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Volumn 23, Issue 15, 2011, Pages

Information transmission in genetic regulatory networks: A review

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; INFORMATION THEORY;

EID: 79953652546     PISSN: 09538984     EISSN: 1361648X     Source Type: Journal    
DOI: 10.1088/0953-8984/23/15/153102     Document Type: Review
Times cited : (153)

References (93)
  • 2
    • 39049098653 scopus 로고    scopus 로고
    • Lewin B 2007 Genes IX (Boston, MA: Jones and Bartlett)
    • (2007) Genes IX
    • Lewin, B.1
  • 4
    • 37349116795 scopus 로고    scopus 로고
    • Deriving structure from evolution: Metazoan segmentation
    • François P, Hakim V and Siggia E D 2007 Deriving structure from evolution: metazoan segmentation Mol. Syst. Biol. 3 154
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 154
    • François, P.1    Hakim, V.2    Siggia, E.D.3
  • 5
    • 48949119102 scopus 로고    scopus 로고
    • A case study of evolutionary computation of biochemical adaptation
    • François P and Siggia E D 2008 A case study of evolutionary computation of biochemical adaptation Phys. Biol. 5 026009
    • (2008) Phys. Biol. , vol.5 , Issue.2 , pp. 026009
    • François, P.1    Siggia, E.D.2
  • 6
    • 67049117729 scopus 로고    scopus 로고
    • Evolutionary selection between alternative modes of gene regulation
    • Gerland U and Hwa T 2009 Evolutionary selection between alternative modes of gene regulation Proc. Natl Acad. Sci. USA 106 8841
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.22 , pp. 8841
    • Gerland, U.1    Hwa, T.2
  • 7
    • 34247619844 scopus 로고    scopus 로고
    • Fundamental limits to position determination by concentration gradient
    • Tostevin F, ten Wolde P R and Howard M 2007 Fundamental limits to position determination by concentration gradient PLoS Comput. Biol. 3 e78
    • (2007) PLoS Comput. Biol. , vol.3 , Issue.4 , pp. 78
    • Tostevin, F.1    Ten Wolde, P.R.2    Howard, M.3
  • 8
    • 50449096238 scopus 로고    scopus 로고
    • Information flow and optimization in transcriptional regulation
    • Tkaik G, Callan C G Jr and Bialek W 2008 Information flow and optimization in transcriptional regulation Proc. Natl Acad. Sci. USA 105 12265-70
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.34 , pp. 12265-12270
    • Tkaik, G.1    Callan, C.G.2    Bialek, W.3
  • 9
    • 76549110816 scopus 로고    scopus 로고
    • Bacterial strategies for chemotaxis response
    • Celani A and Vergassola M 2010 Bacterial strategies for chemotaxis response Proc. Natl Acad. Sci. USA 107 1391
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.4 , pp. 1391
    • Celani, A.1    Vergassola, M.2
  • 10
    • 71449101586 scopus 로고    scopus 로고
    • Signal integration and information processing in bacterial quorum sensing
    • Mehta P, Goyal S, Long T, Bassler B and Wingreen N S 2009 Signal integration and information processing in bacterial quorum sensing Mol. Syst. Biol. 5 325
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 325
    • Mehta, P.1    Goyal, S.2    Long, T.3    Bassler, B.4    Wingreen, N.S.5
  • 11
    • 70449368774 scopus 로고    scopus 로고
    • Morphogen profiles can be optimised to buffer against noise
    • Saunders T and Howard M 2009 Morphogen profiles can be optimised to buffer against noise Phys. Rev. E 80 041902
    • (2009) Phys. Rev. , vol.80 , Issue.4 , pp. 041902
    • Saunders, T.1    Howard, M.2
  • 12
    • 77954656146 scopus 로고    scopus 로고
    • Predicting embryonic patterning using mutual entropy fitness and in silico evolution
    • François P and Siggia E D 2010 Predicting embryonic patterning using mutual entropy fitness and in silico evolution Development 137 2385
    • (2010) Development , vol.137 , Issue.14 , pp. 2385
    • François, P.1    Siggia, E.D.2
  • 13
    • 0017635932 scopus 로고
    • Design of molecular control mechanisms and the demand for gene expression
    • Savageau M A 1977 Design of molecular control mechanisms and the demand for gene expression Proc. Natl Acad. Sci. USA 74 5647
    • (1977) Proc. Natl Acad. Sci. USA , vol.74 , Issue.12 , pp. 5647
    • Savageau, M.A.1
  • 17
    • 0037337551 scopus 로고    scopus 로고
    • AraC protein: A love-hate relationship
    • Schleif R 2003 AraC protein: a love-hate relationship Bioessays 25 274
    • (2003) Bioessays , vol.25 , Issue.3 , pp. 274
    • Schleif, R.1
  • 18
    • 0032698634 scopus 로고    scopus 로고
    • Transcription activation by catabolite activator protein (CAP)
    • Busby S and Ebright R 1999 Transcription activation by catabolite activator protein (CAP) J. Mol. Biol. 293 199
    • (1999) J. Mol. Biol. , vol.293 , Issue.2 , pp. 199
    • Busby, S.1    Ebright, R.2
  • 19
    • 0020671929 scopus 로고
    • Autoregulation of the Escherichia coli crp gene: CRP is a transcriptional repressor for its own gene
    • Aiba H 1983 Autoregulation of the Escherichia coli crp gene: CRP is a transcriptional repressor for its own gene Cell 32 141
    • (1983) Cell , vol.32 , Issue.1 , pp. 141
    • Aiba, H.1
  • 20
    • 78651369529 scopus 로고    scopus 로고
    • The gap gene network
    • Jaeger J 2011 The gap gene network Cell Mol. Life Sci. 68 243-74
    • (2011) Cell Mol. Life Sci. , vol.68 , Issue.2 , pp. 243-274
    • Jaeger, J.1
  • 21
    • 0037369952 scopus 로고    scopus 로고
    • Collaborative competition mechanism for gene activation in vivo
    • Miller J A and Widom J 2003 Collaborative competition mechanism for gene activation in vivo Mol. Cell Biol. 23 1623
    • (2003) Mol. Cell Biol. , vol.23 , Issue.5 , pp. 1623
    • Miller, J.A.1    Widom, J.2
  • 23
    • 67649826220 scopus 로고    scopus 로고
    • From DNA sequence to transcriptional behaviour: A quantitative approach
    • Segal E and Widom J 2009 From DNA sequence to transcriptional behaviour: a quantitative approach Nat. Rev. Genet. 10 443
    • (2009) Nat. Rev. Genet. , vol.10 , Issue.7 , pp. 443
    • Segal, E.1    Widom, J.2
  • 24
    • 77950669526 scopus 로고    scopus 로고
    • Predicting gene-regulation functions: Lessons from temperate bacteriophages
    • Teif V B 2010 Predicting gene-regulation functions: lessons from temperate bacteriophages Biophys. J. 98 1247-56
    • (2010) Biophys. J. , vol.98 , Issue.7 , pp. 1247-1256
    • Teif, V.B.1
  • 28
    • 66149144779 scopus 로고    scopus 로고
    • A stochastic spectral analysis of transcriptional regulatory cascades
    • Walczak A M, Mugler A and Wiggins C H 2009 A stochastic spectral analysis of transcriptional regulatory cascades Proc. Natl Acad. Sci. USA 106 6529
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.16 , pp. 6529
    • Walczak, A.M.1    Mugler, A.2    Wiggins, C.H.3
  • 29
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie D 1977 Exact stochastic simulation of coupled chemical reactions J. Phys. Chem. 81 2340
    • (1977) J. Phys. Chem. , vol.81 , Issue.25 , pp. 2340
    • Gillespie, D.1
  • 31
    • 33845442827 scopus 로고    scopus 로고
    • Diffusion of transcription factors can drastically enhance the noise in gene expression
    • DOI 10.1529/biophysj.106.086157
    • van Zon J S, Morelli M J, Tanase-Nicola S and ten Wolde P R 2006 Diffusion of transcription factors can drastically enhance the noise in gene expression Biophys. J. 91 4350-67 (Pubitemid 44904223)
    • (2006) Biophysical Journal , vol.91 , Issue.12 , pp. 4350-4367
    • Van Zon, J.S.1    Morelli, M.J.2    Tanase-Nicola, S.3    Ten Wolde, P.R.4
  • 32
    • 66549110304 scopus 로고    scopus 로고
    • Diffusion, dimensionality and noise in transcriptional regulation
    • Tkaik G and Bialek W 2009 Diffusion, dimensionality and noise in transcriptional regulation Phys. Rev. E 79 051901
    • (2009) Phys. Rev. , vol.79 , Issue.5 , pp. 051901
    • Tkaik, G.1    Bialek, W.2
  • 35
    • 78650216734 scopus 로고    scopus 로고
    • Transcription by the numbers redux: Experiments and calculations that surprise
    • Garcia H G, Sanchez A, Kuhlman T, Kondev J and Phillips R 2010 Transcription by the numbers redux: experiments and calculations that surprise Trends Cell Biol. 20 723-33
    • (2010) Trends Cell Biol. , vol.20 , Issue.12 , pp. 723-733
    • Garcia, H.G.1    Sanchez, A.2    Kuhlman, T.3    Kondev, J.4    Phillips, R.5
  • 36
    • 48349119924 scopus 로고    scopus 로고
    • Information capacity of genetic regulatory elements
    • Tkaik G, Callan C G Jr and Bialek W 2008 Information capacity of genetic regulatory elements Phys. Rev. E 78 011910
    • (2008) Phys. Rev. , vol.78 , Issue.1 , pp. 011910
    • Tkaik, G.1    Callan, C.G.2    Bialek, W.3
  • 39
    • 78651189765 scopus 로고
    • On the nature of allosteric transitions: A plausible model
    • Monod J, Wyman J and Changeaux J P 1965 On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12 88-118
    • (1965) J. Mol. Biol. , vol.12 , Issue.1 , pp. 88-118
    • Monod, J.1    Wyman, J.2    Changeaux, J.P.3
  • 40
    • 78651107675 scopus 로고    scopus 로고
    • Nucleosome-mediated cooperativity between transcription factors
    • Mirny L A 2010 Nucleosome-mediated cooperativity between transcription factors Proc. Natl Acad. Sci. USA 107 22534-9
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.52 , pp. 22534-22539
    • Mirny, L.A.1
  • 42
    • 34347232364 scopus 로고    scopus 로고
    • Quantitative characterization of combinatorial transcriptional control of the lactose operon of E. coli
    • Kuhlman T, Zhang Z, Saier M H Jr and Hwa T 2007 Quantitative characterization of combinatorial transcriptional control of the lactose operon of E. coli Proc. Natl Acad. Sci. USA 104 6043
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.14 , pp. 6043
    • Kuhlman, T.1    Zhang, Z.2    Saier, M.H.3    Hwa, T.4
  • 43
    • 50449099063 scopus 로고    scopus 로고
    • The role of input noise in transcriptional regulation
    • Tkaik G, Gregor T and Bialek W 2008 The role of input noise in transcriptional regulation PLoS One 3 e2774
    • (2008) PLoS One , vol.3 , Issue.7 , pp. 2774
    • Tkaik, G.1    Gregor, T.2    Bialek, W.3
  • 44
    • 21244447564 scopus 로고    scopus 로고
    • Self-consistent proteomic field theory of stochastic gene switches
    • Walczak A M, Sasai M and Wolynes P G 2005 Self-consistent proteomic field theory of stochastic gene switches Biophys. J. 88 828
    • (2005) Biophys. J. , vol.88 , Issue.2 , pp. 828
    • Walczak, A.M.1    Sasai, M.2    Wolynes, P.G.3
  • 48
    • 34447099234 scopus 로고    scopus 로고
    • Probing the limits to positional information
    • Gregor T, Tank D W, Wieschaus E F and Bialek W 2007 Probing the limits to positional information Cell 130 153
    • (2007) Cell , vol.130 , Issue.1 , pp. 153
    • Gregor, T.1    Tank, D.W.2    Wieschaus, E.F.3    Bialek, W.4
  • 49
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • DOI 10.1126/science.1070919
    • Elowitz M B, Levine A J, Siggia E D and Swain P S 2002 Stochastic gene expression in a single cell Science 297 1183-6 (Pubitemid 36193353)
    • (2002) Science , vol.297 , Issue.5584 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 50
    • 84856043672 scopus 로고
    • A mathematical theory of communication
    • and 623
    • Shannon C E 1948 A mathematical theory of communication Bell Syst. Tech. J. 27 379 and 623
    • (1948) Bell Syst. Tech. J. , vol.27 , pp. 379
    • Shannon, C.E.1
  • 54
    • 0019620028 scopus 로고
    • A simple coding procedure enhances a neuron's information capacity
    • Laughlin S 1981 A simple coding procedure enhances a neuron's information capacity Z. Naturf. c 36 910
    • (1981) Z. Naturf. , vol.36 , pp. 910
    • Laughlin, S.1
  • 55
    • 23744504171 scopus 로고    scopus 로고
    • Characterization and computation of optimal distributions for channel coding
    • Huang J and Meyn S P 2005 Characterization and computation of optimal distributions for channel coding IEEE Trans. Inf. Theory 51 2336
    • (2005) IEEE Trans. Inf. Theory , vol.51 , Issue.7 , pp. 2336
    • Huang, J.1    Meyn, S.P.2
  • 58
    • 27644547453 scopus 로고    scopus 로고
    • Bicoid determines sharp and precise target gene expression in the Drosophila embryo
    • Crauk O and Dostatni N 2005 Bicoid determines sharp and precise target gene expression in the Drosophila embryo Curr. Biol. 15 1888
    • (2005) Curr. Biol. , vol.15 , Issue.21 , pp. 1888
    • Crauk, O.1    Dostatni, N.2
  • 59
    • 77649158519 scopus 로고    scopus 로고
    • The bicoid morphogen system
    • Porcher A and Dostatni N 2010 The bicoid morphogen system Curr. Biol. 20 R249
    • (2010) Curr. Biol. , vol.20 , Issue.5 , pp. 249
    • Porcher, A.1    Dostatni, N.2
  • 61
    • 0015376113 scopus 로고    scopus 로고
    • Computation of channel capacity and rate-distortion functions
    • Bhaut R 2002 Computation of channel capacity and rate-distortion functions IEEE Trans. Inf. Theory 18 460-73
    • (2002) IEEE Trans. Inf. Theory , vol.18 , pp. 460-473
    • Bhaut, R.1
  • 62
    • 70349924640 scopus 로고    scopus 로고
    • Characterization and computation of optimal distributions for channel coding
    • Emberly E 2008 Characterization and computation of optimal distributions for channel coding Phys. Rev. E 77 041903
    • (2008) Phys. Rev. , vol.77 , Issue.4 , pp. 041903
    • Emberly, E.1
  • 63
    • 42749102564 scopus 로고    scopus 로고
    • Reliable biological communication with realistic constraints
    • de Polavieja G G 2004 Reliable biological communication with realistic constraints Phys. Rev. E 70 061910
    • (2004) Phys. Rev. , vol.70 , Issue.6 , pp. 061910
    • De Polavieja, G.G.1
  • 64
    • 70349976815 scopus 로고    scopus 로고
    • Optimizing information flow in small genetic networks
    • Tkaik G, Walczak A M and Bialek W 2009 Optimizing information flow in small genetic networks Phys. Rev. E 80 031920
    • (2009) Phys. Rev. , vol.80 , Issue.3 , pp. 031920
    • Tkaik, G.1    Walczak, A.M.2    Bialek, W.3
  • 65
    • 77950960454 scopus 로고    scopus 로고
    • Optimizing information flow in small genetic networks. II. Feed-forward interactions
    • Walczak A M, Tkaik G and Bialek W 2010 Optimizing information flow in small genetic networks. II. Feed-forward interactions Phys. Rev. E 81 041905
    • (2010) Phys. Rev. , vol.81 , Issue.4 , pp. 041905
    • Walczak, A.M.1    Tkaik, G.2    Bialek, W.3
  • 66
    • 42549099171 scopus 로고    scopus 로고
    • Optimal signal processing in small stochastic biochemical networks
    • Ziv E, Nemenman I and Wiggins C H 2007 Optimal signal processing in small stochastic biochemical networks PLoS One 2 e1077
    • (2007) PLoS One , vol.2 , Issue.10 , pp. 1077
    • Ziv, E.1    Nemenman, I.2    Wiggins, C.H.3
  • 67
    • 66349109628 scopus 로고    scopus 로고
    • Mutual information between input and output trajectories of biochemical networks
    • Tostevin F and ten Wolde P R 2009 Mutual information between input and output trajectories of biochemical networks Phys. Rev. Lett. 102 218101
    • (2009) Phys. Rev. Lett. , vol.102 , Issue.21 , pp. 218101
    • Tostevin, F.1    Ten Wolde, P.R.2
  • 68
    • 70449127534 scopus 로고    scopus 로고
    • Spectral solutions to stochastic models of gene expression with bursts and regulation
    • Mugler A, Walczak A M and Wiggins C H 2009 Spectral solutions to stochastic models of gene expression with bursts and regulation Phys. Rev. E 80 041921
    • (2009) Phys. Rev. , vol.80 , Issue.4 , pp. 041921
    • Mugler, A.1    Walczak, A.M.2    Wiggins, C.H.3
  • 69
    • 77955154492 scopus 로고    scopus 로고
    • Spectral solutions to stochastic models of gene expression with bursts and regulation
    • Mugler A, Walczak A M and Wiggins C H 2010 Spectral solutions to stochastic models of gene expression with bursts and regulation Phys. Rev. Lett. 105 058101
    • (2010) Phys. Rev. Lett. , vol.105 , Issue.5 , pp. 058101
    • Mugler, A.1    Walczak, A.M.2    Wiggins, C.H.3
  • 70
    • 33746869356 scopus 로고    scopus 로고
    • Signal detection, modularity, and the correlation between extrinsic and intrinsic noise in biochemical networks
    • Tanase-Nicola S, Warren P B and ten Wolde P R 2010 Signal detection, modularity, and the correlation between extrinsic and intrinsic noise in biochemical networks Phys. Rev. Lett. 97 068102
    • (2010) Phys. Rev. Lett. , vol.97 , Issue.6 , pp. 068102
    • Tanase-Nicola, S.1    Warren, P.B.2    Ten Wolde, P.R.3
  • 71
    • 77953665126 scopus 로고    scopus 로고
    • Mutual information in time-varying biochemical systems
    • Tostevin F and ten Wolde P R 2009 Mutual information in time-varying biochemical systems Phys. Rev. E 81 061917
    • (2009) Phys. Rev. , vol.81 , Issue.6 , pp. 061917
    • Tostevin, F.1    Ten Wolde, P.R.2
  • 72
    • 78651234253 scopus 로고    scopus 로고
    • Effect of feedback on the fidelity of information transmission for time-varying signals
    • de Ronde W H, Tostevin F and ten Wolde P R 2010 Effect of feedback on the fidelity of information transmission for time-varying signals Phys. Rev. E 82 031914
    • (2010) Phys. Rev. , vol.82 , Issue.3 , pp. 031914
    • De Ronde, W.H.1    Tostevin, F.2    Ten Wolde, P.R.3
  • 74
    • 0000302918 scopus 로고
    • Towards a theory of early visual processing
    • Atick J J and Redlich A N 1990 Towards a theory of early visual processing Neural Comput. 2 308-20
    • (1990) Neural Comput. , vol.2 , Issue.3 , pp. 308-320
    • Atick, J.J.1    Redlich, A.N.2
  • 75
    • 0030864981 scopus 로고    scopus 로고
    • Mosaic arrangement of ganglion cell receptive fields in rabbit retina
    • Devries S H and Baylor D A 1997 Mosaic arrangement of ganglion receptive fields in rabbit retina J. Neurophysiol. 78 2048-60 (Pubitemid 27446986)
    • (1997) Journal of Neurophysiology , vol.78 , Issue.4 , pp. 2048-2060
    • DeVries, S.H.1    Baylor, D.A.2
  • 77
    • 70349487750 scopus 로고    scopus 로고
    • Predictable irregularities in retinal receptive fields
    • Liu Y S, Stevens C F and Sharpee T O 2009 Predictable irregularities in retinal receptive fields Proc. Natl Acad. Sci. USA 106 16499-504
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.38 , pp. 16499-16504
    • Liu, Y.S.1    Stevens, C.F.2    Sharpee, T.O.3
  • 79
    • 0030442805 scopus 로고    scopus 로고
    • Colour vision as an adaptation to fruigivory in primates
    • Osorio D and Vorobyev M 1996 Colour vision as an adaptation to fruigivory in primates Proc. R. Soc. B 263 593-9
    • (1996) Proc. R. Soc. , vol.263 , Issue.1370 , pp. 593-599
    • Osorio, D.1    Vorobyev, M.2
  • 81
    • 0033714122 scopus 로고    scopus 로고
    • Adaptive rescaling optimizes information transmission
    • Brenner N, Bialek W and van Steveninck R R 2000 Adaptive rescaling optimizes information transmission Neuron 26 695-702
    • (2000) Neuron , vol.26 , Issue.3 , pp. 695-702
    • Brenner, N.1    Bialek, W.2    Van Steveninck, R.R.3
  • 82
  • 84
    • 62549144942 scopus 로고    scopus 로고
    • The minimum information principle and its application to neural code analysis
    • Globerson A, Stark E, Vaadia E and Tishby N 2009 The minimum information principle and its application to neural code analysis Proc. Natl Acad. Sci. USA 106 3490-5
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.9 , pp. 3490-3495
    • Globerson, A.1    Stark, E.2    Vaadia, E.3    Tishby, N.4
  • 86
    • 33846553228 scopus 로고    scopus 로고
    • 'Infotaxis' as a strategy for searching without gradients
    • DOI 10.1038/nature05464, PII NATURE05464
    • Vergassola M, Villermaux E and Shraiman B I 2007 'Infotaxis' as a strategy for searching without gradients Nature 445 406-9 (Pubitemid 46160905)
    • (2007) Nature , vol.445 , Issue.7126 , pp. 406-409
    • Vergassola, M.1    Villermaux, E.2    Shraiman, B.I.3
  • 87
    • 34548378653 scopus 로고    scopus 로고
    • An information-theoretic characterization of the optimal gradient sensing response of cells
    • Andrews B W and Iglesias P A 2007 An information-theoretic characterization of the optimal gradient sensing response of cells PLoS Comput. Biol. 3 e153
    • (2007) PLoS Comput. Biol. , vol.3 , Issue.8 , pp. 153
    • Andrews, B.W.1    Iglesias, P.A.2
  • 89
    • 25444489027 scopus 로고    scopus 로고
    • Phenotypic diversity, population growth, and information in fluctuating environments
    • Kussel E and Leibler S 2005 Phenotypic diversity, population growth, and information in fluctuating environments Science 309 2075
    • (2005) Science , vol.309 , Issue.5743 , pp. 2075
    • Kussel, E.1    Leibler, S.2
  • 92
    • 70349961774 scopus 로고    scopus 로고
    • Different gene regulation strategies revealed by analysis of binding motifs
    • Mirny L A and Wunderlich Z 2008 Different gene regulation strategies revealed by analysis of binding motifs Trends Genet. 25 434 arXiv:0812.3910
    • (2008) Trends Genet. , vol.25 , pp. 434
    • Mirny, L.A.1    Wunderlich, Z.2
  • 93
    • 0033251411 scopus 로고    scopus 로고
    • The idea of information in biology
    • Maynard Smith J 1999 The idea of information in biology Q. Rev. Biol. 74 395
    • (1999) Q. Rev. Biol. , vol.74 , Issue.4 , pp. 395
    • Maynard Smith, J.1


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