Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia

Journal of Proteome Research

Volumn 10, Issue 4, 2011, Pages 1468-1480

  Kahn, Jean Emmanuel ^a,b   Dutoit Lefevre, Virginie ^b   Duban Deweer, Sophie ^c   Chafey, Philippe ^d   Pottiez, Gwenael ^c   Lefranc, Didier ^b   Fain, Olivier ^e   Cordier, Jean Francois ^f   Hatron, Pierre Yves ^b   Bletry, Olivier ^a   Prin, Lionel ^b  

^a FOCH HOSPITAL   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ D'ARTOIS   (France)

^d INSTITUT COCHIN   (France)

^e HÔPITAL JEAN VERDIER   (France)

^f EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

15 lipoxygenase 1; chronic eosinophilic leukemia; eosinophil; FIP1L1 PDGFRA; hydrogen peroxide; hypereosinophilic syndrome; mass spectrometry; peroxiredoxin 2; proteomic analysis; reactive oxygene species; SHP 1

Indexed keywords

IMATINIB; PEROXIREDOXIN 2; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE OXYGEN METABOLITE;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIC LEUKEMIA; FIP1L1 GENE; FUSION GENE; GENE; HUMAN; HYPEREOSINOPHILIC SYNDROME; MALE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PDGFRA GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION;

ADULT; AGED; ANIMALS; CELL LINE; DATABASES, PROTEIN; EOSINOPHILS; FEMALE; HUMANS; HYPEREOSINOPHILIC SYNDROME; MALE; MASS SPECTROMETRY; MIDDLE AGED; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; ONCOGENE PROTEINS, FUSION; OXIDATION-REDUCTION; PEROXIREDOXINS; PROTEOME; REACTIVE OXYGEN SPECIES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SIGNAL TRANSDUCTION; TWO-DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

ANIMALIA;

EID: 79953706633     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100836p     Document Type: Article

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