Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG

Clinical and Experimental Immunology

Volumn 164, Issue 2, 2011, Pages 218-226

  Pankhurst, T ^a   Nash, G ^b   Williams, J ^a   Colman, R ^a   Hussain, A ^a   Savage, C ^a  

^a School of Immunity   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

ANCA; IgG subclass; Lymphocyte; Neutrophil; Vasculitis

Indexed keywords

CALCIUM; CD16 ANTIGEN; CD32 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; NEUTROPHIL CYTOPLASMIC ANTIBODY; PADGEM PROTEIN;

ARTICLE; CALCIUM SIGNALING; CELL ACTIVATION; CELL ADHESION; CLINICAL ASSESSMENT; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NEUTROPHIL; PHYSIOLOGY; PRIORITY JOURNAL; SURFACE PROPERTY;

ANIMALS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, IMMOBILIZED; ANTIGENS, CD; CYTOPLASM; ENDOTHELIAL CELLS; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; LEUKOCYTE ROLLING; MICE; NEUTROPHILS; P-SELECTIN; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; RESPIRATORY BURST; RHEOLOGY; SUPEROXIDES;

EID: 79953800630     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04367.x     Document Type: Article

References (43)

1. Hogan SL, Nachman PH, Wilkman AS, Jennette JC, Falk RJ. Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996; 7:23-32.
2. Little MA, Smyth CL, Yadav R etal. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood 2005; 106:2050-8.
3. Nolan SL, Kalia N, Nash GB, Kamel D, Heeringa P, Savage CO. Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo. J Am Soc Nephrol 2008; 19:973-84.
4. Xiao H, Heeringa P, Hu P etal. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110:955-63.
5. Lesavre P. Antineutrophil cytoplasmic autoantibodies antigen specificity. Am J Kidney Dis 1991; 18:159-63.
6. Jefferis R, Lund J, Pound J. Molecular definition of interaction sites on human IgG for Fc receptors (huFc gamma R). Mol Immunol 1990; 27:1237-40.
7. Roitt I, Brostoff J, Male D. Immunology, 4th edn. London: Mosby, 1996.
8. Stitis D, Stobo J, Wells J. Basic and clinical immunology, 7th edn. Stamford, CT: Appleton and Lange, 1991.
9. Holland M, Hewins P, Goodall M, Adu D, Jefferis R, Savage CO. Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass. Clin Exp Immunol 2004; 138:183-92.
10. Mulder AH, Stegeman CA, Kallenberg CG. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis: a predominant role for the IgG3 subclass of ANCA. Clin Exp Immunol 1995; 101:227-32.
11. Jayne DR, Weetman AP, Lockwood CM. IgG subclass distribution of autoantibodies to neutrophil cytoplasmic antigens in systemic vasculitis. Clin Exp Immunol 1991; 84:476-81.
12. Brouwer E, Tervaert JW, Horst G etal. Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders. Clin Exp Immunol 1991; 83:379-86.
13. Harper L, Radford D, Plant T, Drayson M, Adu D, Savage CO. IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients. Arthritis Rheum 2001; 44:921-30.
14. Segelmark M, Wieslander J. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). Nephrol Dial Transplant 1993; 8:696-702.
15. Mellbye OJ, Mollnes TE, Steen LS. IgG subclass distribution and complement activation ability of autoantibodies to neutrophil cytoplasmic antigens (ANCA). Clin Immunol Immunopathol 1994; 70:32-9.
16. Ben-Smith A, Dove SK, Martin A, Wakelam MJO, Savage COS. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signalingcascades: comparison with conventional Fcg receptor ligation. Blood 2001; 98:1448-55.
17. Williams JM, Ben-Smith A, Hewins P etal. Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. J Am Soc Nephrol 2003; 14:661-9.
18. Pankhurst T, Savage CO, Little MA. Review article: leukocyte-endothelial dysregulation in systemic small vessel vasculitis. Nephrology (Carlton) 2009; 14:3-10. Epub 2009 8 January.
19. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986; 137:245-54.
20. Woodfin A, Reichel CA, Khandoga A etal. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood 2007; 110:1848-56.
21. Coxon A, Cullere X, Knight S etal. Fc gamma RIII mediates neutrophil recruitment to immune complexes. A mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 2001; 14:693-704.
22. D'Arrigo C, Candal-Couto JJ, Greer M, Veale DJ, Woof JM. Human neutrophil Fc receptor-mediated adhesion under flow: a hollow fibre model of intravascular arrest. Clin Exp Immunol 1995; 100:173-9.
23. Skilbeck CA, Lu X, Sheikh S, Savage CO, Nash GB. Capture of flowing human neutrophils by immobilised immunoglobulin: roles of Fc-receptors CD16 and CD32. Cell Immunol 2006; 241:26-31. Epub 2006 24 August.
24. Colman R, Hussain A, Goodall M etal. Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils. Ann Rheum Dis 2007; 66:676-82.
25. Hussain A, Pankhurst T, Goodall M etal. Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors. Immunology 2009; 128:236-44.
26. Sheikh S, Nash GB. Continuous activation and deactivation of integrin CD11b/CD18 during de novo expression enables rolling neutrophils to immobilize on platelets. Blood 1996; 87:5040-50.
27. Luu NT, Rainger GE, Nash GB. Kinetics of the different steps during neutrophil migration through cultured endothelial monolayers treated with tumour necrosis factor-alpha. J Vasc Res 1999; 36:477-85.
28. Bahra P, Rainger GE, Wautier JL, Nguyet-Thin L, Nash GB. Each step during transendothelial migration of flowing neutrophils is regulated by the stimulatory concentration of tumour necrosis factor-alpha. Cell Adhes Commun 1998; 6:491-501.
29. Rainger GE, Rowley AF, Nash GB. Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. Blood 1998; 92:4819-27.
30. Jefferis R, Kumararatne DS. Selective IgG subclass deficiency: quantification and clinical relevance. Clin Exp Immunol 1990; 81:357-67.
31. Buckle AM, Jayaram Y, Hogg N. Colony-stimulating factors and interferon-gamma differentially affect cell surface molecules shared by monocytes and neutrophils. Clin Exp Immunol 1990; 81:339-45.
32. Parren PW, Warmerdam PA, Boeije LC etal. On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest 1992; 90:1537-46.
33. Voice JK, Lachmann PJ. Neutrophil Fc gamma and complement receptors involved in binding soluble IgG immune complexes and in specific granule release induced by soluble IgG immune complexes. Eur J Immunol 1997; 27:2514-23.
34. Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol 2005; 26:388-95.
35. Zhu X, Subbaraman R, Sano H etal. A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. J Immunol Methods 2000; 240:157-64.
36. Radford DJ, Luu NT, Hewins P, Nash GB, Savage CO. Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis Rheum 2001; 44:2851-61.
37. Heijnen IA, van de Winkel JG. Human IgG Fc receptors. Int Rev Immunol 1997; 16:29-55.
38. Greenwood J, Clark M, Waldmann H. Structural motifs involved in human IgG antibody effector functions. Eur J Immunol 1993; 23:1098-104.
39. Aalberse RC, Schuurman J. IgG4 breaking the rules. Immunology 2002; 105:9-19.
40. Sarmay G, Lund J, Rozsnyay Z, Gergely J, Jefferis R. Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor. Mol Immunol 1992; 29:633-9.
41. Shields RL, Namenuk AK, Hong K etal. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 2001; 276:6591-604.
42. Canfield SM, Morrison SL. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J Exp Med 1991; 173:1483-91.
43. Luo J, Xu T, Wang X etal. PI3K is involved in L-selectin- and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly. J Cell Biochem 2010; 110:910-19.