JG, Olson MS. 1993. Regulation of the pyruvate dehydrogenase multienzyme complex. Annu Rev Nutr 13: 497-520.
25. Holness MJ, French TJ, Sugden MC. 1986. Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. Biochem J 235: 441-445.
26. Soemitro S, Block KP, Crowell PL, Harper AE. 1989. Activities of branched-chain amino acid-degrading enzymes in liver from rats fed different dietary levels of protein. J Nutr 119: 1203-1212.
27. Zhao Y, Popov KM, Shimomura Y, Kedishvili NY, Jaskiewicz J, Kuntz MJ, Kain J, Zhang B, Harris RA. 1994. Effect of dietary protein on the liver content and subunit composition of the branched-chain α-ketoacid dehydrogenase complex. Arch Biochem Biophys 308: 446-453.
28. Kobayashi R, Shimomura Y, Murakami T, Nakai N, Otsuka M, Arakawa N, Shimizu K, Harris RA. 1999. Hepatic branched-chain α-keto acid dehydrogenase complex in female rats: Activation by exercise and starvation. J Nutr Sci Vitaminol 45: 303-309.