Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry

Clinical Pharmacokinetics

Volumn 50, Issue 5, 2011, Pages 307-318

  Sinha, Vikash K ^a   Vaarties, Karin ^a   De Buck, Stefan S ^b   Fenu, Luca A ^c   Nijsen, Marjoleen ^d   Gilissen, Ron A H J ^a   Sanderson, Wendy ^a   Van Uytsel, Kelly ^a   Hoeben, Eva ^a   Van Peer, Achiel ^a   MacKie, Claire E ^a   Smit, Johan W ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UPPSALA UNIVERSITY   (Sweden)

^d ABBOTT LABORATORIES   (United States)

Author keywords

Dose prediction; Metabolism; Pharmacokinetic modelling; Pharmacokinetics

Indexed keywords

ALLOMETRY; AREA UNDER THE CURVE; ARTICLE; BRAIN WEIGHT; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CACO-2 CELLS; DOGS; HALF-LIFE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MACACA FASCICULARIS; METABOLIC CLEARANCE RATE; MICE; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PROTEIN BINDING; RATS; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY;

EID: 79953326144     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/11539250-000000000-00000     Document Type: Article

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