Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases

Protein Engineering

Volumn 9, Issue 10, 1996, Pages 849-856

  Guruprasad, Kunchur ^a   Blundell, Tom L ^a   Xie, Sancai ^b   Green, Jonathan ^c   Szafranska, Bozena ^b   Nagel, Robert J ^b   McDowell, Karen ^d   Baker, C Ben ^d   Roberts, R Michael ^b,c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF MISSOURI   (United States)

^c University of Missouri   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Comparative protein modelling; Peptide binding subsites; Pregnancy associated glycoproteins; Site directed mutagenesis

Indexed keywords

ARGININE; ASPARTIC PROTEINASE; CHYMOSIN; COMPLEMENTARY DNA; LYSINE; PEPSIN A; PEPSTATIN; PREGNANCY ASSOCIATED PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATTLE; CHORION; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HORSE; MOLECULAR MODEL; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SHEEP; SWINE; UNGULATE;

BOS TAURUS; BOVINAE; EQUIDAE; EQUUS CABALLUS; OVIS; OVIS ARIES; SUIDAE; SUS SCROFA; UNGULATA;

EID: 0029975814     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.10.849     Document Type: Article

References (37)

1. Abola, E.E., Bernstein, F.C., Bryant, S.H., Koetzle, T.F. and Weng, J. (1987) In Allen, F.H., Bergerhoff, G. and Sievers, R. (eds), Cristallographic Databases - Information Content, Software Systems, Scientific Applications. Data Commission of the International Union of Crystallography, Bonn, pp. 107-132.
2. Atkinson, Y.H., Gogolin-Ewens, K.J., Hounsell, E.F. Davies, M.J., Brandon, M.R. and Seamark, R.F. (1993) J. Biol. Chem., 268, 26679-26685.
3. Baldwin, E.T., et al. (1993) Proc. Natl Acad. Sci. USA, 90, 6796-6800.
4. Bernstein, F.C. et al. (1977) J. Mol. Biol., 112, 535-542.
5. Cooper, J.B., Khan, G., Taylor, G., Tickle, I.J. and Blundell, T.L. (1990) J. Mol. Biol., 214, 199-222.
6. Davies, D.R. (1990) Annu. Rev. Biophys. Chem., 19, 189-215.
7. DeAlwis, C.G. et al. (1994) J. Mol. Biol., 236, 342-360.
8. Fitsch, W.M. and Margoliash, E. (1967) Science, 155, 279-284.
9. Green, J., Xie, S., Newman, A., Szafranska, B., Roberts, R.M., Baker, C.B. and McDowell, K. (1994) Biol. Reproduct., 50 (Suppl. 1), 152 (Abstract).
10. Guruprasad, K., Törmäkangas, K., Kervinen, J. and Blundell, T.L. (1994) FEBS Lett., 352, 131-136.
11. Haigh, J.C. Gates, C., Ruder, A. and Sasser, R. (1991) Theriogenology, 36, 749-754.
12. Houston, D.B., Robbins, C.T., Ruder, C.A. and Sasser, R.G. (1986) J. Wildl. Manage., 50, 740-742.
13. Humblot, P., Camous, S., Martal, J., Charlery, J., Jeanguyot, N., Thibier, M. and Sasser, R.G. (1988) Theriogenology, 30, 257-268.
14. Johnson, M.S., Overington, J.P. and Blundell, T.L. (1993) J. Mol. Biol., 231, 735-752.
15. Jones, T.A. and Thirup, S. (1986) EMBO J., 5, 819-822.
16. Laskowski, R.A., MacArthur, M.W., Moss, D.S. and Thornton, J.M. (1993) J. Appl. Crystallogr., 26, 283-291.
17. Nagel, R.J., Xie, S. and Roberts, R.M. (1993) Biol. Reproduct., 48 (Suppl 1), 139 (abstract).
18. Naik, C.R., Guruprasad, K., Batley, B., Rapundalo, S., Hill, J., Blundell, T. Kay, J. and Dunn, B.M. (1995) Proteins: Struct. Funct. Genet., 22, 168-181.
19. Newman, M., Safro, M., Frazao, C., Khan, G., Zdanov, A., Tickle, I.J., Blundell, T.L. and Andreeva, N. (1991). J. Mol. Biol., 221, 1295-1309.
20. Nichols, A. and Honig, B. (1991) J. Comput. Chem., 12, 435-445.
21. Roberts, R.M., Kramer, K.K., Xie, S., Duffy, J., Nagel, R.J. and Wooding, F.B.P. (1994) In Mastroianni, L., Coelingh Bennink, H.J.T., Suzuki, S. and Vemer, H.M.G. (eds), Gamete and Embryo Quality. Parthenon Publishing, London, pp. 209-223.
22. Ruder, C.A., Stellflug, J.N., Dahmen, J.J. and Sasser, R.G. (1988) Theriogenology, 29, 905-912.
23. Sasser, R.G., Ruder, C.A., Ivani, K.A., Butler, J.E. and Hamilton, W.C. (1986) Biol. Reproduct., 35, 936-942.
24. Scarborough, P.E. and Dunn, B.M. (1994) Protein Engng, 7, 495-502.
25. Scarborough, P.E., Guruprasad, K., Topham, C., Richo, G.R., Conner, G.E., Blundell, T.L. and Dunn, B.M. (1993) Protein Sci., 2, 264-276.
26. Sutcliffe, M.J., Haneef, L. Carney, D. and Blundell, T.L. (1987a) Protein Engng. 1, 377-384.
27. Sutcliffe, M.J., Hayes, F.R.F. and Blundell, T.L. (1987b) Protein Engng, 1, 385-392.
28. Szafranska, B., Xie, S., Green, J. and Roberts, R.M. (1995) Biol. Reproduct., 53, 21-28.
29. Tang, J. and Wong, R.N.S. (1987) J. Cell. Biochem., 33, 53-63.
30. Van Soest, E. (1982) Nutritional Ecology of the Ruminant. O&B Books, New York.
31. Warren, W.C., Liang, R., Krivi, G.G., Siegel, N.R. and Anthony, R.V. (1990) J. Endocrinol., 126, 141-149.
32. Wood, A.K., Short, R.E., Darling, A.-E., Dusek, G.L. Sasser, R.G. and Ruder, C.A. (1986) J. Wildl. Manage., 50, 684-687.
33. Xie, S., Low, B.G., Kramer, K.K., Nagel, R.J., Anthony, R.V., Zoli, A.P., Beckers, J.-F. and Roberts, R.M. (1991) Proc. Natl Acad. Sci. USA, 88, 10247-10251.
34. Xie, S., Low, B.G., Nagel, R.J., Beckers, J.-F. and Roberts, R.M. (1994) Biol. Reproduct., 51, 1145-1153.
35. Xie, S., Green, J., Beckers, J.-F. and Roberts, R.M. (1996) Gene, in press.
36. Zoli, A.P., Demez, P., Beckers, J.F., Reznik, M. and Beckers, A. (1992a) Biol. Reproduct., 46, 623-629.
37. Zoli, A.P., Guilbault, L.A., Delabaut, P., Ortiz, W.B. and Beckers, J.F. (1992b) Biol. Reproduct., 46, 83-92.