Hypoxic and hypercapnic challenges unveil respiratory vulnerability of Surf1 knockout mice, an animal model of Leigh syndrome

Mitochondrion

Volumn 11, Issue 3, 2011, Pages 413-420

  Stettner, Georg M ^a   Viscomi, Carlo ^b   Zeviani, Massimo ^b   Wilichowski, Ekkehard ^a   Dutschmann, Mathias ^c,d  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d Deutsche Forschungsgemeinschaft   (Germany)

Author keywords

Brainstem; Ca2+ homeostasis; Chemosensitivity; COX deficiency; Hyperventilation; Hypoxia; Leigh syndrome; Mitochondria; Respiratory rhythm; Surf1 gene

Indexed keywords

MITOCHONDRIAL PROTEIN; PROTEIN SURF1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; DISEASE PREDISPOSITION; HYPERCAPNIA; HYPOXIA; KNOCKOUT MOUSE; LEIGH DISEASE; MALE; MOTOR NERVE CONDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY FUNCTION; WILD TYPE;

ANIMALS; ANOXIA; CHEMORECEPTOR CELLS; HUMANS; HYPERCAPNIA; LEIGH DISEASE; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MODELS, ANIMAL; RESPIRATORY RATE;

ANIMALIA; MUS;

EID: 79953733128     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2010.12.011     Document Type: Article

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