-
1
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137:216-33.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
2
-
-
0033193157
-
The Notch-Hes pathway in mammalian neural development
-
Kageyama R, Ohtsuka T. The Notch-Hes pathway in mammalian neural development [In Process Citation]. Cell Res 1999; 9:179-88. (Pubitemid 129623500)
-
(1999)
Cell Research
, vol.9
, Issue.3
, pp. 179-188
-
-
Kageyama, R.1
Ohtsuka, T.2
-
3
-
-
77956306573
-
Notch signaling in solid tumors
-
Koch U, Radtke F. Notch signaling in solid tumors. Curr Top Dev Biol 2010; 92:411-55.
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 411-455
-
-
Koch, U.1
Radtke, F.2
-
4
-
-
8544262178
-
T cell acute lymphoblastic leukemia/lymphoma: A human cancer commonly associated with aberrant NOTCH1 signaling
-
DOI 10.1097/01.moh.0000143965.90813.70
-
Pear WS, Aster JC. T cell acute lymphoblastic leukemia/ lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. Curr Opin Hematol 2004; 11:426-33. (Pubitemid 39491437)
-
(2004)
Current Opinion in Hematology
, vol.11
, Issue.6
, pp. 426-433
-
-
Pear, W.S.1
Aster, J.C.2
-
5
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
DOI 10.1126/science.1102160
-
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306:269-71. (Pubitemid 39336870)
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris IV, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
6
-
-
0035860804
-
Functional interaction between SEL-10, an F-box protein and the nuclear form of activated Notch1 receptor
-
Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, et al. Functional interaction between SEL-10, an F-box protein and the nuclear form of activated Notch1 receptor. J Biol Chem 2001; 276:34371-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 34371-34378
-
-
Gupta-Rossi, N.1
Le Bail, O.2
Gonen, H.3
Brou, C.4
Logeat, F.5
Six, E.6
-
7
-
-
34547820257
-
FBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
DOI 10.1084/jem.20070872
-
Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G, et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 2007; 204:1825-35. (Pubitemid 47236320)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.8
, pp. 1825-1835
-
-
Thompson, B.J.1
Buonamici, S.2
Sulis, M.L.3
Palomero, T.4
Vilimas, T.5
Basso, G.6
Ferrando, A.7
Aifantis, I.8
-
8
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
DOI 10.1084/jem.183.5.2283
-
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated notch alleles. J Exp Med 1996; 183:2283-91. (Pubitemid 26158919)
-
(1996)
Journal of Experimental Medicine
, vol.183
, Issue.5
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
Hasserjian, R.P.4
Soffer, B.5
Sklar, J.6
Baltimore, D.7
-
9
-
-
34948908663
-
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
-
DOI 10.1038/nm1636, PII NM1636
-
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007; 13:1203-10. (Pubitemid 47530629)
-
(2007)
Nature Medicine
, vol.13
, Issue.10
, pp. 1203-1210
-
-
Palomero, T.1
Sulis, M.L.2
Cortina, M.3
Real, P.J.4
Barnes, K.5
Ciofani, M.6
Caparros, E.7
Buteau, J.8
Brown, K.9
Perkins, S.L.10
Bhagat, G.11
Agarwal, A.M.12
Basso, G.13
Castillo, M.14
Nagase, S.15
Cordon-Cardo, C.16
Parsons, R.17
Zuniga-Pflucker, J.C.18
Dominguez, M.19
Ferrando, A.A.20
more..
-
10
-
-
25844459154
-
NF-kappaB: Linking inflammation and immunity to cancer development and progression
-
DOI 10.1038/nri1703
-
Karin M, Greten FR. NFkappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5:749-59. (Pubitemid 41400849)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.10
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
11
-
-
67650724069
-
Regulation and function of NFkappaB transcription factors in the immune system
-
Vallabhapurapu S, Karin M. Regulation and function of NFkappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27:693-733.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
12
-
-
23144449789
-
Ubiquitin signalling in the NFkappaB pathway
-
Chen ZJ. Ubiquitin signalling in the NFkappaB pathway. Nat Cell Biol 2005; 7:758-65.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 758-765
-
-
Chen, Z.J.1
-
13
-
-
33847791586
-
Notches, NFkappaBs and the making of T cell leukemia
-
Aifantis I, Vilimas T, Buonamici S. Notches, NFkappaBs and the making of T cell leukemia. Cell Cycle 2007; 6:403-6.
-
(2007)
Cell Cycle
, vol.6
, pp. 403-406
-
-
Aifantis, I.1
Vilimas, T.2
Buonamici, S.3
-
14
-
-
33846048039
-
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
-
DOI 10.1038/nm1524, PII NM1524
-
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NFkappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med 2007; 13:70-7. (Pubitemid 46067388)
-
(2007)
Nature Medicine
, vol.13
, Issue.1
, pp. 70-77
-
-
Vilimas, T.1
Mascarenhas, J.2
Palomero, T.3
Mandal, M.4
Buonamici, S.5
Meng, F.6
Thompson, B.7
Spaulding, C.8
Macaroun, S.9
Alegre, M.-L.10
Kee, B.L.11
Ferrando, A.12
Miele, L.13
Aifantis, I.14
-
15
-
-
77956511912
-
The Notch/Hes1 pathway sustains NFkappaB activation through CYLD repression in T cell leukemia
-
Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, et al. The Notch/Hes1 pathway sustains NFkappaB activation through CYLD repression in T cell leukemia. Cancer Cell 2010; 18:268-81.
-
(2010)
Cancer Cell
, vol.18
, pp. 268-281
-
-
Espinosa, L.1
Cathelin, S.2
D'Altri, T.3
Trimarchi, T.4
Statnikov, A.5
Guiu, J.6
-
16
-
-
9344233282
-
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression
-
DOI 10.1073/pnas.0404429101
-
Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L, Bigas A. Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci USA 2004; 101:16537-42. (Pubitemid 39557748)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.47
, pp. 16537-16542
-
-
Aguilera, C.1
Hoya-Arias, R.2
Haegeman, G.3
Espinosa, L.4
Bigas, A.5
-
17
-
-
78649363017
-
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
-
Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Bruning JC, et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 2010; 33:671-84.
-
(2010)
Immunity
, vol.33
, pp. 671-684
-
-
Wendorff, A.A.1
Koch, U.2
Wunderlich, F.T.3
Wirth, S.4
Dubey, C.5
Bruning, J.C.6
-
19
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464:1052-7.
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
De Leon, G.P.5
Chen, Y.6
-
20
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, et al. Direct inhibition of the NOTCH transcription factor complex. Nature 2009; 462:182-8.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
-
21
-
-
70349334513
-
Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol
-
Mansour MR, Sulis ML, Duke V, Foroni L, Jenkinson S, Koo K, et al. Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol. J Clin Oncol 2009; 27:4352-6.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4352-4356
-
-
Mansour, M.R.1
Sulis, M.L.2
Duke, V.3
Foroni, L.4
Jenkinson, S.5
Koo, K.6
-
22
-
-
34547562418
-
Frequent Engagement of the Classical and Alternative NF-kappaB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
-
DOI 10.1016/j.ccr.2007.07.004, PII S1535610807002036
-
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, et al. Frequent engagement of the classical and alternative NFkappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007; 12:115-30. (Pubitemid 47199123)
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
Dave, S.11
Hurt, E.M.12
Tan, B.13
Zhao, H.14
Stephens, O.15
Santra, M.16
Williams, D.R.17
Dang, L.18
Barlogie, B.19
Shaughnessy Jr., J.D.20
Kuehl, W.M.21
Staudt, L.M.22
more..
-
23
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NFkappaB pathway in multiple myeloma
-
Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, et al. Promiscuous mutations activate the noncanonical NFkappaB pathway in multiple myeloma. Cancer Cell 2007; 12:131-44.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.J.6
-
24
-
-
66649112854
-
Frequent inactivation of A20 in B-cell lymphomas
-
Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature 2009; 459:712-6.
-
(2009)
Nature
, vol.459
, pp. 712-716
-
-
Kato, M.1
Sanada, M.2
Kato, I.3
Sato, Y.4
Takita, J.5
Takeuchi, K.6
-
25
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NFkappaB in diffuse large B-cell lymphoma
-
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, et al. Mutations of multiple genes cause deregulation of NFkappaB in diffuse large B-cell lymphoma. Nature 2009; 459:717-21.
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
Shen, Q.6
-
26
-
-
33645103440
-
Regulation of T cell development by the deubiquitinating enzyme CYLD
-
Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, et al. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 2006; 7:411-7.
-
(2006)
Nat Immunol
, vol.7
, pp. 411-417
-
-
Reiley, W.W.1
Zhang, M.2
Jin, W.3
Losiewicz, M.4
Donohue, K.B.5
Norbury, C.C.6
-
27
-
-
0032527915
-
Prevention of Brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: Involvement of NF-kappaB activation in drug resistance
-
Lin ZP, Boller YC, Amer SM, Russell RL, Pacelli KA, Patierno SR, et al. Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NFkappaB activation in drug resistance. Cancer Res 1998; 58:3059-65. (Pubitemid 28335087)
-
(1998)
Cancer Research
, vol.58
, Issue.14
, pp. 3059-3065
-
-
Lin, Z.P.1
Boiler, Y.C.2
Amer, S.M.3
Russell, R.L.4
Pacelli, K.A.5
Patierno, S.R.6
Kennedy, K.A.7
-
28
-
-
0031810458
-
Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells
-
Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM. Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells. Blood 1998; 91:4624-31. (Pubitemid 28270311)
-
(1998)
Blood
, vol.91
, Issue.12
, pp. 4624-4631
-
-
Jeremias, I.1
Kupatt, C.2
Baumann, B.3
Herr, I.4
Wirth, T.5
Debatin, K.M.6
-
29
-
-
0028831128
-
Characterization of mechanisms involved in transrepression of NFkappaB by activated glucocorticoid receptors
-
Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr. Characterization of mechanisms involved in transrepression of NFkappaB by activated glucocorticoid receptors. Mol Cell Biol 1995; 15:943-53.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 943-953
-
-
Scheinman, R.I.1
Gualberto, A.2
Jewell, C.M.3
Cidlowski, J.A.4
Baldwin Jr., A.S.5
-
30
-
-
58149336788
-
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
-
Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 2009; 15:50-8.
-
(2009)
Nat Med
, vol.15
, pp. 50-58
-
-
Real, P.J.1
Tosello, V.2
Palomero, T.3
Castillo, M.4
Hernando, E.5
De Stanchina, E.6
-
31
-
-
64749088834
-
Emerging treatments for multiple myeloma: Beyond immunomodulatory drugs and bortezomib
-
Mitsiades CS, Hideshima T, Chauhan D, McMillin DW, Klippel S, Laubach JP, et al. Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib. Semin Hematol 2009; 46:166-75.
-
(2009)
Semin Hematol
, vol.46
, pp. 166-175
-
-
Mitsiades, C.S.1
Hideshima, T.2
Chauhan, D.3
McMillin, D.W.4
Klippel, S.5
Laubach, J.P.6
-
32
-
-
60549102324
-
Downregulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
-
Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, Spruss T, et al. Downregulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med 2009; 206:221-32.
-
(2009)
J Exp Med
, vol.206
, pp. 221-232
-
-
Massoumi, R.1
Kuphal, S.2
Hellerbrand, C.3
Haas, B.4
Wild, P.5
Spruss, T.6
-
33
-
-
9144229104
-
Requirement for cyclin D3 in lymphocyte development and T cell leukemias
-
DOI 10.1016/S1535-6108(03)00301-5
-
Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 2003; 4:451-61. (Pubitemid 38050042)
-
(2003)
Cancer Cell
, vol.4
, Issue.6
, pp. 451-461
-
-
Sicinska, E.1
Aifantis, I.2
Le, C.L.3
Swat, W.4
Borowski, C.5
Yu, Q.6
Ferrando, A.A.7
Levin, S.D.8
Geng, Y.9
Von Boehmer, H.10
Sicinski, P.11
|