Brain-derived neurotrophic factor and neuron-specific enolase, but not S100β, levels are associated to the occurrence of delirium in intensive care unit patients

Journal of Critical Care

Volumn 26, Issue 2, 2011, Pages 133-137

  Grandi, Carmen ^a   Tomasi, Cristiane Damiani ^a   Fernandes, Keiti ^a   Stertz, Laura ^b   Kapczinski, Flávio ^b   Quevedo, João ^a   Dal Pizzol, Felipe ^a,c   Ritter, Cristiane ^a,c  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c HOSPITAL SÃO JOSÉ   (Brazil)

Author keywords

Biomarkers; Brain damage; Delirium; ICU

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NEURON SPECIFIC ENOLASE; PROTEIN S100B;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTENSIVE CARE PSYCHOSIS; INTENSIVE CARE UNIT; MALE; MOLECULAR PATHOLOGY; PROTEIN BLOOD LEVEL; PSYCHOLOGIC ASSESSMENT;

ADULT; AGED; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; CRITICAL ILLNESS; DELIRIUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PHOSPHOPYRUVATE HYDRATASE; S100 PROTEINS;

EID: 79953771388     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2010.10.006     Document Type: Article

References (15)

1. Ely E.W., Shintani A., Truman B., et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004, 291:1753-1762.
2. Gunther M.L., Morandi A., Ely E.W. Pathophysiology of delirium in the intensive care unit. Crit Care Clin 2008, 24:45-65.
3. Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annu Rev Neurosci 1996, 19:289-317.
4. Kochanek P.M., Berger R.P., Bayir H., Wagner A.K., Jenkins L.W., Clark R.S. Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making. Curr Opin Crit Care 2008, 14:135-141.
5. Ely E.W., Margolin R., Francis J., May L., Truman B., Dittus B., Speroff T., Gautam S., Bernard G., Inouye S. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med 2001, 29:1370-1379.
6. Sessler C.N., Gosnell M., Grap M.J., Brophy G.T., O'Neal P.V., Keane K.A., Tesoro E.P., Elswick R.K. The Richmond agitation-sedation scale: validity and reliability in adult intensive care patients. Am J Respir Crit Care Med 2002, 166:1338-1344.
7. Meyer N.J., Hall J.B. Brain dysfunction in critically ill patients-the intensive care unit and beyond. Crit Care 2006, 10:223.
8. Ali M.S., Harmer M., Vaughan R. Serum S100 protein as a marker of a cerebral damage during cardiac surgery. Br J Anaesth 2000, 85:287-298.
9. Routsi C., Stamataki E., Nanas S., Psachoulia C., Stathopoulos A., Koroneos A., Zervou M., Jullien G., Roussos C. Increased levels of serum S100B protein in critically ill patients without brain injury. Shock 2006, 26:20-24.
10. Cotton B.A., Girard T.D., Ely E.W. Increased levels of serum S100B protein in critically ill patients without brain injury. Shock 2008, 30:222.
11. Machado-Vieira R., Dietrich M.O., Leke R., Cereser V.H., Zanatto V., Kapczinski F., Souza D.O., Portela L.V., Gentil V. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biol Psychiatry 2007, 61:142-144.
12. Siironen J., Juvela S., Kanarek K., Vilkki J., Hernesniemi J., Lappalainen J. The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage. Stroke 2007, 38:2858-2860.
13. Gustafsson E., Andsberg G., Darsalia V., et al. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Eur J Neurosci 2003, 17:2667-2678.
14. Nguyen D.N., Spapen H., Su F., Schiettecatte J., Shi L., Hachimi-Idrissi S., Huyghens L. Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit Care Med 2006, 34:1967-1974.
15. van Munster B.C., Korse C.M., de Rooij S.E., Bonfrer J.M., Zwinderman A.H., Korevaar J.C. Markers of cerebral damage during delirium in elderly patients with hip fracture. BMC Neurol 2009, 9:21.