Review article: Leukocyte-endothelial dysregulation in systemic small vessel vasculitis

Nephrology

Volumn 14, Issue 1, 2009, Pages 3-10

  Pankhurst, Tanya ^a   Savage, Caroline O S ^a   Little, Mark A ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Anti neutrophil cytoplasm antibody; Endothelium; Inflammation; Leukocyte; Neutrophil; Vasculitis

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; ENDOTHELIAL CELL ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; INTEGRIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEINASE; SELECTIN; SERINE PROTEINASE;

CELL INTERACTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GLOMERULUS; HUMAN; LEUKOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; REVIEW; SMALL VESSEL VASCULITIS;

ANIMALS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOANTIBODIES; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; INTEGRINS; NEUTROPHILS; P-SELECTIN; RESPIRATORY BURST; VASCULITIS;

EID: 63149106025     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2008.01076.x     Document Type: Review

References (57)

1. Lim YC, Garcia-Cardena G, Allport JR et al. Heterogeneity of endothelial cells from different organ sites in t-cell subset recruitment. Am. J. Pathol. 2003 162 : 1591 601.
2. Lou O, Alcaide P, Luscinskas FW, Muller WA. CD99 is a key mediator of the transendothelial migration of neutrophils. J. Immunol. 2007 178 : 1136 43.
3. Savage CO, Brooks CJ, Adu D, Richards G, Howie AJ. Cell adhesion molecule expression within human glomerular and kidney organ culture. J. Pathol. 1997 181 : 111 15.
4. Li X, Zhou T, Hao C, Dong D, Cheng F, Chen S. Significance of P-selectin expression in human glomerulonephritis. Chin. Med. J. 1997 110 : 512 14.
5. Segawa C, Wada T, Takaeda M et al. In situ expression and soluble form of P-selectin in human glomerulonephritis. Kidney Int. 1997 52 : 1054 63.
6. Harari OA, Marshall D, McHale JF, Ahmed S, Haskard DO. Limited endothelial E- and P-selectin expression in MRL/lpr lupus-prone mice. Rheumatology (Oxford) 2001 40 : 889 95.
7. De Vriese AS, Endlich K, Elger M et al. The role of selectins in glomerular leukocyte recruitment in rat anti-glomerular basement membrane glomerulonephritis. J. Am. Soc. Nephrol. 1999 10 : 2510 17.
8. von Asmuth EJ, van der Linden CJ, Leeuwenberg JF, Buurman WA. Involvement of the CD11b/CD18 integrin, but not of the endothelial cell adhesion molecules ELAM-1 and ICAM-1 in tumor necrosis factor-alpha-induced neutrophil toxicity. J. Immunol. 1991 147 : 3869 75.
9. Radford DJ, Savage CO, Nash GB. Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin-mediated adhesion. Arthritis Rheum. 2000 43 : 1337 45.
10. Muller Kobold AC, van Wijk RT, Franssen CF, Molema G, Kallenberg CG, Tervaert JW. In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. Clin. Exp. Rheumatol. 1999 17 : 433 40.
11. Yang JJ, Kettritz R, Falk RJ, Jennette JC, Gaido ML. Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. Am. J. Pathol. 1996 149 : 1617 26.
12. Yang JJ, Preston GA, Pendergraft WF et al. Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. Am. J. Pathol. 2001 158 : 581 92.
13. Preston GA, Zarella CS, Pendergraft WF 3rd. et al. Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. J. Am. Soc. Nephrol. 2002 13 : 2840 49.
14. Pendergraft WF 3rd., Rudolph EH, Falk RJ et al. Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis. Kidney Int. 2004 65 : 75 84.
15. Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. U.S.A. 1990 87 : 4115 19.
16. Zhao T, Benard V, Bohl BP, Bokoch GM. The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J. Clin. Invest. 2003 112 : 1732 40.
17. Zhao T, Bokoch GM. Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J. Immunol. 2005 174 : 8049 55.
18. Lu X, Garfield A, Rainger GE, Savage CO, Nash GB. Mediation of endothelial cell damage by serine proteases, but not superoxide, released from antineutrophil cytoplasmic antibody-stimulated neutrophils. Arthritis Rheum. 2006 54 : 1619 28.
19. Mayet WJ, Csernok E, Szymkowiak C, Gross WL, Meyer zum Buschenfelde KH. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. Blood 1993 82 : 1221 9.
20. De Bandt M, Meyer O, Dacosta L, Elbim C, Pasquier C. Anti-proteinase-3 (PR3) antibodies (C-ANCA) recognize various targets on the human umbilical vein endothelial cell (HUVEC) membrane. Clin. Exp. Immunol. 1999 115 : 362 8.
21. Mayet WJ, Meyer zum Buschenfelde KH. Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells. Clin. Exp. Immunol. 1993 94 : 440 46.
22. Sibelius U, Hattar K, Schenkel A et al. Wegener's granulomatosis: Anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. J. Exp. Med. 1998 187 : 497 503.
23. Henshaw TJ, Malone CC, Gabay JE, Williams RC Jr. Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa. Arthritis Rheum. 1994 37 : 104 12.
24. King WJ, Adu D, Daha MR et al. Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3. Clin. Exp. Immunol. 1995 102 : 98 105.
25. Pendergraft WF, Alcorta DA, Segelmark M et al. ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells. Kidney Int. 2000 57 : 1981 90.
26. Nagao T, Matsumura M, Mabuchi A et al. Up-regulation of adhesion molecule expression in glomerular endothelial cells by anti-myeloperoxidase antibody. Nephrol. Dial. Transplant. 2007 22 : 77 87.
27. Aarli A, Matre R, Thunold S. IgG Fc receptors on epithelial cells of distal tubuli and on endothelial cells in human kidney. Int. Arch. Allergy Appl. Immunol. 1991 95 : 64 9.
28. Muro H, Shirasawa H, Kosugi I, Nakamura S. Defect of Fc receptors and phenotypical changes in sinusoidal endothelial cells in human liver cirrhosis. Am. J. Pathol. 1993 143 : 105 20.
29. Pan LF, Kreisle RA, Shi YD. Detection of Fcgamma receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Clin. Exp. Immunol. 1998 112 : 533 8.
30. Guilpain P, Mouthon L. Antiendothelial cells autoantibodies in vasculitis-associated systemic diseases. Clin. Rev. Allergy Immunol. 2008 35 : 59 65.
31. Praprotnik S, Rozman B, Blank M, Shoenfeld Y. Pathogenic role of anti-endothelial cell antibodies in systemic vasculitis. Wien. Klin. Wochenschr. 2000 112 : 660 64.
32. Yu F, Zhao MH, Zhang YK, Zhang Y, Wang HY. Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity. Clin. Exp. Immunol. 2005 139 : 569 74.
33. Carvalho D, Savage CO, Isenberg D, Pearson JD. IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner. Arthritis Rheum. 1999 42 : 631 40.
34. Bordron A, Dueymes M, Levy Y et al. The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis. J. Clin. Invest. 1998 101 : 2029 35.
35. Williams JM, Colman R, Brookes CJ, Savage CO, Harper L. Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis. Rheumatology (Oxford) 2005 44 : 879 84.
36. Del Papa N, Guidali L, Sironi M et al. Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum. 1996 39 : 758 66.
37. Savage CO, Pottinger BE, Gaskin G, Lockwood CM, Pusey CD, Pearson JD. Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: Presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies. Clin. Exp. Immunol. 1991 85 : 14 19.
38. Chan TM, Frampton G, Jayne DR, Perry GJ, Lockwood CM, Cameron JS. Clinical significance of anti-endothelial cell antibodies in systemic vasculitis: A longitudinal study comparing anti-endothelial cell antibodies and anti-neutrophil cytoplasm antibodies. Am. J. Kidney Dis. 1993 22 : 387 92.
39. Holmen C, Elsheikh E, Stenvinkel P et al. Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement. J. Am. Soc. Nephrol. 2005 16 : 3110 20. Epub 2005 Aug 17.
40. Sebastian JK, Mahr AD, Ahmed SS et al. Antiendothelial cell antibodies in patients with Wegener's granulomatosis: Prevalence and correlation with disease activity and manifestations. J. Rheumatol. 2007 34 : 1027 31.
41. Varagunam M, Nwosu AC, Adu D et al. Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis. Adv. Exp. Med. Biol. 1993 336 : 419 22.
42. Florey OJ, Johns M, Esho OO, Mason JC, Haskard DO. Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1/2. Blood 2007 109 : 3881 9.
43. Harper L, Radford D, Plant T, Drayson M, Adu D, Savage CO. IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients. Arthritis Rheum. 2001 44 : 921 30.
44. Brouwer E, Huitema MG, Mulder AH et al. Neutrophil activation in vitro and in vivo in Wegener's granulomatosis. Kidney Int. 1994 45 : 1120 31.
45. Ohlsson S, Wieslander J, Segelmark M. Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies- associated systemic vasculitis in remission. Clin. Exp. Immunol. 2003 131 : 528 35.
46. Calderwood JW, Williams JM, Morgan MD, Nash GB, Savage CO. ANCA induces beta2 integrin and CXC chemokine-dependent neutrophil-endothelial cell interactions that mimic those of highly cytokine-activated endothelium. J. Leukoc. Biol. 2005 77 : 33 43.
47. Radford DJ, Luu NT, Hewins P, Nash GB, Savage CO. Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis Rheum. 2001 44 : 2851 61.
48. Little MA, Smyth CL, Yadav R et al. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood 2005 106 : 2050 58.
49. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 2002 110 : 955 63.
50. Little MA, Bhangal G, Smyth CL et al. Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis. J. Am. Soc. Nephrol. 2006 17 : 160 69.
51. Nolan SL, Kalia N, Nash GB et al. A-mediated leukocyte-endothelial cell interactions in vivo. J. Am. Soc. Nephrol. 2008 19 : 973 84.
52. Jacquemin M, Neyrinck A, Hermanns MI et al. FVIII production by human lung microvascular endothelial cells. Blood 2006 108 : 515 7.
53. Eremina V, Sood M, Haigh J et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 2003 111 : 707 16.
54. Ruth AJ, Kitching AR, Kwan RY et al. Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J. Am. Soc. Nephrol. 2006 17 : 1940 49. Epub 2006 Jun 12.
55. Haas M, Eustace JA. Immune complex deposits in ANCA-associated crescentic glomerulonephritis: A study of 126 cases. Kidney Int. 2004 65 : 2145 52.
56. Woywodt A, Streiber F, de Groot K, Regelsberger H, Haller H, Haubitz M. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003 361 : 206 10.
57. Segal MS, Bihorac A, Koç M. Circulating endothelial cells: Tea leaves for renal disease. Am. J. Physiol. 2002 283 : F11 19.