A glimpse of biology's first enzyme

Science

Volumn 315, Issue 5818, 2007, Pages 1507-1508

  Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; NUCLEOSIDE TRIPHOSPHATE; RNA; RNA DIRECTED RNA POLYMERASE; RNA LIGASE; RIBONUCLEOTIDE; RIBOZYME;

CATALYSIS; ENZYME ACTIVITY; MOLECULAR ANALYSIS; RNA;

CATALYSIS; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME MECHANISM; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA REPLICATION; CHEMISTRY; CONFORMATION; CRYSTALLIZATION; DIRECTED MOLECULAR EVOLUTION; DNA TEMPLATE; HYDROGEN BOND; METABOLISM; NOTE; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; HYDROGEN BONDING; NUCLEIC ACID CONFORMATION; RIBONUCLEOTIDES; RNA, CATALYTIC; TEMPLATES, GENETIC;

EID: 33947377391     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140736     Document Type: Review

References (10)

1. C. Woese, The Genetic Code: The Molecular Basis for Genetic Expression (Harper & Row, New York, 1967), pp. 179-195.
2. F. H. C. Crick, J. Mol. Biol. 38, 367 (1968).
3. L. E. Orgel, J. Mol. Biol. 38, 381 (1968).
4. W. Gilbert, Nature 319, 618 (1986).
5. M. P. Robertson, W. G. Scott, Science 315, 1549 (2007).
6. D. P. Bartel, J. W. Szostak, Science 261, 1411 (1993).
7. W. K. Johnston, P. J. Unrau, M. S. Lawrence, M. E. Glasner, D. P. Bartel, Science 292, 1319 (2001).
8. M. P. Robertson, A. D. Ellington, Nature Biotechnol. 17, 62 (1999).
9. J. Rogers, G. F. Joyce, RNA 7, 395 (2001).
10. Y. Ikawa, K. Tsuda, S. Matsumura, T. Inoue, Proc. Natl. Acad. Sci. U.S.A. 101, 13750 (2004).