A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

BMC Biotechnology

Volumn 11, Issue , 2011, Pages

  Staunstrup, Nicklas H ^a   Sharma, Nynne ^a   Bak, Rasmus O ^a   Svensson, Lars ^b   Petersen, Thomas K ^b   Aarenstrup, Lene ^c   Kristiansen, Karsten ^d   Bolund, Lars ^a   Mikkelsen, Jacob G ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b LEO Pharma ^*  (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDATE DRUGS; COMPARATIVE EVALUATIONS; COMPARATIVE STUDIES; DRUG DETECTION; EXPRESSION CASSETTE; FUNCTIONAL SCREENING; FUNCTIONAL TESTING; HUMAN KERATINOCYTES; LOW CONCENTRATIONS; REACTION CATALYZED; REPORTER PROTEIN; SCREENING METHODS; SENSITIVE SENSORS; SKIN DISEASE; SLEEPING BEAUTY; SYNTHETIC ANALOGUES; TRANSGENIC ANIMALS; TRANSPOSASE;

ANIMALS; DERMATOLOGY; DISEASES; DRUG DELIVERY; NUCLEIC ACIDS; PLANTS (BOTANY);

SENSORS;

COLECALCIFEROL DERIVATIVE; DNA; TRANSPOSASE; 1-HYDROXYCHOLECALCIFEROL; ALFACALCIDOL; CALCIPOTRIOL; CALCITRIOL; COLECALCIFEROL; DRUG DERIVATIVE; GREEN FLUORESCENT PROTEIN; HYDROXYCOLECALCIFEROL; RETINOID X RECEPTOR; VITAMIN D BINDING PROTEIN;

ARTICLE; BIOSENSOR; COMPARATIVE STUDY; CONTROLLED STUDY; DNA VECTOR; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; EMBRYO; GENETIC MARKER; GENOME; HUMAN; HUMAN CELL; KERATINOCYTE; NEOPLASM; PROTEIN EXPRESSION; PSORIASIS; REPORTER GENE; TRANSPOSON; ANIMAL; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY;

ANIMALIA;

ANIMALS; CALCITRIOL; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHOLECALCIFEROL; DNA TRANSPOSABLE ELEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROXYCHOLECALCIFEROLS; KERATINOCYTES; MICROSCOPY, FLUORESCENCE; MUTAGENESIS, INSERTIONAL; RESPONSE ELEMENTS; RETINOID X RECEPTORS; TRANSFECTION; TRANSPOSASES; VITAMIN D-BINDING PROTEIN;

EID: 79953680483     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-33     Document Type: Article

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