Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model

Infection and Immunity

Volumn 73, Issue 11, 2005, Pages 7772-7774

  Nannini, Esteban C ^a,b   Teng, Fang ^a   Singh, Kavindra V ^a   Murray, Barbara E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; KANAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL ENDOCARDITIS; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BACTERIUM COLONY; BACTERIUM CULTURE; BACTERIUM MUTANT; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; EXPERIMENTAL MODEL; GENE DISRUPTION; GENE FUNCTION; GENE INACTIVATION; GLS24 GENE; HISTOPATHOLOGY; INOCULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; ENDOCARDITIS, BACTERIAL; ENTEROCOCCUS FAECALIS; HEAT-SHOCK PROTEINS; KIDNEY; MUTATION; RATS; SPLEEN; VIRULENCE;

EID: 27744505626     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.11.7772-7774.2005     Document Type: Article

References (13)

1. Aldea, M., T. Garrido, C. Hernandez-Chico, M. Vicente, and S. R. Kushner. 1989. Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia cou morphogene. EMBO J. 8:3923-3931.
2. Beuzon, C. R., S. Meresse, K. E. Unsworth, J. Ruiz-Albert, S. Garvis, S. R. Waterman, T. A. Ryder, E. Boucrot, and D. W. Holden. 2000. Salmonella maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J. 19:3235-3249.
3. Giard, J. C., A. Hartke, S. Flahaut, P. Boutibonnes, and Y. Auffray. 1997. Glucose starvation response in Enterococcus faecalis JH2-2: survival and protein analysis. Res. Microbiol. 148:27-35.
4. Giard, J. C., A. Rince, H. Capiaux, Y. Auffray, and A. Hartke. 2000. Inactivation of the stress- and starvation-inducible gls24 operon has a pleiotrophic effect on cell morphology, stress sensitivity, and gene expression in Enterococcus faecalis. J. Bacteriol. 182:4512-4520.
5. Gould, K., C. H. Ramirez-Ronda, R. K. Holmes, and J. P. Sanford. 1975. Adherence of bacteria to heart valves in vitro. J. Clin. Investig. 56:1364-1370.
6. Hienz, S. A., T. Schennings, A. Heimdahl, and J. I. Flock. 1996. Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis. J. Infect. Dis. 174:83-88.
7. Megran, D. W. 1992. Enterococcal endocarditis. Clin. Infect. Dis. 15:63-71.
8. Nicholson, W. L., P. Fajardo-Cavazos, R. Rebeil, T. A. Slieman, P. J. Riesenman, J. F. Law, and Y. Xue. 2002. Bacterial endospores and their significance in stress resistance. Antonie Leeuwenhoek 81:27-32.
9. Shepard, B. D., and M. S. Gilmore. 2002. Differential expression of virulence-related genes in Enterococcus faecalis in response to biological cues in serum and urine. Infect. Immun. 70:4344-4352.
10. Singh, K. V., S. R. Nallapareddy, E. C. Nannini, and B. E. Murray. 2005. Fsr-independent production of protease(s) may explain the lack of attenuation of an Enterococcus faecalis fsr mutant versus a gelE-sprE mutant in induction of endocarditis. Infect. Immun. 73:4888-4894.
11. Teng, F., E. C. Nannini, and B. E. Murray. 2005. Importance of gls24 in virulence and stress response of Enterococcus faecalis and use of the Gls24 protein as a possible immunotherapy target. J. Infect. Dis. 191:472-480.
12. Weichart, D., R. Lange, N. Henneberg, and R. Hengge-Aronis. 1993. Identification and characterization of stationary phase-inducible genes in Escherichia coli. Mol. Microbiol. 10:407-420.
13. Winberg, J., R. Mollby, J. Bergstrom, K. A. Karlsson, I. Leonardsson, M. A. Milh, S. Teneberg, D. Haslam, B. I. Marklund, and S. Normark. 1995. The PapG-adhesin at the tip of P-fimbriae provides Escherichia coli with a competitive edge in experimental bladder infections of cynomolgus monkeys. J Exp. Med. 182:1695-1702.