Mesenchymal stem cells pretreated with delivered Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury

Stem Cells

Volumn 27, Issue 9, 2009, Pages 2283-2292

  Chang, Woochul ^a   Song, Byeong Wook ^b   Lim, Soyeon ^c   Song, Heesang ^d   Chi, Young Shim ^b   Cha, Min Ji ^b   Dong, Hyuck Ahn ^e   Jung, Young Gook ^e   Lee, Dong Ho ^f   Ji, Hyung Chung ^g   Choi, Ki Doo ^f   Lee, Seung Kyou ^f   Chung, Namsik ^b   Lee, Sang Kyou ^e   Jang, Yangsoo ^b   Hwang, Ki Chul ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yonsei University College of Medicine   (South Korea)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d WASHINGTON UNIVERSITY   (United States)

^e Yonsei University   (South Korea)

^f ForHumanTech Co Ltd   (South Korea)

^g Yonsei University College of Medicine   (South Korea)

Author keywords

Mesenchymal stem cells; Myocardial infarction; Protein transduction domains

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; PROTEIN BAX; PROTEIN BCL 2; PROTEIN HPH 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRESS; CELL TRANSPLANTATION; CONTROLLED STUDY; DRUG ACTIVITY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE INJURY; HEART PROTECTION; HYPOXIA; LEFT CORONARY ARTERY; MESENCHYMAL STEM CELL; MICROVASCULATURE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CASPASE 3; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; HSP70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 70349849518     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.153     Document Type: Article

References (32)

1. Makino S, Fukuda K, Miyoshi S et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705. (Pubitemid 29122423)
2. Shake JG, Gruber PJ, Baumgartner WA et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects. Ann Thorac Surg 2002;73:1919-1925.
3. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002;105:93-98. (Pubitemid 34049148)
4. Jäättelä M. Heat shock proteins as cellular lifeguards. Ann Med 1999; 31:261-271. (Pubitemid 29366608)
5. Latchman DS. Heat shock proteins and cardiac protection. Cardiovasc Res 2001;51:637-646. (Pubitemid 32800706)
6. Beere HM, Green DR. Stress management-heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol 2001;11:6-10. (Pubitemid 32056181)
7. Höhfeld J. Regulation of the heat shock conjugate Hsc70 in the mammalian cell: The characterization of the anti-apoptotic protein BAG-1 provides novel insights. Biol Chem 1998;379:269-274. (Pubitemid 28152089)
8. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology. Pharmacol Ther 1998;80:183-201. (Pubitemid 28498227)
9. Brar BK, Stephanou A, Wagstaff MJ et al. Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. J Mol Cell Cardiol 1999;31:135-146. (Pubitemid 29078225)
10. Gray CC, Amrani M, Yacoub MH. Heat stress proteins and myocardial protection: Experimental model or potential clinical tool. Int J Biochem Cell Biol 1999;31:559-573. (Pubitemid 29219402)
11. Okubo S, Wildner O, Shah MR, Chelliah JC, Hess ML, Kukreja RC. Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart. Circulation 2001;103:877-881. (Pubitemid 32163888)
12. Zhang M, Methot D, Poppa V, Fujio Y, Walsh K, Murry CE. Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies. J Mol Cell Cardiol 2001;33:907-921. (Pubitemid 32545326)
13. Mangi AA, Noiseux N, Kong D et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9:1195-1201. (Pubitemid 37173705)
14. Würtele H, Little KC, Chartrand P. Illegitimate DNA integration in mammalian cells. Gene Ther 2003;10:1791-1799. (Pubitemid 37185136)
15. Martin JL, Mestril R, Hilal-Dandan R, Brunton LL, Dillmann WH. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 1997;96:4343-4348. (Pubitemid 28007464)
16. Suzuki K, Sawa Y, Kaneda Y, Ichihara H, Shirakura R, Matsuda H. In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat. J Clin Invest 1997;99:1645-1650.
17. Anderson WF. Human gene therapy. Nature 1998;392:25-30.
18. Choi JM, Ahn MH, Chae WJ et al. Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat Med 2006;12:574-579.
19. Song H, Chang W, Lim S et al. Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells. Stem Cells 2007;25:1431-1438.
20. Langeland S, D'hooge J, Wouters PF et al. Experimental validation of a new ultrasound method for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle. Circulation 2005;112:2157-2162.
21. Nagaya N, Kangawa K, Itoh T et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005;112:1128-1138. (Pubitemid 41216119)
22. Ho KK, Anderson KM, Kannel WB et al. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation 1993;88:107-115. (Pubitemid 23195439)
23. Davani S, Deschaseaux F, Chalmers D et al. Can stem cells mend a broken heart?Cardiovasc Res 2005;65:305-316.
24. Guërette B, Skuk D, Celestin F et al. Prevention by anti-LFA-1 of acute myoblast death following transplantation. J Immunol 1997;159:2522-2531. (Pubitemid 127681048)
25. Meredith JE, Jr Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-961. (Pubitemid 23309430)
26. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998;17:6124-6134. (Pubitemid 28497786)
27. Gabai VL, Yaglom JA, Volloch V et al. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol 2000;20:6826-6836. (Pubitemid 30700800)
28. Park HS, Lee JS, Huh SH, Seo JS, Choi EJ. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J 2001;20:446-456. (Pubitemid 32126980)
29. Meldrum DR, Meng X, Shames BD et al. Liposomal delivery of heatshock protein 72 into the heart prevents endotoxin-induced myocardial contractile dysfunction. Surgery 1999;126:135-141. (Pubitemid 29382772)
30. Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 1988;55:1179-1188. (Pubitemid 19020070)
31. Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988;55:1189-1193. (Pubitemid 19020071)
32. Kabakov AE, Budagova KR, Latchman DS et al. Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion. Am J Physiol Cell Physiol 2002;283:C521-C534.