Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions - a taskforce report

Journal of Oral Rehabilitation

Volumn 38, Issue 5, 2011, Pages 366-394

  Svensson, P ^a   Baad Hansen, L ^a   Pigg, M ^b   List, T ^b   Eliav, E ^c   Ettlin, D ^d   Michelotti, A ^e   Tsukiyama, Y ^f   Matsuka, Y ^g   Jaaskelainen S K ^h   Essick, G ⁱ   Greenspan, J D ^j   Drangsholt, M ^k  

^a AARHUS UNIVERSITY   (Denmark)

^b MALMÖ UNIVERSITY   (Sweden)

^c RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f KYUSHU UNIVERSITY   (Japan)

^g OKAYAMA UNIVERSITY   (Japan)

^h UNIVERSITY OF TURKU   (Finland)

ⁱ UNIVERSITY OF NORTH CAROLINA   (United States)

^j UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^k UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

Intraoral quantitative sensory testing; Neuropathic pain; Orofacial pain; Psychophysics; Quantitative sensory testing

Indexed keywords

AGE; FACE PAIN; HUMAN; NEUROLOGIC EXAMINATION; PATHOPHYSIOLOGY; PERCEPTIVE THRESHOLD; PRACTICE GUIDELINE; REPRODUCIBILITY; RESEARCH; REVIEW; SEX DIFFERENCE; SOMATOSENSORY DISORDER; STIMULATION;

AGE FACTORS; FACIAL PAIN; HUMANS; NEUROLOGIC EXAMINATION; PHYSICAL STIMULATION; REPRODUCIBILITY OF RESULTS; RESEARCH REPORT; SENSORY THRESHOLDS; SEX FACTORS; SOMATOSENSORY DISORDERS;

EID: 79953694461     PISSN: 0305182X     EISSN: 13652842     Source Type: Journal    
DOI: 10.1111/j.1365-2842.2010.02196.x     Document Type: Review

References (245)

1. Hansson P, Backonja M, Bouhassira D. Usefulness and limitations of quantitative sensory testing: clinical and research application in neuropathic pain states. Pain. 2007;129:256-259.
2. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70:1630-1635.
3. Teerijoki-Oksa T, Jääskeläinen S, Forssell K, Virtanen A, Forssell H. An evaluation of clinical and electrophysiologic tests in nerve injury diagnosis after mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg. 2003;32:15-23.
4. Teerijoki-Oksa T, Jääskeläinen SK, Forssell K, Virtanen A, Forssell H. Recovery of nerve injury after mandibular sagittal split osteotomy. Diagnostic value of clinical and electrophysiologic tests in the follow-up. Int J Oral Maxillofac Surg. 2004;33:134-140.
5. Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol. 2010;17:1010-1018.
6. Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006;123:231-243.
7. Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F et al. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain. 2006;10:77-88.
8. Blankenburg M, Boekens H, Hechler T, Maier C, Krumova E, Scherens A et al. Reference values for quantitative sensory testing in children and adolescents: developmental and gender differences of somatosensory perception. Pain. 2010;149:76-88.
9. Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 2010;150:439-450.
10. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25.
11. Jääskeläinen SK. Clinical neurophysiology and quantitative sensory testing in the investigation of orofacial pain and sensory function. J Orofac Pain. 2004;18:85-107.
12. Jääskeläinen SK. Neuropathic pain in the orofacial area. In: Olesen J, Jensen TS, eds. Frontiers in headache research. Oxford: Oxford University Press, 2006:63-75.
13. Jääskeläinen SK. Traumatic nerve injury: diagnosis, recovery, and risk factors for neuropathic pain. In: Castro-Lopes J, ed. Current topics in pain: 12th World Congress on pain (plenary lectures). Seattle (WA): IASP Press, 2009:165-184.
14. Svensson P, Baad-Hansen L, Thygesen T, Juhl GI, Jensen TS. Overview on tools and methods to assess neuropathic trigeminal pain. J Orofac Pain. 2004;18:332-338.
15. Cruccu G, Anand P, Attal N, Garcia-Larrea L, Haanpää M, Jørum E et al. EFNS guidelines on neuropathic pain assessment. Eur J Neurol. 2004;11:153-162.
16. Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M et al. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010;14:339.
17. Goldscheider A. Zur Dualität des Temperatursinns. Pflügers Arch Ges Physiol. 1886;39:96-120.
18. Weber EH. Handwörterbuch der Physiologie, vol 3. Vieweg: Braunsweig, 1846;481-588.
19. Fechner GT. Elemente der Psychophysik. Leipzig: Breitkopf & Härtel, 1860.
20. Von Frey M. Beiträge zur Sinnesphysiologie der Haut. III. Ber Sach Ges Wiss Leipzig Math-Phys. 1895;47:166-184.
21. Stevens SS. On the psychophysical law. Psychol Rev. 1957;64:153-181.
22. Schmidt RF. Somatovisceral sensibility. In: Schmidt RF, ed. Fundamentals of Sensory Physiology. Berlin: Springer-Verlag, 1986:30-67.
23. Gescheider GA. Psychophysics - the fundamentals. Mahwah (NJ): LEA Publishers; 1997.
24. Gracely RH. Studies of pain in human subjects. In: Mcmahon SB, Koltzenburg M, eds. Wall and Melzack's textbook of pain. Philadelphia (PA): Elsevier Churchill Livingstone; 2006:267-289.
25. Dyck PJ, Karnes JL, O'brien PC, Zimmerman IR. Detection thresholds of cutaneous sensation in humans. In: Dyck PJ, Thomas PK, Griffin J, Low PA, Poduslo JF, eds. Peripheral neuropathy. 3rd ed. Philadelphia (PA): WB Saunders; 1993:706-728.
26. Verdugo R, Ochoa JL. Quantitative somatosensory thermotest. A key method for functional evaluation of small calibre afferent channels. Brain. 1992;115:893-913.
27. Jamal G, Hansen S, Weir AI, Ballantyne JP. An improved automated method for the measurement of thermal thresholds. 1. Normal subjects. J Neurol Neurosurg Psychiatr. 1985;48:354-360.
28. Lindblom U. Analysis of abnormal touch, pain, and temperature sensations in patients. In: Boivie J, Hansson P, Lindblom U, eds. Touch, temperature, and pain in health and disease: mechanisms and assessments. Seattle (WA): IASP Press, 1994:63-84.
29. Yarnitsky D. Quantitative sensory testing. Muscle Nerve. 1997;20:198-204.
30. Harvey LO. Efficient estimation of sensory thresholds. Behav Res Methods Instrum Comput. 1986;18:623-632.
31. Gracely RH, Lota L, Walter DJ, Dubner R. A multiple random staircase method of psychophysical pain assessment. Pain. 1988;32:55-63.
32. Yarnitsky D, Sprecher E. Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci. 1994;125:39-45.
33. Shy ME, Frohman EM, So YT, Arezzo JC, Cornblath DR, Giuliani MJ et al. Quantitative sensory testing. Neurology. 2003;60:898-904.
34. Valmunen T, Pertovaara A, Virtanen A, Parkkola R, Jääskeläinen SK. Modulation of facial sensitivity by navigated rTMS in healthy subjects. Pain. 2009;142:149-158.
35. Gruener G, Dyck PJ. Quantitative sensory testing: methodology, applications, and future directions. J Clin Neurophysiol. 1994;11:568-583.
36. Essick G, Guest S, Martinez E, Chen C, Mcglone F. Site-dependent and subject-related variations in perioral thermal sensitivity. Somatosens Mot Res. 2004;21:159-175.
37. Yarnitsky D, Sprecher E, Tamir A, Zaslansky R, Hemli JA. Variance of sensory threshold measurements: discrimination of feigners from trustworthy performers. J Neurol Sci. 1994;125:186-189.
38. Cascio C, Mcglone F, Folger S, Tannan V, Baranek G, Pelphrey KA et al. Tactile perception in adults with autism: a multidimensional psychophysical study. J Autism Dev Disord. 2008;38:127-137.
39. Clark WC. The psyche in the psychophysics of pain: an introduction to sensory decision theory. In: Boivie J, Hansson P, Lindblom U, eds. Touch, temperature, and pain in health and disease: mechanisms and assessments. Seattle (WA): IASP Press, 1994:41-62.
40. Tan CW, Palmer ST, Martin DJ, Roche PA. Detection theory analysis of scaling and discrimination tasks: responses to noxious thermal stimuli. Percept Psychophys. 2007;69:994-1001.
41. Abdi H. Signal detection theory (SDT). In: Salkind N, ed. Encyclopedia of measurements and statistics. Thousand Oaks (CA): Sage; 2007:886-889.
42. Price DD. Psychological and neural mechanisms of pain. New York: Raven Press, 1988.
43. Svensson P, Graven-Nielsen T, Arendt-Nielsen L. Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles. Pain. 1998;74:93-100.
44. Svensson P, Wang K, Arendt-Nielsen L, Cairns BE. Effects of NGF-induced muscle sensitization on proprioception and nociception. Exp Brain Res. 2008;189:1-10.
45. Essick GK, Patel S, Trulsson M. Mechanosensory and thermosensory changes across the border of impaired sensitivity to pinprick after mandibular nerve injury. J Oral Maxillofac Surg. 2002;60:1250-1266.
46. Morin C, Duncan GH, Lavigne G, Boily J-G, Bushnell MC. Differential effects of morphine on pain and temperature perception in human volunteers. Eur J Pain. 1999;3:193-204.
47. Price DD, Patel R, Robinson ME, Staud R. Characteristics of electronic visual analogue and numerical scales for ratings of experimental pain in healthy subjects and fibromyalgia patients. Pain. 2008;140:158-166.
48. Gracely RH, Mcgrath F, Dubner R. Ratio scales of sensory and affective verbal pain descriptors. Pain. 1978;5:5-18.
49. Green BG, Shaffer GS, Gilmore MM. Derivation and evaluation of a semantic scale of oral sensation magnitude with apparent ratio properties. Chem Senses. 1993;18:683-702.
50. Borg G. Psychophysical scaling: an overview. In: Boivie J, Hansson P, Lindblom U, eds. Touch, temperature, and pain in health and disease: mechanisms and assessments. Seattle (WA): IASP Press, 1994:27-39.
51. Dionne RA, Bartoshuk L, Mogil J, Witter J. Individual responder analyses for pain: does one pain scale fit all? Trends Pharmacol Sci. 2005;26:125-130.
52. Lamotte RH, Campbell JN. Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain. J Neurophysiol. 1978;41:509-528.
53. Feldman JA, Essick GK, Zuniga JR, Phillips C. Inter-examiner reliability of three subjective clinical neurosensory tests. Int J Adult Orthod Orthognath Surg. 1997;12:273-285.
54. Green BG. Thermal perception on lingual and labial skin. Percept Psychophys. 1984;36:209-220.
55. Green BG. Oral perception of the temperature of liquids. Percept Psychophys. 1986;39:19-24.
56. Green BG. Temperature perception and nociception. J Neurobiol. 2004;61:13-29.
57. Green BG, Gelhard B. Perception of temperature on oral and facial skin. Somatosens Res. 1987;4:191-200.
58. Price DD, Harkins SW. Combined use of experimental pain and visual analogue scales in providing standardized measurement of clinical pain. Clin J Pain. 1987;3:1-8.
59. Stevens JC, Marks LE. Spatial summation and the dynamics of warmth sensation. Percept Psychophys. 1971;9:391-398.
60. Svensson P, Rosenberg B, Beydoun A, Morrow TJ, Casey KL. Comparative psychophysical characteristics of cutaneous CO2 laser and contact heat stimulation. Somatosens Motor Res. 1997;14:113-118.
61. Lautenbacher S, Möltner A, Strian F. Psychophysical features of the transition from pure heat perception to heat pain perception. Percept Psychophys. 1992;52:685-690.
62. Witting N, Svensson P, Arendt-Nielsen L, Jensen TS. Repetitive intradermal capsaicin: differential effect on pain and areas of allodynia and punctate hyperalgesia. Somatosens Motor Res. 2000;17:5-12.
63. Gazerani P, Wang K, Cairns BE, Svensson P, Arendt-Nielsen L. Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women. Pain. 2006;124:338-348.
64. Ayesh EE, Jensen TS, Svensson P. Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints. J Dent Res. 2007;86:1187-1192.
65. Gazerani P, Pedersen NS, Staahl C, Drewes AM, Arendt-Nielsen L. Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin. Pain. 2009;141:60-69.
66. Thygesen T, Jensen J, Nørholt SE, Svensson P. Spatial and temporal assessment of orofacial somatosensory sensitivity: a methodological study. J Orofac Pain. 2007;21:19-28.
67. Thygesen TH, Bardow A, Nørholt SE, Jensen J, Svensson P. Surgical risk factors and maxillary nerve function following Le Fort I osteotomy. J Oral Maxillofac Surg. 2009;67:528-536.
68. Zuniga JR, Essick GK. A contemporary approach to the clinical evaluation of trigeminal nerve injuries. Oral Maxillofac Surg Clin North Am. 1992;4:353.
69. Van Boven RW, Johnson KO. A psychophysical study of the mechanisms of sensory recovery following nerve injury in humans. Brain. 1994;117:149-167.
70. Jacobs R, Wu CH, Goossens K, Van Loven K, Van Hees J, Van Steenberghe D. Oral mucosal versus cutaneous sensory testing: a review of the literature. J Oral Rehabil. 2002;29:923-950.
71. Jacobs R, Wu CH, Van Loven K, Desnyder M, Kolenaar B, Van Steenberghe D. Methodology of oral sensory tests. J Oral Rehabil. 2002;29:720-730.
72. Essick GK. Psychophysical assessment of patients with posttraumatic neuropathic trigeminal pain. J Orofac Pain. 2004;18:345-354.
73. Eliav E, Gracely RH, Nahlieli O, Benoliel R. Quantitative sensory testing in trigeminal nerve damage assessment. J Orofac Pain. 2004;18:339-344.
74. Poort LJ, van Neck JW, van der Wal KG. Sensory testing of inferior alveolar nerve injuries: a review of methods used in prospective studies. J Oral Maxillofac Surg. 2009;67:292-300.
75. Koltzenburg M, Lundberg LE, Torebjörk HE. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain. 1992;51:207-219.
76. Kilo S, Schmelz M, Koltzenburg M, Handwerker HO. Different patterns of hyperalgesia induced by experimental infLammation in human skin. Brain. 1994;117:385-396.
77. Grushka M, Sessle BJ, Howley TP. Psychophysical assessment of tactile, pain and thermal sensory functions in burning mouth syndrome. Pain. 1987;28:169-184.
78. Jensen TS, Gottrup H. Assessment of neuropathic pain. In: Jensen TS, Wilson PR, Rice ASC, eds. Clinical pain management: chronic pain. London: Arnold, 2003:113-124.
79. List T, Leijon G, Svensson P. Somatosensory abnormalities in atypical odontalgia: a case-control study. Pain. 2008;139:333-341.
80. Murray RA, Essick GK, Kelly DG. Effect of stimulus force on perioral direction discrimination: clinical implications. J Oral Maxillofac Surg. 1994;52:688-697.
81. Komiyama O, De Laat A. Tactile and pain thresholds in the intra- and extra-oral regions of symptom-free subjects. Pain. 2005;115:308-315.
82. Michelotti A, Farella M, Stallato A, Martina R, De Laat A. Tactile and pain thresholds in patients with myofascial pain of the jaw muscles: a case-control study. J Orofac Pain. 2008;22:139-145.
83. Fruhstorfer H, Gross W, Selbmann O. von Frey hairs: new materials for a new design. Eur J Pain. 2001;5:341-342.
84. Trulsson M, Essick GK. Chapter 6: mechanosensation. In: Miles TS, Nauntofte B, Svensson P, eds. Clinical oral physiology. Copenhagen: Quintessence Books, 2004:165-197.
85. Essick GK, Trulsson M. Tactile sensation in oral region. In: Binder MD, Hirokawa N, Windhorst U, eds. Encyclopedia of neuroscience. New York: Springer-Verlag, 2009:3999-4005.
86. Cairns BE, Dong X, Mann MK, Svensson P, Sessle BJ, Arendt-Nielsen L et al. Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers. Pain. 2007;132:33-41.
87. Dong XD, Mann MK, Kumar U, Svensson P, Arendt-Nielsen L, Hu JW et al. Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. Neuroscience. 2007;146:822-832.
88. Essick GK, Afferica T, Aldershof B, Nestor J, Kelly D, Whitsel B. Human perioral directional sensitivity. Exp Neurol. 1988;100:506-523.
89. Megias-Alguacil D, Keller T, Lutz K, Barlow AP, Ettlin DA. Design and construction of a magnetic resonance compatible multi-injector gas jet delivery system. Rev Sci Instrum. 2008;79:014301.
90. Ettlin D, Hitz T, Ramel C, Meier M, Gallo L, Ioannidis A et al. Quantitative sensory testing of intraoral wounds. Abstract IADR General Session, Barcelona, Spain 2010.
91. Dyck PJ, Zimmerman IR, O'brien PC, Ness A, Caskey PE, Karnes J et al. Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man. Ann Neurol. 1978;4:502-510.
92. Chong PS, Cros DP. Technology literature review: quantitative sensory testing. Muscle Nerve. 2004;29:734-747.
93. Verrillo RT, Ecker AD. Effects of root or nerve destruction on vibrotactile sensitivity in trigeminal neuralgia. Pain. 1977;3:239-255.
94. Hollins M, Delemos KA, Goble AK. Vibrotactile adaptation on the face. Percept Psychophys. 1991;49:21-30.
95. James A, Essick GK, Kelly DG, Tappouni H, Mcglone FP. Frequency and site-dependent variations in vibration detection thresholds on the face. Somatosens Mot Res. 2000;17:349-360.
96. Andreatta RD, Davidow JH. Mechanical frequency and stimulation-site-related differences in vibrotactile detection capacity along the lip vermilion in young adults. Clin Oral Investig. 2006;10:17-22.
97. Hollins M, Sigurdsson A, Fillingim L, Goble AK. Vibrotactile threshold is elevated in temporomandibular disorders. Pain. 1996;67:89-96.
98. Hollins M, Sigurdsson A. Vibrotactile amplitude and frequency discrimination in temporomandibular disorders. Pain. 1998;75:59-67.
99. Kelly DH. Oral vibrotactile sensation: an evaluation of children with normal and defective articulation. J Commun Disord. 1977;10:359-368.
100. Fucci D, Petrosino L, Harris D. Instrumentation for assessment of oral vibrotactile sensation and perception. Int J Orofacial Myology. 1990;16:8-12.
101. Fucci D, Petrosino L. Oral vibrotactile assessment procedures: modifications. Int J Orofacial Myology. 1995;21:48-52.
102. Pigg M, Baad-Hansen L, Svensson P, Drangsholt M, List T. Reliability of intraoral quantitative sensory testing (QST). Pain. 2010;148:220-226.
103. Ringel RL. Oral region two-point discrimination in normal and myopathic subjects. In: Bosma JF, ed. Oral sensation and perception. Springfield (IL): CC Thomas, 1970:309-322.
104. Chen CC, Essick GK, Kelly DG, Young MG, Nestor JM, Masse B. Gender-, side- and site-dependent variations in human perioral spatial resolution. Arch Oral Biol. 1995;40:539-548.
105. Essick GK, Phillips C, Kim SH, Zuniga J. Sensory retraining following orthognathic surgery: effect on threshold measures of sensory function. J Oral Rehabil. 2009;36:415-426.
106. Patel J, Essick GK, Kelly DG. Utility of square-wave gratings to assess perioral spatial acuity. J Oral Maxillofac Surg. 1997;55:593-601.
107. Essick GK, Chen CC, Kelly DG. A letter-recognition task to assess lingual tactile acuity. J Oral Maxillofac Surg. 1999;57:1324-1330.
108. Dellon AL, Andonian E, Dejesus RA. Measuring sensibility of the trigeminal nerve. Plast Reconstr Surg. 2007;120:1546-1550.
109. Essick GK, Phillips C, Turvey TA, Tucker M. Facial altered sensation and sensory impairment after orthognathic surgery. Int J Oral Maxillofac Surg. 2007;36:577-582.
110. Vriens JP, van der Glas HW. Extension of normal values on sensory function for facial areas using clinical tests on touch and two-point discrimination. Int J Oral Maxillofac Surg. 2009;38:1154-1158.
111. Yamada M, Maruhashi J, Miyake N. The distribution of sensory spots on the oral mucous membrane. Jpn J Physiol. 1952;2:328-332.
112. Lee J, Essick GK. Spatial and gender-dependent variations in perioral pinprick sensitivity. J Dent Res. 1993;72:1206-1214.
113. Greenspan JD, Mcgillis SL. Stimulus features relevant to the perception of sharpness and mechanically evoked cutaneous pain. Somatosens Mot Res. 1991;8:137-147.
114. Greenspan JD, Mcgillis SL. Thresholds for the perception of pressure, sharpness, and mechanically evoked cutaneous pain: effects of laterality and repeated testing. Somatosens Mot Res. 1994;11:311-317.
115. Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD. Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain. 2002;96:141-151.
116. Adriaensen H, Gybels J, Handwerker HO, Van Hees J. Nociceptor discharges and sensations due to prolonged noxious mechanical stimulation - a paradox. Hum Neurobiol. 1984;3:53-58.
117. Forster C, Anton F, Reeh PW, Weber E, Handwerker HO. Measurement of the analgesic effects of aspirin with a new experimental algesimetric procedure. Pain. 1988;32:215-222.
118. Biasiotta A, Peddireddy A, Wang K, Romaniello A, Frati A, Svensson P et al. Effect of pinching-evoked pain on jaw-stretch reflexes and exteroceptive suppression periods in healthy subjects. Clin Neurophysiol. 2007;118:2180-2188.
119. Hampf G, Bowsher D, Wells C, Miles J. Sensory and autonomic measurements in idiopathic trigeminal neuralgia before and after radiofrequency thermocoagulation: differentiation from some other causes of facial pain. Pain. 1990;40:241-248.
120. Mcmillan AS, Walshaw D. Pressure-pain threshold in the human tongue. J Orofac Pain. 2000;14:93-97.
121. Baad-Hansen L, Arima T, Arendt-Nielsen L, Neumann Jensen B, Svensson P. Quantitative sensory tests before and 11/2 years after orthognathic surgery: a cross-sectional study. J Oral Rehabil. 2010;37:313-321.
122. Ohrbach R, Gale EN. Pressure pain thresholds in normal muscles: reliability, measurement effects, and topographic differences. Pain. 1989;37:257-263.
123. Ohrbach R, Gale EN. Pressure pain thresholds, clinical assessment, and differential diagnosis: reliability and validity in patients with myogenic pain. Pain. 1989;39:157-169.
124. Farella M, Michelotti A, Steenks MH, Romeo R, Cimino R, Bosman F. The diagnostic value of pressure algometry in myofascial pain of the jaw muscles. J Oral Rehabil. 2000;27:9-14.
125. Treede RD, Rolke R, Andrews K, Magerl W. Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Pain. 2002;98:235-240.
126. Svensson P, Graven-Nielsen T. Craniofacial muscle pain: review of mechanisms and clinical manifestations. J Orofac Pain. 2001;15:117-145.
127. Visscher CM, Lobbezoo F, Naeije M. Comparison of algometry and palpation in the recognition of temporomandibular disorder pain complaints. J Orofac Pain. 2004;18:214-219.
128. Bernhardt O, Schiffman EL, Look JO. Reliability and validity of a new fingertip-shaped pressure algometer for assessing pressure pain thresholds in the temporomandibular joint and masticatory muscles. J Orofac Pain. 2007;21:29-38.
129. Gomes MB, Guimarães JP, Guimarães FC, Neves AC. Palpation and pressure pain threshold: reliability and validity in patients with temporomandibular disorders. Cranio. 2008;26:202-210.
130. Bendtsen L, Jensen R, Jensen NK, Olesen J. Muscle palpation with controlled finger pressure: new equipment for the study of tender myofascial tissues. Pain. 1994;59:235-239.
131. Fischer AA. Pressure algometry over normal muscles: standard values, validity and reproducibility of pressure threshold. Pain. 1987;30:115-126.
132. List T, Helkimo M, Karlsson R. Influence of pressure rates on the reliability of a pressure threshold meter. J Craniomandib Disord. 1991;5:173-178.
133. Graven-Nielsen T, Mense S, Arendt-Nielsen L. Painful and non-painful pressure sensations from human skeletal muscle. Exp Brain Res. 2004;159:273-283.
134. Stohler CS, Ashton-Miller JA. Servo-controlled stepped and ramped mechanical tissue algometry. J Biomech. 2007;40:1635-1640.
135. Davenport JC. Pressure-pain thresholds in the oral cavity in man. Arch Oral Biol. 1969;14:1267-1274.
136. Mcmillan AS. Pain-pressure threshold in human gingivae. J Orofac Pain. 1995;9:44-50.
137. Ogimoto T, Ogawa T, Sumiyoshi K, Matsuka Y, Koyano K. Pressure-pain threshold determination in the oral mucosa: validity and reliability. J Oral Rehabil. 2002;29:620-626.
138. McDonald ET, Aungst LF. Studies in oral sensorimotor function. In: Bosma JF, ed. Oral sensation and perception. Springfield (IL): CC Thomas, 1967:202-220.
139. Arndt WB, Gauer J, Shelton RL, Crary D, Chisum L. Refinement of a test of oral stereognosis. In: Bosma JF, ed. Oral sensation and perception. Springfield (IL): CC Thomas, 1970:363-378.
140. Laine P, Siirilä HS. Oral and manual stereognosis and two-point tactile discrimination of the tongue. Acta Odontol Scand. 1971;29:197-204.
141. Jacobs R, Bou Serhal C, van Steenberghe D. Oral stereognosis: a review of the literature. Clin Oral Investig. 1998;2:3-10.
142. Tryde G, Frydenberg O, Brill N. An assessment of the tactile sensibility in human teeth. An evaluation of a quantitative method. Acta Odontol Scand. 1962;20:233-256.
143. Kogawa EM, Calderon PD, Lauris JR, Pegoraro LF, Conti PC. Evaluation of minimum interdental threshold ability in dentate female temporomandibular disorder patients. J Oral Rehabil. 2010;37:322-328.
144. Khan AA, Mccreary B, Owatz CB, Schindler WG, Schwartz SA, Keiser K et al. The development of a diagnostic instrument for the measurement of mechanical allodynia. J Endod. 2007;33:663-666.
145. Strughold H. Die topographie des Kältesinnes in der Mundhöhle. Zeitschrift für Biologie. 1925;83:515-534.
146. Schriever VH, Strughold H. Über die Nasen- und Rachenschleimhaut eigentumlichen Empfindungsqualitaten. Zeitschrift für Biologie. 1926;84:193-206.
147. Hirsch L, Schriever H. Beitrag zur Sensibilität der Zunge, des Kehlkopfes und der hinteren Rachenwand. Zeitschrift für Biologie. 1929;89:1-20.
148. Margarida R, Hardy JD, Hammel HT. Measurement of the thermal pain threshold of the hard palate. J Appl Physiol. 1962;17:338-342.
149. Gottrup H, Kristensen AD, Bach FW, Jensen TS. Aftersensations in experimental and clinical hypersensitivity. Pain. 2003;103:57-64.
150. Baron R. Neuropathic pain: a clinical perspective. Handb Exp Pharmacol. 2009;194:3-30.
151. Juhl GI, Jensen TS, Norholt SE, Svensson P. Central sensitization phenomena after third molar surgery: a quantitative sensory testing study. Eur J Pain. 2008;12:116-127.
152. Fruhstorfer H, Detering I. A simple thermode for rapid temperature change. Pflügers Arch. 1974;349:83-85.
153. Kenshalo DR, Bergen DC. A device to measure cutaneous temperature sensitivity in humans and subhuman species. J Appl Physiol. 1975;39:1038-1040.
154. Morrow TJ, Casey KL. A contact thermal stimulator for neurobehavioral research on temperature sensation. Brain Res Bull. 1981;6:281-284.
155. Taylor JD, Mcgillis SLB, Greenspan JD. Body site variation of heat pain sensitivity. Somatosens Motor Res. 1993;10:455-465.
156. Nielsen J, Arendt-Nielsen L. Spatial summation of heat induced pain within and between dermatomes. Somatosens Motor Res. 1997;14:119-125.
157. Lautenbacher S, Roscher S, Strian F. Tonic pain evoked by pulsating heat: temporal summation mechanisms and perceptual qualities. Somatosens Motor Res. 1995;12:59-70.
158. Nielsen J. Evaluation of temporal and spatial parameters involved in summation of heat pain. PhD Thesis, Aalborg University, Aalborg, Denmark; 1997.
159. Svensson P, Johannsen P, Jensen TS, Arendt-Nielsen L, Nielsen J, Jørgensen HS et al. Cerebral blood flow changes evoked by two levels of painful tonic and phasic heat stimulation: a positron emission tomography study. Eur J Pain. 1998;2:95-107.
160. Pigg M, Svensson P, List T. Orofacial thermal thresholds: time-dependent variability and influence of spatial summation and test site. J Orofac Pain. in press 2010
161. Hardy JD, Wolff HG, Goodell H. Pain sensations and reactions. Baltimore (MD): Williams & Wilins Company, 1952.
162. Mor J, Carmon A. Laser emitted radiant heat for pain research. Pain. 1975;1:233-237.
163. Meyer RA, Walker RE, Mountcastle VB. A laser stimulator for the study of cutaneous thermal and pain sensations. IEEE Trans Biomed Eng. 1976;23:54-60.
164. Arendt-Nielsen L. Induction and assessment of experimental pain from human skin, muscle, and viscera. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z, eds. Proceedings of the 8th World Congress on Pain. Progress in Pain Research and Management, vol 8. Seattle (WA): IASP Press, 1997:393-425.
165. Svensson P, Arendt-Nielsen L, Kaaber S, Bjerring P. Vertex potentials evoked by nociceptive laser stimulation of oral mucosa: relationship to stimulus intensity. Anesth Pain Control Dent. 1993;2:27-33.
166. Cruccu C, Romaniello A, Amantini A, Lombardi M, Innocenti P, Manfredi M. Assessment of trigeminal small-fiber function: brain and reflex responses evoked by CO2 laser stimulation. Muscle Nerve. 1999;22:508-516.
167. Cruccu G, Deuschl G. The clinical use of brainstem reflexes and hand-muscle reflexes. Clin Neurophysiol. 2000;111:371-387.
168. Cruccu G, Romaniello A. Jaw opening reflex after CO2 laser stimulation of the perioral region in man. Exp Brain Res. 1998;118:564-568.
169. Ellrich J, Hopf HC, Treede R-D. Nociceptive masseter inhibitory reflexes evoked by laser radiant heat and electrical stimuli. Brain Res. 1997;764:214-220.
170. Romaniello A, Arendt-Nielsen L, Cruccu G, Svensson P. Modulation of trigeminal laser evoked potentials and laser silent periods by homotopical experimental pain. Pain. 2002;98:217-228.
171. Romaniello A, Cruccu G, Frisardi G, Arendt-Nielsen L, Svensson P. Assessment of nociceptive trigeminal pathways by laser-evoked potentials and laser silent periods in patients with painful temporomandibular disorders. Pain. 2003;103:31-39.
172. Galeotti F, Truini A, Cruccu G. Neurophysiological assessment of craniofacial pain. J Headache Pain. 2006;7:61-69.
173. Svensson P, Bjerring P, Arendt-Nielsen L, Kaaber S. Variability of argon laser-induced sensory and pain thresholds on human oral mucosa and skin. Anesth Prog. 1991;38:79-83.
174. Svensson P, Bjerring P, Arendt-Nielsen L, Nielsen JC, Kaaber S. Comparison of four different laser types for experimental pain stimulation on oral mucosa and hairy skin. Lasers Surg Med. 1991;11:313-324.
175. Svensson P, Bjerring P, Arendt-Nielsen L, Kaaber S. Quantitative determinations of sensory and pain thresholds on human oral mucosa by argon laser stimulation. Pain. 1992;49:233-239.
176. Svensson P, Bjerring P, Arendt-Nielsen L, Kaaber S. Sensory and pain thresholds to orofacial argon laser stimulation in patients with chronic burning mouth syndrome. Clin J Pain. 1993;9:207-215.
177. Kazarians H, Scharein E, Bromm B. Laser evoked brain potentials in response to painful trigeminal nerve activation. Int J Neurosci. 1995;81:111-122.
178. Gülsoy M, Durak K, Kurt A, Karamürsel S, Cilesiz I. The 980nm diode laser as a new stimulant for LEP studies. Lasers Surg Med. 2001;28:244-247.
179. Tzabazis A, Klyukinov M, Manering N, Nemenov MI, Shafer SL, Yeomans DC. Differential activation of trigeminal C or A[delta] nociceptors by infrared diode laser in rats: behavioral evidence. Brain Res. 2005;1037:148-156.
180. Eliav E, Gracely RH. Sensory changes in the territory of the lingual and inferior alveolar nerves following lower third molar extraction. Pain. 1999;77:191-199.
181. Ayesh EE, Baad-Hansen L, Svensson P. Hypersensitivity to menthol in temporomandibular joint arthralgia patients. Abstract IASP World Congress on Pain, Glasgow 2008.
182. Kaube H, Katsarava Z, Käufer T, Diener H, Ellrich J. A new method to increase nociception specificity of the human blink reflex. Clin Neurophysiol. 2000;111:413-416.
183. Woolf CJ, Salter MW. Plasticity and pain: role of the dorsal horn. In: Mcmahon SB, Koltzenburg M, eds. Wall and Melzack's textbook of pain. Philadelphia (PA): Churchill Livingstone; 2006:91-106.
184. Baad-Hansen L, List T, Jensen TS, Svensson P. Increased pain sensitivity to intraoral capsaicin in patients with atypical odontalgia. J Orofac Pain. 2006;20:107-114.
185. Green BG. Capsaicin sensitization and desensitization on the tongue produced by brief exposures to a low concentration. Neurosci Lett. 1989;107:173-178.
186. Cliff MA, Green BG. Sensitization and desensitization to capsaicin and menthol in the oral cavity: interactions and individual differences. Physiol Behav. 1996;59:487-494.
187. Ngom PI, Dubray C, Woda A, Dallel R. A human oral capsaicin pain model to assess topical anesthetic-analgesic drugs. Neurosci Lett. 2001;316:149-152.
188. Wasner G, Schattschneider J, Binder A, Baron R. Topical menthol - a human model for cold pain by activation and sensitization of C nociceptors. Brain. 2004;127:1159-1171.
189. Calhoun KH, Gibson B, Hartley L, Minton J, Hokanson JA. Age-related changes in oral sensation. Laryngoscope. 1992;102:109-116.
190. Stevens JC, Choo KK. Temperature sensitivity of the body surface over the life span. Somatosens Motor Res. 1998;15:13-28.
191. Meh D, Denislic M. Quantitative assessment of thermal and pain sensitivity. J Neurol Sci. 1994;127:164-169.
192. Heft MW, Cooper BY, O'brien KK, Hemp E, O'brien R. Aging effects on the perception of noxious and non-noxious thermal stimuli applied to the face. Aging. 1996;8:35-41.
193. Yekta SS, Smeets R, Stein JM, Ellrich J. Assessment of trigeminal nerve functions by quantitative sensory testing in patients and healthy volunteers. J Oral Maxillofac Surg. 2010;68:2437-2451.
194. Feine JS, Bushnell MC, Miron D, Duncan GH. Sex differences in the perception of noxious heat stimuli. Pain. 1991;44:255-262.
195. Dao TTT, LeResche L. Gender differences in pain. J Orofac Pain. 2000;14:169-184.
196. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009;10:447-485.
197. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB et al. Consensus Working Group of the sex, gender, and pain SIG of the IASP. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132(Suppl 1):S26-S45.
198. Cimino R, Farella M, Michelotti A, Pugliese R, Martina R. Does the ovarian cycle influence the pressure-pain threshold of the masticatory muscles in symptom-free women? J Orofac Pain. 2000;14:105-111.
199. Genvert HA, Mcglone B. The distribution of cold and warm spots in the mucous membranes of the gingival, alveolar and palatal surfaces. J Dent Res. 1931;11:526.
200. Greenspan JD, Kenshalo DR. The primate as a model for the human temperature sensing system: area of skin receiving thermal stimulation (spatial summation). Somatosens Res. 1985;2:315-324.
201. Grossman RC, Hattis BF. Oral mucosal sensory innervation and sensory experience. In: Bosma JF, ed. Symposium on oral sensation and perception. Springfield (IL): CC Thomas, 1967:5-62.
202. Agostino R, Cruccu G, Iannetti G, Romaniello A, Truini A, Manfredi M. Topographical distribution of pinprick and warmth thresholds to CO2 laser stimulation in the human skin. Neurosci Lett. 2000;285:115-118.
203. Costas PD, Heatley G, Seckel BR. Normal sensation of the human face and neck. Plast Reconstr Surg. 1994;93:1141-1145.
204. Komiyama O, Kawara M, De Laat A. Ethnic differences regarding tactile and pain thresholds in the trigeminal region. J Pain. 2007;8:363-369.
205. Trulsson M, Essick GK. Low-threshold mechanoreceptive afferents in the human lingual nerve. J Neurophysiol. 1997;77:737-748.
206. Becser N, Sand T, Zwart J-A. Reliability of cephalic thermal thresholds in healthy subjects. Cephalalgia. 1998;18:574-582.
207. Agostinho CMS, Scherens A, Richter H, Schaub C, Rolke R, Treede RD et al. Habituation and short-term repeatability of thermal testing in healthy human subjects and patients with chronic non-neuropathic pain. Eur J Pain. 2009;13:779-785.
208. Gregg JM, Walter JR, Driscoll R. Neurosensory studies of trigeminal dysesthesia following peripheral nerve injury. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG, eds. Advances in pain research and therapy, vol 3. New York: Raven Press, 1979:311-315.
209. Hansson P, Ekblom A, Lindblom U, Marchettini P. Does acute intraoral pain alter cutaneous sensibility? J Neurol Neurosurg Psychiatr. 1988;51:1032-1036.
210. Farella M, Michelotti A, Bocchino T, Cimino R, Laino A, Steenks MH. Effects of orthognathic surgery for class III malocclusion on signs and symptoms of temporomandibular disorders and on pressure pain thresholds of the jaw muscles. Int J Oral Maxillofac Surg. 2007;36:583-587.
211. Jääskeläinen SK, Teerijoki-Oksa T, Forssell K, Virtanen A, Forssell H. Sensory regeneration following intraoperatively verified trigeminal nerve injury. Neurology. 2004;62:1951-1957.
212. Robinson PP. Observations on the recovery of sensation following inferior alveolar nerve injuries. Br J Oral Maxillofac Surg. 1988;26:177-189.
213. Cunningham LL, Tiner BD, Clark GM, Bays RA, Keeling SD, Rugh JD. A comparison of questionnaire versus monofiLament assessment of neurosensory deficit. J Oral Maxillofac Surg. 1996;54:454-459.
214. Becser N, Sand T, Pareja JA, Zwart J-A. Thermal sensitivity in unilateral headaches. Cephalalgia. 1998;18:675-683.
215. Langemark M, Jensen K, Jensen TS, Olesen J. Pressure pain thresholds and thermal nociceptive thresholds in chronic tension-type headache. Pain. 1989;38:203-210.
216. Jensen R, Olesen J. Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia. 1996;16:175-182.
217. Maixner W, Fillingim R, Sigurdsson A, Kincaid S, Silva S. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence of altered temporal summation of pain. Pain. 1998;76:71-81.
218. Sarlani E, Grace EG, Reynolds MA, Greenspan JD. Evidence for up-regulated central nociceptive processing in patients with masticatory myofascial pain. J Orofac Pain. 2004;18:41-55.
219. Sarlani E, Garrett PH, Grace EG, Greenspan JD. Temporal summation of pain characterizes women but not men with temporomandibular disorders. J Orofac Pain. 2007;21:309-317.
220. Baad-Hansen L, Leijon G, Svensson P, List T. Comparison of clinical findings and psychosocial factors in patients with atypical odontalgia and temporomandibular disorders. J Orofac Pain. 2008;22:7-14.
221. Hollins M, Harper D, Gallagher S, Owings EW, Lim PF, Miller V et al. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis. Pain. 2009;141:215-221.
222. Pfau DB, Rolke R, Nickel R, Treede RD, Daublaender M. Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome. Pain. 2009;147:72-83.
223. Fernández-de-Las-Peñas C, Galán-Del-Río F, Alonso-Blanco C, Jiménez-García R, Arendt-Nielsen L, Svensson P. Referred pain from muscle trigger points in the masticatory and neck-shoulder musculature in women with temporomandibular disorders. J Pain. 2010;11:1295-1304.
224. Nebel MB, Folger S, Tommerdahl M, Hollins M, Mcglone F, Essick G. Temporomandibular disorder modifies cortical response to tactile stimulation. J Pain. 2010;11:1083-1094.
225. Forssell H, Jääskeläinen S, Tenovuo O, Hinkka S. Sensory dysfunction in burning mouth syndrome. Pain. 2000;99:41-47.
226. Ito M, Kurita K, Ito T, Arao M. Pain threshold and pain recovery after experimental stimulation in patients with burning mouth syndrome. Psychiatry Clin Neurosci. 2002;56:161-168.
227. Granot M, Nagler RM. Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensory complaints. J Pain. 2005;6:581-587.
228. Lauria G, Majorana A, Borgna M, Lombardi R, Penza P, Padovani A et al. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain. 2005;115:332-337.
229. Yilmaz Z, Renton T, Yiangou Y, Zakrzewska J, Chessell IP, Bountra C et al. Burning mouth syndrome as a trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci. 2007;14:864-871.
230. Lindblom U, Verrillo RT. Sensory function in chronic neuralgia. J Neurol Neurosurg Psychiatr. 1979;42:422-435.
231. Forssell H, Tenovuo O, Silvoniemi P, Jääskeläinen SK. Differences and similarities between atypical facial pain and neuropathic trigeminal pain. Neurology. 2007;69:1451-1459.
232. Eide PK, Rabben T. Trigeminal neuropathic pain: pathophysiological mechanisms examined by quantitative assessment of abnormal pain and sensory perception. Neurosurgery. 1998;43:1103-1110.
233. Kalladka M, Proter N, Benoliel R, Czerninski R, Eliav E. Mental nerve neuropathy: patient characteristics and neurosensory changes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:364-370.
234. Benoliel R, Birenboim R, Regev E, Eliav E. Neurosensory changes in the infraorbital nerve following zygomatic fractures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:657-665.
235. Jääskeläinen SK, Teerijoki-Oksa T, Forssell H. Neurophysiologic and quantitative sensory testing in the diagnosis of trigeminal neuropathy and neuropathic pain. Pain. 2005;117:349-357.
236. Lahuerta J, Miotti A, Campbell J, Leandri M. Quantitative examination of facial sensation: an aid in the evaluation of patients with chronic pain syndromes. Schmerz Pain Douleur. 1987;2:83-87.
237. Nurmikko TJ. Altered cutaneous sensation in trigeminal neuralgia. Arch Neurol. 1991;48:523-527.
238. Bowsher D, Miles JB, Haggett CE, Eldridge PR. Trigeminal neuralgia. a quantitative sensory perception threshold study in patients who had not undergone previous invasive procedures. Neurosurgery. 1997;86:190-192.
239. Nurmikko T, Bowsher D. Somatosensory findings in postherpetic neuralgia. J Neurol Neurosurg Psychiatr. 1990;53: 135-141.
240. Woda A, Pionchon P. A unified concept of idiopathic orofacial pain: pathophysiologic features. J Orofac Pain. 2000;14:196-212.
241. Lang E, Kaltenhäuser M, Seidler S, Mattenklodt P, Neundörfer B. Persistent idiopathic facial pain exists independent of somatosensory input from the painful region: findings from quantitative sensory functions and somatotopy of the primary somatosensory cortex. Pain. 2005; 118:80-91.
242. Barlow SM. Mechanical frequency detection thresholds in the human face. Exp Neurol. 1987;96:253-261.
243. Baron R, Tölle TR, Gockel U, Brosz M, Freynhagen R. A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: differences in demographic data and sensory symptoms. Pain. 2009;146:34-40.
244. Pigg M, Elmasry Ivanovic S, Baad-Hansen L, Svensson P, List T, Drangsholt M. Reliability of intraoral chair-side somatosensory examination - preliminary report. Abstract IADR General Session, Barcelona, Spain 2010c.
245. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord. 1992;6: 301-355.