Gender Differences in Pain

Journal of Orofacial Pain

Volumn 14, Issue 3, 2000, Pages 169-184

  Dao, Thuan T T ^a   LeResche, Linda ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Epidemiology; Gender differences; Orofacial pain; Pain; Pain measurement

Indexed keywords

SEX HORMONE;

CHRONIC DISEASE; FACE PAIN; FEMALE; HEALTH BEHAVIOR; HUMAN; MALE; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVALENCE; PSYCHOLOGICAL ASPECT; REVIEW; SEXUAL DEVELOPMENT; SOCIAL PSYCHOLOGY; TEMPOROMANDIBULAR JOINT DISORDER;

CHRONIC DISEASE; FACIAL PAIN; FEMALE; GONADAL STEROID HORMONES; HEALTH BEHAVIOR; HUMANS; MALE; PAIN MEASUREMENT; PREVALENCE; SEX CHARACTERISTICS; SOCIAL CONFORMITY; TEMPOROMANDIBULAR JOINT DISORDERS;

EID: 0034209160     PISSN: 10646655     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (138)

1. Von Korff M, Dworkin SF, LcResche L, Kruger A. An epidemiologic comparison of pain complaints. Pain 1988;32:173-183.
2. Unruh AM. Gender variations in clinical pain experience. Pain 1996;65:123-167.
3. Andersson HI, Ejlertsson G, Leden I, Rosenberg C. Chronic pain in a geographically defined general population: Studies of differences in age, gender, social class, and pain localization. Clin J Pain 1993;9:174-182.
4. Berkley KJ. Sex differences in pain. Behav Brain Sci 1997;20:371-380.
5. Scheurer PA, Firestone AR, Burgin WB. Perception of pain as a result of orthodontic treatment with fixed appliances. Eur J Orthod 1996;18:349-357.
6. LeResche L. Epidemiologic perspectives on sex differences in pain. In: Fillingim R (ed). Sex, Gender and Pain: From the Benchtop to the Clinic. Seattle: IASP Press (in press).
7. LeResche L. Gender considerations in the epidemiology of pain. In: Crombie IK, Croft PR, Linton SJ, LeResche L, Von Korff M leds). Epidemiology of Pain. Seattle: IASP Press, 1999.
8. LeResche L. Epidemiology of temporomandibular disorders: Implications for the investigation of etiologic factors. Crit Rev Oral Biol Med 1997;8:291-305.
9. Katusic S, Beard CM, Bergstralh E, Kurland LT. Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945-1984. Ann Neurol 1990;27:89-95.
10. Rothman KJ, Monson RR. Epidemiology of trigeminal neuralgia. J Chronic Dis 1973;26:3-12.
11. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 1993;124:115-121.
12. Tammiala-Salonen T, Hiidenkari T, Parvinen T. Burning mouth in a Finnish adult population. Community Dent Oral Epidemiol 1993;21:67-71.
13. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: Preliminary results of a mail survey. Community Dent Oral Epidemiol 1987;15:169-172.
14. Van Der Donk J, Schouten JS, Passchier J, van Romunde LK, Valkenburg HA. The associations of neck pain with radiological abnormalities of the cervical spine and personality traits in a general population. J Rheumatol 1991;18:1884-1889.
15. Rasmussen BK, Jensen R, Schroll M, Olesen J. Interrelations between migraine and tension-type headache in the general population. Arch Neurol 1992;49:914-918.
16. Goldberg RJ, O'Donnell C, Yarzebski J, Bigelow C, Savageau J, Gore JM. Sex differences in symptom presentation associated with acute myocardial infarction: A population-based perspective. Am Heart J 1998;136:189-195.
17. Walsh K, Cruddas M, Coggon D. Interaction of height and mechanical loading of the spine in the development of low-back pain. Scand J Work Environ Health 1991;17:420-424.
18. Eskelinen M, Ikonen J, Lipponen P. Sex-specific diagnostic scores for acute appendicitis. Scand J Gastroenterol 1994;29:59-66.
19. Sullivan AK, Holdright DR, Wright CA, Sparrow JL, Cunningham D, Fox KM. Chest pain in women: Clinical, investigative, and prognostic features. Br Med J 1994;308:883-886.
20. Garber CE, Carleton RA, Heller GV. Comparison of "Rose Questionnaire Angina" to exercise thallium scintigraphy: Different findings in males and females. J Clin Epidemiol 1992;45:715-720.
21. Turk DC, Melzack R. Handbook of Pain Assessment. New York: Guilford Press, 1992.
22. Agerberg G, Carlsson GE. Functional disorders of the masticatory system. I. Distribution of symptoms according to age and sex as judged from investigation by questionnaire. Acta Odontol Scand 1972;30:597-613.
23. Von Korff M, Wagner EH, Dworkin SF, Saunders KW. Chronic pain and ambulatory health care. Psychosom Med 1991;53:61-79.
24. Weir R, Browne G, Tunks E, Gafni A, Roberts J. Gender differences in psychosocial adjustment to chronic pain and expenditures for health care services used. Clin J Pain 1996;12:277-290.
25. Linton SJ, Hellsing AL, Hallden K. A population-based study of spinal pain among 35-45-year-old individuals. Prevalence, sick leave, and health care use. Spine 1998; 23:1457-1463.
26. Fillingim RB, Maixner W. Gender differences in the responses to noxious stimuli. Pain Forum 1995;4:209-221.
27. Lautenbacher S, Rollman GB. Sex differences in responsiveness to painful and non-painful stimuli are dependent upon the stimulation method. Pain 1993;53:255-264.
28. Fillingim RB, Maixner W, Kincaid S, Silva S. Sex differences in temporal summation but not sensory-discriminative processing of thermal pain. Pain 1998;75:121-127.
29. Riley JL, Robinson ME, Wise EA, Myers CD, Fillingim RB. Sex differences in the perception of noxious experimental stimuli: A meta-analysis. Pain 1998;74:181-187.
30. Levine FM, De Simone LL. The effects of experimenter gender on pain report in male and female subjects. Pain 1991;44:69-72.
31. Blitz B, Dinnerstein AJ. Effects of different types of instructions on pain parameters. J Abnorm Psychol 1968;73:276-280.
32. LeResche L, Burgess J, Dworkin SF. Reliability of visual analog and verbal descriptor scales for "objective" measurement of temporomandibular disorder pain. J Dent Res 1988;67:33-36.
33. Blitz B, Dinnerstein AJ. Role of attentional focus in pain perception: Manipulation of response to noxious stimulation by instructions. J Abnorm Psychol 197l;77:42-45.
34. LeResche L. Gender differences in pain. Epidemiologic perspectives. Pain Forum 1995;4:228-230.
35. Bayer TL, Baer PE, Early C. Situational and psychophysiological factors in psychologically induced pain. Pain 1991;44:45-50.
36. Shiomi K. Relations of pain threshold and pain tolerance in cold water with scores on Maudsley Personality Inventory and Manifest Anxiety Scale. Percept Mot Skills 1978;47:1155-1158.
37. Arntz A, Dreessen L, Dejong P. The influence of anxiety on pain: Attentional and attributional mediators. Pain 1994;56:307-314.
38. Kepler KL, Kest B, Kiefel JM, Cooper ML, Bodnar RJ. Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine in rats. Pharmacol Biochem Behav 1989;34:119-127.
39. Rollman GB. Gender differences in pain. Role of anxiety. Pain Forum 1995;4:231-234.
40. Marcus DA. Interrelationships of neurochemicals, oestrogen, and recurring headache. Pain 1995;62:129-139.
41. Dao TTT, Knight K, Ton-That V. Modulation of myofascial pain patterns by oral contraceptives: A preliminary report [abstract]. J Dent Res 1997;76(special issue): 148.
42. Ahmed SA, Penhale WJ, Talal N. Sex hormones, immune responses, and autoimmune diseases. Am J Pathol 1985;121:531-551.
43. Case AM, Reid RL. Effects of the menstrual cycle on medical disorders. Arch Intern Med 1998;158:1405-1412.
44. Aylward M, Holly F, Parker RJ. An evaluation of clinical response to piperazine oestrone sulphate ("Harmogen") in menopausal patients. Curr Med Res Opin 1974;2:417-423.
45. Kudrow L. The relationship of headache frequency to hormone use in migraine. Headache 1975;April:36-40.
46. Murray SC, Muse KN. Effective treatment of severe menstrual migraine headaches with gonadotropin-releasing hormone agonist and "add-back" therapy. Fertil Steril 1997;67:390-393.
47. Dao TT, Knight K, Ton-That V. Modulation of myofascial pain by the reproductive hormones: A preliminary report. J Prosthet Dent 1998;79:663-670.
48. LeResche L, Saunders K, Barlow W, Von Korff M, Dworkin SF. Does oral contraceptive use increase the risk of temporomandibular (TMD) pain? In: IASP Scientific Program Committee. 7th World Congress on Pain: Abstracts: August 22-27, 1993, Paris, France. Seattle: IASP Publications, 1993:294-295.
49. LeResche L, Saunders K, Von Korff MR, Barlow W, Dworkin SF. Use of exogenous hormones and risk of temporomandibular disorder pain. Pain 1997;69:153-160.
50. Brynhildsen JO, Bjors E, Skarsgard C, Hammar ML. Is hormone replacement therapy a risk factor for low back pain among postmenopausal women? Spine 1998; 23:809-813.
51. Wreje U, Isacsson D, Aberg H. Oral contraceptives and back pain in women in a Swedish community. Int J Epidemiol 1997;26:71-74.
52. Goolkasian P. Cyclic changes in pain perception: An ROC analysis. Percept Psychophys 1980;27:499-504.
53. Goolkasian P. An ROC analysis of pain reactions in dysmenorrheic and non dysmenorrheic women. Percept Psychophys 1983;34:381-386.
54. Fillingim RB, Maixner W, Girdler SS, Light KC, Harris MB, Sheps DS, Mason GA. Ischemic but not thermal pain sensitivity varies across the menstrual cycle. Psychosom Med 1997;59:512-520.
55. Giamberardino MA, Berkley KJ, Iezzi S, De Bigontina P, Vecchiet L. Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men. Pain 1997;71:187-197.
56. Herren RG. The effects of high and low sex hormone concentration on the two-point threshold of pain and touch upon tactile sensitivity. J Exp Psychol 1933;16:324-327.
57. Kenshalo DR. Changes in the cool threshold associated with phases of the menstrual cycle. Appl Physiol 1966;21:1031-1039.
58. Procacci P, Corte MD, Zoppi M, Maresca M. Rhythmic changes of the cutaneous pain threshold in man. A general view. Chronobiologia 1973; 1:77-96.
59. Tedford WH Jr, Warren DE, Flynn WE. Alteration of shock aversion threshold during the menstrual cycle. Percept Psychophys 1977;21:193-196.
60. Kuczmierczyk AR, Adams HE. Autonomic arousal and pain sensitivity in women with premenstrual syndrome at different phases of the menstrual cycle. J Psychosom Res 1986;30:421-428.
61. Hapidou EG, De Catanzaro D. Sensitivity to cold pressor pain in dysmenorrheic and non-dysmenorrheic women as a function of menstrual cycle phase. Pain 1988;34:277-283.
62. Veith JL, Anderson J, Slade SA, Thompson P, Laugel G, Getzlaf S. Plasma β-endorphin, pain thresholds and anxiety levels across the menstrual cycle. Physiol Behav 1984;32:31-34.
63. Amodei N, Nelson-Gray RO. Reactions of dysmenorrheic and nondysmenorrheic women to experimentally induced pain throughout the menstrual cycle. J Behav Med 1989;12:373-385.
64. Hapidou EG, Rollman GB. Menstrual cycle modulation of tender points. Pain 1998;77:151-161.
65. Martinez-Gomez M, Cruz Y, Salas M, Hudson R, Pacheco P. Assessing pain threshold in the rat: Changes with estrus and time of day. Physiol Behav 1994;55:651-657.
66. Gintzler AR, Bohan MC. Pain thresholds are elevated during pseudopregnancy. Brain Res 1990;507:312-316.
67. McCarthy MM, Caba M, Komisaruk BR, Beyer C. Modulation by estrogen and progesterone of the effect of muscimol on nociception in the spinal cord. Pharmacol Biochem Behav 1990;37:123-128.
68. Guicheney P, Leger D, Barrat J, Trevoux R, De Lignieres B, Roques P. Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: Variations with plasma oestrogen levels and depressive symptoms. Eur J Clin Invest 1988; 18:297-304.
69. Maswood S, Stewart G, Uphouse L. Gender and estrous cycle effects of the 5-HT1A agonist, 8-OH-DPAT, on hypothalamic serotonin. Pharmacol Biochem Behav 1995;51:807-813.
70. Gundlah C, Simon LD, Auerbach SB. Differences in hypothalamic serotonin between estrous phases and gender: An in vivo microdialysis study. Brain Res 1998;785:91-96.
71. Heritage AS, Stumpf WE, Sar M, Grant L. Brainstem catecholamine neurons are target sites for sex steroid hormones. Science 1980;207:1377-1379.
72. Ramsay B, Johnson MR, Leone AM, Steer PJ. The effect of exogenous oestrogen on nitric oxide production in women: A placebo controlled crossover study. Br J Obstet Gynaecol 1995; 102:417-419.
73. Sudhir K, Jennings GL, Funder JW, Komesaroff PA. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension 1996;28:330-334.
74. Imthurn B, Rosselli M, Jaeger AW. Keller PJ, Dubey RK. Differential effects of hormone-replacement therapy on endogenous nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol valerate and cyproterone acetate or medroxyprogesterone acetate. J Clin Endocrinol Metab 1997;82:388-394.
75. Meller ST, Gebhart GF. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 1993;52:127-136.
76. Meller ST, Gebhart GF. Spinal mediators of hyperalgesia. Drugs 1994;47(suppl 5):10-20.
77. Olesen J, Iversen HK, Thomsen LL. Nitric oxide supersensitivity: A possible molecular mechanism of migraine pain. Neuroreport 1993;4:1027-1030.
78. Olesen J, Thomsen LL, Iversen H. Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol Sci 1994; 15:149-153.
79. Iversen HK. Experimental headache in humans. Cephalalgia 1995;15:281-287.
80. Thomsen LL, Iversen HK, Brinck TA, Olesen J. Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia 1993;13:395-399.
81. Thomsen LL, Brennum J, Iversen HK, Olesen J. Effect of a nitric oxide donor (glyceryl trinitrate) on nociceptive thresholds in man. Cephalalgia 1996;16:169-174.
82. Stohler CS. Masticatory myalgias. Emphasis on the nerve growth factor-estrogen link. Pain Forum 1997;6:176-180.
83. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 1994;62:327-331.
84. Petty BG, Cornblath DR, Adornato BT, Chaudhry V, Flexner C, Wachsman M, et al. The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Ann Neurol 1994;36:244-246.
85. Toran-Allerand CD, Miranda RC, Bentham WD, Sohrabji F, Brown TJ, Hochberg RB, MacLusky NJ. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc Natl Acad Sci USA 1992;89:4668-4672.
86. Sohrabji F, Miranda RC, Toran-Allerand CD. Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons. J Neurosci 1994;14:459-471.
87. Toran-Allerand CD. Mechanisms of estrogen action during neural development: Mediation by interactions with the neurotrophins and their receptors? J Steroid Biochem Mol Biol 1996;56:169-178.
88. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 1993;21:498-503.
89. Ettinger SM, Silber DH, Collins BG, Gray KS, Sutliff G, Whisler SK, et al. Influences of gender on sympathetic nerve responses to static exercise. J Appl Physiol 1996; 80:245-251.
90. Cooke JP, Creager MA, Osmundson PJ, Shepherd JT. Sex differences in control of cutaneous blood flow. Circulation 1990;82:1607-1615.
91. Maixner W, Humphrey C. Gender differences in pain and cardiovascular responses to forearm ischemia. Clin J Pain 1993;9:16-25.
92. Frascarolo P, Schutz Y, Jequier E. Influence of the menstrual cycle on the sweating response measured by direct calorimetry in women exposed to warm environmental conditions. Eur J Appl Physiol 1992;64:449-454.
93. Bartelink ML, Wollersheim H, Theeuwes A, van Duren D, Thien T. Changes in skin blood flow during the menstrual cycle: The influence of the menstrual cycle on the peripheral circulation in healthy female volunteers. Clin Sci 1990;78:527-532.
94. Frascarolo P, Schutz Y, Jequier E. Decreased thermal conductance during the luteal phase of the menstrual cycle in women. J Appl Physiol 1990;69:2029-2033.
95. Hassan AA, Carter G, Tooke JE. Postural vasoconstriction in women during the normal menstrual cycle. Clin Sci 1990;78:39-47.
96. Milner TA, Loy R. Interaction of age and sex in sympathetic axon ingrowth into the hippocampus following septal afferent damage. Anat Embryol 1980;161: 159-168.
97. Ryan SM, Maier SF. The estrous cycle and estrogen modulate stress-induced analgesia. Behav Neurosci 1988; 102:371-380.
98. Ratka A, Simpkins JW. Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats. Horm Behav 1991 ;25:217-228.
99. Mogil JS, Sternberg WF, Kest B, Marek P, Liebeskind JC. Sex differences in the antagonism of swim stress-induced analgesia: Effects of gonadectomy and estrogen replacement. Pain 1993;53:17-25.
100. Brown TJ, Hochberg RB, Zielinski JE, MacLusky NJ. Regional sex differences in cell nuclear estrogen-binding capacity in the rat hypothalamus and preoptic area. Endocrinology 1988;123:1761-1770.
101. Morrell JI, McGinty JF, Pfaff DW. A subset of beta-endorphin or dynorphin containing neurons in the medial basal hypothalamus accumulates estradiol. Neuroendocrinology 1985;41:417-426.
102. Morrell JI, Krieger MS, Pfaff DW. Quantitative autoradiographic analysis of estradiol retention by cells in the preoptic area, hypothalamus and amygdala. Exp Brain Res 1986;62:343-354.
103. Banerjee P, Chatterjee T, Ghosh J. Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats. Eur J Pharmacol 1983;96:291-294.
104. Gear RW, Gordon NC, Heller PH, Paul S, Miaskowski C, Levine JD. Gender difference in analgesic response to the kappa-opioid pentazocine. Neurosci Lett 1996;205: 207-209.
105. Miaskowski C, Levine JD. Does opioid analgesia show a gender preference for females? Pain Forum 1999;8:34-44.
106. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD. The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain 1999;83:339-345.
107. Page GG. The multi-issue nature of sex differences in opioid analgesia. Pain Forum 1999;8:45-47.
108. Mogil JS, Kest B. Sex differences in opioic analgesia. Of mice and women. Pain Forum 1999;8:48-50.
109. Mogil JS, Richards SP, O'Toole LA, Helms ML, Mitchell SR, Kest B, Belknap JK. Identification of a sex-specific quantitative trait locus mediating nonopioid stress induced analgesia in female mice. J Neurosci 1997; 17:7995-8002.
110. Gandelman R. Gonadal hormones and sensory function. Neurosci Biobehav Rev 1983;7:1-17.
111. Velle W. Sex differences in sensory functions. Perspect Biol Med 1987;30:490-522.
112. Gijsbers van Wijk CM, van Vliet KP, Kolk AM, Everaerd WT. Symptom sensitivity and sex differences in physical morbidity: A review of health surveys in the United States and The Netherlands. Women Health 1991;17:91-124.
113. Bush FM, Harkins SW, Harrington WG, Price DD. Analysis of gender effects on pain perception and symptom presentation in temporomandibular pain. Pain 1993;53:73-80.
114. Hall J. Nonverbal Sex Differences. Baltimore: John Hopkins University Press, 1984.
115. Karasek RA, Theorell T, Schwartz JE, Schnall PL, Pieper CF, Michela JL. Job characteristics in relation to the prevalence of myocardial infarction in the US Health Examination Survey (HES) and the Health and Nutrition Examination Survey (HANES). Am J Public Health 1988;78:910-918.
116. Amick BC III, Kawachi I, Coakley EH, Lerner D, Levine S, Colditz GA. Relationship of job strain and iso-strain to health status in a cohort of women in the United States. Scand J Work Environ Health 1998;24:54-61.
117. Hagen KB, Magnus P, Vetlesen K. Neck/shoulder and low-back disorders in the forestry industry: Relationship to work tasks and perceived psychosocial job stress. Ergonomics 1998;41:1510-1518.
118. Josephson M, Lagerstrom M, Hagberg M, Wigaeus HE. Musculoskeletal symptoms and job strain among nursing personnel: A study over a three-year period. Occup Environ Med 1997;54:681-685.
119. Brisson C, Laflamme N, Moisan J, Milot A, Masse B, Vezina M. Effect of family responsibilities and job strain on ambulatory blood pressure among white-collar women. Psychosom Med 1999;61:205-213.
120. Colameco S, Becker LA, Simpson M. Sex bias in the assessment of patient complaints. J Fam Pract 1983; 16:1117-1121.
121. Aufdemorte TB, Van Sickels JE, Dolwick MF, Sheridan PJ, Holt GR, Aragon SB, Gates GA. Estrogen receptors in the temporomandibular joint of the baboon (Papio cynocephalus): An autoradiographic study. Oral Surg Oral Med Oral Pathol 1986;61:307-314.
122. Milam SB, Aufdemorte TB, Sheridan PJ, Triplett RG, Van Sickels JE, Holt GR. Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon. Oral Surg Oral Med Oral Pathol 1987;64:527-532.
123. Abubaker AO, Hebda PC, Gunsolley JN. Effects of sex hormones on protein and collagen content of the temporomandibular joint disc of the rat. J Oral Maxillofac Surg 1996;54:721-727.
124. Abubaker AO, Raslan WF, Sotereanos GC. Estrogen and progesterone receptors in temporomandibular joint discs of symptomatic and asymptomatic persons: A preliminary study. J Oral Maxillofac Surg 1993;51:1096-1100.
125. Kapila S, Xie Y. Targeted induction of collagenase and stromelysin by relaxin in unprimed and beta-estradiolprimed diarthrodial joint fibrocartilaginous cells but not in synoviocytes. Lab Invest 1998;78:925-938.
126. Larsson LG, Baum J, Mudholkar GS. Hypermobility: Features and differential incidence between the sexes. Arthritis Rheum 1987;30:1426-1430.
127. Harinstein D, Buckingham RB, Braun T, Oral K, Bauman DH, Killian PJ, Bidula LP. Systemic joint laxity (the hypermobile joint syndrome) is associated with temporomandibular joint dysfunction. Arthritis Rheum 1988; 31:1259-1264.
128. Bates RE Jr, Stewart CM, Atkinson WB. The relationship between internal derangements of the temporomandibular joint and systemic joint laxity. J Am Dent Assoc 1984;109:446-447.
129. Westling L. Craniomandibular disorders and general joint mobility. Acta Odontol Scand 1989;47:293-299.
130. Westling L, Carlsson GE, Helkimo M. Background factors in Craniomandibular disorders with special reference to general joint hypermobility, parafunction, and trauma. J Craniomandib Disord Facial Oral Pain 1990;4:89-98.
131. Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain 1995;63:341-351.
132. Maixner W, Fillingim R, Sigurdsson A, Kincaid S, Silva S. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: Evidence for altered temporal summation of pain. Pain 1998;76:71-81.
133. Mogil JS, Richards SP, O'Toole LA, Helms ML, Mitchell SR, Belknap JK. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: Possible sex-specific mediation by delta2-opioid receptors. Pain 1997;70:267-277.
134. Paulson PE, Minoshima S, Morrow TJ, Casey KL. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 1998;76:223-229.
135. Vallerand AH. Gender differences in pain. Image J Nurs Sch 1995;27:235-237.
136. Cleeland CS, Gonin R, Hatfield AK, Edmonson JH, Blum RH, Stewart JA, Pandya KJ. Pain and its treatment in outpatients with metastatic cancer. N Eng J Med 1994; 330:592-596.
137. Lehmann JE, Wehner PS, Lehmann CU, Savory LM. Gender bias in the evaluation of chest pain in the emergency department. Am J Cardiol 1996:77:641-644.
138. Heston TF, Lewis LM. Gender bias in the evaluation and management of acute nontraumatic chest pain. The St. Louis Emergency Physicians' Association Research Group. Earn Pract Res J 1992;12:383-389.