Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Huber, Reinhard ^a   Braselmann, Herbert ^a   Geinitz, Hans ^b   Jaehnert, Irene ^a   Baumgartner, Adolf ^a   Thamm, Reinhard ^b   Figel, Markus ^a   Molls, Michael ^b   Zitzelsberger, Horst ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE TOXICITY; ARTICLE; BLOOD SAMPLING; BREAST CANCER; CANCER PATIENT; CHROMOSOME ABERRATION; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE FREQUENCY; HUMAN; IN VITRO STUDY; METAPHASE CHROMOSOME; RADIATION RESPONSE; RADIOSENSITIVITY; SKIN MANIFESTATION; STUDENT T TEST; X RAY; BREAST TUMOR; COMET ASSAY; FEMALE; GENETICS; HUMAN CHROMOSOME; IN SITU HYBRIDIZATION; RADIATION DOSE; RADIATION EXPOSURE; RADIOTHERAPY;

BREAST NEOPLASMS; CHROMOSOMES, HUMAN; COMET ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; IN SITU HYBRIDIZATION; RADIATION TOLERANCE; RADIOTHERAPY;

EID: 79953687976     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-6-32     Document Type: Article

References (38)

1. Barber JB, Burrill W, Spreadborough AR, Levine E, Warren C, Kiltie AE, Roberts SA, Scott D. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother Oncol 2000, 55:179-186. 10.1016/S0167-8140(99)00158-9, 10799730.
2. Sprung CN, Chao M, Leong T, McKay J. Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res 2005, 11:6352-6358. 10.1158/1078-0432.CCR-04-1931, 16144940.
3. Sprung CN, Davey DS, Withana NP, Distel LV, McKay MJ. Telomere length in lymphoblast cell lines derived from clinically radiosensitive cancer patients. Cancer Biol Ther 2008, 638-644.
4. Dyomina EA, Ryabchenko NM. Increased individual chromosomal radiosensitivity of human lymphocytes as a parameter of cancer risk. Exp Oncol 2007, 29:217-220.
5. de Ruyck K, de Gelder V, van Eijkeren M, Boterberg T, De Neve W, Vral A, Thierens H. Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?. Br J Cancer 2008, 98:1723-1738. 10.1038/sj.bjc.6604345, 2391130, 18414410.
6. Borgmann K, Haeberle D, Doerk T, Busjahn A, Stephan G, Dikomey E. Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes. Radiother Oncol 2007, 83:196-202. 10.1016/j.radonc.2007.04.010, 17499867.
7. Distel LV, Neubauer S, Keller U, Sprung CN, Sauer R, Grabenbauer G. Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients. Radiother Oncol 2006, 81:257-263. 10.1016/j.radonc.2006.10.012, 17113667.
8. Keller U, Grabenbauer G, Kuechler A, Sprung CN, Mueller E, Sauer R, Distel L. Cytogenetic instability in young patients with multiple primary cancers. Cancer Genet Cytogenet 2005, 157:25-32. 10.1016/j.cancergencyto.2004.05.018, 15676143.
9. Jones LA, Scott D, Cowan R, Roberts SA. Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. Int J Radiat Biol 1995, 67:519-528. 10.1080/09553009514550631, 7775827.
10. Sterpone S, Cornetta T, Padua L, Mastellone V, Giammarino D, Testa A, Tirindelli D, Cozzi R, Donato V. DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients. Mutat Res 2010, 684:43-48. 10.1016/j.mrfmmm.2009.11.009, 19962393.
11. Popanda O, Ebbeler R, Twardella D, Helmbold I, Gotzes F, Schmezer P, Thielmann HW, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Bartsch H, Chang-Claude J. Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy. Int J Radiat Oncol Biol Phys 2003, 55:1216-1225. 10.1016/S0360-3016(02)04415-2, 12654430.
12. Dunst J, Neubauer S, Becker A, Gebhart E. Chromosomal in vitro radiosensitivity of lymphocytes in radiotherapy patients and AT-homozygotes. Strahlenther Onkol 1998, 174:510-516. 10.1007/BF03038983, 9810318.
13. Borgmann K, Roper B, El-Awady R, Brackrock S, Bigalke M, Dork T, Alberti W, Dikomey E, Dahm-Daphi J. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 2002, 64:141-152. 10.1016/S0167-8140(02)00167-6, 12242123.
14. Hoeller U, Borgmann K, Bonacker M, Kuhlmey A, Bajrovic A, Jung H, Alberti W, Dikomey E. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 2003, 69:137-144. 10.1016/j.radonc.2003.10.001, 14643950.
15. Ramsay J, Birrell G. Normal tissue radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys 1995, 31:339-344. 10.1016/0360-3016(94)00478-4, 7836087.
16. Keller U, Grabenbauer G, Kuechler A, Sauer R, Distel L. Technical report. Radiation sensitivity testing by fluorescence in-situ hybridisation: how many metaphases have to be analysed?. Int J Radiat Biol 2004, 80:615-620. 10.1080/09553000410001724568, 15370973.
17. Keller U, Kuechler A, Liehr T, Mueller E, Grabenbauer G, Sauer R, Distel L. Impact of various parameters in detecting chromosomal aberrations by FISH to describe radiosensitivity. Strahlenther Onkol 2004, 180:289-296. 10.1007/s00066-004-1200-y, 15127159.
18. Tucker JD. Sensitivity, specificity, and persistence of chromosome translocations for radiation biodosimetry. Mil Med 2002, 167:8-9.
19. Huber R, Kulka U, Loerch T, Braselmann H, Engert D, Figel M, Bauchinger M. Technical report: application of the Metafer2 fluorescence scanning system for the analysis of radiation-induced chromosome aberrations measured by FISH-chromosome painting. Mutat Res 2001, 492:51-57.
20. Huber R, Braselmann H, Kulka U, Schumacher-Georgiadou V, Bayerl A, Molls M, Bauchinger M. Follow-up analysis of translocation and dicentric frequencies, measured by FISH-chromosome painting in breast cancer patients after partial-body radiotherapy with little bone marrow exposure. Mutat Res 1999, 446:103-109.
21. Mueller I, Geinitz H, Braselmann H, Baumgartner A, Fasan A, Thamm R, Molls M, Meineke V, Zitzelsberger H. Time-course of radiation-induced chromosomal aberrations in tumor patients after radiotherapy. Int J Radiat Oncol Biol Phys 2005, 63:1214-1220. 10.1016/j.ijrobp.2005.03.056, 16253775.
22. Kulka U, Huber R, Mueller P, Knehr S, Bauchinger M. Combined FISH painting and harlequin staining for cell cycle-controlled chromosome analysis in human lymphocytes. Int J Radiat Biol 1995, 68:25-27. 10.1080/09553009514550881, 7629434.
23. Tucker JD, Morgan WF, Awa AA, Bauchinger M, Blakey D, Cornforth MN, Littlefield LG, Natarajan AT, Shasserre C. PAINT: a proposed nomenclature for structural aberrations detected by whole chromosome painting. Mutat Res 1995, 347:21-24. 10.1016/0165-7992(95)90028-4, 7596363.
24. Greve B, Dreffke K, Rickinger A, Koenemann S, Fritz E, Eckardt-Schupp F, Amler S, Sauerland C, Braselmann H, Sauter W, Illig T, Schmezer P, Gomolka M, Willich N, Boelling T. Multicentric investigation of ionising radiation-induced cell death as a predictive parameter of individual radiosensitivity. Apoptosis 2009, 14:226-235. 10.1007/s10495-008-0294-6, 19142732.
25. Terzoudi GI, Manola KN, Pantelias GE, Iliakis G. Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells. Cancer Res 2005, 65:11292-11296. 10.1158/0008-5472.CAN-05-2148, 16357135.
26. Mozdarani H, Mansouri Z, Haeri SA. Cytogenetic radiosensitivity of G0-lymphocytes of breast and esophageal cancer patients as determined by micronucleus assay. J Radiat Res (Tokyo) 2005, 46:111-116. 10.1269/jrr.46.111, 15802866.
27. Vral A, Thierens H, Baeyens A, De Ridder L. The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionizing radiation: limitations imposed by intraindividual variability. Radiat Res 2002, 157:472-477. 10.1667/0033-7587(2002)157[0472:TMAGPA]2.0.CO;2, 11893251.
28. Schmid E, Bauchinger M, Bunde E, Ferbert HF, von Lieven H. Comparison of the chromosome damage and its dose response after medical whole-body exposure to 60Co gamma-rays and irradiation of blood in vitro. Int J Radiat Biol Relat Stud Phys Chem Med 1974, 26:31-37. 10.1080/09553007414550911, 4547374.
29. Evans HJ, Buckton KE, Hamilton GE, Carothers A. Radiation-induced chromosome aberrations in nuclear-dockyard workers. Nature 1979, 277:531-534. 10.1038/277531a0, 763341.
30. Pantelias GE, Iliakis GE, Sambani CD, Politis G. Biological dosimetry of absorbed radiation by C-banding of interphase chromosomes in peripheral blood lymphocytes. Int J Radiat Biol 1993, 63:349-354. 10.1080/09553009314550461, 8095285.
31. Bauchinger M, Braselmann H, Savage JR, Natarajan AT, Terzoudi GI, Pantelias GE, Darroudi F, Figgitt M, Griffin CS, Knehr S, Okladnikova ND, Santos S, Snigiryova G. Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel. Int J Radiat Biol 2001, 77:259-267. 10.1080/09553000010018693, 11258840.
32. Rao BS, Natarajan AT. Retrospective biological dosimetry of absorbed radiation. Radiat Prot Dosimetry 2001, 95:17-23.
33. Montoro A, Rodriguez P, Almonacid M, Villaescusa JI, Verdú G, Caballín MR, Barrios L, Barquinero JF. Biological dosimetry in a group of radiologists by the analysis of dicentrics and translocations. Radiat Res 2005, 164:612-617. 10.1667/RR3444.1, 16238438.
34. Bauchinger M, Schmid E, Braselmann H. Time-course of translocation and dicentric frequencies in a radiation accident case. Int J Radiat Biol 2001, 77:553-557. 10.1080/09553000010022382, 11382333.
35. Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A. Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. Br J Cancer 2002, 87:1379-1385. 10.1038/sj.bjc.6600628, 2376291, 12454765.
36. Slonina D, Biesaga B, Urbanski K, Kojs Z. Comparison of chromosomal radiosensitivity of normal cells with and without HRS-like response and normal tissue reactions in patients with cervix cancer. Int J Radiat Biol 2008, 84:421-428. 10.1080/09553000802029910, 18464071.
37. Huber R, Braselmann H, Bauchinger M. Intra- and inter-individual variation of background and radiation-induced micronucleus frequencies in human lymphocytes. Int J Radiat Biol 1992, 61:655-661. 10.1080/09553009214551461, 1349629.
38. Bryant PE, Gray L, Riches AC, Poppe B, Messiaen L, De Ridder L, Vral A. The G2 chromosomal radiosensitivity assay. Int J Radiat Biol 2002, 78:863-866. 10.1080/09553000210144484, 12428927.