Importance of two Enterococcus faecium loci encoding Gls-like proteins for in vitro bile salts stress response and virulence

Journal of Infectious Diseases

Volumn 203, Issue 8, 2011, Pages 1147-1154

  Choudhury, Tina ^a   Singh, Kavindra V ^a   Sillanpää, Jouko ^a   Nallapareddy, Sreedhar R ^a   Murray, Barbara E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BILE SALT; GLS LIKE PROTEIN; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DELETION MUTANT; ENTEROCOCCUS FAECIUM; GENE CLUSTER; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; GLS20 GENE; GLS24 GENE; GLS33 GENE; GLSB GENE; GLSB1 GENE; IN VITRO STUDY; INTESTINE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; BILE ACIDS AND SALTS; ENTEROCOCCUS FAECIUM; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; MICE; MULTIGENE FAMILY; PERITONITIS; STRESS, PHYSIOLOGICAL; VIRULENCE;

EID: 79953325691     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq160     Document Type: Article

References (41)

1. Arias CA, Murray BE. Antibiotic-resistant bugs in the 21st Century-a clinical super-challenge. N Engl J Med 2009; 360:439-43.
2. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Erratum in Infect Control Hosp Epidemiol 2009; 30:107.
3. Top J, Willems R, van der Velden S, Asbroek M, Bonten M. Emergence of clonal complex 17 Enterococcus faecium in The Netherlands. J Clin Microbiol 2008; 46:214-9.
4. Werner G, Coque TM, Hammerum AM, et al. Emergence and spread of vancomycin resistance among enterococci in Europe. Euro Surveill 2008: 13.
5. Eliopoulos GM. Antimicrobial agents for treatment of serious infections caused by resistant Staphylococcus aureus and enterococci. Eur J Clin Microbiol Infect Dis 2005; 24:826-31. (Pubitemid 43042789)
6. Murray BE. Vancomycin-resistant enterococcal infections. N Engl J Med 2000; 342:710-21. (Pubitemid 30131425)
7. Rice LB. Antimicrobial resistance in gram-positive bacteria. Am J Med 2006; 119:S11-9.
8. Nallapareddy SR, Singh KV, Murray BE. Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis. Infect Immun 2008; 76:4120-8.
9. Nallapareddy SR, Singh KV, Okhuysen PC, Murray BE. A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogen. Infect Immun 2008; 76:4110-9.
10. Efm-containing virulence plasmid in Enterococcus faecium. Antimicrob Agents Chemother 2009; 53:4240-6.
11. Efm, predominates in Enterococcus faecium of clinical origin. J Infect Dis 2003; 187:508-12.
12. Rice LB, Lakticova V, Carias LL, Rudin S, Hutton R, Marshall SH. Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model. J Infect Dis 2009; 199:342-9.
13. Leendertse M, Heikens E, Wijnands LM, et al. Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice. J Infect Dis 2009; 200:1162-5.
14. Willems RJ, Homan W, Top J, et al. Variant esp gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faecium spreading in hospitals. Lancet 2001; 357:853-5. (Pubitemid 32239372)
15. Sillanpaa J, Nallapareddy SR, Prakash VP, et al. Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology 2008; 154:3199-211.
16. Sillanpaa J, Prakash VP, Nallapareddy SR, Murray BE. Distribution of genes encoding MSCRAMMs and pili in clinical and natural populations of Enterococcus faecium. J Clin Microbiol 2009; 47:896-901.
17. Hendrickx AP, van Wamel WJ, Posthuma G, Bonten MJ, Willems RJ. Five genes encoding surface-exposed LPXTG proteins are enriched in hospital-adapted Enterococcus faecium clonal complex 17 isolates. J Bacteriol 2007; 189:8321-32. (Pubitemid 350178944)
18. Sillanpaa J, Nallapareddy SR, Singh KV, et al. Characterization of the ebp pilus-encoding operon of Enterococcus faecium and its role in biofilm formation and virulence in a murine model of urinary tract infection. Virulence 2010; 1:236-46.
19. Hendrickx AP, Bonten MJ, van Luit-Asbroek M, Schapendonk CM, Kragten AH, Willems RJ. Expression of two distinct types of pili by a hospital-acquired Enterococcus faecium isolate. Microbiology 2008; 154:3212-23.
20. Hendrickx AP, van Luit-Asbroek M, Schapendonk CM, et al. SgrA, a nidogen-binding LPXTG surface adhesin implicated in biofilm formation, and EcbA, a collagen binding MSCRAMM, are two novel adhesins of hospital-acquired Enterococcus faecium. Infect Immun 2009; 77:5097-106.
21. Abranches J, Martinez AR, Kajfasz JK, Chavez V, Garsin DA, Lemos JA. The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis. J Bacteriol 2009; 191:2248-56.
22. La Carbona S, Sauvageot N, Giard JC, et al. Comparative study of the physiological roles of three peroxidases (NADH peroxidase, Alkyl hydroperoxide reductase and Thiol peroxidase) in oxidative stress response, survival inside macrophages and virulence of Enterococcus faecalis. Mol Microbiol 2007; 66:1148-63. (Pubitemid 350115023)
23. Brenot A, King KY, Janowiak B, Griffith O, Caparon MG. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect Immun 2004; 72:408-13. (Pubitemid 38018202)
24. Janulczyk R, Ricci S, Bjorck L. MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes. Infect Immun 2003; 71:2656-64. (Pubitemid 36519881)
25. Cotter PD, Emerson N, Gahan CG, Hill C. Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes. J Bacteriol 1999; 181:6840-3. (Pubitemid 29518003)
26. Giard JC, Hartke A, Flahaut S, Boutibonnes P, Auffray Y. Glucose starvation response in Enterococcus faecalis JH2-2: survival and protein analysis. Res Microbiol 1997; 148:27-35. (Pubitemid 27062269)
27. Teng F, Nannini EC, Murray BE. Importance of gls24 in virulence and stress response of Enterococcus faecalis and use of the Gls24 protein as a possible immunotherapy target. J Infect Dis 2005; 191:472-80. (Pubitemid 40139773)
28. Giard JC, Rince A, Capiaux H, Auffray Y, Hartke A. Inactivation of the stress- and starvation-inducible gls24 operon has a pleiotrophic effect on cell morphology, stress sensitivity, and gene expression in Enterococcus faecalis. J Bacteriol 2000; 182:4512-20. (Pubitemid 30599815)
29. Nannini EC, Teng F, Singh KV, Murray BE. Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model. Infect Immun 2005; 73:7772-4. (Pubitemid 41587685)
30. Arduino RC, Jacques-Palaz K, Murray BE, Rakita RM. Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis. Infect Immun 1994; 62:5587-94. (Pubitemid 24365005)
31. Coque TM, Patterson JE, Steckelberg JM, Murray BE. Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons. J Infect Dis 1995; 171:1223-9.
32. Bryan EM, Bae T, Kleerebezem M, Dunny GM. Improved vectors for nisin-controlled expression in gram-positive bacteria. Plasmid 2000; 44:183-90.
33. Nallapareddy SR, Singh KV, Murray BE. Construction of improved temperature-sensitive and mobilizable vectors and their use for constructing mutations in the adhesin-encoding acm gene of poorly transformable clinical Enterococcus faecium strains. Appl Environ Microbiol 2006; 72:334-45.
34. Arthur M, Depardieu F, Snaith HA, Reynolds PE, Courvalin P. Contribution of VanY D, D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob Agents Chemother 1994; 38:1899-903.
35. Wilson K. Preparation of genomic DNA from bacteria. In: Ausubel FM, Brent R, Kingston RE, Current Protocols in Molecular Biology. Brooklyn, NY: Green Publishing Associates 1994; 2.4.1-2.4.2.
36. Murray BE, Singh KV, Heath JD, Sharma BR, Weinstock GM. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J Clin Microbiol 1990; 28:2059-63. (Pubitemid 20260989)
37. Singh KV, Qin X, Weinstock GM, Murray BE. Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model. J Infect Dis 1998; 178:1416-20.
38. Nallapareddy SR, Wenxiang H, Weinstock GM, Murray BE. Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island. J Bacteriol 2005; 187:5709-18. (Pubitemid 41134307)
39. Palmer KL, Carniol K, Manson JM, et al. High-quality draft genome sequences of 28 Enterococcus sp. isolates. J Bacteriol 2010; 192:2469-70.
40. Willems RJ, Top J, van Santen M, et al. Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex. Emerg Infect Dis 2005; 11:821-8. (Pubitemid 40720841)
41. Van Deest BW, Fordtran JS, Morawski SG, Wilson JD. Bile salt and micellar fat concentration in proximal small bowel contents of ileectomy patients. J Clin Invest 1968; 47:1314-24.