Structural rationale for the Recognition of Arginine at P3 in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin v

Protein and Peptide Letters

Volumn 18, Issue 6, 2011, Pages 634-641

  Guruprasad, Lalitha ^a   Tanneeru, Karunakar ^a   Guruprasad, Kunchur ^b  

^a UNIVERSITY OF HYDERABAD   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Aspartic protease; PEXEL motif; Plasmepsin V; Plasmodium falciparum; RxLxE Q D sequence motif; Structure function correlation; Substrate specificity

Indexed keywords

PLASMODIUM FALCIPARUM;

EID: 79953325518     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986611795222786     Document Type: Article

References (35)

1. Wickham, M.E.; Rug, M.; Ralph, S.A.; Klonis, N.; McFadden, G.I.; Tilley, L.; Cowman, A.F. Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes. EMBO J., 2001, 20(20), 5636-5649 (Pubitemid 33010041)
2. Lopez-Estrano, C.; Bhattacharjee, S.; Harrison, T.; Haldar, K. Cooperative domains define a unique host cell-targeting signal in Plasmodium falciparum-infected erythrocytes. Proc. Natl. Acad. Sci. USA, 2003, 100(21), 12402-12407 (Pubitemid 37271572)
3. Haldar, K.; Mohandas, N. Erythrocyte remodeling by malaria parasites. Curr. Opin. Hematol., 2007, 14(3), 203-209 (Pubitemid 46597604)
4. Maier, A.G.; Cooke, B.M.; Cowman, A.F.; Tilley, L. Malaria parasite proteins that remodel the host erythrocyte. Nat. Rev. Microbiol., 2009, 7(5), 341-354
5. Hiller, N.L.; Bhattacharjee, S.; van Ooij, C.; Liolios. K.; Harrison. T.; Lopez-Estraño, C.; Haldar, K. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science, 2004, 306(5703), 1934-1937 (Pubitemid 39627857)
6. Marti, M.; Good, R.T.; Rug, M.; Knuepfer, E.; Cowman, A.F. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science, 2004, 306(5703), 1930-1933 (Pubitemid 39627856)
7. Sargeant, T.J.; Marti, M.; Caler, E.; Carlton, J.M.; Simpson, K.; Speed, T.P.; Cowman, A.F. Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol., 2006, 7(2), R12
8. van Ooij, C.; Tamez, P.; Bhattacharjee, S.; Hiller, N.L.; Harrison, T.; Liolios, K.; Kooij, T.; Ramesar, J.; Balu, B.; Adams, J.; Waters, A.P.; Janse, C.J.; Haldar, K. The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathog., 2008, 4(6), e1000084
9. Boddey, J.A.; Hodder, A.N.; Günther, S.; Gilson, P.R.; Patsiouras, H.; Kapp, E.A.; Pearce, J.A.; de Koning-Ward, T.F.; Simpson, R. J.; Crabb, B. S.; Cowman A.F. An aspartyl protease directs malaria effector proteins to the host cell. Nature, 2010, 463(7281), 627-631
10. Russo, I.; Babbitt, S.; Muralidharan, V.; Butler, T.; Oksman, A.; Goldberg, D.E. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature, 2010, 463(7281), 632-636
11. Boddey, J.A.; Moritz, R.L.; Simpson, R.J.; Cowman, A.F. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic, 2009, 10(3), 285-299
12. Coombs, G.H.; Goldberg, D.E.; Klemba, M.; Berry, C.; Kay, J.; Mottram, J.C. Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol., 2001, 17(11), 532-537 (Pubitemid 34185360)
13. Rawlings, N.D.; Barrett, A.J.; Bateman, A. MEROPS: the peptidase database. Nucleic Acids Res., 2010, 38, D227-233
14. Banerjee, R.; Liu, J.; Beatty, W.; Pelosof, L.; Klemba, M.; Goldberg, D, E. Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proc. Natl. Acad. Sci., USA, 2002, 99(2), 990-995 (Pubitemid 34106623)
15. Liu, J.; Gluzman, I.Y.; Drew, M.E.; Goldberg, D.E. The role of Plasmodium falciparum food vacuole plasmepsins. J. Biol. Chem., 2005, 280(2), 1432-1437
16. Le Bonniec, S.; Deregnaucourt, C.; Redeker, V.; Banerjee, R.; Grellier, P.; Goldberg, D.E.; Schrével, J. Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. J. Biol. Chem., 1999, 274(20), 14218-14223
17. Wyatt, D.M.; Berry, C. Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum. FEBS Lett., 2002, 513(2-3), 159-62 (Pubitemid 34251256)
18. Papadopoulos, J.S.; Agarwala, R. COBALT: constraint-based alignment tool for multiple protein sequences. Bioinformatics, 2007, 23(9), 1073-1079 (Pubitemid 47050558)
19. Liu, P.; Marzahn, M.R.; Robbins, A.H.; Gutierrez-de-Teran, H.; Rodriguez, D.; McClung, S.H.; Stevens, S.M.; Yowell, C.A.; Dame, J.B.; McKenna, R.; Dunn, B.M. Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis. BioChem.istry, 2009, 48(19), 4086-4099
20. Bhaumik, P.; Xiao, H.; Parr, C.L.; Kiso, Y.; Gustchina, A.; Yada, R.Y.; Wlodawer, A. Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. J. Mol. Biol., 2009, 388(3), 520-540
21. Asojo, O.A.; Gulnik, S.V.; Afonina, E.; Yu, B.; Ellman, J.A.; Haque, T.S.; Silva, A.M. Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum. J. Mol. Biol., 2003, 327(1), 173-181 (Pubitemid 36293310)
22. Shi, J.; Blundell, T.L.; Mizuguchi, K. FUGUE: sequence-structure homology recognition using environment-specific substitution ta bles and structure-dependent gap penalties. J. Mol. Biol., 2001, 310(1), 243-257 (Pubitemid 32619966)
23. Sali, A.; Blundell, T.L. Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol., 1993, 234(3), 779-815 (Pubitemid 24007801)
24. Laskowski, R.A.; MacArthur, M.W.; Moss, D.S.; Thornton, J.M. PROCHECK: a program to check the stereoChem.ical quality of protein structures. J. App. Cryst., 1993, 26, 283-291
25. Ilinkin, I.; Ye, J.; Janardan, R. Multiple structure alignment and consensus identification for proteins. BMC Bioinformatics, 2010,11, 71
26. Bernstein, N.K.; Cherney, M.M.; Yowell, C.A.; Dame, J.B.; James, M.N. Structural insights into the activation of P. vivax plasmepsin. J. Mol. Biol., 2003, 329(3), 505-524 (Pubitemid 36593209)
27. Fujinaga, M.; Chernaia, M.M.; Tarasova, N.I.; Mosimann, S.C.; James, M.N. Crystal structure of human pepsin and its complex with pepstatin. Protein Sci., 1995, 4(5), 960-972
28. Rao-Naik, C.; Guruprasad, K.; Batley, B.; Rapundalo, S.; Hill, J.; Blundell, T.; Kay, J.; Dunn, B.M. Exploring the binding preferences/ specificity in the active site of human cathepsin E. Proteins, 1995, 22(2), 168-181
29. Guruprasad, K.; Blundell, T.L.; Xie, S.; Green, J.; Szafranska, B.; Nagel, R.J.; McDowell, K.; Baker, C.B.; Roberts, R.M. Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Protein Eng., 1996, 9(10), 849-856 (Pubitemid 26366510)
30. Olsen, V.; Guruprasad, K.; Cawley, N.X.; Chen, H.C.; Blundell, T.L.; Loh, Y.P. Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling. BioChem.istry, 1998, 37(9), 2768-2777 (Pubitemid 28145729)
31. Guruprasad, K.; Törmäkangas, K.; Kervinen, J.; Blundell, T.L. Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity. FEBS Lett., 1994, 352(2), 131-136 (Pubitemid 24298403)
32. Parr, C.L.; Tanaka, T.; Xiao, H.; Yada, R.Y. The catalytic significance of the proposed active site residues in Plasmodium falciparum histoaspartic protease. FEBS J., 2008, 275(8), 1698-1707 (Pubitemid 351463988)
33. Ramachandran, G.N.; Ramakrishnan, C.; Sasisekharan V. StereoChem.istry of polypeptide chain configurations. J. Mol. Biol., 1963, 7, 95-99
34. Nascimento, A.S.; Krauchenco, S.; Golubev, A.M.; Gustchina, A.; Wlodawer, A.; Polikarpov, I. Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A. J. Mol. Biol., 2008, 382(3), 763-778
35. Bailey, D.; Cooper, J.B.; Veerapandian, B.; Blundell, T.L.; Atrash, B.; Jones, D.M.; Szelke, M. X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. BioChem. J., 1993, 289(Pt 2), 363-371 (Pubitemid 23042041)