Exhumational variability within the Himalaya of northwest India

Earth and Planetary Science Letters

Volumn 305, Issue 1-2, 2011, Pages 103-114

  Deeken, A ^a   Thiede, R C ^a   Sobel, E R ^a   Hourigan, J K ^b   Strecker, M R ^a  

^a UNIVERSITY OF POTSDAM   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apatite fission track; Exhumation; Haimantas; Himalaya; Thermochronology; Zircon uranium thorium helium

Indexed keywords

APATITE FISSION TRACKS; EXHUMATION; HAIMANTAS; HIMALAYAS; THERMOCHRONOLOGY;

APATITE; FISSION REACTIONS; HELIUM; PHOSPHATE MINERALS; SILICATE MINERALS; THORIUM; URANIUM; ZIRCON;

EROSION;

DEFORMATION; EXHUMATION; FAULTING; FISSION TRACK DATING; OROGENY; PRECIPITATION (CLIMATOLOGY); TECTONIC EVOLUTION; THERMOCHRONOLOGY; UPLIFT;

CHAMBA; HIMACHAL PRADESH; HIMALAYAS; INDIA;

LEUCAENA TRICHODES;

EID: 79953755524     PISSN: 0012821X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.epsl.2011.02.045     Document Type: Article

References (102)

1. Avouac J.P. Mountain building, erosion and the seismic cycle in the Nepal Himalaya. Adv. Geophys. 2003, 46:1-79.
2. Avouac J.P. Mountain building: from earthquakes to geological deformation. Treat. Geophys. 2007, 7.
3. Beaumont C., Fullsack P., Hamilton J. Erosional control of active compressional orogens. Thrust Tectonics 1992, 19-31. Chapman and Hall, New York. K.R. McClay (Ed.).
4. Beaumont C., Jamieson R.A., Nguyen M.H., Lee B. Himalayan tectonics explained by extrusion of a low-viscosity crustal channel coupled to focused surface denudation. Nature 2001, 414:738-742.
5. Bettinelli P., Avouac J.P., Flouzat M., Jouanne F., Bollinger L., Willis P., Chitrakar G.R. Plate motion of India and interseismic strain in the Nepal Himalaya from GPS and DORIS measurements. J. Geod. 2006, 80:567-589.
6. Bilham R., Larson K., Freymueller J., Members P.I. GPS measurements of present-day convergence across the Nepal Himalaya. Nature 1997, 386:61-64.
7. Bojar A.-V., Fritz H., Nicolescu S., Bregar M., Gupta R.P. Timing and mechanism of Central Himalayan exhumation: discriminating between tectonic and erosion processes. Terra Nova 2005, 17:427-433. 10.1111/j.1365-3121.2005.00629.x.
8. Bollinger L., Avouac J.P., Catlos E.J., Harrison T.M., Grove M., Beyssac O., Goffé B., Sapkota S. Thermal structure and exhumation history of the Lesser Himalaya in central Nepal. Tectonics 2004, 23:TC5015. 10.1029/2003TC001564.
9. Bollinger L., Henry P., Avouac J.P. Mountain building in the Nepal Himalaya: thermal and kinematic model. Earth Planet. Sci. Lett. 2006, 244:58-71.
10. Bookhagen B., Burbank D.W. Topography, relief, and TRMM-derived rainfall variations along the Himalaya. Geophys. Res. Lett. 2006, 33:L08405. 10.1029/2006GL026037.
11. Bookhagen B., Burbank D.W. Toward a complete Himalayan hydrological budget: spatiotemporal distribution of snowmelt and rainfall and their impact on river discharge. J. Geophys. Res. 2010, 115:F03019. 10.1029/2009JF001426.
12. Bookhagen B., Thiede R.C., Strecker M.R. Late Quaternary intensified monsoon phases control landscape evolution in the NW Himalaya. Geology 2005, 33:149-152. 10.1130/G20982.1.
13. Brandon M.T., Roden-Tice M.K., Garver J.I. Late Cenozoic exhumation of the Cascadia accretionary wedge in the Olympic Mountains, northwest Washington State. Geol. Soc. Am. Bull. 1998, 110:985-1009.
14. Braun J. Estimating exhumation rate and relief evolution by spectral analysis of age-elevation datasets. Terra Nova 2002, 14:210-214.
15. Burbank D.W., Beck R.A., Mulder T. The Himalayan foreland. Asian Tectonics 1996, 149-188. Cambridge Univ. Press, Cambridge. Y. An, T.M. Harrison (Eds.).
16. Burbank D.W., Blythe A.E., Putkonen J., Pratt-Sitaula B., Gabet E., Oskin M., Barros A., Ojha T.P. Decoupling of erosion and precipitation in the Himalayas. Nature 2003, 426:652-655.
17. Caddick M.J., Bickle M.J., Harris N.B.W., Holland T.J.B., Horstwood M.S.A., Parrish R.R., Ahmad T. Burial and exhumation history of a Lesser Himalayan schist: recording the formation of an inverted metamorphic sequence in NW India. Earth Planet. Sci. Lett. 2007, 264:375-390. 10.1016/j.epsl.2007.09.011.
18. Catlos E.J., Harrison T.M., Grove M., Yin A., Kohn M.J., Ryerson F.J., Le Fort P. Further evidence for late Miocene reactivation of the Main Central Thrust (Nepal Himalaya) and the significance of the MCT-1. EOS Trans. Am. Geophys. Union 1997, 78:651.
19. Cattin R., Avouac J.P. Modeling mountain building and the seismic cycle in the Himalaya of Nepal. J. Geophys. Res. 2000, 105:13389-13407. 10.1029/2000JB900032.
20. Célérier J., Harrison T.M., Webb A.A.G., Yin A. The Kumaun and Garwhal Lesser Himalaya, India; part 1. Structure and stratigraphy. GSA Bull. 2009, 121:1262-1280.
21. Célérier J., Harrison T.M., Beyssac O., Herman F., Dunlap W.J., Webb A.A.G. The Kumaun and Garwhal Lesser Himalaya, India: part 2. Thermal and deformation histories. GSA Bull. 2009, 121:1281-1297.
22. Clift P.D., Gaedicke C. Accelerated mass flux to the Arabian Sea during the middle to late Miocene. Geology 2002, 30:207-210.
23. Clift P.D., Sun Z. The sedimentary and tectonic evolution of the Yinggehai-Song Hong basin and the southern Hainan margin, South China Sea: implications for Tibetan uplift and monsoon intensification. J. Geophys. Res. 2006, 111:B06405. 10.1029/2005JB004048.
24. Copel P., Harrison M.T. Episodic rapid uplift in the Himalaya revealed by 40Ar/39Ar analysis of detrital K-felspar and muscovite, Bengal fan. Geology 1990, 18:354-359.
25. Dahlen F.A., Suppe J. Mechanics, growth, and erosion of mountain belts. GSA Special Paper 1988, 218:161-178. S.P. Clark (Ed.).
26. DeCelles P.G., Robinson D.M., Quade J., Ojha T.P., Garzione C.N., Copeland P., Upreti B.N. Stratigraphy, structure, and tectonic evolution of the Himalayan fold-thrust belt in western Nepal. Tectonics 2001, 20:487-509. 10.1029/2000TC001226.
27. Dettman D.L., Kohn M.J., Quade J., Ryerson F.J., Ojha T.P., Hamidullah S. Seasonal stable isotope evidence for a strong Asian monsoon throughout the past 10.7m.y. Geology 2001, 29:31-34. 10.1130/0091-7613(2001)029<0031:SSIEFA>2.0.CO;2.
28. Dettman D.L., Fang X.M., Garzione C.N., Li J.J. Uplift-driven climate change at 12Ma: a long δ18O record from the NE margin of the Tibetan Plateau. Earth Planet. Sci. Lett. 2003, 214:267-277. 10.1016/S0012-821X(03)00383-2.
29. Dèzes P.J., Vannay J.C., Steck A., Bussy F., Cosca M. Synorogenic extension: quantitative constraints on the age and displacement of the Zanskar shear zone (northwest Himalaya). Geol. Soc. Am. Bull. 1999, 111:364-374. 10.1130/0016-7606(1999) 111<0364:SEQCOT>2.3.CO;2.
30. DiPietro J.A., Pogue K.R. Tectonostratigraphic subdivisions of the Himalaya: a view from the west. Tectonics 2004, 23:TC5001. 10.1029/2003TC001554.
31. Donelick R.A., Ketcham R.A., Carlson W.D. Variability of apatite fission-track annealing kinetics: II. Crystallographic orientation effects. Am. Mineral. 1999, 84(9):1224-1234.
32. Duncan C., Masek J., Fielding E. How steep are the Himalaya? Characteristics and implications of along-strike topographic variations. Geology 2003, 31:75-78.
33. Einsele G., Ratschbacher L., Wetzel A. The Himalaya-Bengal fan denudation-accumulation system during the past 20Ma. J. Geol. 1996, 104:163-184.
34. Frank W., Grasemann B., Guntli P., Miller C. Geological map of the Kishtwar-Chamba-Kulu region (NW Himalaya India). Jahrb. Geol. Bundesanst. 1995, 138(2):299-308.
35. Fuchs G., Linner M. Geological traverse across the western Himalaya - a contribution to the geology of eastern Ladakh, Lahul, and Chamba. Jahrb. Geol. Bundesanst. 1995, 138(4):655-685.
36. Gansser A. Geology of the Himalayas 1964, Interscience Publishers, London, 289 pp.
37. Garzanti E., Vezzoli G., Ando S., Lavé J., Attal M., France-Lanord C., DeCelles P. Quantifying sand provenance and erosion (Marsyandi River, Nepal Himalaya). Earth Planet. Sci. Lett. 2007, 258:500-515. 10.1016/j.epsl.2007.04.010.
38. Griesbach C.L. Geology of the Central Himalayas. Mem. Geol. Surv. Ind. 1891, 23:1-232.
39. Harrison T.M., Ryerson F.J., Le Fort P., Yin A., Lovera O.M., Catlos E.J. A late Miocene-Pliocene origin for the central Himalayan inverted metamorphism. Earth Planet. Sci. Lett. 1997, 146:E1-E7.
40. Heim A.A., Gansser A. Central Himalaya: Geological Observations of the Swiss Expedition, 1936 1939, 26. Hindustan Publishing, Delhi, India.
41. Herman F., Copeland P., Avouac J.-P., Bollinger L., Mahéo G., Le Fort P., Rai S., Foster D., Pêcher A., Stüwe K., Henry P. Exhumation, crustal deformation, and thermal structure of the Nepal Himalaya derived from the inversion of thermochronological and thermobarometric data and modeling of the topography. J. Geophys. Res. 2010, 115:B06407. 10.1029/2008JB006126.
42. Herren E. Zanskar shear zone: northeast-southwest extension within the Higher Himalayas (Ladakh, India). Geology 1987, 15:409-413.
43. Hilley G.E., Strecker M.R. Steady state erosion of critical Coulomb wedges with applications to Taiwan and the Himalaya. J. Geophys. Res. 2004, 109(BO1411):1-17.
44. Hodges K.V. Tectonics of the Himalaya and southern Tibet from two perspectives. Geol. Soc. Am. Bull. 2000, 112:324-350.
45. Hodges K.V., Parrish R.R., Housh T.B., Lux D.R., Burchfiel B.C., Royden L.H., Chen Z. Simultaneous Miocene extension and shortening in the Himalayan orogen. Science 1992, 258:1466-1470.
46. Hodges K.V., Wobus C., Ruhl K., Schildgen T., Whipple K. Quaternary deformation, river steepening, and heavy precipitation at the front of the Higher Himalayan ranges. Earth Planet. Sci. Lett. 2004, 220:379-389. 10.1016/S0012-821X(04)00063-9.
47. Hoth S., Adam J., Kukowski N., Oncken O. Influence of erosion on the kinematics of bivergent orogens. Results from scaled sandbox simulations. Tectonics, Climate and Landscape Evolution, GSA Special Paper 398, Penrose Conference Series 2006, 201-225. S. Willett, N. Hovius, M. Brandon, D. Fisher (Eds.).
48. Hourigan J.K., Reiners P.W., Brandon M.T. U-Th zonation-dependent alpha-ejection in (U-Th)/He chronometry. Geochim. Cosmochim. Acta 2005, 69(13):3349-3365. 10.1016/j.gca.2005.01.024.
49. Huyghe P., Galy A., Mugnier J.-L., France-Lanord C. Propagation of the thrust system and erosion in the Lesser Himalaya: geochemical and sedimentological evidence. Geology 2001, 29:1007-1010. 10.1130/0091-7613(2001) 029<1007:POTTSA>2.0.CO;2.
50. Jain A.K., Kumar D., Singh S., Kumar A., Lal N. Timing, quantification and tectonic modelling of Pliocene-Quaternary movements in the NW Himalaya: evidence from fission track dating. Earth Planet. Sci. Lett. 2000, 179:437-451. 10.1016/S0012-821X(00)00133-3.
51. Ketcham R.A., Donelick R.A., Carlson W.D. Variability of apatite fission-track annealing kinetics: III. Extrapolation to geological time scales. Am. Mineral. 1999, 84(9):1235-1255.
52. Kumar S., Mahajan A.K. Seismotectonics of the Kangra region, Northwest Himalaya. Tectonophysics 2001, 331:359-371.
53. Kumar A., Lal N., Jain A.K., Sorkhabi R.B. Late Cenozoic-Quaternary thermo-tectonic history of Higher Himalayan Crystalline (HHC) in Kishtwar-Padar-Zanskar region, NW Himalaya: evidence from fission-track ages. J. Geol. Soc. India 1995, 45(4):375-391.
54. Lal N., Mehta Y.D., Kumar D., Kumar A., Jain A.K. Cooling and exhumation history of the Mandi granite and adjoining tectonic units, Himachal Pradesh, and estimation of closure temperature from external surface of zircon. report 1999, 207-216. Gondwana Research Group, Osaka, Japan. A.K. Jain, R.M. Manickavasagam (Eds.).
55. Lavé J., Avouac J.P. Fluvial incision and tectonic uplift across the Himalayas of Central Nepal. J. Geophys. Res. 2001, 106:26561-26592.
56. Le Fort P. Himalaya: the collided range: present knowledge of the continental arc. Am. J. Sci. 1975, 275A:1-44.
57. Mancktelow N.S., Grasemann B. Time-dependent effects of heat advection and topography on cooling histories during erosion. Tectonophysics 1997, 270:167-195.
58. Meigs A., Burbank D.W., Beck R.A. Middle-late Miocene (pre-10Ma) initiation of the Main Boundary Thrust in the western Himalaya. Geology 1995, 23:423-426. 10.1130/0091-7613(1995) 023<0423:MLMMFO>2.3.CO;2.
59. Métivier F., Guademer Y., Tapponier P., Klein M. Mass accumulation rates in Asia during the Cenozoic. Geophys. J. Int. 1999, 137:280-318.
60. Najman Y., Bickle M., Garzanti E., Pringle M., Barfod D., Brozovic N., Burbank D., Ando S. Reconstructing the exhumation history of the Lesser Himalaya, NW India, from a multitechnique provenance study of the foreland basin Siwalik Group. Tectonics 2009, 28. 10.1029/2009TC002506.
61. Nanda M.M., Singh M.P. Stratigraphy and sedimentation of the Zaskar area, Ladakh and adjoining parts of the Lahaul region of Himachal Pradesh. Himalayan Geology 1976, 365-388. S. Nautiyal (Ed.).
62. Prell W.L., Kutzbach J.E. Sensitivity of the Indian monsoon to forcing parameters and implications for its evolution. Nature 1992, 360:647-652. 10.1038/360647a0.
63. Rautela P., Thakur V.C. Structural analysis of the Panjal Thrust Zone, Himachal Himalaya, India. J. Himalayan Geol. 1992, 3:195-207.
64. Rea D.K. Delivery of Himalayan sediment to the northern Indian Ocean and its relation to global climate, sea level, uplift, and seawater strontium. Geophys. Monogr. Ser. 1993, 70:387-402. AGU, Washington, D. C. R.A. Duncan (Ed.).
65. Reiners P.W., Brandon M.T. Using thermochronology to understand orogenic erosion. Annu. Rev. Earth Planet. Sci. 2006, 34:419-466.
66. Reiners P.W., Spell T.L., Nicolescu S., Zanetti K.A. Zircon (U-Th)/He thermochronometry: He diffusion and comparisons with 40Ar/39Ar dating. Geochim. Cosmochim. Acta 2004, 68(8):1857-1887.
67. Robert X., van der Beek P., Braun J., Perry C., Dubille M., Mugnier J.-L. Assessing Quaternary reactivation of the Main Central thrust zone (central Nepal Himalaya): new thermochronologic data and numerical modeling. Geology 2009, 37:731-734. 10.1130/G25736A.1.
68. Robyr M., Vannay J.-C., Epard J.-L., Steck A. Thrusting, extension, and doming during the polyphase tectonometamorphic evolution of the High Himalayan Crystalline Zone in NW India. J. Asian Earth Sci. 2002, 21:221-239.
69. Robyr M., Hacker B.R., Mattison J.M. Doming in compressional orogenic settings: new geochronological constraints from the NW Himalaya. Tectonics 2006, 25:TC2007. 10.1029/2004TC001774.
70. Safran E.B. Geomorphic interpretation of low-temperature thermochronologic data: insights from two-dimensional thermal modeling. J. Geophys. Res. B Solid Earth Planet. 2003, 108. art.-no. 2189.
71. Schlup, M., 2003. Exhumation history of the western Himalaya: the Rupshu-Lahul-Kullu geochronological transect (NW-India). Thèse de doctorat, Université de Lausanne, Faculté des Sciencies, Institut de Minéralogie et Géochimie.
72. Schlup M., Carter A., Cosca M., Steck A. Exhumation history of eastern Ladakh revealed by Ar-40/Ar-39 and fission-track ages: the Indus River-Tso Morari transect, NW Himalaya. J. Geol. Soc. 2003, 160:385-399.
73. Schulte-Pelkum V., Monsalve G., Sheehan A., Pandey M.R., Sapkota S., Bilham R., Wu F. Imaging the Indian subcontinent beneath the Himalaya. Nature 2005, 435:1222-1225. 10.1038/nature03678.
74. Searle M.P., Noble S.R., Hurford A.J., Rex D.C. Age of crustal melting, emplacement and exhumation history of the Shivling leucogranite, Garhwal Himalaya. Geol. Mag. 1999, 136:513-525. 10.1017/S0016756899002885.
75. Seeber L., Gornitz V. River profiles along the Himalayan arc as indicators of active tectonics. Tectonophysics 1983, 92:335-367.
76. Sorkhabi R.B., Stump E., Foland K.A., Jain A.K. Fission-track and Ar-40/Ar-39 evidence for episodic denudation of the Gangotri granites in the Garhwal Higher Himalaya, India. Tectonophysics 1996, 260:187-199.
77. Steck A. Geology of the NW Indian Himalaya. Eclogae Geol. Helv. 2003, 96. 147-U13.
78. Stephenson B.J., Waters D.J., Searle M.P. Inverted metamorphism and the Main Central Thrust: field relations and thermobarometric constraints from the Kishtwar Window, NW Indian Himalaya. J. Metamorph. Geol. 2000, 18:571-590.
79. Stephenson B.J., Searle M.P., Waters D.J., Rex D.C. Structure of the Main Central Thrust zone and extrusion of the High Himalayan deep crustal wedge, Kishtwar-Zanskar Himalaya. J. Geol. Soc. Lond. 2001, 158:637-652.
80. Stüwe K., Hintermüller M. Topography and isotherms revisited: the influence of laterally migrating drainage divides. Earth Planet. Sci. Lett. 2000, 184:287-303.
81. Thakur V.C. Structure of the Chamba nappe and position of the Main Central Thrust in Kashmir Himalaya. J. Asian Earth Sci. 1998, 16:269-282.
82. Thakur, V.C., Rawat, B.S., 1992. Geological Map of Western Himalaya, 1:1,000,000. Wadia Institute of Himalayan Geology, Dehra Dun, India.
83. Thiede R.C., Bookhagen B., Arrowsmith J.R., Sobel E.R., Strecker M.R. Climatic control on rapid exhumation along the Southern Himalayan Front. Earth Planet. Sci. Lett. 2004, 222:791-806. 10.1016/j.epsl.2004.03.015.
84. Thiede R.C., Arrowsmith J.R., Bookhagen B., McWilliams M.O., Sobel E.R., Strecker M.R. From tectonically to erosionally controlled development of the Himalayan orogen. Geology 2005, 33:689-692. 10.1130/G21483.1.
85. Thiede R.C., Ehlers T.A., Bookhagen B., Strecker M.R. Erosional variability along the northwest Himalaya. J. Geophys. Res. 2009, 114:F01015. 10.1029/2008JF001010.
86. Valla P.G., Herman F., van der Beek P.A., Braun J. Inversion of thermochronological age-elevation profiles to extract independent estimates of denudation and relief history - I: theory and conceptual model. Earth Planet. Sci. Lett. 2010, 295:511-522.
87. Vance D., Harris N. Timing of prograde metamorphism in the Zanskar Himalaya. Geology 1999, 27:395-398. 10.1130/0091-7613(1999) 027<0395:TOPMIT>2.3.CO;2.
88. Vannay J.C., Grasemann B. Himalayan inverted metamorphism and syn-convergence extension as a consequence of a general shear extrusion. Geol. Mag. 2001, 138:253-276. 10.1017/S0016756801005313.
89. Vannay J.C., Hodges K.V. Tectonometamorphic evolution of the Himalayan metamorphic core between the Annapurna and Dhaulagiri, central Nepal. J. Metamorph. Geol. 1996, 14:635-656.
90. Vannay J.C., Steck A. Tectonic evolution of the High Himalaya in Upper Lahul (NW Himalaya, India). Tectonics 1995, 14:253-263.
91. Vannay J.C., Grasemann B., Rahn M., Frank W., Carter A., Baudraz V. Miocene to Holocene exhumation of metamorphic crustal wedges in the Himalayan orogen: evidence for tectonic extrusion coupled to fluvial erosion. Tectonics 2004, 23:TC1014. 10.1029/2002TC001429.
92. Wang Q., Zhang P.-Z., Freymueller J.T., Bilham R., Larson K.M., Lai X.A., You X., Niu Z., Jianchun W., Li Y., Liu J., Yang Z. Present-day crustal deformation in China constrained by global positioning system measurements. Science 2001, 294:574-577. 10.1126/science.1063647.
93. White N.M., Parrish R.R., Bickle M.J., Najman Y.M.R., Burbank D., Maithani A. Metamorphism and exhumation of the NW Himalaya constrained by U-Th-Pb analyses of detrital monazite grains from early foreland basin sediments. J. Geol. Soc. Lond. 2001, 158:625-635.
94. White N.M., Pringle M., Garzanti E., Bickle M., Najman Y., Chapman H., Friend P. Constraints on the exhumation and erosion of the High Himalayan Slab, NW India, from foreland basin deposits. Earth Planet. Sci. Lett. 2002, 195:29-44.
95. Willett S.D. Orogeny and orography: the effects of erosion on the structure of mountain belts. J. Geophys. Res. 1999, 104:28957-28982.
96. Willett S.D., Brandon M.T. On steady states in mountain belts. Geology 2002, 30:175-178.
97. Wobus C.W., Hodges K.V., Whipple K.X. Has focused denudation sustained active thrusting at the Himalayan topographic front?. Geology 2003, 31:861-864.
98. Wobus C., Heimsath A., Whipple K., Hodges K. Active out-of-sequence thrust faulting in the central Nepalese Himalaya. Nature 2005, 434:1008-1011.
99. Yin A. Cenozoic evolution of the Himalayan orogen as constrained by along-strike variations of structural geometry, exhumation history, and foreland sedimentation. Earth Sci. Rev. 2006, 76:1-131.
100. Zeitler P.K., Koons P.O., Bishop M.P., Chamberlain C.P., Craw D., Edwards M.A., Hamidullah S., Qasim Jan M., Asif Khan M., Umar Khan Khattak M., Kidd W.S.F., Mackie R.L., Meltzer A.S., Park S.K., Pecher A., Poage M.A., Sarker G., Schneider D.A., Seeber L., Shroder J.F. Crustal reworking at Nanga Parbat, Pakistan: metamorphic consequences of thermal-mechanical coupling facilitated by erosion. Tectonics 2001, 20:712-728.
101. Zhao W., Nelson K.D. Deep seismic reflection evidence for continental underthrusting beneath southern Tibet. Nature 1993, 366:557-559. and the Project INDEPTH Team.
102. Zhisheng A., Kutzbach J.E., Prell W.L., Porter S.C. Evolution of Asian monsoons and phased uplift of the Himalayan Tibetan Plateau since late Miocene times. Nature 2001, 411:62-66. 10.1038/35075035.