Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine

International Journal of Molecular Sciences

Volumn 12, Issue 3, 2011, Pages 1595-1604

  Yin, Tao ^a,b   Wei, Hongji ^a   Gou, Shanmiao ^a   Shi, Pengfei ^a   Yang, Zhiyong ^a   Zhao, Gang ^a   Wang, Chunyou ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Hubei Key Laboratory of Biological Targeted Therapy   (China)

Author keywords

Bmi 1; Chemoresistance; Invasion; Pancreatic cancer; Tumorigenesis

Indexed keywords

BMI1 PROTEIN; BREAST CANCER RESISTANCE PROTEIN; CYCLIN D1; GEMCITABINE; PROTEIN P16; UVOMORULIN; VIMENTIN; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; BMI1 PROTEIN, HUMAN; CADHERIN; CD24 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DEOXYCYTIDINE; HERMES ANTIGEN; TUMOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CANCER STEM CELL; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE OVEREXPRESSION; METASTASIS; PANCREAS CANCER; PHENOTYPE; TARGET CELL; ANALOGS AND DERIVATIVES; CELL LINE; CELL MOTION; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; METABOLISM; PANCREAS TUMOR; PATHOLOGY;

ANTIGENS, CD24; ANTIGENS, CD44; ATP-BINDING CASSETTE TRANSPORTERS; CADHERINS; CELL LINE; CELL MOVEMENT; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; POLYCOMB REPRESSIVE COMPLEX 1; VIMENTIN;

EID: 79953332194     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12031595     Document Type: Article

References (30)

1. Jemal, A.; Tiwari, R.C.; Murray, T. Cancer statistics, 2004. CA Cancer J. Clin. 2004, 54, 8-29.
2. Polyak, K.; Hahn, W.C. Roots and stems, stem cells in cancer. Nat. Med. 2006, 12, 296-300.
3. Li, F.; Tiede, B.; Massagué, J.; Kang, Y. Beyond tumorigenesis, cancer stem cells in metastasis. Cell Res. 2007, 17, 3-14.
4. Kakarala, M.; Wicha, M.S. Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J. Clin. Oncol. 2008, 26, 2813-2820.
5. Singh, S.K.; Clarke, I.D.; Terasaki, M.; Bonn, V.E.; Hawkins, C.; Squire, J.; Dirks, P.B. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003, 63, 5821-5828.
6. Ricci-Vitiani, L.; Lombardi, D.G.; Pilozzi, E.; Biffoni1, M.; Todaro, M.; Peschle1, C.; De Maria1, R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445, 111-115.
7. Ponti, D.; Costa, A.; Zaffaroni, N.; Pratesi, G.; Petrangolini, G.; Coradini, D.; Pilotti, S.; Pierotti, M.A.; Daidone, M.G. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005, 65, 5506-5511.
8. Bonnet, D.; Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3, 730-737.
9. Li, C.; Heidt, D.G.; Dalerba, P.; Burant, C.F.; Zhang, L.; Adsay, V.; Wicha, M.; Clarke, M.F.; Simeone, D.M. Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67, 1030-1037.
10. Gou, S.; Liu, T.; Wang, C.; Yin, T.; Li, K.; Yang, M.; Zhou, J. Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. Pancreas 2007, 34, 429-435.
11. Huang, P.; Wang, C.Y.; Gou, S.M.; Wu, H.-S.; Liu, T.; Xiong, J.-X. Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma. World J. Gastroenterol. 2008, 14, 3903-3907.
12. Balic, M.; Lin, H.; Young, L.; Hawes, D.; Giuliano, A.; McNamara, G.; Datar, R.H.; Cote1, R.J. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin. Cancer Res. 2006, 12, 5615-5621.
13. Thiery, J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2, 442-454.
14. Polyak, K.; Hahn, W.C. Roots and stems, stem cells in cancer. Nat. Med. 2006, 12, 296-300.
15. Ischenko, I.; Seeliger, H.; Schaffer, M. Cancer stem cells, how can we target them? Curr. Med. Chem. 2008, 15, 3171-3184.
16. Dylla, S.J.; Beviglia, L.; Park, I.K.; Chartier, C.; Raval, J.; Ngan, L.; Pickell, K.; Aguilar, J.; Lazetic, S.; Smith-Berdan, S.; et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 2008, 3, e2428:1- e2428:13.
17. Rizo, A.; Olthof, S.; Han, L.; Vellenga, E.; de Haan, G.; Schuringa, J.J. Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. Blood 2009, 114, 1498-1505.
18. Datta, S.; Hoenerhoff, M.J.; Bommi, P.; Sainger, R.; Guo, W.J.; Dimri, M.; Band, H.; Band, V.; Green, J.E.; Dimri, G.P. Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res. 2007, 67, 10286-10295.
19. Song, W.; Tao, K.; Li, H.; Jin, C.; Song, Z.; Li, J.; Shi, H.; Li, X.; Dang, Z.; Dou, K. Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. Cancer Sci. 2010, 101, 1754-1760.
20. Ejendal, K.F.; Hrycyna, C.A. Multidrug resistance and cancer, the role of the human ABC transporter ABCG2. Curr. Protein Pept. Sci. 2002, 3, 503-511.
21. Kim, M.; Turnquist, H.; Jackson, J.; Sgagias, M.; Yan, Y.; Gong, M.; Dean, M.; Sharp, J.G.; Cowan, K. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin. Cancer Res. 2002, 8, 22-28.
22. Attri, J.; Srinivasan, R.; Majumdar, S.; Radotra, B.D.; Wig, J. Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. BMC Gastroenterol. 2005, 5, 22:1-22:10.
23. Halloran, C.M.; Ghaneh, P.; Shore, S.; Greenhalf, W.; Zumstein, L.; Wilson, D.; Neoptolemos, J.P.; Costello, E. 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. J. Gene Med. 2004, 6, 514-525.
24. Gansauge, S.; Gansauge, F.; Ramadani, M.; Stobbe, H.; Rau, B.; Harada, N.; Beger H.G. Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res. 1997, 57, 1634-1637.
25. Biliran, H., Jr.; Wang, Y.; Banerjee, S.; Xu, H.; Heng, H.; Thakur, A.; Bollig, A.; Sarkar, F.H.; Liao, J.D. Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin. Cancer Res. 2005, 11, 6075-6086.
26. Jeselsohn, R.; Brown, N.E.; Arendt, L.; Klebba, I.; Hu, M.G.; Kuperwasser, C.; Hinds, P.W. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell 2010, 17 (1), 65-76.
27. Mani, S.A.; Guo, W.; Liao, M.J.; Eaton, E.N.; Ayyanan, A.; Zhou1, A.Y.; Brooks, M.; Reinhard, F.; Zhang, C.C.; Shipitsin, M.; et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133, 704-715.
28. Larue, L.; Bellacosa, A. Epithelial-mesenchymal transition in development and cancer, role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 24, 7443-7454.
29. Robson, E.J.; Khaled, W.T.; Abell, K.; Watson, C.J. Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines. Differentiation 2006, 74, 254-264.
30. Lee, J.M.; Dedhar, S.; Kalluri, R.; Thompson, E.W. The epithelial-mesenchymal transition, new insights in signaling, development, and disease. J. Cell Biol. 2006, 172, 973-981.