메뉴 건너뛰기




Volumn 63, Issue 5, 2011, Pages 291-308

Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes

Author keywords

Apoptosis; Autoimmunity; Diabetes; Lupus; Macrophage; Rodent

Indexed keywords

LIPID; LIPOPOLYSACCHARIDE;

EID: 79953817129     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-010-0507-3     Document Type: Article
Times cited : (3)

References (43)
  • 2
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in SLE are clustered in two population of surface structures on apoptotic keratinocytes. J Exp Med 179:1317-1330 (Pubitemid 24091790)
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.4 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 5
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1
    • DOI 10.1016/j.immuni.2007.11.014, PII S1074761307005493
    • Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X (2007) Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27:952-964 (Pubitemid 350251222)
    • (2007) Immunity , vol.27 , Issue.6 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3    Zhang, Y.4    Brendolan, A.5    Saggese, M.6    Han, J.7    Silverstein, R.8    Selleri, L.9    Ma, X.10
  • 6
    • 2342517413 scopus 로고    scopus 로고
    • Murine lupus autoantibodies identify distinct subsets of apoptotic bodies
    • DOI 10.1080/0891693042000196219
    • Cline AM, Radic MZ (2004) Murine autoantibodies identify distinct sets of apoptotic bodies. Autoimmunity 37:85-93 (Pubitemid 38594272)
    • (2004) Autoimmunity , vol.37 , Issue.2 , pp. 85-93
    • Cline, A.M.1    Radic, M.Z.2
  • 7
    • 0035163803 scopus 로고    scopus 로고
    • Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure
    • Cocco RE, Ucker DS (2001) Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure. Mol Biol Cell 12:919-930 (Pubitemid 33051988)
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.4 , pp. 919-930
    • Cocco, R.E.1    Ucker, D.S.2
  • 9
    • 25844441709 scopus 로고    scopus 로고
    • Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
    • DOI 10.2337/diabetes.54.10.2995
    • Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS (2005) Evidence for susceptibility loci from four genome-wide linkage scans in 1, 435 multiplex families. Diabetes 54:2995-3001 (Pubitemid 41401098)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2995-3001
    • Concannon, P.1    Erlich, H.A.2    Julier, C.3    Morahan, G.4    Nerup, J.5    Pociot, F.6    Todd, J.A.7    Rich, S.S.8
  • 10
    • 1642536490 scopus 로고    scopus 로고
    • Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription is Coupled Directly to Specific Recognition
    • Cvetanovic M, Ucker DS (2004) Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J Immunol 172:880-889 (Pubitemid 38113745)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 880-889
    • Cvetanovic, M.1    Ucker, D.S.2
  • 12
    • 22544480574 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells: Matter of balance
    • de Almeida CJG, Linden R (2005) Phagocytosis of apoptotic cells: matter of balance. Cell Mol Life Sci 62:1532-1546
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1532-1546
    • De Almeida, C.J.G.1    Linden, R.2
  • 13
    • 0025226068 scopus 로고
    • Aberrant regulation of interleukin 1 expression in macrophages from young autoimmune-prone mice
    • Donnelly RP, Levine J, Hartwell DW, Frendl G, Fenton MJ, Beller DI (1990) Aberrant regulation of interleukin 1 expression in macrophages from young autoimmune-prone mice. J Immunol 145:3231-3239
    • (1990) J Immunol , vol.145 , pp. 3231-3239
    • Donnelly, R.P.1    Levine, J.2    Hartwell, D.W.3    Frendl, G.4    Fenton, M.J.5    Beller, D.I.6
  • 14
    • 34548060149 scopus 로고    scopus 로고
    • Early environmental exposure and development of lupus
    • Edwards CJ, Cooper C (2006) Early environmental exposure and development of lupus. Lupus 15:814-819
    • (2006) Lupus , vol.15 , pp. 814-819
    • Edwards, C.J.1    Cooper, C.2
  • 15
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig L-P, Henson PM (2008) Clearance of apoptotic cells by phagocytes. Cell Death Differ 15:243-250
    • (2008) Cell Death Differ , vol.15 , pp. 243-250
    • Erwig, L.-P.1    Henson, P.M.2
  • 16
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J Clin Invest 101:890-898 (Pubitemid 28096086)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 17
    • 34447099218 scopus 로고    scopus 로고
    • Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
    • DOI 10.1016/S0065-2776(06)92001-X, PII S006527760692001X
    • Fairhurst AM, Wandstrat AE, Wakeland EK (2006) Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol 92:1-69 (Pubitemid 44828118)
    • (2006) Advances in Immunology , vol.92 , pp. 1-69
    • Fairhurst, A.1    Wandstrat, A.E.2    Wakeland, E.K.3
  • 18
    • 1842477156 scopus 로고    scopus 로고
    • Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Macrophages from Nonobese Diabetic and Systemic Lupus Erythematosus-Prone Mice
    • Fan H, Longacre A, Meng F, Patel V, Hsiao K, Koh JS, Levine JS (2004) Cytokine dysregulation induced by apoptotic cells is a shared characteristic of macrophages from NOD and SLE-prone mice. J Immunol 172:4834-4843 (Pubitemid 38456406)
    • (2004) Journal of Immunology , vol.172 , Issue.8 , pp. 4834-4843
    • Fan, H.1    Longacre, A.2    Meng, F.3    Patel, V.4    Hsiao, K.5    Koh, J.S.6    Levine, J.S.7
  • 19
    • 30144446005 scopus 로고    scopus 로고
    • Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity
    • DOI 10.1189/jlb.0705408
    • Fan H, Patel VA, Longacre A, Levine JS (2006) Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity. J Leukoc Biol 79:155-165 (Pubitemid 43054261)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.1 , pp. 155-165
    • Fan, H.1    Patel, V.A.2    Longacre, A.3    Levine, J.S.4
  • 20
    • 0030046707 scopus 로고    scopus 로고
    • SRB1, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells
    • DOI 10.1006/excr.1996.0030
    • Fukasawa M, Adachi H, Hirota K, Tsujimoto M, Arai H, Inoue K (1996) SRB1, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells. Exp Cell Res 222:246-250 (Pubitemid 26043731)
    • (1996) Experimental Cell Research , vol.222 , Issue.1 , pp. 246-250
    • Fukasawa, M.1    Adachi, H.2    Hirota, K.3    Tsujimoto, M.4    Arai, H.5    Inoue, K.6
  • 21
    • 18944365579 scopus 로고    scopus 로고
    • Impaired clearance of dying cells in systemic lupus erythematosus
    • DOI 10.1016/j.autrev.2004.10.007, PII S1568997204002216
    • Gaipl US, Voll RE, Sheriff A, Franz S, Kalden JR, Herrmann M (2005) Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev 4:189-194 (Pubitemid 40704701)
    • (2005) Autoimmunity Reviews , vol.4 , Issue.4 , pp. 189-194
    • Gaipl, U.S.1    Voll, R.E.2    Sheriff, A.3    Franz, S.4    Kalden, J.R.5    Herrmann, M.6
  • 23
    • 0034667989 scopus 로고    scopus 로고
    • Cytokine dysregulation induced by apoptotic cells is a shared characteristic of murine lupus
    • Koh JS, Wang Z, Levine JS (2000) Cytokine dysregulation induced by apoptotic cells is a shared characteristic of murine lupus. J Immunol 165:4190-4201
    • (2000) J Immunol , vol.165 , pp. 4190-4201
    • Koh, J.S.1    Wang, Z.2    Levine, J.S.3
  • 24
    • 33748522053 scopus 로고    scopus 로고
    • Clearance of apoptotic and necrotic cells and its immunological consequences
    • DOI 10.1007/s10495-006-9527-8
    • Krysko DV, D'Herde K, Vandenabeele P (2006) Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 11:1709-1726 (Pubitemid 44371047)
    • (2006) Apoptosis , vol.11 , Issue.10 , pp. 1709-1726
    • Krysko, D.V.1    D'Herde, K.2    Vandenabeele, P.3
  • 26
    • 33750310767 scopus 로고    scopus 로고
    • Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus
    • Levine JS, Subang R, Nasr SH, Fournier S, Rauch J (2006) Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of SLE. J Immunol 177:6504-6516 (Pubitemid 44628870)
    • (2006) Journal of Immunology , vol.177 , Issue.9 , pp. 6504-6516
    • Levine, J.S.1    Subang, R.2    Nasr, S.H.3    Fournier, S.4    Lajoie, G.5    Wither, J.6    Rauch, J.7
  • 28
    • 7644229530 scopus 로고    scopus 로고
    • Macrophages from lupus-prone MRL mice are characterized by abnormalities in Rho activity, cytoskeletal organization, and adhesiveness to extracellular matrix proteins
    • DOI 10.1189/jlb.0604346
    • Longacre A, Koh JS, Hsiao K-H, Gilligan H, Fan H, Patel VA, Levine JS (2004) Macrophages from lupus-prone MRL mice are characterized by abnormalities in Rho activity, cytoskeletal organization, and adhesiveness to extracellular matrix proteins. J Leukoc Biol 76:971-984 (Pubitemid 39458709)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.5 , pp. 971-984
    • Longacre, A.1    Koh, J.S.2    Hsiao, K.K.-H.3    Gilligan, H.4    Fan, H.5    Patel, V.A.6    Levine, J.S.7
  • 30
    • 0032547818 scopus 로고    scopus 로고
    • Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
    • DOI 10.1084/jem.188.8.1493
    • Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel RM (1998) Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med 188:1493-1501 (Pubitemid 28489586)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.8 , pp. 1493-1501
    • Ludewig, B.1    Odermatt, B.2    Landmann, S.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 33
    • 33646201769 scopus 로고    scopus 로고
    • Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: Implications for the delayed clearance model of autoimmunity
    • DOI 10.1074/jbc.M508342200
    • Patel VA, Longacre A, Hsiao K, Fan H, Meng F, Mitchell JE, Rauch J, Ucker DS, Levine JS (2006) Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: implications for the delayed clearance model of autoimmunity. J Biol Chem 281:4663-4670 (Pubitemid 43847725)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.8 , pp. 4663-4670
    • Patel, V.A.1    Longacre, A.2    Hsiao, K.3    Fan, H.4    Meng, F.5    Mitchell, J.E.6    Rauch, J.7    Ucker, D.S.8    Levine, J.S.9
  • 35
    • 0037100507 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: Activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2
    • Reddy SM, Hsiao KH, Abernethy VE, Fan H, Longacre A, Lieberthal W, Rauch J, Koh JS, Levine JS (2002) Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2. J Immunol 169:702-713 (Pubitemid 34753425)
    • (2002) Journal of Immunology , vol.169 , Issue.2 , pp. 702-713
    • Reddy, S.M.1    Hsiao, K.-H.K.2    Abernethy, V.E.3    Fan, H.4    Longacre, A.5    Lieberthal, W.6    Rauch, J.7    Koh, J.S.8    Levine, J.S.9
  • 36
    • 79953821714 scopus 로고    scopus 로고
    • Preparation and analysis of RNA
    • Coligan JE, Kruisbeek AM, Marguilies DH, Shevach EM, Strober W (eds) Wiley, New York
    • Ribaudo R, Gilman M, Kingston RE, Chomczynski P, Sacchi N (2002) Preparation and analysis of RNA. In: Coligan JE, Kruisbeek AM, Marguilies DH, Shevach EM, Strober W (eds) Current protocols in immunology. Wiley, New York, pp 10.11.1-10.11.14
    • (2002) Current Protocols in Immunology
    • Ribaudo, R.1    Gilman, M.2    Kingston, R.E.3    Chomczynski, P.4    Sacchi, N.5
  • 37
    • 37849186218 scopus 로고    scopus 로고
    • Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs
    • Richardson NI, MM KSN, Nicolo D, Monestier M, Radic MZ (2007) Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs. Mol Immunol 44:1914-1921
    • (2007) Mol Immunol , vol.44 , pp. 1914-1921
    • Richardson, N.I.1    Ksn, M.M.2    Nicolo, D.3    Monestier, M.4    Radic, M.Z.5
  • 39
    • 47949087445 scopus 로고    scopus 로고
    • Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFFindependent, SLE-like autoimmunity
    • Stohl W, Jacob N, Quinn WJ III, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN (2008) Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFFindependent, SLE-like autoimmunity. J Immunol 181:833-841
    • (2008) J Immunol , vol.181 , pp. 833-841
    • Stohl, W.1    Jacob, N.2    Quinn III, W.J.3    Cancro, M.P.4    Gao, H.5    Putterman, C.6    Gao, X.7    Pricop, L.8    Koss, M.N.9
  • 41
    • 25444476976 scopus 로고    scopus 로고
    • B cell abnormality and autoimmune disorders
    • Tsubata T (2004) B cell abnormality and autoimmune disorders. Autoimmunity 38:331-337
    • (2004) Autoimmunity , vol.38 , pp. 331-337
    • Tsubata, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.